Pathogenic profiles and molecular signatures of antinuclear autoantibodies rescued from NZM2410 lupus mice (Q36399144)

14 August 2017

Pathogenic profiles and molecular signatures of antinuclear autoantibodies rescued from NZM2410 lupus mice (English)

1 reference

14 August 2017

1 reference

Zhiyan Liang

1

1 reference

14 August 2017

Chun Xie

2

1 reference

14 August 2017

Cui Chen

3

1 reference

14 August 2017

Desi Kreska

4

1 reference

14 August 2017

Kelvin Hsu

5

1 reference

14 August 2017

Liunan Li

6

1 reference

14 August 2017

Xin J Zhou

7

1 reference

14 August 2017

Chandra Mohan

8

1 reference

14 August 2017

language of work or name

English

0 references

publication date

1 February 2004

1 reference

Journal of Experimental Medicine

14 August 2017

1 reference

14 August 2017

199

1 reference

14 August 2017

3

1 reference

14 August 2017

381-398

1 reference

Enhanced susceptibility to end-organ disease in the lupus-facilitating NZW mouse strain

14 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2211797

Genetic dissection of SLE: SLE1 and FAS impact alternate pathways leading to lymphoproliferative autoimmunity

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2211797

Alpha-actinin is a cross-reactive renal target for pathogenic anti-DNA antibodies

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2211797

Crystal structure of an antigen-binding fragment bound to single-stranded DNA

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2211797

Anti-DNA and autoantibodies

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2211797

Genetic reconstitution of systemic lupus erythematosus immunopathology with polycongenic murine strains.

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2211797

Genetic dissection of lupus pathogenesis: a recipe for nephrophilic autoantibodies

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2211797

Immunochemical, structural and translocating properties of anti-DNA antibodies from (NZBxNZW)F1 mice

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2211797

Genetic dissection of SLE pathogenesis. Sle1 on murine chromosome 1 leads to a selective loss of tolerance to H2A/H2B/DNA subnucleosomes

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2211797

Light chain usage in anti-double-stranded DNA B cell subsets: role in cell fate determination

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2211797

Studies on the structure, regulation, and pathogenic potential of anti-dsDNA antibodies

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2211797

An in vitro assay for detection of glomerular binding IgG autoantibodies in patients with systemic lupus erythematosus

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2211797

Heterogeneity and clinical significance of glomerular-binding antibodies in systemic lupus erythematosus

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2211797

Nephritogenic autoantibodies in lupus: current concepts and continuing controversies

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2211797

Ligand recognition by murine anti-DNA autoantibodies. II. Genetic analysis and pathogenicity

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2211797

Genesis and evolution of antichromatin autoantibodies in murine lupus implicates T-dependent immunization with self antigen

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2211797

Nephritogenic autoantibodies in systemic lupus erythematosus: immunochemical properties, mechanisms of immune deposition, and genetic origins

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2211797

Structure-function studies on a polyreactive (natural) autoantibody. Polyreactivity is dependent on somatically generated sequences in the third complementarity-determining region of the antibody heavy chain

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2211797

Sequencing and modeling of anti-DNA immunoglobulin Fv domains. Comparison with crystal structures.

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2211797

Mutational analysis of an autoantibody: differential binding and pathogenicity

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2211797

Anti-nucleosome antibodies complexed to nucleosomal antigens show anti-DNA reactivity and bind to rat glomerular basement membrane in vivo

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2211797

The central role of chromatin in autoimmune responses to histones and DNA in systemic lupus erythematosus

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2211797

Genetic and structural evidence for antigen selection of anti-DNA antibodies.

