Nrf2 in ischemic neurons promotes retinal vascular regeneration through regulation of semaphorin 6A. (Q36394244)

13 August 2017

Nrf2 in ischemic neurons promotes retinal vascular regeneration through regulation of semaphorin 6A. (English)

1 reference

13 August 2017

Yanhong Wei

1

1 reference

13 August 2017

Junsong Gong

2

1 reference

13 August 2017

Zhenhua Xu

3

1 reference

13 August 2017

Rajesh K Thimmulappa

4

1 reference

13 August 2017

Katherine L Mitchell

5

1 reference

13 August 2017

Derek S Welsbie

6

1 reference

13 August 2017

Shyam Biswal

7

1 reference

13 August 2017

Elia J Duh

8

1 reference

13 August 2017

language of work or name

English

0 references

publication date

30 November 2015

1 reference

Proceedings of the National Academy of Sciences of the United States of America

13 August 2017

1 reference

13 August 2017

112

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13 August 2017

50

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13 August 2017

E6927-36

1 reference

Endothelial PGC-1α mediates vascular dysfunction in diabetes.

13 August 2017

1 reference

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NRF2 plays a protective role in diabetic retinopathy in mice

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4687549

On and off retinal circuit assembly by divergent molecular mechanisms

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4687549

Nrf2 acts cell-autonomously in endothelium to regulate tip cell formation and vascular branching

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4687549

Endothelin-2 signaling in the neural retina promotes the endothelial tip cell state and inhibits angiogenesis

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4687549

Neuronal sirtuin1 mediates retinal vascular regeneration in oxygen-induced ischemic retinopathy.

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4687549

Functional genomic screening identifies dual leucine zipper kinase as a key mediator of retinal ganglion cell death

30 September 2017

1 reference

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Emerging roles of Nrf2 and phase II antioxidant enzymes in neuroprotection

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4687549

Semaphorin 6A regulates angiogenesis by modulating VEGF signaling

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4687549

Endothelial Semaphorin 7A promotes neutrophil migration during hypoxia

30 September 2017

1 reference

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Eyeing central neurons in vascular growth and reparative angiogenesis

30 September 2017

1 reference

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Injury and repair in the neurovascular unit

30 September 2017

1 reference

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Identification of novel NRF2-regulated genes by ChIP-Seq: influence on retinoid X receptor alpha.

30 September 2017

1 reference

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MEF2C ablation in endothelial cells reduces retinal vessel loss and suppresses pathologic retinal neovascularization in oxygen-induced retinopathy

30 September 2017

1 reference

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Disruption of Nrf2 signaling impairs angiogenic capacity of endothelial cells: implications for microvascular aging

30 September 2017

1 reference

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Inhibition of pathological retinal angiogenesis by the integrin αvβ3 antagonist tetraiodothyroacetic acid (tetrac).

30 September 2017

1 reference

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Enhancing Nrf2 pathway by disruption of Keap1 in myeloid leukocytes protects against sepsis

30 September 2017

1 reference

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Semaphorin 3E-Plexin-D1 signaling regulates VEGF function in developmental angiogenesis via a feedback mechanism

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4687549

Nrf2 has a protective role against neuronal and capillary degeneration in retinal ischemia-reperfusion injury

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4687549

Sema3E-PlexinD1 signaling selectively suppresses disoriented angiogenesis in ischemic retinopathy in mice

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4687549

Ischemic neurons prevent vascular regeneration of neural tissue by secreting semaphorin 3A

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4687549

TNFalpha is required for late BRB breakdown in diabetic retinopathy, and its inhibition prevents leukostasis and protects vessels and neurons from apoptosis

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4687549

Role of ROS in ischemia-induced lung angiogenesis

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4687549

The science of stroke: mechanisms in search of treatments

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4687549

Cis interaction between Semaphorin6A and Plexin-A4 modulates the repulsive response to Sema6A

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4687549

The mouse retina as an angiogenesis model

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4687549

Global mapping of binding sites for Nrf2 identifies novel targets in cell survival response through ChIP-Seq profiling and network analysis

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4687549

Inhibition of semaphorin as a novel strategy for therapeutic angiogenesis

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4687549

Quantification of oxygen-induced retinopathy in the mouse: a model of vessel loss, vessel regrowth and pathological angiogenesis

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4687549

Histone H2AX is integral to hypoxia-driven neovascularization

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4687549

Guidance of vascular development: lessons from the nervous system.

