Failure to censor forbidden clones of CD4 T cells in autoimmune diabetes. (Q36371424)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12417628%20AND%20SRC:MED&resulttype=core&format=json

14 December 2019

title

Failure to censor forbidden clones of CD4 T cells in autoimmune diabetes (English)

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14 December 2019

1

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14 December 2019

Chris Goodnow

6

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14 December 2019

author name string

Suzanne B Hartley

2

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14 December 2019

Srinivas Akkaraju

3

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14 December 2019

Judith Wilson

4

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14 December 2019

Michelle Townsend

5

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14 December 2019

language of work or name

English

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publication date

1 November 2002

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Journal of Experimental Medicine

14 December 2019

published in

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14 December 2019

volume

196

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14 December 2019

issue

9

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14 December 2019

page(s)

1175-1188

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Understanding autoimmune diabetes: insights from mouse models.

14 December 2019

cites work

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NKT cells derive from double-positive thymocytes that are positively selected by CD1d

30 September 2017

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Tolerance to islet autoantigens in type 1 diabetes

30 September 2017

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B7/CD28 costimulation is essential for the homeostasis of the CD4+CD25+ immunoregulatory T cells that control autoimmune diabetes

30 September 2017

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30 September 2017

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Thymus and autoimmunity: production of CD25+CD4+ naturally anergic and suppressive T cells as a key function of the thymus in maintaining immunologic self-tolerance

30 September 2017

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30 September 2017

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Analysis of the role of variation of major histocompatibility complex class II expression on nonobese diabetic (NOD) peripheral T cell response

30 September 2017

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CD4 T cell tolerance to human C-reactive protein, an inducible serum protein, is mediated by medullary thymic epithelium

30 September 2017

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Endogenous myelin basic protein inactivates the high avidity T cell repertoire

30 September 2017

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The Fas/Fas ligand pathway and Bcl-2 regulate T cell responses to model self and foreign antigens

30 September 2017

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Autoreactivity of T cells from nonobese diabetic mice: an I-Ag7-dependent reaction

30 September 2017

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The nonobese diabetic mouse as a model of autoimmune diabetes: immune dysregulation gets the NOD.

30 September 2017

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An autoimmune disease, APECED, caused by mutations in a novel gene featuring two PHD-type zinc-finger domains

30 September 2017

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Positional cloning of the APECED gene

30 September 2017

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Spontaneous autoimmune diabetes in monoclonal T cell nonobese diabetic mice

30 September 2017

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Impaired plasma membrane targeting of Grb2-murine son of sevenless (mSOS) complex and differential activation of the Fyn-T cell receptor (TCR)-zeta-Cbl pathway mediate T cell hyporesponsiveness in autoimmune nonobese diabetic mice

30 September 2017

1 reference

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Apoptosis resistance of nonobese diabetic peripheral lymphocytes linked to the Idd5 diabetes susceptibility region

30 September 2017

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I-E+ nonobese diabetic mice develop insulitis and diabetes

30 September 2017

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Evidence that the T cell repertoire of normal rats contains cells with the potential to cause diabetes. Characterization of the CD4+ T cell subset that inhibits this autoimmune potential

30 September 2017

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T-cell tolerance toward a transgenic beta-cell antigen and transcription of endogenous pancreatic genes in thymus

30 September 2017

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Resting and anergic B cells are defective in CD28-dependent costimulation of naive CD4+ T cells.

30 September 2017

1 reference

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Genetic and pathogenic basis of autoimmune diabetes in NOD mice

30 September 2017

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Genetic control of autoimmune diabetes in the NOD mouse

30 September 2017

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Tolerance induced by thymic epithelial grafts in birds

30 September 2017

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Identification of the T-cell and Ia contact residues of a T-cell antigenic epitope

30 September 2017

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The murine autoimmune diabetes model: NOD and related strains

30 September 2017

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Evidence for a thymus-dependent form of tolerance that is not based on elimination or anergy of reactive T cells

30 September 2017

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Differential tolerance is induced in T cells recognizing distinct epitopes of myelin basic protein.

30 September 2017

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CD4+CD25+ T cells inhibit both the induction and effector function of autoreactive T cells and represent a unique lineage of immunoregulatory cells.

28 June 2018

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Analysis of susceptibility of NOD mice to spontaneous and experimentally induced thyroiditis

28 June 2018

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The insulin gene is transcribed in the human thymus and transcription levels correlated with allelic variation at the INS VNTR-IDDM2 susceptibility locus for type 1 diabetes.

28 June 2018

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Insulin expression in human thymus is modulated by INS VNTR alleles at the IDDM2 locus.

28 June 2018

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Iodine-induced autoimmune thyroiditis in NOD-H-2h4 mice.

