Astrocyte dysfunction in neurological disorders: a molecular perspective (Q36404127)

14 August 2017

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title

Astrocyte dysfunction in neurological disorders: a molecular perspective (English)

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14 August 2017

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Gerald Seifert

1

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14 August 2017

Karl Schilling

series ordinal

2

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14 August 2017

Christian Steinhäuser

series ordinal

3

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14 August 2017

language of work or name

English

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publication date

1 March 2006

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Nature Reviews Neuroscience

14 August 2017

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14 August 2017

7

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14 August 2017

194-206

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14 August 2017

3

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https://scigraph.springernature.com/pub.10.1038/nrn1870

14 August 2017

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cites work

Glutamate-mediated astrocyte-neuron signalling

1 reference

Properties of GABA and glutamate responses in identified glial cells of the mouse hippocampal slice.

21 January 2018

1 reference

Synaptic transmission onto hippocampal glial cells with hGFAP promoter activity

21 January 2018

1 reference

Distinct types of astroglial cells in the hippocampus differ in gap junction coupling

21 January 2018

1 reference

More than just water channels: unexpected cellular roles of aquaporins

21 January 2018

1 reference

Anchoring of aquaporin-4 in brain: molecular mechanisms and implications for the physiology and pathophysiology of water transport

21 January 2018

1 reference

Emerging complexities in identity and function of glial connexins

21 January 2018

1 reference

New roles for astrocytes: redefining the functional architecture of the brain

21 January 2018

1 reference

21 January 2018

1 reference

Clearance of glutamate inside the synapse and beyond

21 January 2018

1 reference

Astrocytes, from brain glue to communication elements: the revolution continues

21 January 2018

1 reference

Neuron-to-astrocyte signaling is central to the dynamic control of brain microcirculation.

21 January 2018

1 reference

Calcium transients in astrocyte endfeet cause cerebrovascular constrictions

21 January 2018

1 reference

Astrocyte-mediated control of cerebral blood flow

21 January 2018

1 reference

21 January 2018

Pathology of epilepsy

1 reference

New facets of the neuropathology and molecular profile of human temporal lobe epilepsy

21 January 2018

1 reference

Effects of barium on stimulus-induced rises of [K+]o in human epileptic non-sclerotic and sclerotic hippocampal area CA1.

21 January 2018

1 reference

Astrocytes in the hippocampus of patients with temporal lobe epilepsy display changes in potassium conductances.

21 January 2018

1 reference

Properties of human glial cells associated with epileptic seizure foci.

21 January 2018

1 reference

Functional and molecular properties of human astrocytes in acute hippocampal slices obtained from patients with temporal lobe epilepsy.

21 January 2018

1 reference

Increased seizure duration and slowed potassium kinetics in mice lacking aquaporin-4 water channels.

21 January 2018

1 reference

Loss of perivascular aquaporin 4 may underlie deficient water and K+ homeostasis in the human epileptogenic hippocampus

21 January 2018

1 reference

An alpha-syntrophin-dependent pool of AQP4 in astroglial end-feet confers bidirectional water flow between blood and brain

21 January 2018

1 reference

Epilepsy and exacerbation of brain injury in mice lacking the glutamate transporter GLT-1

21 January 2018

1 reference

Knockout of glutamate transporters reveals a major role for astroglial transport in excitotoxicity and clearance of glutamate

21 January 2018

1 reference

Glutamate transporters regulate excitability in local networks in rat neocortex

21 January 2018

1 reference

Glutamate transporters prevent the generation of seizures in the developing rat neocortex.

21 January 2018

1 reference

Impaired glial glutamate transport in a mouse tuberous sclerosis epilepsy model.

21 January 2018

1 reference

Expression of the glutamate transporters in human temporal lobe epilepsy.

21 January 2018

1 reference

Hippocampal GABA and glutamate transporter immunoreactivity in patients with temporal lobe epilepsy

21 January 2018

1 reference

Distribution of glutamate transporters in the hippocampus of patients with pharmaco-resistant temporal lobe epilepsy

21 January 2018

1 reference

Extracellular hippocampal glutamate and spontaneous seizure in the conscious human brain.

