PKCtheta signals activation versus tolerance in vivo (Q36402354)

14 August 2017

PKCtheta signals activation versus tolerance in vivo (English)

1 reference

14 August 2017

7

Dan R Littman

1 reference

14 August 2017

Nancy N Berg-Brown

1

1 reference

14 August 2017

Matthew A Gronski

2

1 reference

14 August 2017

Russell G Jones

3

1 reference

14 August 2017

Alisha R Elford

4

1 reference

14 August 2017

Elissa K Deenick

5

1 reference

14 August 2017

Bernhard Odermatt

6

1 reference

14 August 2017

Pamela S Ohashi

8

1 reference

14 August 2017

language of work or name

English

0 references

publication date

1 March 2004

1 reference

Journal of Experimental Medicine

14 August 2017

1 reference

14 August 2017

199

1 reference

14 August 2017

6

1 reference

14 August 2017

743-752

1 reference

Unifying concepts in CD28, ICOS and CTLA4 co-receptor signalling

14 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2212730

Protein kinase C theta affects Ca2+ mobilization and NFAT cell activation in primary mouse T cells

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2212730

The PKC gene module: molecular biosystematics to resolve its T cell functions

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2212730

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2212730

A temporal and spatial summation model for T-cell activation: signal integration and antigen decoding

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2212730

CD28-dependent activation of protein kinase B/Akt blocks Fas-mediated apoptosis by preventing death-inducing signaling complex assembly.

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2212730

The CD28 signaling pathway regulates glucose metabolism

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2212730

PKC-beta controls I kappa B kinase lipid raft recruitment and activation in response to BCR signaling

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2212730

CD28 plays a critical role in the segregation of PKC theta within the immunologic synapse

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2212730

Protein kinase C beta controls nuclear factor kappaB activation in B cells through selective regulation of the IkappaB kinase alpha

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2212730

Increased proliferation of B cells and auto-immunity in mice lacking protein kinase Cdelta

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2212730

Translocation of PKC[theta] in T cells is mediated by a nonconventional, PI3-K- and Vav-dependent pathway, but does not absolutely require phospholipase C

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2212730

Protein kinase C(theta) in T cell activation

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2212730

Tumor growth enhances cross-presentation leading to limited T cell activation without tolerance

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2212730

Anergy in peripheral memory CD4(+) T cells induced by low avidity engagement of T cell receptor

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2212730

Complex formation and cooperation of protein kinase C theta and Akt1/protein kinase B alpha in the NF-kappa B transactivation cascade in Jurkat T cells

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2212730

Protein kinase C theta cooperates with Vav1 to induce JNK activity in T-cells

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2212730

The immunological synapse.

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2212730

Altered composition of the immunological synapse in an anergic, age-dependent memory T cell subset

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2212730

Protein kinase B regulates T lymphocyte survival, nuclear factor kappaB activation, and Bcl-X(L) levels in vivo

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2212730

Protein kinase C-theta participates in NF-kappaB activation induced by CD3-CD28 costimulation through selective activation of IkappaB kinase beta

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2212730

NF-kappa B activation induced by T cell receptor/CD28 costimulation is mediated by protein kinase C-theta

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2212730

Three-dimensional segregation of supramolecular activation clusters in T cells

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2212730

Calcineurin preferentially synergizes with PKC-theta to activate JNK and IL-2 promoter in T lymphocytes

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2212730

Impaired CD28-mediated interleukin 2 production and proliferation in stress kinase SAPK/ERK1 kinase (SEK1)/mitogen-activated protein kinase kinase 4 (MKK4)-deficient T lymphocytes.

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2212730

Single cell analysis reveals regulated hierarchical T cell antigen receptor signaling thresholds and intraclonal heterogeneity for individual cytokine responses of CD4+ T cells

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2212730

Selective modulation of protein kinase C-theta during T-cell activation

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2212730

B cell differentiation and isotype switching is related to division cycle number

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2212730

Immunodeficiency in protein kinase cbeta-deficient mice

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2212730

T cell activation determined by T cell receptor number and tunable thresholds.

