β-Site amyloid precursor protein (APP)-cleaving enzyme 1 (BACE1)-deficient mice exhibit a close homolog of L1 (CHL1) loss-of-function phenotype involving axon guidance defects (Q36385744)

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English	β-Site amyloid precursor protein (APP)-cleaving enzyme 1 (BACE1)-deficient mice exhibit a close homolog of L1 (CHL1) loss-of-function phenotype involving axon guidance defects	scientific article

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13 February 2020

β-Site amyloid precursor protein (APP)-cleaving enzyme 1 (BACE1)-deficient mice exhibit a close homolog of L1 (CHL1) loss-of-function phenotype involving axon guidance defects (English)

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13 February 2020

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William A Eimer

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13 February 2020

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Brian Hitt

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13 February 2020

Sean M Riordan

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13 February 2020

Lokesh Kukreja

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13 February 2020

Tharinda W Rajapaksha

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13 February 2020

Robert Vassar

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17 September 2012

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13 February 2020

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Journal of Biological Chemistry

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13 February 2020

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13 February 2020

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13 February 2020

38408-38425

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13 February 2020

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11 June 2022

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A mutation in APP protects against Alzheimer’s disease and age-related cognitive decline

1 reference

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Secretome protein enrichment identifies physiological BACE1 protease substrates in neurons

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1 reference

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12 December 2020

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13 February 2020

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13 February 2020

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13 February 2020

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