Vegetable-derived isothiocyanates: anti-proliferative activity and mechanism of action (Q36379685)

13 August 2017

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title

Vegetable-derived isothiocyanates: anti-proliferative activity and mechanism of action (English)

1 reference

13 August 2017

Yuesheng Zhang

1

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PubMed ID

16441946

13 August 2017

Song Yao

series ordinal

2

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PubMed ID

16441946

13 August 2017

Jun Li

series ordinal

3

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13 August 2017

1 February 2006

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Proceedings of the Nutrition Society

13 August 2017

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13 August 2017

65

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13 August 2017

1

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13 August 2017

68-75

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Allyl isothiocyanate, a constituent of cruciferous vegetables, inhibits growth of PC-3 human prostate cancer xenografts in vivo

13 August 2017

1 reference

https://api.crossref.org/works/10.1079%2FPNS2005475

Cell cycle arrest, apoptosis induction and inhibition of nuclear factor kappa B activation in anti-proliferative activity of benzyl isothiocyanate against human pancreatic cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1079%2FPNS2005475

Allyl-isothiocyanate causes mitotic block, loss of cell adhesion and disrupted cytoskeletal structure in HT29 cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1079%2FPNS2005475

Sulforaphane-induced cell death in human prostate cancer cells is initiated by reactive oxygen species.

21 January 2018

1 reference

https://api.crossref.org/works/10.1079%2FPNS2005475

Sulforaphane-induced G2/M phase cell cycle arrest involves checkpoint kinase 2-mediated phosphorylation of cell division cycle 25C.

21 January 2018

1 reference

https://api.crossref.org/works/10.1079%2FPNS2005475

Sulforaphane induces caspase-mediated apoptosis in cultured PC-3 human prostate cancer cells and retards growth of PC-3 xenografts in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1079%2FPNS2005475

Oxidative stress and cell cycle checkpoint function.

21 January 2018

1 reference

https://api.crossref.org/works/10.1079%2FPNS2005475

Dietary isothiocyanates, glutathione S-transferase polymorphisms and colorectal cancer risk in the Singapore Chinese Health Study

21 January 2018

1 reference

https://api.crossref.org/works/10.1079%2FPNS2005475

Regulation of bad phosphorylation and association with Bcl-x(L) by the MAPK/Erk kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1079%2FPNS2005475

beta-Phenylethyl isothiocyanate-mediated apoptosis in hepatoma HepG2 cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1079%2FPNS2005475

Beta-phenylethyl isothiocyanate mediated apoptosis; contribution of Bax and the mitochondrial death pathway.

21 January 2018

1 reference

https://api.crossref.org/works/10.1079%2FPNS2005475

Reactive oxygen species-related induction of multidrug resistance-associated protein 2 expression in primary hepatocytes exposed to sulforaphane

21 January 2018

1 reference

https://api.crossref.org/works/10.1079%2FPNS2005475

Involvement of the mitochondrial death pathway in chemopreventive benzyl isothiocyanate-induced apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1079%2FPNS2005475

A novel mechanism of chemoprotection by sulforaphane: inhibition of histone deacetylase.

21 January 2018

1 reference

https://api.crossref.org/works/10.1079%2FPNS2005475

Allyl isothiocyanate is selectively toxic to transformed cells of the human colorectal tumour line HT29.

21 January 2018

1 reference

https://api.crossref.org/works/10.1079%2FPNS2005475

A link between benzyl isothiocyanate-induced cell cycle arrest and apoptosis: involvement of mitogen-activated protein kinases in the Bcl-2 phosphorylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1079%2FPNS2005475

A novel form of Epstein-Barr virus latency in normal B cells in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1079%2FPNS2005475

Isothiocyanates. A new class of uncouplers

21 January 2018

1 reference

https://api.crossref.org/works/10.1079%2FPNS2005475

Requirement of a carbon spacer in benzyl isothiocyanate-mediated cytotoxicity and MAPK activation in head and neck squamous cell carcinoma.

21 January 2018

1 reference

https://api.crossref.org/works/10.1079%2FPNS2005475

Isothiocyanates, glutathione S-transferase M1 and T1 polymorphisms, and lung-cancer risk: a prospective study of men in Shanghai, China.

21 January 2018

1 reference

https://api.crossref.org/works/10.1079%2FPNS2005475

The role of c-Jun in the AP-1 activation induced by naturally occurring isothiocyanates

21 January 2018

1 reference

https://api.crossref.org/works/10.1079%2FPNS2005475

Cleavage of BID by caspase 8 mediates the mitochondrial damage in the Fas pathway of apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1079%2FPNS2005475

Induction of histone acetylation in mouse erythroleukemia cells by some organosulfur compounds including allyl isothiocyanate

21 January 2018

1 reference

https://api.crossref.org/works/10.1079%2FPNS2005475

Chemoprevention by isothiocyanates and their underlying molecular signaling mechanisms

21 January 2018

1 reference

https://api.crossref.org/works/10.1079%2FPNS2005475

Effect of organic isothiocyanates on breast cancer resistance protein (ABCG2)-mediated transport

21 January 2018

1 reference

https://api.crossref.org/works/10.1079%2FPNS2005475

Determination of phenethyl isothiocyanate in human plasma and urine by ammonia derivatization and liquid chromatography–tandem mass spectrometry

21 January 2018

1 reference

https://api.crossref.org/works/10.1079%2FPNS2005475

Sulforaphane: a naturally occurring mammary carcinoma mitotic inhibitor, which disrupts tubulin polymerization

21 January 2018

1 reference

https://api.crossref.org/works/10.1079%2FPNS2005475

Allyl isothiocyanate: comparative disposition in rats and mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1079%2FPNS2005475

Comparison of phenethyl and 6-phenylhexyl isothiocyanate-induced toxicity in rat esophageal cell lines with and without glutathione depletion.

