Functional polymorphisms of the brain serotonin synthesizing enzyme tryptophan hydroxylase-2. (Q36353771)

13 August 2017

8 references

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Functional polymorphisms of the brain serotonin synthesizing enzyme tryptophan hydroxylase-2. (English)

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13 August 2017

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21 April 2021

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12 September 2019

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14 September 2019

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28 September 2019

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7 November 2019

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29 April 2021

2

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13 August 2017

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M G Caron

1 reference

13 August 2017

X Zhang

1

1 reference

13 August 2017

1 January 2006

9 references

Cellular and Molecular Life Sciences

13 August 2017

19 June 2019

30 June 2019

12 September 2019

14 September 2019

28 September 2019

7 November 2019

21 April 2021

29 April 2021

9 references

13 August 2017

19 June 2019

30 June 2019

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7 November 2019

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63

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13 August 2017

1

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6-11

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https://scigraph.springernature.com/pub.10.1007/s00018-005-5417-4

13 August 2017

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cites work

Transmission disequilibrium of polymorphic variants in the tryptophan hydroxylase-2 gene in attention-deficit/hyperactivity disorder

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Analysis of tryptophan hydroxylase I and II mRNA expression in the human brain: a post-mortem study

30 September 2017

1 reference

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Tryptophan hydroxylase 2 (TPH2) gene variants associated with ADHD.

30 September 2017

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5-HTTLPR polymorphism impacts human cingulate-amygdala interactions: a genetic susceptibility mechanism for depression

30 September 2017

1 reference

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Possible association between autism and variants in the brain-expressed tryptophan hydroxylase gene (TPH2).

30 September 2017

1 reference

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Suicidal behavior: relationship between phenotype and serotonergic genotype

30 September 2017

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Loss-of-function mutation in tryptophan hydroxylase-2 identified in unipolar major depression

30 September 2017

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Correction of kinetic and stability defects by tetrahydrobiopterin in phenylketonuria patients with certain phenylalanine hydroxylase mutations

30 September 2017

1 reference

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Single nucleotide polymorphism and haplotype analysis of a novel tryptophan hydroxylase isoform (TPH2) gene in suicide victims

30 September 2017

1 reference

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Lessons from models of SOD1-linked familial ALS.

30 September 2017

1 reference

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Discovering endophenotypes for major depression

30 September 2017

1 reference

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Molecular genetics of autism spectrum disorder.

30 September 2017

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Gene-environment interaction and the genetics of depression

30 September 2017

1 reference

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Identification of genetic variants in the neuronal form of tryptophan hydroxylase (TPH2).

30 September 2017

1 reference

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SNP and haplotype analysis of a novel tryptophan hydroxylase isoform (TPH2) gene provide evidence for association with major depression

30 September 2017

1 reference

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Pharmacogenetics of psychotropic drug response

30 September 2017

1 reference

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Recent advances in the neurobiology of schizophrenia

30 September 2017

1 reference

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Disruption of the nonneuronal tph1 gene demonstrates the importance of peripheral serotonin in cardiac function

30 September 2017

1 reference

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Influence of life stress on depression: moderation by a polymorphism in the 5-HTT gene

30 September 2017

1 reference

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Genetics of the serotonergic system in suicidal behavior

30 September 2017

1 reference

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Phenylketonuria: genotype-phenotype correlations based on expression analysis of structural and functional mutations in PAH.

30 September 2017

1 reference

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How PAH gene mutations cause hyper-phenylalaninemia and why mechanism matters: insights from in vitro expression

30 September 2017

1 reference

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PAHdb 2003: what a locus-specific knowledgebase can do.