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4687549

The Nrf2/ARE pathway as a potential therapeutic target in neurodegenerative disease

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4687549

Cycling hypoxia and free radicals regulate angiogenesis and radiotherapy response

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4687549

Reactive oxygen species regulate angiogenesis and tumor growth through vascular endothelial growth factor

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4687549

Regulation of multiple angiogenic pathways by Dll4 and Notch in human umbilical vein endothelial cells

30 September 2017

1 reference

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Triterpenoids and rexinoids as multifunctional agents for the prevention and treatment of cancer.

30 September 2017

1 reference

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Neurogenesis, angiogenesis, and MRI indices of functional recovery from stroke

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4687549

Cell survival responses to environmental stresses via the Keap1-Nrf2-ARE pathway

30 September 2017

1 reference

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Reactive oxygen species regulate insulin-induced VEGF and HIF-1alpha expression through the activation of p70S6K1 in human prostate cancer cells

30 September 2017

1 reference

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Activation of the Keap1/Nrf2 pathway for neuroprotection by electrophilic [correction of electrophillic] phase II inducers

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4687549

Up-regulation of the Notch ligand Delta-like 4 inhibits VEGF-induced endothelial cell function

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4687549

Disruption of Nrf2 enhances susceptibility to severe airway inflammation and asthma in mice

30 September 2017

1 reference

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The synthetic triterpenoids, CDDO and CDDO-imidazolide, are potent inducers of heme oxygenase-1 and Nrf2/ARE signaling

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4687549

Recombinant semaphorin 6A-1 ectodomain inhibits in vivo growth factor and tumor cell line-induced angiogenesis

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4687549

The deletion of Math5 disrupts retinal blood vessel and glial development in mice

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4687549

Angiogenesis and improved cerebral blood flow in the ischemic boundary area detected by MRI after administration of sildenafil to rats with embolic stroke.

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4687549

Cathepsin B regulates the intrinsic angiogenic threshold of endothelial cells

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4687549

Neuropilin-1 mediates myeloid cell chemoattraction and influences retinal neuroimmune crosstalk.

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4687549

Knockdown of Nrf2 suppresses glioblastoma angiogenesis by inhibiting hypoxia-induced activation of HIF-1α.

21 September 2018

1 reference

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Sulforaphane preconditioning of the Nrf2/HO-1 defense pathway protects the cerebral vasculature against blood-brain barrier disruption and neurological deficits in stroke

21 September 2018

1 reference

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Neuronal ER stress impedes myeloid-cell-induced vascular regeneration through IRE1α degradation of netrin-1.

21 September 2018

1 reference

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MicroRNA-27a/b controls endothelial cell repulsion and angiogenesis by targeting semaphorin 6A.

21 September 2018

1 reference

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NRF2 blockade suppresses colon tumor angiogenesis by inhibiting hypoxia-induced activation of HIF-1α.

21 September 2018

1 reference

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Ablation of the transcription factor Nrf2 promotes ischemia-induced neovascularization by enhancing the inflammatory response

21 September 2018

1 reference

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Hypoxia-inducible factor-1-mediated regulation of semaphorin 4D affects tumor growth and vascularity.

21 September 2018

1 reference

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The succinate receptor GPR91 in neurons has a major role in retinal angiogenesis

21 September 2018

1 reference

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Tissue factor pathway inhibitor-2 is upregulated by vascular endothelial growth factor and suppresses growth factor-induced proliferation of endothelial cells.

21 September 2018

1 reference

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GFAP-expressing progenitors are the principal source of constitutive neurogenesis in adult mouse forebrain

21 September 2018

1 reference

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Quantitative assessment of the integrity of the blood-retinal barrier in mice

21 September 2018

1 reference

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Targeted delivery to PEPT1-overexpressing cells: acidic, basic, and secondary floxuridine amino acid ester prodrugs

21 September 2018

1 reference

Crossref

https://api.crossref.org/works/10.1073%2FPNAS.1512683112

Subcellular localization of coagulation factor II receptor-like 1 in neurons governs angiogenesis

21 January 2018

1 reference

12 December 2020

Retina- and ventral forebrain-specific Cre recombinase activity in transgenic mice

1 reference

12 December 2020

Oxygen-induced retinopathy in the mouse

1 reference

12 December 2020

Reactive oxygen species regulate epidermal growth factor-induced vascular endothelial growth factor and hypoxia-inducible factor-1α expression through activation of AKT and P70S6K1 in human ovarian cancer cells

1 reference

12 December 2020

Identifiers

DOI

10.1073/PNAS.1512683112

1 reference

13 August 2017

0 references

1 reference

13 August 2017

PubMed publication ID

26621751

1 reference