21 January 2018

1 reference

Loss of glutamine synthetase in the human epileptogenic hippocampus: possible mechanism for raised extracellular glutamate in mesial temporal lobe epilepsy

21 January 2018

1 reference

Glutamate-glutamine cycling in the epileptic human hippocampus

21 January 2018

1 reference

Beta-lactam antibiotics offer neuroprotection by increasing glutamate transporter expression.

21 January 2018

1 reference

Changes in flip/flop splicing of astroglial AMPA receptors in human temporal lobe epilepsy.

21 January 2018

1 reference

Enhanced relative expression of glutamate receptor 1 flip AMPA receptor subunits in hippocampal astrocytes of epilepsy patients with Ammon's horn sclerosis.

21 January 2018

1 reference

AMPA receptor-mediated modulation of inward rectifier K+ channels in astrocytes of mouse hippocampus.

21 January 2018

1 reference

Glial membrane channels and receptors in epilepsy: impact for generation and spread of seizure activity

21 January 2018

1 reference

Expression of the group II and III metabotropic glutamate receptors in the hippocampus of patients with mesial temporal lobe epilepsy

21 January 2018

1 reference

Expression and cell distribution of group I and group II metabotropic glutamate receptor subtypes in taylor-type focal cortical dysplasia.

21 January 2018

1 reference

Expression and functional role of mGluR3 and mGluR5 in human astrocytes and glioma cells: opposite regulation of glutamate transporter proteins

21 January 2018

1 reference

Astrocytic glutamate release-induced transient depolarization and epileptiform discharges in hippocampal CA1 pyramidal neurons

21 January 2018

1 reference

An astrocytic basis of epilepsy

21 January 2018

1 reference

Decreased glutamate transport by the brain and spinal cord in amyotrophic lateral sclerosis

21 January 2018

1 reference

Selective loss of glial glutamate transporter GLT-1 in amyotrophic lateral sclerosis

21 January 2018

1 reference

Expression of the glutamate transporter GLT1 in neural cells of the rat central nervous system: non-radioactive in situ hybridization and comparative immunocytochemistry

21 January 2018

1 reference

Aberrant RNA processing in a neurodegenerative disease: the cause for absent EAAT2, a glutamate transporter, in amyotrophic lateral sclerosis

21 January 2018

1 reference

Glutamate transporter EAAT2 splice variants occur not only in ALS, but also in AD and controls

21 January 2018

1 reference

Mutations in Cu/Zn superoxide dismutase gene are associated with familial amyotrophic lateral sclerosis

21 January 2018

1 reference

SOD1 mutants linked to amyotrophic lateral sclerosis selectively inactivate a glial glutamate transporter.

21 January 2018

1 reference

Focal loss of the glutamate transporter EAAT2 in a transgenic rat model of SOD1 mutant-mediated amyotrophic lateral sclerosis (ALS).

21 January 2018

1 reference

ALS-linked SOD1 mutant G85R mediates damage to astrocytes and promotes rapidly progressive disease with SOD1-containing inclusions.

21 January 2018

1 reference

Unraveling the mechanisms involved in motor neuron degeneration in ALS

21 January 2018

1 reference

Wild-Type Nonneuronal Cells Extend Survival of SOD1 Mutant Motor Neurons in ALS Mice

21 January 2018

1 reference

Chromogranin-mediated secretion of mutant superoxide dismutase proteins linked to amyotrophic lateral sclerosis

21 January 2018

1 reference

Excitotoxic and oxidative cross-talk between motor neurons and glia in ALS pathogenesis

21 January 2018

1 reference

Increased expression of the pro-inflammatory enzyme cyclooxygenase-2 in amyotrophic lateral sclerosis.

21 January 2018

1 reference

Marked increase in cyclooxygenase-2 in ALS spinal cord: implications for therapy

21 January 2018

1 reference

Expression of a mitogen-inducible cyclooxygenase in brain neurons: regulation by synaptic activity and glucocorticoids

21 January 2018

1 reference

In vivo activation of N-methyl-D-aspartate receptors in the rat hippocampus increases prostaglandin E(2) extracellular levels and triggers lipid peroxidation through cyclooxygenase-mediated mechanisms.

21 January 2018

1 reference

Prostaglandins stimulate calcium-dependent glutamate release in astrocytes.