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2212730

Protein kinase C-theta isoenzyme selective stimulation of the transcription factor complex AP-1 in T lymphocytes

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2212730

In vivo anergized CD4+ T cells express perturbed AP-1 and NF-kappa B transcription factors

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2212730

Kinetics of T-cell receptor binding to peptide/I-Ek complexes: correlation of the dissociation rate with T-cell responsiveness

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2212730

Differential T cell costimulatory requirements in CD28-deficient mice

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2212730

CD28 costimulation can promote T cell survival by enhancing the expression of Bcl-XL.

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2212730

CD28-mediated signalling co-stimulates murine T cells and prevents induction of anergy in T-cell clones

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2212730

Regulation of protein kinase Ctheta function during T cell activation by Lck-mediated tyrosine phosphorylation

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2212730

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2212730

Different nuclear signals are activated by the B cell receptor during positive versus negative signaling.

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2212730

A TCR binds to antagonist ligands with lower affinities and faster dissociation rates than to agonists

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2212730

Tolerance induction in double specific T-cell receptor transgenic mice varies with antigen

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2212730

Analysis of the kinetics of antiviral memory T help in vivo: characterization of short-lived cross-reactive T help

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2212730

Viral escape by selection of cytotoxic T cell-resistant virus variants in vivo

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2212730

Transactivation by AP-1 is a molecular target of T cell clonal anergy

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2212730

Antigen-induced translocation of PKC-theta to membrane rafts is required for T cell activation

28 June 2018

1 reference

https://api.crossref.org/works/10.1084%2FJEM.20031022

The physical association of protein kinase C theta with a lipid raft-associated inhibitor of kappa B factor kinase (IKK) complex plays a role in the activation of the NF-kappa B cascade by TCR and CD28.

21 January 2018

1 reference

https://api.crossref.org/works/10.1084%2FJEM.20031022

A novel functional interaction between Vav and PKCtheta is required for TCR-induced T cell activation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1084%2FJEM.20031022

A point mutation in CD28 distinguishes proliferative signals from survival signals

21 January 2018

1 reference

https://api.crossref.org/works/10.1084%2FJEM.20031022

The duration of antigenic stimulation determines the fate of naive and effector T cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1084%2FJEM.20031022

Regulation of Lck activity by CD4 and CD28 in the immunological synapse

21 January 2018

1 reference

https://api.crossref.org/works/10.1084%2FJEM.20031022

CD28 is required for germinal center formation.

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2212730

PKC-θ is required for TCR-induced NF-κB activation in mature but not immature T lymphocytes

21 September 2018

1 reference

https://api.crossref.org/works/10.1084%2FJEM.20031022

Induction of T-cell anergy by altered T-cell-receptor ligand on live antigen-presenting cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1084%2FJEM.20031022

Protein kinase Cδ controls self-antigen-induced B-cell tolerance

21 January 2018

1 reference

https://api.crossref.org/works/10.1084%2FJEM.20031022

Blocked Signal Transduction to the ERK and JNK Protein Kinases in Anergic CD4+ T Cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1084%2FJEM.20031022

Synergistic activation of NF-kappa B by functional cooperation between vav and PKCtheta in T lymphocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1084%2FJEM.20031022

Protein kinase Ctheta, a selective upstream regulator of JNK/SAPK and IL-2 promoter activation in Jurkat T cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1084%2FJEM.20031022

Synergistic action of protein kinase C θ and calcineurin is sufficient for Fas ligand expression and induction of a crmA-sensitive apoptosis pathway in Jurkat T cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1084%2FJEM.20031022

Distinct roles for LFA-1 and CD28 during activation of naive T cells: adhesion versus costimulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1084%2FJEM.20031022

A receptor/cytoskeletal movement triggered by costimulation during T cell activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1084%2FJEM.20031022

T lymphocyte costimulation mediated by reorganization of membrane microdomains

21 January 2018

1 reference

https://api.crossref.org/works/10.1084%2FJEM.20031022

Duration of TCR stimulation determines costimulatory requirement of T cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1084%2FJEM.20031022

Calcineurin Aalpha plays an exclusive role in TCR signaling in mature but not in immature T cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1084%2FJEM.20031022

Blocked Ras activation in anergic CD4+ T cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1084%2FJEM.20031022

Protein kinase ctheta cooperates with calcineurin to induce Fas ligand expression during activation-induced T cell death

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/15024044

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1084/JEM.20031022

1 reference

14 August 2017

1 reference

14 August 2017

1 reference