28 June 2018

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Polygenic control of autoimmune diabetes in nonobese diabetic mice.

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2194101

Ablation of "tolerance" and induction of diabetes by virus infection in viral antigen transgenic mice

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2194101

Genetic analysis of autoimmune type 1 diabetes mellitus in mice

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2194101

The NOD mouse: recessive diabetogenic gene in the major histocompatibility complex

28 June 2018

1 reference

https://api.crossref.org/works/10.1084%2FJEM.20020735

Transgenic mice that express a myelin basic protein-specific T cell receptor develop spontaneous autoimmunity

21 January 2018

1 reference

https://api.crossref.org/works/10.1084%2FJEM.20020735

A range of CD4 T cell tolerance: partial inactivation to organ-specific antigen allows nondestructive thyroiditis or insulitis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1084%2FJEM.20020735

Promiscuous gene expression in medullary thymic epithelial cells mirrors the peripheral self.

21 January 2018

1 reference

https://api.crossref.org/works/10.1084%2FJEM.20020735

Pancreatic gene expression in rare cells of thymic medulla: evidence for functional contribution to T cell tolerance

21 January 2018

1 reference

https://api.crossref.org/works/10.1084%2FJEM.20020735

Shaping of the autoreactive T-cell repertoire by a splice variant of self protein expressed in thymic epithelial cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1084%2FJEM.20020735

NOD Idd5 locus controls insulitis and diabetes and overlaps the orthologous CTLA4/IDDM12 and NRAMP1 loci in humans.

21 January 2018

1 reference

https://api.crossref.org/works/10.1084%2FJEM.20020735

Subcongenic analysis of the Idd13 locus in NOD/Lt mice: evidence for several susceptibility genes including a possible diabetogenic role for beta 2-microglobulin.

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2194101

Autoimmune diabetes as a consequence of locally produced interleukin-2

21 September 2018

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Autoimmune diseases: the failure of self tolerance

21 January 2018

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Early quantitative and functional deficiency of NK1+-like thymocytes in the NOD mouse

21 January 2018

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Association between alphabetaTCR+CD4-CD8- T-cell deficiency and IDDM in NOD/Lt mice

21 January 2018

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A defect in central tolerance in NOD mice

21 January 2018

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Defective CD8+ T Cell Peripheral Tolerance in Nonobese Diabetic Mice

21 January 2018

1 reference

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High incidence of spontaneous autoimmune encephalomyelitis in immunodeficient anti-myelin basic protein T cell receptor transgenic mice

21 January 2018

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A role for non-MHC genetic polymorphism in susceptibility to spontaneous autoimmunity

21 January 2018

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On the various manifestations of spontaneous autoimmune diabetes in rodent models

21 January 2018

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https://api.crossref.org/works/10.1084%2FJEM.20020735

Following a diabetogenic T cell from genesis through pathogenesis

21 January 2018

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Genetic control of diabetes progression

21 January 2018

1 reference

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Thymic selection of CD4+CD25+ regulatory T cells induced by an agonist self-peptide

21 January 2018

1 reference

https://api.crossref.org/works/10.1084%2FJEM.20020735

Type 1 diabetes and the control of dexamethazone-induced apoptosis in mice maps to the same region on chromosome 6

21 January 2018

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https://api.crossref.org/works/10.1084%2FJEM.20020735

Programmed cell death in the pathogenesis of murine IDDM: resistance to apoptosis induced in lymphocytes by cyclophosphamide

21 January 2018

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Crosses of NOD mice with the related NON strain. A polygenic model for IDDM

21 January 2018

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https://api.crossref.org/works/10.1084%2FJEM.20020735

Normal lymphoid homeostasis and lack of lethal autoimmunity in mice containing mature T cells with severely impaired IL-2 receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1084%2FJEM.20020735

RNA and protein expression of the murine autoimmune regulator gene (Aire) in normal, RelB-deficient and in NOD mouse

21 January 2018

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https://api.crossref.org/works/10.1084%2FJEM.20020735

21 January 2018

12 December 2020

Antigen concentration and precursor frequency determine the rate of CD8+ T cell tolerance to peripherally expressed antigens

1 reference

PubMed

12 December 2020

Defective activation of T suppressor cell function in nonobese diabetic mice. Potential relation to cytokine deficiencies

1 reference

PubMed

12 December 2020

Two mechanisms for the non-MHC-linked resistance to spontaneous autoimmunity

1 reference

PubMed

12 December 2020

Identifiers

DOI

10.1084/JEM.20020735

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12417628%20AND%20SRC:MED&resulttype=core&format=json

14 December 2019

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12417628%20AND%20SRC:MED&resulttype=core&format=json

14 December 2019

1 reference