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2211797

Structure-function correlates of autoantibodies to nucleic acids. Lessons from immunochemical, genetic and structural studies

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2211797

Preparation, characterization and crystallization of an antibody Fab fragment that recognizes RNA. Crystal structures of native Fab and three Fab-mononucleotide complexes

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2211797

Structure of the DNA-Eco RI endonuclease recognition complex at 3 A resolution

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2211797

Anti-DNA antibodies from autoimmune mice arise by clonal expansion and somatic mutation

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2211797

An autoantibody to single-stranded DNA: Comparison of the three-dimensional structures of the unliganded fab and a deoxynucleotide-fab complex

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2211797

Antibodies to histones in systemic lupus erythematosus and drug-induced lupus syndromes

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2211797

The role of somatic mutation in the pathogenic anti-DNA response

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2211797

Both IgM and IgG anti-DNA antibodies are the products of clonally selective B cell stimulation in (NZB x NZW)F1 mice

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2211797

Selection of immunoglobulin variable regions in autoimmunity to DNA

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2211797

Autoantibodies associated with lupus induced by diverse drugs target a similar epitope in the (H2A-H2B)-DNA complex

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2211797

Sequence-specific recognition of double helical nucleic acids by proteins

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2211797

Molecular signatures of antinuclear antibodies-contributions of heavy chain CDR residues

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2211797

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2211797

Influence of VH CDR3 arginine and light chain pairing on DNA reactivity of a bacterial DNA-induced anti-DNA antibody from a BALB/c mouse

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2211797

Structural and affinity studies of IgM polyreactive natural autoantibodies.

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2211797

Murine glomerulotropic monoclonal antibodies are highly oligoclonal and exhibit distinctive molecular features.

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2211797

Residues that mediate DNA binding of autoimmune antibodies

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2211797

Molecular characterization of anti-DNA antibodies induced in normal mice by immunization with bacterial DNA. Differences from spontaneous anti-DNA in the content and location of VH CDR3 arginines

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2211797

Molecular analysis of spontaneous nephrotropic anti-laminin antibodies in an autoimmune MRL-lpr/lpr mouse

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2211797

Comparison of pathogenic and non-pathogenic murine antibodies to DNA: antigen binding and structural characteristics

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2211797

Light chain contribution to specificity in anti-DNA antibodies

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2211797

Murine lupus glomerulotropic monoclonal antibodies exhibit differing specificities but bind via a common mechanism

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2211797

Restricted Ig variable region gene expression among Ly-1+ B cell lymphomas.

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2211797

Ig H and L chain contributions to autoimmune specificities

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2211797

Synovium as a source of increased amino-terminal parathyroid hormone-related protein expression in rheumatoid arthritis. A possible role for locally produced parathyroid hormone-related protein in the pathogenesis of rheumatoid arthritis

28 June 2018

1 reference

https://api.crossref.org/works/10.1084%2FJEM.20030132

Comparison of structural characteristics of antisubnucleosome and anti-DNA monoclonal antibodies derived from lupus mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1084%2FJEM.20030132

Molecular Signatures of Anti-nuclear Antibodies: Contributions of Specific Light Chain Residues and a Novel New Zealand BlackVκ1Germline Gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1084%2FJEM.20030132

In vivo localization and pathological effects of passively transferred antibodies to type IV collagen and laminin in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1084%2FJEM.20030132

Use of a novel elution regimen reveals the dominance of polyreactive antinuclear autoantibodies in lupus kidneys

21 January 2018

1 reference

https://api.crossref.org/works/10.1084%2FJEM.20030132

Uncoupling of immune complex formation and kidney damage in autoimmune glomerulonephritis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1084%2FJEM.20030132

DNA antibodies focus on the light chain

21 January 2018

1 reference

https://api.crossref.org/works/10.1084%2FJEM.20030132

Editors and editing of anti-DNA receptors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1084%2FJEM.20030132

Characterization of anti-DNA B cells that escape negative selection.

