Insulin resistance and endothelial dysfunction: the road map to cardiovascular diseases (Q36408698)

14 August 2017

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title

Insulin resistance and endothelial dysfunction: the road map to cardiovascular diseases (English)

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14 August 2017

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cardiovascular disease

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2

Ralph A DeFronzo

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14 August 2017

Eugenio Cersosimo

1

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14 August 2017

1 November 2006

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14 August 2017

14

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Diabetes - Metabolism: Research and Reviews

inferred from page(s)

published in

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14 August 2017

22

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14 August 2017

423-436

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14 August 2017

6

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The metabolic syndrome and total and cardiovascular disease mortality in middle-aged men

14 August 2017

1 reference

7 January 2021

Coronary vasomotor abnormalities in insulin-resistant individuals

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7 January 2021

Obesity, insulin resistance, and the metabolic syndrome: determinants of endothelial dysfunction in whites and blacks

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7 January 2021

Endothelial dysfunction in human diabetes

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7 January 2021

The Seventh Report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure<SUBTITLE>The JNC 7 Report</SUBTITLE>

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7 January 2021

Endothelial dysfunction is detectable in young normotensive first-degree relatives of subjects with type 2 diabetes in association with insulin resistance

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7 January 2021

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7 January 2021

Banting lecture 1988. Role of insulin resistance in human disease

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7 January 2021

Lipid Infusion Decreases the Expression of Nuclear Encoded Mitochondrial Genes and Increases the Expression of Extracellular Matrix Genes in Human Skeletal Muscle

1 reference

7 January 2021

Role of tissue-specific blood flow and tissue recruitment in insulin-mediated glucose uptake of human skeletal muscle

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7 January 2021

Visceral obesity: a "civilization syndrome".

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7 January 2021

Insulin infusion in conscious dogs. Effects on systemic and coronary hemodynamics, regional blood flows, and plasma catecholamines.

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7 January 2021

Microvascular recruitment is an early insulin effect that regulates skeletal muscle glucose uptake in vivo

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7 January 2021

Physiologic hyperinsulinemia enhances human skeletal muscle perfusion by capillary recruitment

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7 January 2021

Insulin-mediated skeletal muscle vasodilation contributes to both insulin sensitivity and responsiveness in lean humans

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7 January 2021

Insulin-stimulated production of nitric oxide is inhibited by wortmannin. Direct measurement in vascular endothelial cells

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7 January 2021

Inhibiting NOS blocks microvascular recruitment and blunts muscle glucose uptake in response to insulin

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7 January 2021

Regulation of endothelial nitric oxide synthase: location, location, location

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7 January 2021

Regulatory functions of the vascular endothelium

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7 January 2021

Microvascular and macrovascular reactivity is reduced in subjects at risk for type 2 diabetes

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7 January 2021

Paradoxical vasoconstriction induced by acetylcholine in atherosclerotic coronary arteries

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7 January 2021

Clinical utility of endothelial function testing: ready for prime time?

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7 January 2021

Non-invasive measurement of human endothelium dependent arterial responses: accuracy and reproducibility

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7 January 2021

Carotid artery vasoreactivity in response to sympathetic stress correlates with coronary disease risk and is independent of wall thickness

1 reference

7 January 2021

Pharmacologic versus flow-mediated assessments of peripheral vascular endothelial vasodilatory function in humans

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7 January 2021

Inflammatory cytokines and the risk to develop type 2 diabetes: results of the prospective population-based European Prospective Investigation into Cancer and Nutrition (EPIC)-Potsdam Study

1 reference

7 January 2021

Soluble vascular cell adhesion molecule-1 and E-selectin levels in relation to vascular risk factors and to E-selectin genotype in the first degree relatives of NIDDM patients and in NIDDM patients.

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7 January 2021

C-reactive protein, interleukin 6, and risk of developing type 2 diabetes mellitus

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7 January 2021

Impaired nitric oxide-mediated vasodilation in patients with non-insulin-dependent diabetes mellitus

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7 January 2021

Obesity/insulin resistance is associated with endothelial dysfunction. Implications for the syndrome of insulin resistance

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7 January 2021

Insulin-mediated skeletal muscle vasodilation is nitric oxide dependent. A novel action of insulin to increase nitric oxide release

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7 January 2021

Non-invasive detection of endothelial dysfunction in children and adults at risk of atherosclerosis

1 reference

7 January 2021

The clinical implications of endothelial dysfunction

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7 January 2021

Contribution of nitric oxide and prostaglandins to reactive hyperemia in human forearm

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7 January 2021

Nitric oxide is responsible for flow-dependent dilatation of human peripheral conduit arteries in vivo.

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7 January 2021

Resistance responses in proximal arterial vessels, arterioles and veins during reactive hyperaemia in skeletal muscle and their underlying regulatory mechanisms.

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7 January 2021

Responses of the skin microcirculation to acetylcholine and sodium nitroprusside in patients with NIDDM.

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7 January 2021

Lilly lecture 1987. The triumvirate: beta-cell, muscle, liver. A collusion responsible for NIDDM.

