The biology and future prospects of antivirulence therapies (Q36397902)

13 August 2017

1 reference

title

The biology and future prospects of antivirulence therapies (English)

1 reference

13 August 2017

1

Lynette Cegelski

1 reference

13 August 2017

4

Scott J Hultgren

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13 August 2017

Garland R Marshall

2

1 reference

13 August 2017

Gary R Eldridge

series ordinal

3

1 reference

13 August 2017

language of work or name

English

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publication date

1 January 2008

1 reference

Nature Reviews Microbiology

13 August 2017

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13 August 2017

6

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13 August 2017

17-27

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13 August 2017

1

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https://scigraph.springernature.com/pub.10.1038/nrmicro1818

13 August 2017

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30 September 2017

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30 September 2017

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30 September 2017

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Small molecule inhibitors of type III secretion in Yersinia block the Chlamydia pneumoniae infection cycle

30 September 2017

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30 September 2017

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30 September 2017

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30 September 2017

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Rationally designed small compounds inhibit pilus biogenesis in uropathogenic bacteria.

30 September 2017

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Shiga toxin-producing Escherichia coli: an overview

30 September 2017

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Escherichia coli from urine of female patients with urinary tract infections is competent for intracellular bacterial community formation

30 September 2017

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The fallacies of hope: will we discover new antibiotics to combat pathogenic bacteria in time?

30 September 2017

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The type III secretion injectisome

30 September 2017

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A small-molecule inhibitor of type III secretion inhibits different stages of the infectious cycle of Chlamydia trachomatis

30 September 2017

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Mechanisms of uropathogenic Escherichia coli persistence and eradication from the urinary tract

30 September 2017

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Treatment of Chlamydia trachomatis with a small molecule inhibitor of the Yersinia type III secretion system disrupts progression of the chlamydial developmental cycle

30 September 2017

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Immunomodulators as an antimicrobial tool

30 September 2017

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Direct detection of bacterial biofilms on the middle-ear mucosa of children with chronic otitis media

30 September 2017

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Pili in gram-positive pathogens

30 September 2017

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Structural classification of bacterial response regulators: diversity of output domains and domain combinations

30 September 2017

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Identification of Helicobacter pylori biofilms in human gastric mucosa

30 September 2017

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30 September 2017

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Identification of genes subject to positive selection in uropathogenic strains of Escherichia coli: a comparative genomics approach.

30 September 2017

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Communication in bacteria: an ecological and evolutionary perspective

30 September 2017

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A pneumococcal pilus influences virulence and host inflammatory responses

30 September 2017

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Human botulism immune globulin for the treatment of infant botulism

30 September 2017

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Bad bugs need drugs: an update on the development pipeline from the Antimicrobial Availability Task Force of the Infectious Diseases Society of America

30 September 2017

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Small-molecule inhibitor of Vibrio cholerae virulence and intestinal colonization

30 September 2017

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A quantitative and highly sensitive luciferase-based assay for bacterial toxins that inhibit protein synthesis

30 September 2017

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Minimising antibiotic resistance

30 September 2017

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Small-molecule inhibitors specifically targeting type III secretion

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2211378

Multivariate design, synthesis, and biological evaluation of peptide inhibitors of FimC/FimH protein-protein interactions in uropathogenic Escherichia coli

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2211378

Quorum-sensing control in Staphylococci -- a target for antimicrobial drug therapy?

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2211378

Antibacterial resistance worldwide: causes, challenges and responses

30 September 2017

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2211378

Making sense of it all: bacterial chemotaxis

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2211378

Fiber assembly by the chaperone-usher pathway

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2211378

The gut microbiota as an environmental factor that regulates fat storage

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2211378

Can virulence factors be viable antibacterial targets?

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2211378

Persistent bacterial infections: the interface of the pathogen and the host immune system

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2211378

Differentiation and developmental pathways of uropathogenic Escherichia coli in urinary tract pathogenesis.

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2211378

Identification of small molecule inhibitors of anthrax lethal factor

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2211378

The structural basis for substrate and inhibitor selectivity of the anthrax lethal factor

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2211378

Why is big Pharma getting out of antibacterial drug discovery?

