CYLD inhibits melanoma growth and progression through suppression of the JNK/AP-1 and β1-integrin signaling pathways (Q36360760)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22832488%20AND%20SRC:MED&resulttype=core&format=json

9 February 2020

title

CYLD inhibits melanoma growth and progression through suppression of the JNK/AP-1 and β1-integrin signaling pathways (English)

1 reference

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9 February 2020

8

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9 February 2020

author name string

Hengning Ke

1

1 reference

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9 February 2020

Christina K Augustine

2

1 reference

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9 February 2020

Vineela D Gandham

3

1 reference

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9 February 2020

Jane Y Jin

4

1 reference

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9 February 2020

Douglas S Tyler

5

1 reference

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9 February 2020

Steven K Akiyama

6

1 reference

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9 February 2020

Russell P Hall

7

1 reference

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9 February 2020

language of work or name

English

0 references

publication date

26 July 2012

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22832488%20AND%20SRC:MED&resulttype=core&format=json

Journal of Investigative Dermatology

9 February 2020

published in

1 reference

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9 February 2020

volume

133

1 reference

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9 February 2020

issue

1

1 reference

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9 February 2020

page(s)

221-229

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Integrin targeted delivery of gene therapeutics

9 February 2020

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3485435

CYLD inhibits tumorigenesis and metastasis by blocking JNK/AP1 signaling at multiple levels

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3485435

CYLD: a deubiquitination enzyme with multiple roles in cancer.

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3485435

c-Jun promotes whereas JunB inhibits epidermal neoplasia

30 September 2017

1 reference

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Integrins: versatile receptors controlling melanocyte adhesion, migration and proliferation

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3485435

Immunotherapy for melanoma: current status and perspectives

30 September 2017

1 reference

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The c-Jun NH2-terminal kinase 2 plays a dominant role in human epidermal neoplasia.

30 September 2017

1 reference

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Phosphorylation of the tumor suppressor CYLD by the breast cancer oncogene IKKepsilon promotes cell transformation

30 September 2017

1 reference

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Increasing burden of melanoma in the United States

30 September 2017

1 reference

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Down-regulation of CYLD expression by Snail promotes tumor progression in malignant melanoma

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3485435

JNK supports survival in melanoma cells by controlling cell cycle arrest and apoptosis.

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3485435

Genistein mediated histone acetylation and demethylation activates tumor suppressor genes in prostate cancer cells

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3485435

Deubiquitinating enzyme CYLD negatively regulates the ubiquitin-dependent kinase Tak1 and prevents abnormal T cell responses

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3485435

The tumor suppressor CYLD regulates entry into mitosis

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3485435

Rewired ERK-JNK signaling pathways in melanoma

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3485435

Tumor necrosis factor receptor 1/c-Jun-NH2-kinase signaling promotes human neoplasia

30 September 2017

1 reference

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Melanoma biology and new targeted therapy

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3485435

Reduced expression of CYLD in human colon and hepatocellular carcinomas

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3485435

Cyld inhibits tumor cell proliferation by blocking Bcl-3-dependent NF-kappaB signaling

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3485435

NF-kappaB activation in melanoma

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3485435

Regulation of T cell development by the deubiquitinating enzyme CYLD

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3485435

The BRG1- and hBRM-associated factor BAF57 induces apoptosis by stimulating expression of the cylindromatosis tumor suppressor gene

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3485435

Negative regulation of JNK signaling by the tumor suppressor CYLD.

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3485435

Conventional and array-based comparative genomic hybridization analyses of novel cell lines harboring HPV18 from glassy cell carcinoma of the uterine cervix.

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3485435

During human melanoma progression AP-1 binding pairs are altered with loss of c-Jun in vitro

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3485435

The tumor suppressor CYLD interacts with TRIP and regulates negatively nuclear factor kappaB activation by tumor necrosis factor

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3485435

The tumour suppressor CYLD negatively regulates NF-kappaB signalling by deubiquitination

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3485435

Loss of the cylindromatosis tumour suppressor inhibits apoptosis by activating NF-kappaB

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3485435

CYLD is a deubiquitinating enzyme that negatively regulates NF-kappaB activation by TNFR family members

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3485435

[Ca2+]i as a potential downregulator of alpha2beta1-integrin-mediated A2058 tumor cell migration to type IV collagen

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3485435

Identification of the familial cylindromatosis tumour-suppressor gene

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3485435

Bcl3, an IkappaB protein, stimulates activating protein-1 transactivation and cellular proliferation

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3485435

Regulation of ubiquitin-dependent processes by deubiquitinating enzymes

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3485435

A mechanism for regulation of melanoma invasion. Ligation of alpha6beta1 integrin by laminin G peptides

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3485435

Inhibition of binding of fibronectin to matrix assembly sites by anti-integrin (alpha 5 beta 1) antibodies.

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3485435

Expression of the alpha7beta1 laminin receptor suppresses melanoma growth and metastatic potential.

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3485435

Retinoic acid-induced AP-1 transcriptional activity regulates B16 mouse melanoma growth inhibition and differentiation

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3485435

Collective cell movement in primary melanoma explants: plasticity of cell-cell interaction, beta1-integrin function, and migration strategies.

22 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3485435

Gene mapping and expression analysis of 16q loss of heterozygosity identifies WWOX and CYLD as being important in determining clinical outcome in multiple myeloma

22 September 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22832488

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Spiradenocylindroma of the kidney: clinical and genetic findings suggesting a role of somatic mutation of the CYLD1 gene in the oncogenesis of an unusual renal neoplasm

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22832488

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identification of a novel anti-integrin monoclonal antibody that recognises a ligand-induced binding site epitope on the β1 subunit

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22832488

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1038/JID.2012.253

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22832488%20AND%20SRC:MED&resulttype=core&format=json

9 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22832488%20AND%20SRC:MED&resulttype=core&format=json

9 February 2020

PubMed publication ID

22832488

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22832488%20AND%20SRC:MED&resulttype=core&format=json