O-acetylation of GD3: an enigmatic modification regulating apoptosis? (Q36376625)

13 August 2017

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O-acetylation of GD3: an enigmatic modification regulating apoptosis? (English)

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13 August 2017

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Helen Y Chen

1

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13 August 2017

Ajit Varki

series ordinal

2

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13 August 2017

language of work or name

English

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publication date

1 December 2002

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Journal of Experimental Medicine

13 August 2017

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13 August 2017

196

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13 August 2017

12

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13 August 2017

1529-1533

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Acetylation suppresses the proapoptotic activity of GD3 ganglioside.

13 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2196069

Trafficking of ganglioside GD3 to mitochondria by tumor necrosis factor-alpha

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2196069

Mitochondria as sensors of sphingolipids

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2196069

Combinatorial ganglioside biosynthesis

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2196069

Chemical diversity in the sialic acids and related alpha-keto acids: an evolutionary perspective.

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2196069

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2196069

Organelle-specific initiation of cell death pathways

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2196069

GD3 glycosphingolipid contributes to Fas-mediated apoptosis via association with ezrin cytoskeletal protein

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2196069

Bid, a widely expressed proapoptotic protein of the Bcl-2 family, displays lipid transfer activity.

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2196069

Inhibition of integrin-linked kinase/protein kinase B/Akt signaling: mechanism for ganglioside-induced apoptosis

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2196069

Analysis of therapeutic and immunologic effects of R(24) anti-GD3 monoclonal antibody in 37 patients with metastatic melanoma

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2196069

Cloning and expression of glycolipid transfer protein from bovine and porcine brain

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2196069

Caspase cleaved BID targets mitochondria and is required for cytochrome c release, while BCL-XL prevents this release but not tumor necrosis factor-R1/Fas death

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2196069

Acidic sphingomyelinase (ASM) is necessary for fas-induced GD3 ganglioside accumulation and efficient apoptosis of lymphoid cells

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2196069

Requirement for GD3 ganglioside in CD95- and ceramide-induced apoptosis.

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2196069

Functional rafts in cell membranes

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2196069

Linkage-specific action of endogenous sialic acid O-acetyltransferase in Chinese hamster ovary cells

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2196069

A unique mitochondria-associated membrane fraction from rat liver has a high capacity for lipid synthesis and contains pre-Golgi secretory proteins including nascent lipoproteins

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2196069

Mouse monoclonal IgG3 antibody detecting GD3 ganglioside: a phase I trial in patients with malignant melanoma

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2196069

Apoptotic signaling through CD95 (Fas/Apo-1) activates an acidic sphingomyelinase.

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2196069

De-N-acetyl-gangliosides in humans: unusual subcellular distribution of a novel tumor antigen.

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2196069

Down-regulation of the expression of O-acetyl-GD3 by the O-acetylesterase cDNA in hamster melanoma cells: effects on cellular proliferation, differentiation, and melanogenesis

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2196069

A cell surface molecule distributed in a dorsoventral gradient in the perinatal rat retina

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2196069

A gradient molecule in developing rat retina: expression of 9-O-acetyl GD3 in relation to cell type, developmental age, and GD3 ganglioside

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2196069

Developmental changes in ganglioside composition and synthesis in embryonic rat brain.

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2196069

Developmental abnormalities in transgenic mice expressing a sialic acid-specific 9-O-acetylesterase

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2196069

Expression and function of ganglioside 9-O-acetyl GD3 in postmitotic granule cell development.

28 June 2018

1 reference

https://api.crossref.org/works/10.1084%2FJEM.20021915

CDW60, which identifies the acetylated form of GD3 gangliosides, is strongly expressed in human basal cell carcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1084%2FJEM.20021915

The T lymphocyte structure CD60 contains a sialylated carbohydrate epitope that is expressed on both gangliosides and glycoproteins.

21 January 2018

1 reference

https://api.crossref.org/works/10.1084%2FJEM.20021915

GD3 recruits reactive oxygen species to induce cell proliferation and apoptosis in human aortic smooth muscle cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1084%2FJEM.20021915

Incorporation of ganglioside analogs into fibroblast cell membranes. A spin-label study

21 January 2018

1 reference

https://api.crossref.org/works/10.1084%2FJEM.20021915

Probing for preferential interactions among sphingolipids in bilayer vesicles using the glycolipid transfer protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1084%2FJEM.20021915

Characterization of the acid stability of glycosidically linked neuraminic acid: use in detecting de-N-acetyl-gangliosides in human melanoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1084%2FJEM.20021915

Characterization of a hamster melanoma-associated ganglioside antigen as 7-O-acetylated disialoganglioside GD3.

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2196069

GD3 ganglioside directly targets mitochondria in a bcl-2-controlled fashion

21 September 2018

1 reference

https://api.crossref.org/works/10.1084%2FJEM.20021915

Ceramide generated by acidic sphingomyelinase contributes to tumor necrosis factor-α-mediated apoptosis in human colon HT-29 cells through glycosphingolipids formation

21 January 2018

1 reference

https://api.crossref.org/works/10.1084%2FJEM.20021915

O-acetylation of disialoganglioside GD3 by human melanoma cells creates a unique antigenic determinant

21 January 2018

1 reference

https://api.crossref.org/works/10.1084%2FJEM.20021915

7-O-acetyl-GD3 in human T-lymphocytes is detected by a specific T-cell-activating monoclonal antibody

21 January 2018

1 reference

https://api.crossref.org/works/10.1084%2FJEM.20021915

Apoptogenic ganglioside GD3 directly induces the mitochondrial permeability transition

21 January 2018

1 reference

https://api.crossref.org/works/10.1084%2FJEM.20021915

b-series Ganglioside deficiency exhibits no definite changes in the neurogenesis and the sensitivity to Fas-mediated apoptosis but impairs regeneration of the lesioned hypoglossal nerve

21 January 2018

1 reference

https://api.crossref.org/works/10.1084%2FJEM.20021915

Beta-amyloid-induced synthesis of the ganglioside GD3 is a requisite for cell cycle reactivation and apoptosis in neurons

21 January 2018

1 reference

12 December 2020

Analysis of the antibody response to immunization with purified O-acetyl GD3 gangliosides in patients with malignant melanoma

1 reference

12 December 2020

Role of acetylated gangliosides on neurite extension

1 reference

12 December 2020

The D1.1 antigen: a cell surface marker for germinal cells of the central nervous system

1 reference

12 December 2020

Expression of GD3 ganglioside in childhood T-cell lymphoblastic malignancies

1 reference

12 December 2020

Melanoma-associated gangliosides in the fish genus Xiphophorus

1 reference

12 December 2020

Phase I evaluation of a combination of monoclonal antibody R24 and interleukin 2 in patients with metastatic melanoma

1 reference

12 December 2020

CDw60 glycolipid antigens of human leukocytes: structural characterization and cellular distribution

1 reference

12 December 2020

Identifiers

DOI

10.1084/JEM.20021915

1 reference

13 August 2017

1 reference

13 August 2017

PubMed publication ID

12486095

1 reference