Poisoning of human DNA topoisomerase I by ecteinascidin 743, an anticancer drug that selectively alkylates DNA in the minor groove (Q36390575)

13 August 2017

Poisoning of human DNA topoisomerase I by ecteinascidin 743, an anticancer drug that selectively alkylates DNA in the minor groove (English)

1 reference

13 August 2017

Y Takebayashi

1

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13 August 2017

P Pourquier

2

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13 August 2017

A Yoshida

3

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13 August 2017

G Kohlhagen

4

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13 August 2017

Y Pommier

5

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13 August 2017

language of work or name

English

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publication date

1 June 1999

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13 August 2017

6

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Proceedings of the National Academy of Sciences of the United States of America

inferred from page(s)

published in

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13 August 2017

96

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13 August 2017

13

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13 August 2017

7196-7201

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describes a project that uses

13 August 2017

ImageQuant

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11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC22050/fullTextXML

inferred from PubMed Central ID database lookup

cites work

Phthalascidin, a synthetic antitumor agent with potency and mode of action comparable to ecteinascidin 743.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=22050

In vitro antitumor activity of the novel marine agent, ecteinascidin-743 (ET-743, NSC-648766) against human tumors explanted from patients

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=22050

Protein-linked DNA strand breaks induced by NSC 314622, a novel noncamptothecin topoisomerase I poison.

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=22050

DNA sequence- and structure-selective alkylation of guanine N2 in the DNA minor groove by ecteinascidin 743, a potent antitumor compound from the Caribbean tunicate Ecteinascidia turbinata

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=22050

Substituted 2,5'-Bi-1H-benzimidazoles: topoisomerase I inhibition and cytotoxicity

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=22050

Localization of an aminoacridine antitumor agent in a type II topoisomerase-DNA complex

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=22050

Differential stabilization of eukaryotic DNA topoisomerase I cleavable complexes by camptothecin derivatives

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=22050

DNA minor groove-binding ligands: a different class of mammalian DNA topoisomerase I inhibitors.

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=22050

Interaction of an alkylating camptothecin derivative with a DNA base at topoisomerase I-DNA cleavage sites

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=22050

Local sequence requirements for DNA cleavage by mammalian topoisomerase II in the presence of doxorubicin.

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=22050

Effects of morpholinyl doxorubicins, doxorubicin, and actinomycin D on mammalian DNA topoisomerases I and II

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=22050

Bioactive compounds from aquatic and terrestrial sources

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=22050

Additional antitumor ecteinascidins from a Caribbean tunicate: crystal structures and activities in vivo

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=22050

Overexpression of human DNA topoisomerase I in insect cells using a baculovirus vector

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=22050

Analysis of topoisomerase I/DNA complexes in patients administered topotecan.

30 September 2017

1 reference

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Phosphorylation of mammalian DNA topoisomerase I and activation by protein kinase C.

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=22050

Mammalian DNA topoisomerase I activity and poisoning by camptothecin are inhibited by simian virus 40 large T antigen

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=22050

Simple procedure for isolation of DNA, RNA and protein fractions from cultured animal cells

21 September 2018

1 reference

Crossref

https://api.crossref.org/works/10.1073%2FPNAS.96.13.7196

Novel 7-alkyl methylenedioxy-camptothecin derivatives exhibit increased cytotoxicity and induce persistent cleavable complexes both with purified mammalian topoisomerase I and in human colon carcinoma SW620 cells

21 January 2018

1 reference

Crossref

https://api.crossref.org/works/10.1073%2FPNAS.96.13.7196

Differential Poisoning of Topoisomerases by Menogaril and Nogalamycin Dictated by the Minor Groove-Binding Nogalose Sugar†

21 January 2018

1 reference

Crossref

https://api.crossref.org/works/10.1073%2FPNAS.96.13.7196

Camptothecin induces protein-linked DNA breaks via mammalian DNA topoisomerase I

21 January 2018

1 reference

12 December 2020

Isolation of intercalator-dependent protein-linked DNA strand cleavage activity from cell nuclei and identification as topoisomerase II

1 reference

12 December 2020

Effect of local DNA sequence on topoisomerase I cleavage in the presence or absence of camptothecin

1 reference

12 December 2020

Molecular and crystal structures of ecteinascidins: potent antitumor compounds from the Caribbean tunicate Ecteinascidia turbinata

1 reference

12 December 2020

Aclacinomycin A stabilizes topoisomerase I covalent complexes

1 reference

12 December 2020

Ecteinascidin-743, a new marine natural product with potent antitumor activity on human ovarian carcinoma xenografts

1 reference

12 December 2020

Mechanism of action of eukaryotic DNA topoisomerase I and drugs targeted to the enzyme

1 reference

12 December 2020

Rapid purification and characterization of DNA topoisomerase I from cultured mouse mammary carcinoma FM3A cells

1 reference

12 December 2020

Identifiers

DOI

10.1073/PNAS.96.13.7196

1 reference

13 August 2017

0 references

1 reference

13 August 2017

PubMed publication ID

10377391

1 reference