21 January 2018

1 reference

Cyclooxygenase 2 inhibition protects motor neurons and prolongs survival in a transgenic mouse model of ALS.

21 January 2018

1 reference

Immunohistochemical localization of group I and II metabotropic glutamate receptors in control and amyotrophic lateral sclerosis human spinal cord: upregulation in reactive astrocytes.

21 January 2018

1 reference

Peroxynitrite inhibits glutamate transporter subtypes.

21 January 2018

1 reference

Metabotropic glutamate receptor subtypes as targets for neuroprotective drugs

21 January 2018

1 reference

Aquaporin-4 deletion in mice reduces brain edema after acute water intoxication and ischemic stroke.

21 January 2018

1 reference

Endothelin-1 overexpression leads to further water accumulation and brain edema after middle cerebral artery occlusion via aquaporin 4 expression in astrocytic end-feet.

21 January 2018

1 reference

Aquaporin-4 gene disruption in mice protects against impaired retinal function and cell death after ischemia

21 January 2018

1 reference

Targeted inactivation of dystrophin gene product Dp71: phenotypic impact in mouse retina

21 January 2018

1 reference

Differential assembly of inwardly rectifying K+ channel subunits, Kir4.1 and Kir5.1, in brain astrocytes

21 January 2018

1 reference

Kir6.1 is the principal pore-forming subunit of astrocyte but not neuronal plasma membrane K-ATP channels

21 January 2018

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Characterisation of Kir2.0 proteins in the rat cerebellum and hippocampus by polyclonal antibodies

21 January 2018

1 reference

Alterations in metabolism and gap junction expression may determine the role of astrocytes as "good samaritans" or executioners.

21 January 2018

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Increased apoptosis and inflammation after focal brain ischemia in mice lacking connexin43 in astrocytes

21 January 2018

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Role of gap junctional coupling in astrocytic networks in the determination of global ischaemia-induced oxidative stress and hippocampal damage.

21 January 2018

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Chronic endothelin exposure inhibits connexin43 expression in cultured cortical astroglia

21 January 2018

1 reference

Receptor-mediated glutamate release from volume sensitive channels in astrocytes

21 January 2018

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Differential expressions of glycine transporter 1 and three glutamate transporter mRNA in the hippocampus of gerbils with transient forebrain ischemia.

21 January 2018

1 reference

Glutamate transporters in neurologic disease

21 January 2018

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Knocking out the glial glutamate transporter GLT-1 reduces glutamate uptake but does not affect hippocampal glutamate dynamics in early simulated ischaemia

21 January 2018

1 reference

Role of the GLT-1 subtype of glutamate transporter in glutamate homeostasis: the GLT-1-preferring inhibitor WAY-855 produces marginal neurotoxicity in the rat hippocampus

21 January 2018

1 reference

CNS region-specific regulation of glial glutamate transporter expression.

21 January 2018

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Chronic restraint stress up-regulates GLT-1 mRNA and protein expression in the rat hippocampus: reversal by tianeptine

21 January 2018

1 reference

Differential promotion of glutamate transporter expression and function by glucocorticoids in astrocytes from various brain regions.

21 January 2018

1 reference

Volume-regulated anion channels are the predominant contributors to release of excitatory amino acids in the ischemic cortical penumbra

21 January 2018

1 reference

Altered properties of volume-sensitive osmolyte and anion channels (VSOACs) and membrane protein expression in cardiac and smooth muscle myocytes from Clcn3-/- mice

21 January 2018

1 reference

Molecular structure and physiological function of chloride channels

21 January 2018

1 reference

Behavioral and histological neuroprotection by tamoxifen after reversible focal cerebral ischemia

21 January 2018

1 reference

Tamoxifen inhibits nitrotyrosine formation after reversible middle cerebral artery occlusion in the rat.

21 January 2018

1 reference

Astrocytic swelling in cerebral ischemia as a possible cause of injury and target for therapy

21 January 2018

1 reference

Glial glutamate transporter expression patterns in brains from multiple mammalian species

21 January 2018

1 reference

Common mechanisms of nerve and blood vessel wiring

21 January 2018

1 reference

Perinatal hypoxia-/ischemia-induced endothelin-1 mRNA in astrocyte-like and endothelial cells.