30 September 2017

1 reference

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A polygenic basis for late-onset disease

30 September 2017

1 reference

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Synthesis of serotonin by a second tryptophan hydroxylase isoform

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2792355

Different data from different labs: lessons from studies of gene-environment interaction

30 September 2017

1 reference

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Three-dimensional structure of human tryptophan hydroxylase and its implications for the biosynthesis of the neurotransmitters serotonin and melatonin

30 September 2017

1 reference

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Listening to silence and understanding nonsense: exonic mutations that affect splicing

30 September 2017

1 reference

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A silent mutation induces exon skipping in the phenylalanine hydroxylase gene in phenylketonuria

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2792355

Putative mechanisms of action of antidepressant drugs in affective and anxiety disorders and pain.

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2792355

Genetics of childhood disorders: XXIII. ADHD, Part 7: The serotonin system

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2792355

Tetrahydropterin-dependent amino acid hydroxylases

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2792355

Immunohistochemical localization of tryptophan hydroxylase in the human and rat gastrointestinal tracts

30 September 2017

1 reference

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Role of serotonin in the paradoxical calming effect of psychostimulants on hyperactivity

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2792355

Association of anxiety-related traits with a polymorphism in the serotonin transporter gene regulatory region

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2792355

The human serotonin N-acetyltransferase (EC 2.3.1.87) gene (AANAT): structure, chromosomal localization, and tissue expression

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2792355

Genetic analysis of different kinds of aggressive behavior

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2792355

High-level expression and deletion mutagenesis of human tryptophan hydroxylase

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2792355

Molecular cloning and characterization of cDNA encoding tryptophan hydroxylase from rat central serotonergic neurons

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2792355

Establishment of a noradrenergic clonal line of rat adrenal pheochromocytoma cells which respond to nerve growth factor

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2792355

Antidepressant-like effects in various mice strains in the tail suspension test

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2792355

Association between Tph2 gene polymorphism, brain tryptophan hydroxylase activity and aggressiveness in mouse strains

29 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2792355

Strain-dependent antidepressant-like effects of citalopram in the mouse tail suspension test

22 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2792355

Haplotype-based linkage of tryptophan hydroxylase 2 to suicide attempt, major depression, and cerebrospinal fluid 5-hydroxyindoleacetic acid in 4 populations

22 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2792355

Genotype-dependent activity of tryptophan hydroxylase-2 determines the response to citalopram in a mouse model of depression.

22 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2792355

Transmission disequilibrium of polymorphic variants in the tryptophan hydroxylase-2 gene in children and adolescents with obsessive-compulsive disorder

22 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2792355

An mTph2 SNP gives rise to alterations in extracellular 5-HT levels, but not in performance on a delayed-reinforcement task

22 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2792355

Lack of association of TPH2 exon XI polymorphisms with major depression and treatment resistance.

22 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2792355

Promoter polymorphism of second tryptophan hydroxylase isoform (TPH2) in schizophrenia and suicidality

22 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2792355

Serotonin synthesis by two distinct enzymes in Drosophila melanogaster

22 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2792355

Different properties of the central and peripheral forms of human tryptophan hydroxylase

22 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2792355

How stress and fluoxetine modulate serotonin 2C receptor pre-mRNA editing.

22 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2792355

Hedgehog and Fgf signaling pathways regulate the development of tphR-expressing serotonergic raphe neurons in zebrafish embryos

22 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2792355

Support for the involvement of TPH2 gene in affective disorders

22 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2792355

Tryptophan hydroxylase-2 controls brain serotonin synthesis

22 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2792355

Analysis of the novel TPH2 gene in bipolar disorder and suicidality

22 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2792355

Investigation of serotonin-related genes in antidepressant response

22 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2792355

Robust and tissue-specific expression of TPH2 versus TPH1 in rat raphe and pineal gland

22 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2792355

A monoclonal antibody to tryptophan hydroxylase: applications and identification of the epitope

22 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2792355

Sensitivity to the effects of pharmacologically selective antidepressants in different strains of mice

22 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2792355

Tryptophan hydroxylation in brain.

22 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2792355

10.1007/S00018-005-5417-4

22 September 2018

Identifiers

DOI

1 reference

13 August 2017

1 reference

13 August 2017

1 reference

PMCID

2792355