Bone marrow microenvironmental changes underlie reduced RAG-mediated recombination and B cell generation in aged mice (Q36399584)

14 August 2017

Bone marrow microenvironmental changes underlie reduced RAG-mediated recombination and B cell generation in aged mice (English)

1 reference

14 August 2017

1 reference

Joseph E Labrie

1

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14 August 2017

Alex P Sah

2

1 reference

14 August 2017

David M Allman

3

1 reference

14 August 2017

Michael P Cancro

4

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14 August 2017

Rachel M Gerstein

5

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14 August 2017

language of work or name

English

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publication date

1 August 2004

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Journal of Experimental Medicine

14 August 2017

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14 August 2017

200

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14 August 2017

4

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14 August 2017

411-423

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Developmental separation of V(D)J recombinase expression and initiation of IgH recombination in B lineage progenitors in vivo

14 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2211932

B lineage-specific regulation of V(D)J recombinase activity is established in common lymphoid progenitors

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2211932

Impaired V(D)J recombination and lymphocyte development in core RAG1-expressing mice.

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2211932

Deletion of the RAG2 C terminus leads to impaired lymphoid development in mice

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2211932

The "dispensable" portion of RAG2 is necessary for efficient V-to-DJ rearrangement during B and T cell development

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2211932

Age-dependent changes in B lymphocyte development in man and mouse

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2211932

Pairs of violet-light-excited fluorochromes for flow cytometric analysis

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2211932

Aging and the immune response to the Haemophilus influenzae type b capsular polysaccharide: retention of the dominant idiotype and antibody function in the elderly

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2211932

EBF and E47 collaborate to induce expression of the endogenous immunoglobulin surrogate light chain genes

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2211932

Simultaneous fluorescence-activated cell sorter analysis of two distinct transcriptional elements within a single cell using engineered green fluorescent proteins

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2211932

The aging immune system: primer and prospectus

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2211932

Peripheral B cell maturation. II. Heat-stable antigen(hi) splenic B cells are an immature developmental intermediate in the production of long-lived marrow-derived B cells

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2211932

Lymphocyte life-span and memory

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2211932

Bone marrow declines as a site of B-cell precursor differentiation with age: relationship to thymus involution

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2211932

The V(D)J recombination activating gene, RAG-1.

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2211932

RAG-1 and RAG-2, adjacent genes that synergistically activate V(D)J recombination

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2211932

Resolution and characterization of pro-B and pre-pro-B cell stages in normal mouse bone marrow

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2211932

Peripheral B cell maturation. I. Immature peripheral B cells in adults are heat-stable antigenhi and exhibit unique signaling characteristics

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2211932

B cell maintenance in aged mice reflects both increased B cell longevity and decreased B cell generation.

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2211932

Effect of age on humoral immunity, selection of the B-cell repertoire and B-cell development.

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2211932

The B-cell biology of aging

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2211932

The response in old mice: positive and negative immune memory after priming in early age.

28 June 2018

1 reference

https://api.crossref.org/works/10.1084%2FJEM.20040845

Repertoire of antibody response in bone marrow and the memory response are differentially affected in aging mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1084%2FJEM.20040845

Aged mice exhibit distinct B cell precursor phenotypes differing in activation, proliferation and apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1084%2FJEM.20040845

The decline in B lymphopoiesis in aged mice reflects loss of very early B-lineage precursors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1084%2FJEM.20040845

Cellular niches controlling B lymphocyte behavior within bone marrow during development.

21 January 2018

1 reference

https://api.crossref.org/works/10.1084%2FJEM.20040845

A conserved transcriptional enhancer regulates RAG gene expression in developing B cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1084%2FJEM.20040845

21 January 2018

1 reference

https://api.crossref.org/works/10.1084%2FJEM.20040845

Impaired rearrangement of IgH V to DJ segments in bone marrow Pro-B cells from old mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1084%2FJEM.20040845

B-cell development: a comparison between mouse and man.

21 January 2018

1 reference

https://api.crossref.org/works/10.1084%2FJEM.20040845

Severe impairment of primary but not memory responses to influenza viral antigens in aged mice: costimulation in vivo partially reverses impaired primary immune responses.

21 January 2018

1 reference

https://api.crossref.org/works/10.1084%2FJEM.20040845

Immunosenescence and germinal center reaction

21 January 2018

1 reference

https://api.crossref.org/works/10.1084%2FJEM.20040845

Senescent BALB/c mice exhibit decreased expression of lambda5 surrogate light chains and reduced development within the pre-B cell compartment.

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2211932

Bcmd governs recruitment of new B cells into the stable peripheral B cell pool in the A/WySnJ mouse.

21 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2211932

Unexpected expansions of CD8-bearing cells in old mice

21 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2211932

The reduced expression of surrogate light chains in B cell precursors from senescent BALB/c mice is associated with decreased E2A proteins

21 October 2018

1 reference

12 December 2020

Hepatitis B immunization of healthy elderly adults: relationship between naïve CD4+ T cells and primary immune response and evaluation of GM-CSF as an adjuvant

1 reference

12 December 2020

Pre-B cells in mouse bone marrow: immunofluorescence stathmokinetic studies of the proliferation of cytoplasmic mu-chain-bearing cells in normal mice

1 reference

12 December 2020

Altered VH gene segment utilization in the response to phosphorylcholine by aged mice

1 reference

12 December 2020

B cell precursors are decreased in senescent BALB/c mice, but retain normal mitotic activity in vivo and in vitro

1 reference

12 December 2020

Effect of age on the expressed B cell repertoire: role of B cell subsets

1 reference

12 December 2020

Age-associated changes in the B-cell repertoire: effect of age on RAG-1 gene expression in murine bone marrow

1 reference

12 December 2020

Stage-specific alterations in murine B lymphopoiesis with age

1 reference

12 December 2020

Development of B cells in aged mice: decline in the ability of pro-B cells to respond to IL-7 but not to other growth factors

1 reference

12 December 2020

1 reference

12 December 2020

Impaired ability of bone marrow stromal cells to support B-lymphopoiesis with age

1 reference

12 December 2020

Maturation of B cell precursors is impaired in thymic-deprived nude and old mice

1 reference

12 December 2020

Age-associated defects in B lymphocyte development

1 reference

12 December 2020

Coordinate regulation of RAG1 and RAG2 by cell type-specific DNA elements 5' of RAG2

1 reference

12 December 2020

RAG2:GFP Knockin Mice Reveal Novel Aspects of RAG2 Expression in Primary and Peripheral Lymphoid Tissues

1 reference

12 December 2020

Identifiers

DOI

10.1084/JEM.20040845

1 reference

14 August 2017

1 reference

14 August 2017

1 reference