21 January 2018

1 reference

Cell type specific expression of vascular endothelial growth factor and angiopoietin-1 and -2 suggests an important role of astrocytes in cerebellar vascularization

21 January 2018

1 reference

Stabilization of the retinal vascular network by reciprocal feedback between blood vessels and astrocytes.

21 January 2018

1 reference

VEGF-induced neuroprotection, neurogenesis, and angiogenesis after focal cerebral ischemia

21 January 2018

1 reference

VEGF is a chemoattractant for FGF-2-stimulated neural progenitors

21 January 2018

1 reference

Angiopoietin-1 promotes neurite outgrowth from dorsal root ganglion cells positive for Tie-2 receptor

21 January 2018

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Vascular-specific growth factor angiopoietin 1 is involved in the organization of neuronal processes

21 January 2018

1 reference

The blockade of endothelin A receptor protects astrocytes against hypoxic injury: common effects of BQ-123 anderythropoietin on the rejuvenation of the astrocyte population.

21 January 2018

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Targets for vascular protection after acute ischemic stroke

21 January 2018

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Blood–brain barrier permeability to ammonia in liver failure: a critical reappraisal

21 January 2018

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Inhibition of glutamine synthetase reduces ammonia-induced astrocyte swelling in rat

21 January 2018

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Glutamine synthetase in brain: effect of ammonia

21 January 2018

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Pathophysiology of hepatic encephalopathy: a new look at ammonia

21 January 2018

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Increased aquaporin-4 expression in ammonia-treated cultured astrocytes

21 January 2018

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The glial glutamate transporter in hyperammonemia and hepatic encephalopathy: relation to energy metabolism and glutamatergic neurotransmission.

21 January 2018

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Decreased glutamate transporter (GLT-1) expression in frontal cortex of rats with acute liver failure.

21 January 2018

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Glutamic acid and glutamine levels in serum and cerebrospinal fluid in hepatic encephalopathy

21 January 2018

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Neuroactive amino acids and glutamate (NMDA) receptors in frontal cortex of rats with experimental acute liver failure.

21 January 2018

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Effects of hyperammonemia and liver failure on glutamatergic neurotransmission

21 January 2018

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Acute insult of ammonia leads to calcium-dependent glutamate release from cultured astrocytes, an effect of pH.

21 January 2018

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Effect of ammonium ions on synaptic transmission in the mammalian central nervous system

21 January 2018

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Selective loss of binding sites for the glutamate receptor ligands [3H]kainate and (S)-[3H]5-fluorowillardiine in the brains of rats with acute liver failure.

21 January 2018

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Glial Cells Generate Neurons—Master Control within CNS Regions: Developmental Perspectives on Neural Stem Cells

21 January 2018

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Neural guidance molecules regulate vascular remodeling and vessel navigation

21 January 2018

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In vivo measurement of brain extracellular space diffusion by cortical surface photobleaching.

21 January 2018

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Glutamate-evoked alterations of glial and neuronal cell morphology in the guinea pig retina.

21 January 2018

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Intrinsic optical signals in the rat optic nerve: role for K(+) uptake via NKCC1 and swelling of astrocytes.

21 January 2018

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Cellular volume homeostasis

21 January 2018

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Biophysical and pharmacological characterization of hypotonically activated chloride currents in cortical astrocytes

21 January 2018

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Immunogold evidence suggests that coupling of K+ siphoning and water transport in rat retinal Müller cells is mediated by a coenrichment of Kir4.1 and AQP4 in specific membrane domains

21 January 2018

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Delayed K+ clearance associated with aquaporin-4 mislocalization: phenotypic defects in brains of alpha-syntrophin-null mice

21 January 2018

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Aquaporin-4 in the central nervous system: cellular and subcellular distribution and coexpression with KIR4.1

21 January 2018

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Aquaporin-4 gene disruption in mice reduces brain swelling and mortality in pneumococcal meningitis

21 January 2018

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Aquaporin-4 gene deletion in mice increases focal edema associated with staphylococcal brain abscess.

21 January 2018

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Neurochemical and morphological changes associated with human epilepsy

21 January 2018

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Segregated expression of AMPA-type glutamate receptors and glutamate transporters defines distinct astrocyte populations in the mouse hippocampus.

