CD4+ but not CD8+ cells are essential for allorejection (Q36367566)

13 August 2017

CD4+ but not CD8+ cells are essential for allorejection (English)

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13 August 2017

N R Krieger

1

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13 August 2017

D P Yin

series ordinal

2

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13 August 2017

C G Fathman

series ordinal

3

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13 August 2017

language of work or name

English

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publication date

1 November 1996

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Journal of Experimental Medicine

13 August 2017

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13 August 2017

184

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13 August 2017

5

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13 August 2017

2013-2018

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Knock-out mice: a new tool for transplantation immunologists.

13 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2192869

Characterization of the Murine Antigenic Determinant, Designated L3T4a, Recognized by Monoclonal Antibody GK 1.5: Expression of L3T4a by Functional T Cell Clones Appears to Correlate Primarily with Class II MHC Antigen-Reactivity

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2192869

Cellular mechanisms in neonatal and adult tolerance

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2192869

Evidence for involvement of dual-function T cells in rejection of MHC class I disparate skin grafts. Assessment of MHC class I alloantigens as in vivo helper determinants

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2192869

Phenotype, specificity, and function of T cell subsets and T cell interactions involved in skin allograft rejection

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2192869

Normal development and function of CD8+ cells but markedly decreased helper cell activity in mice lacking CD4

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2192869

Cells mediating allograft rejection.

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2192869

Cellular basis of skin allograft rejection across a class I major histocompatibility barrier in mice depleted of CD8+ T cells in vivo

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2192869

CD8 is needed for development of cytotoxic T cells but not helper T cells

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2192869

Uncovered skin grafts in mice

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2192869

Alloreactive cytotoxic T cells can develop and function in mice lacking both CD4 and CD8.

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2192869

Evidence that clonal anergy is induced in thymic migrant cells after anti-CD4-mediated transplantation tolerance.

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2192869

Effect of anti-CD4 on CD4 subsets. I. Anti-CD4 preferentially deletes resting, naive CD4 cells and spares activated CD4 cells.

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2192869

Transplantation tolerance induced by antigen pretreatment and depleting anti-CD4 antibody depends on CD4+ T cell regulation during the induction phase of the response

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2192869

The influence of MHC and non-MHC genes on the nature of murine cardiac allograft rejection. I. Kinetic analysis of mononuclear cell infiltrate and MHC-class I/class II expression in donor tissue

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2192869

The induction of skin graft tolerance in major histocompatibility complex-mismatched or primed recipients: primed T cells can be tolerized in the periphery with anti-CD4 and anti-CD8 antibodies

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2192869

Anti-CD8 Abrogates Effect of Anti-CD4–Mediated Islet Allograft Survival in Rat Model

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2192869

T-cell subsets and suppressor cells in human bone marrow

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2192869

CD4-negative cytotoxic T cells with a T cell receptor alpha/beta intermediate expression in CD8-deficient mice.

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2192869

Primarily vascularized allografts of hearts in mice. The role of H-2D, H-2K, and non-H-2 antigens in rejection

21 September 2018

1 reference

12 December 2020

Adoptively transferred CD4+ lymphocytes from CD8 -/- mice are sufficient to mediate the rejection of MHC class II or class I disparate skin grafts

1 reference

12 December 2020

Therapy with monoclonal antibodies by elimination of T-cell subsets in vivo

1 reference

12 December 2020

Immune mechanisms in organ allograft rejection. V. Pivotal role of the cytotoxic-suppressor T cell subset in the rejection of heart grafts bearing isolated class I disparities in the inbred rat

1 reference

12 December 2020

The role of H-2 and non-H-2 antigens and genes in the rejection of murine cardiac allografts

1 reference

12 December 2020

Rejection of murine cardiac allografts. I. Relative roles of major and minor antigens

1 reference

12 December 2020

Monoclonal antibodies to promote marrow engraftment and tissue graft tolerance

1 reference

12 December 2020

Islet allograft survival after a single course of treatment of recipient with antibody to L3T4

1 reference

12 December 2020

CD4 monoclonal antibody pairs for immunosuppression and tolerance induction

1 reference

12 December 2020

The role of class I and class II MHC antigens in the rejection of vascularized heart allografts in mice

1 reference

12 December 2020

Strategies of monoclonal antibody therapy that induce permanent tolerance of organ transplants

1 reference

12 December 2020

The role of CD8+ and CD4+ cells in islet allograft rejection

1 reference

12 December 2020

Tolerance in the mouse to major histocompatibility complex-mismatched heart allografts, and to rat heart xenografts, using monoclonal antibodies to CD4 and CD8

1 reference

12 December 2020

The assessment of transplantation tolerance induced by anti-CD4 monoclonal antibody in the murine model

1 reference

12 December 2020

Comparison of CD4 depleting and nondepleting monoclonal antibodies in the mouse heart allograft model

1 reference

12 December 2020

Tolerance induction with anti-CD8 monoclonal antibodies in the mouse heart transplant model

1 reference

12 December 2020

CD4-positive suppressor cells block allotransplant rejection

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12 December 2020

MHC class I expression and CD8+ T cell development in TAP1/β2-microglobulin double mutant mice

1 reference

12 December 2020

Tissue-specific effects of anti-CD4 therapy in induction of allograft unresponsiveness in high and low responder rats

1 reference

12 December 2020

Identifiers

DOI

10.1084/JEM.184.5.2013

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13 August 2017

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13 August 2017

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