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2211797

Correlation between the amino acid position of arginine in VH-CDR3 and specificity for native DNA among autoimmune antibodies

21 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2211797

Structural Features of Nephritogenic Lupus Autoantibodies

21 September 2018

1 reference

https://api.crossref.org/works/10.1084%2FJEM.20030132

Systemic lupus erythematosus

21 January 2018

1 reference

https://api.crossref.org/works/10.1084%2FJEM.20030132

Anti-DNA antibodies form immune deposits at distinct glomerular and vascular sites

21 January 2018

1 reference

https://api.crossref.org/works/10.1084%2FJEM.20030132

Anti-subnucleosome reactivities in systemic lupus erythematosus (SLE) patients and their first-degree relatives

21 January 2018

1 reference

https://api.crossref.org/works/10.1084%2FJEM.20030132

Nucleosome-restricted antibodies are detected before anti-dsDNA and/or antihistone antibodies in serum of MRL-Mp lpr/lpr and +/+ mice, and are present in kidney eluates of lupus mice with proteinuria

21 January 2018

1 reference

https://api.crossref.org/works/10.1084%2FJEM.20030132

Epistatic modifiers of autoimmunity in a murine model of lupus nephritis

21 January 2018

1 reference

https://api.crossref.org/works/10.1084%2FJEM.20030132

Association of renal injury with increased oxygen free radical activity and altered nitric oxide metabolism in chronic experimental hemosiderosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1084%2FJEM.20030132

Improved ion-exchange resins

21 January 2018

1 reference

https://api.crossref.org/works/10.1084%2FJEM.20030132

The Influence of Variable-Region Somatic Mutations on the Specificity and Pathogenicity of Murine Monoclonal Anti-DNA Antibodies

21 January 2018

1 reference

https://api.crossref.org/works/10.1084%2FJEM.20030132

Significance of anti-nuclear and anti-extracellular matrix autoantibodies for albuminuria in murine lupus nephritis; a longitudinal study on plasma and glomerular eluates in MRL/l mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1084%2FJEM.20030132

High connectivity, natural antibodies preferentially use 7183 and QUPC 52 VH families

21 January 2018

1 reference

https://api.crossref.org/works/10.1084%2FJEM.20030132

Accumulation of splenic B1a cells with potent antigen-presenting capability in NZM2410 lupus-prone mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1084%2FJEM.20030132

Structural properties of a subset of nephritogenic anti-DNA antibodies

21 January 2018

1 reference

https://api.crossref.org/works/10.1084%2FJEM.20030132

Selection of recurrent V genes and somatic mutations in autoantibodies to DNA

21 January 2018

1 reference

https://api.crossref.org/works/10.1084%2FJEM.20030132

Diverse endogenous light chains contribute to basement membrane reactivity in nonautoimmune mice transgenic for an anti-laminin Ig heavy chain

21 January 2018

1 reference

https://api.crossref.org/works/10.1084%2FJEM.20030132

Antigen specificity of anti-nuclear antibodies complexed to nucleosomes determines glomerular basement membrane binding in vivo

21 January 2018

1 reference

12 December 2020

Crystallization and structure determination of an autoimmune anti-poly(dT) immunoglobulin Fab fragment at 3.0 A resolution

1 reference

12 December 2020

Polyreactive autoantibodies are nephritogenic in murine lupus nephritis

1 reference

12 December 2020

Anti-DNA antibodies bind directly to renal antigens and induce kidney dysfunction in the isolated perfused rat kidney

1 reference

12 December 2020

Murine monoclonal anti-DNA antibodies penetrate cells, bind to nuclei, and induce glomerular proliferation and proteinuria in vivo

1 reference

12 December 2020

Differences in expression of lupus nephritis in New Zealand mixed H-2z homozygous inbred strains of mice derived from New Zealand black and New Zealand white mice. Origins and initial characterization

1 reference

12 December 2020

Glomerular binding activity in MRL lpr serum consists of antibodies that bind to a DNA/histone/type IV collagen complex

1 reference

12 December 2020

Identifiers

DOI

10.1084/JEM.20030132

1 reference

14 August 2017

1 reference

14 August 2017

PubMed publication ID

14757744

1 reference