21 January 2018

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Ion channels in glial cells

31 March 2020

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An inwardly rectifying K(+) channel, Kir4.1, expressed in astrocytes surrounds synapses and blood vessels in brain

31 March 2020

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Early-onset epilepsy and postnatal lethality associated with an editing-deficient GluR-B allele in mice

31 March 2020

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GluR3 autoantibodies destroy neural cells in a complement-dependent manner modulated by complement regulatory proteins

31 March 2020

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Excitatory amino acid transporter 1 and 2 immunoreactivity in the spinal cord in amyotrophic lateral sclerosis

31 March 2020

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Glutamate transporter GLT-1 is transiently localized on growing axons of the mouse spinal cord before establishing astrocytic expression

31 March 2020

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The RNA of the glutamate transporter EAAT2 is variably spliced in amyotrophic lateral sclerosis and normal individuals

31 March 2020

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Glutamate uptake inhibition by oxygen free radicals in rat cortical astrocytes.

31 March 2020

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Protein modification by the lipid peroxidation product 4-hydroxynonenal in the spinal cords of amyotrophic lateral sclerosis patients

31 March 2020

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Neuron-specific expression of mutant superoxide dismutase 1 in transgenic mice does not lead to motor impairment.

31 March 2020

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Accumulation of SOD1 mutants in postnatal motoneurons does not cause motoneuron pathology or motoneuron disease

31 March 2020

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Restricted expression of G86R Cu/Zn superoxide dismutase in astrocytes results in astrocytosis but does not cause motoneuron degeneration

31 March 2020

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Disruption of glial glutamate transport by reactive oxygen species produced in motor neurons.

31 March 2020

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Astrocytes interact intimately with degenerating motor neurons in mouse amyotrophic lateral sclerosis (ALS)

31 March 2020

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Increased expression of neuronal nitric oxide synthase spliced variants in reactive astrocytes of amyotrophic lateral sclerosis human spinal cord

31 March 2020

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Increased 3-nitrotyrosine in both sporadic and familial amyotrophic lateral sclerosis

31 March 2020

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Alpha-syntrophin deletion removes the perivascular but not endothelial pool of aquaporin-4 at the blood-brain barrier and delays the development of brain edema in an experimental model of acute hyponatremia

31 March 2020

1 reference

New possible roles for aquaporin-4 in astrocytes: cell cytoskeleton and functional relationship with connexin43.

31 March 2020

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Connexin mediates gap junction-independent resistance to cellular injury.

31 March 2020

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Functional hemichannels in astrocytes: a novel mechanism of glutamate release.

31 March 2020

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Functional changes of glial glutamate transporter GLT-1 during ischemia: an in vivo study in the hippocampal CA1 of normal mice and mutant mice lacking GLT-1.

31 March 2020

1 reference

Antisense knockdown of the glial glutamate transporter GLT-1, but not the neuronal glutamate transporter EAAC1, exacerbates transient focal cerebral ischemia-induced neuronal damage in rat brain.

31 March 2020

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Neuronal regulation of glutamate transporter subtype expression in astrocytes.

31 March 2020

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Acute treatment with tamoxifen reduces ischemic damage following middle cerebral artery occlusion

31 March 2020

1 reference

The astrocytic endothelin system: toward solving a mystery focus on "distinct pharmacological properties of ET-1 and ET-3 on astroglial gap junctions and Ca(2+) signaling"

31 March 2020

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Methionine sulfoximine, a glutamine synthetase inhibitor, attenuates increased extracellular potassium activity during acute hyperammonemia

31 March 2020

1 reference

Effects of ammonia on L-glutamate uptake in cultured astrocytes

31 March 2020

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Swelling of Müller cells induced by AP3 and glutamate transport substrates in rat retina

31 March 2020

1 reference

Specialized membrane domains for water transport in glial cells: high-resolution immunogold cytochemistry of aquaporin-4 in rat brain.

31 March 2020

1 reference

A novel role of vasopressin in the brain: modulation of activity-dependent water flux in the neocortex.

31 March 2020

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Signaling at the gliovascular interface.

31 March 2020

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31 March 2020

Identifiers

DOI

10.1038/NRN1870

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14 August 2017

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