21 January 2018

1 reference

https://api.crossref.org/works/10.1079%2FPNS2005475

Effects of benzyl-, phenethyl-, and alpha-naphthyl isothiocyanates on P-glycoprotein- and MRP1-mediated transport

21 January 2018

1 reference

https://api.crossref.org/works/10.1079%2FPNS2005475

The roles of JNK and apoptotic signaling pathways in PEITC-mediated responses in human HT-29 colon adenocarcinoma cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1079%2FPNS2005475

Inhibition of carcinogenesis by isothiocyanates

21 January 2018

1 reference

https://api.crossref.org/works/10.1079%2FPNS2005475

Review: The role of glutathione in the regulation of apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1079%2FPNS2005475

Glucosinolates and their breakdown products in food and food plants

21 January 2018

1 reference

https://api.crossref.org/works/10.1079%2FPNS2005475

Cancer-preventive isothiocyanates: dichotomous modulators of oxidative stress

21 January 2018

1 reference

https://api.crossref.org/works/10.1079%2FPNS2005475

Broccoli sprouts: an exceptionally rich source of inducers of enzymes that protect against chemical carcinogens

21 January 2018

1 reference

https://api.crossref.org/works/10.1079%2FPNS2005475

Expression and regulation of glutathione S-transferase P1-1 in cultured human epidermal cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1079%2FPNS2005475

Isothiocyanates as cancer chemopreventive agents: their biological activities and metabolism in rodents and humans

21 January 2018

1 reference

https://api.crossref.org/works/10.1079%2FPNS2005475

High cellular accumulation of sulphoraphane, a dietary anticarcinogen, is followed by rapid transporter-mediated export as a glutathione conjugate

21 January 2018

1 reference

https://api.crossref.org/works/10.1079%2FPNS2005475

Decomposition rates of isothiocyanate conjugates determine their activity as inhibitors of cytochrome p450 enzymes

21 January 2018

1 reference

https://api.crossref.org/works/10.1079%2FPNS2005475

Cancer-preventive isothiocyanates: measurement of human exposure and mechanism of action.

21 January 2018

1 reference

https://api.crossref.org/works/10.1079%2FPNS2005475

Molecular mechanism of rapid cellular accumulation of anticarcinogenic isothiocyanates

21 January 2018

1 reference

https://api.crossref.org/works/10.1079%2FPNS2005475

Role of glutathione in the accumulation of anticarcinogenic isothiocyanates and their glutathione conjugates by murine hepatoma cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1079%2FPNS2005475

Total intracellular accumulation levels of dietary isothiocyanates determine their activity in elevation of cellular glutathione and induction of Phase 2 detoxification enzymes

21 January 2018

1 reference

https://api.crossref.org/works/10.1079%2FPNS2005475

Quantitative determination of dithiocarbamates in human plasma, serum, erythrocytes and urine: pharmacokinetics of broccoli sprout isothiocyanates in humans

21 January 2018

1 reference

https://api.crossref.org/works/10.1079%2FPNS2005475

Bax and Bak are required for apoptosis induction by sulforaphane, a cruciferous vegetable-derived cancer chemopreventive agent

21 January 2018

1 reference

https://api.crossref.org/works/10.1079%2FPNS2005475

Ingestion of an isothiocyanate metabolite from cruciferous vegetables inhibits growth of human prostate cancer cell xenografts by apoptosis and cell cycle arrest

21 January 2018

1 reference

https://api.crossref.org/works/10.1079%2FPNS2005475

Cellular accumulation of dietary anticarcinogenic isothiocyanates is followed by transporter-mediated export as dithiocarbamates

21 January 2018

1 reference

https://api.crossref.org/works/10.1079%2FPNS2005475

Signal transduction activated by the cancer chemopreventive isothiocyanates: cleavage of BID protein, tyrosine phosphorylation and activation of JNK

21 January 2018

1 reference

https://api.crossref.org/works/10.1079%2FPNS2005475

Oxidative stress as a mediator of apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1079%2FPNS2005475

Involvement of glutathione metabolism in the cytotoxicity of the phenethyl isothiocyanate and its cysteine conjugate to human leukaemia cells in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1079%2FPNS2005475

The metabolism of benzyl isothiocyanate and its cysteine conjugate

21 January 2018

1 reference

https://api.crossref.org/works/10.1079%2FPNS2005475

Studies on the mechanism of the inhibition of human leukaemia cell growth by dietary isothiocyanates and their cysteine adducts in vitro.

21 January 2018

1 reference

https://api.crossref.org/works/10.1079%2FPNS2005475

Death receptors: signaling and modulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1079%2FPNS2005475

Caspase-dependent apoptosis induction by phenethyl isothiocyanate, a cruciferous vegetable-derived cancer chemopreventive agent, is mediated by Bak and Bax.

21 January 2018

1 reference

https://api.crossref.org/works/10.1079%2FPNS2005475

Allyl isothiocyanate, a constituent of cruciferous vegetables, inhibits proliferation of human prostate cancer cells by causing G2/M arrest and inducing apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1079%2FPNS2005475

21 January 2018

Caspases: enemies within

1 reference

https://api.crossref.org/works/10.1079%2FPNS2005475

Mitochondria are the primary target in isothiocyanate-induced apoptosis in human bladder cancer cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1079%2FPNS2005475

Tumor-selective action of HDAC inhibitors involves TRAIL induction in acute myeloid leukemia cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1079%2FPNS2005475

Inhibitors of histone deacetylases induce tumor-selective apoptosis through activation of the death receptor pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1079%2FPNS2005475

21 January 2018

Identifiers

DOI

10.1079/PNS2005475

1 reference

13 August 2017

1 reference

PubMed ID

16441946