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2211378

Targeting virulence for antimicrobial chemotherapy

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2211378

Attenuation of Pseudomonas aeruginosa virulence by quorum sensing inhibitors

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2211378

Targeting bacterial virulence: inhibitors of type III secretion in Yersinia

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2211378

Parallel quorum sensing systems converge to regulate virulence in Vibrio cholerae.

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2211378

Yersinia type III secretion: send in the effectors

30 September 2017

1 reference

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Screening inhibitors of anthrax lethal factor

30 September 2017

1 reference

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Adhesion and entry of uropathogenic Escherichia coli.

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2211378

Humans as the world's greatest evolutionary force

30 September 2017

1 reference

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Quorum-sensing signals indicate that cystic fibrosis lungs are infected with bacterial biofilms

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2211378

Passive immunity in prevention and treatment of infectious diseases

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2211378

Assembly and function of type III secretory systems

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2211378

Type 1 pilus-mediated bacterial invasion of bladder epithelial cells

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2211378

Bacterial pili: molecular mechanisms of pathogenesis

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2211378

Bacterial toxins: friends or foes?

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2211378

Pilus biogenesis via the chaperone/usher pathway: an integration of structure and function

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2211378

Structure-activity analysis of synthetic autoinducing thiolactone peptides from Staphylococcus aureus responsible for virulence

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2211378

Two-component signal transduction as a target for microbial anti-infective therapy

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2211378

General secretion pathway (eps) genes required for toxin secretion and outer membrane biogenesis in Vibrio cholerae

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2211378

Common themes in microbial pathogenicity revisited

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2211378

Regulation of VanB-type vancomycin resistance gene expression by the VanS(B)-VanR (B) two-component regulatory system in Enterococcus faecalis V583

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2211378

Adaptive evolution of highly mutable loci in pathogenic bacteria

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2211378

FimH adhesin of type 1 pili is assembled into a fibrillar tip structure in the Enterobacteriaceae

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2211378

Functional conservation of the secretion and translocation machinery for virulence proteins of yersiniae, salmonellae and shigellae.

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2211378

Production of mucoid microcolonies by Pseudomonas aeruginosa within infected lungs in cystic fibrosis

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2211378

Aromatic alpha-glycosides of mannose are powerful inhibitors of the adherence of type 1 fimbriated Escherichia coli to yeast and intestinal epithelial cells

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2211378

Coordinate regulation and sensory transduction in the control of bacterial virulence

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2211378

The VanS-VanR two-component regulatory system controls synthesis of depsipeptide peptidoglycan precursors in Enterococcus faecium BM4147

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2211378

Structure and function of cholera toxin and the related Escherichia coli heat-labile enterotoxin

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2211378

Urinary tract infection--a dangerous and unrecognised forerunner of systemic sepsis

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2211378

Microbial ecology of the gastrointestinal tract

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2211378

The Yersinia Yop virulon: a bacterial system for subverting eukaryotic cells

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2211378

Pathogen profiling for disease management and surveillance.

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2211378

Evidence that halogenated furanones from Delisea pulchra inhibit acylated homoserine lactone (AHL)-mediated gene expression by displacing the AHL signal from its receptor protein.

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2211378

The major Vibrio cholerae autoinducer and its role in virulence factor production.

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2211378

Development of intracellular bacterial communities of uropathogenic Escherichia coli depends on type 1 pili.

21 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2211378

Antibacterial discovery and development--the failure of success?

21 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2211378

Antibacterial lysine analogs that target lysine riboswitches.

21 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2211378

Intracellular bacterial biofilm-like pods in urinary tract infections.

21 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2211378

Design and evaluation of pilicides: potential novel antibacterial agents directed against uropathogenic Escherichia coli.

21 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2211378

Induction and evasion of host defenses by type 1-piliated uropathogenic Escherichia coli

21 September 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO1818

Receptor binding studies disclose a novel class of high-affinity inhibitors of the Escherichia coli FimH adhesin

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO1818

Urinary tract infection in adults: research priorities and strategies

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO1818

Do marine natural products interfere with prokaryotic AHL regulatory systems?

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO1818

31 March 2020

Identifiers

DOI

10.1038/NRMICRO1818

1 reference

release_3ot4s36hbnbelcikfwq4nt6zte

13 August 2017

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/3ot4s36hbnbelcikfwq4nt6zte

mapped directly with Wikidata item

24 November 2022

based on heuristic

1 reference

13 August 2017

1 reference