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7 January 2021

Vascular defects in the aetiology of peripheral insulin resistance in diabetes. A critical review of hypotheses and facts

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7 January 2021

Decreased effect of insulin to stimulate skeletal muscle blood flow in obese man. A novel mechanism for insulin resistance

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7 January 2021

Relationship Between Fasting Plasma Insulin Level and Resistance to Insulin-Mediated Glucose Uptake in Normal and Diabetic Subjects

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7 January 2021

Delayed transcapillary transport of insulin to muscle interstitial fluid in obese subjects

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7 January 2021

Mechanism of enhanced insulin sensitivity in athletes. Increased blood flow, muscle glucose transport protein (GLUT-4) concentration, and glycogen synthase activity

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7 January 2021

Free fatty acid elevation impairs insulin-mediated vasodilation and nitric oxide production

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7 January 2021

The effects of euglycemic hyperinsulinemia and amino acid infusion on regional and whole body glucose disposal in man

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7 January 2021

Normal effect of insulin to stimulate leg blood flow in NIDDM.

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7 January 2021

Insulin-induced vasodilatation: physiology or pharmacology?

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7 January 2021

Insulin resistance and vasodilation in essential hypertension. Studies with adenosine.

1 reference

7 January 2021

Role of blood flow in regulating insulin-stimulated glucose uptake in humans. Studies using bradykinin, [15O]water, and [18F]fluoro-deoxy-glucose and positron emission tomography

1 reference

7 January 2021

Angiotensin mediates forearm glucose uptake by hemodynamic rather than direct effects.

1 reference

7 January 2021

Capillary supply of the quadriceps femoris muscle of man: adaptive response to exercise

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7 January 2021

Skeletal muscle microvascular recruitment by physiological hyperinsulinemia precedes increases in total blood flow

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7 January 2021

Nitric oxide release accounts for insulin's vascular effects in humans

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7 January 2021

Roles for insulin receptor, PI3-kinase, and Akt in insulin-signaling pathways related to production of nitric oxide in human vascular endothelial cells

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7 January 2021

Regulation of endothelial constitutive nitric oxide synthase gene expression in endothelial cells and in vivo : a specific vascular action of insulin.

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7 January 2021

The pathogenesis of vasodilatory shock

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7 January 2021

Signaling mechanisms underlying the vascular myogenic response

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7 January 2021

Vascular function, insulin resistance and fatty acids

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7 January 2021

Transient triglyceridemia decreases vascular reactivity in young, healthy men without risk factors for coronary heart disease

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7 January 2021

Insulin causes endothelial dysfunction in humans: sites and mechanisms.

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7 January 2021

Elevation of free fatty acids induces inflammation and impairs vascular reactivity in healthy subjects

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7 January 2021

Vascular effects of improving metabolic control with metformin or rosiglitazone in type 2 diabetes

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7 January 2021

Antiatherogenic effect of pioglitazone in type 2 diabetic patients irrespective of the responsiveness to its antidiabetic effect

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7 January 2021

Insulin sensitivity of muscle capillary recruitment in vivo

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7 January 2021

Long-term follow-up of patients with mild coronary artery disease and endothelial dysfunction

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7 January 2021

Association between multiple cardiovascular risk factors and atherosclerosis in children and young adults. The Bogalusa Heart Study

1 reference

7 January 2021

Paradoxical blood flow responses in the diabetic neuropathic foot: an assessment of the contribution of vascular denervation and microangiopathy

1 reference

7 January 2021

Prognostic impact of coronary vasodilator dysfunction on adverse long-term outcome of coronary heart disease

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7 January 2021

Prognostic value of coronary vascular endothelial dysfunction

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7 January 2021

Coronary endothelial dysfunction after heart transplantation predicts allograft vasculopathy and cardiac death

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7 January 2021

Close relation of endothelial function in the human coronary and peripheral circulations

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7 January 2021

Arterial abnormalities in the offspring of patients with premature myocardial infarction

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7 January 2021

Markers of inflammation and cardiovascular disease: application to clinical and public health practice: A statement for healthcare professionals from the Centers for Disease Control and Prevention and the American Heart Association

1 reference

7 January 2021

Elevated levels of acute-phase proteins and plasminogen activator inhibitor-1 predict the development of type 2 diabetes: the insulin resistance atherosclerosis study

1 reference

7 January 2021

The effect of interventions to prevent cardiovascular disease in patients with type 2 diabetes mellitus

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7 January 2021

Multifactorial intervention and cardiovascular disease in patients with type 2 diabetes

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7 January 2021

Two decades of progress in preventing vascular disease

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7 January 2021

Glycometabolic state at admission: important risk marker of mortality in conventionally treated patients with diabetes mellitus and acute myocardial infarction: long-term results from the Diabetes and Insulin-Glucose Infusion in Acute Myocardial Inf

1 reference

7 January 2021

Intensive insulin therapy in critically ill patients

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7 January 2021

In type 2 diabetes, rosiglitazone therapy for insulin resistance ameliorates endothelial dysfunction independent of glucose control

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7 January 2021

Decreased plasma adiponectin concentrations are closely related to hepatic fat content and hepatic insulin resistance in pioglitazone-treated type 2 diabetic patients

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7 January 2021

Effects of an angiotensin-converting-enzyme inhibitor, ramipril, on cardiovascular events in high-risk patients

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7 January 2021

Acute and chronic angiotensin-1 receptor antagonism reverses endothelial dysfunction in atherosclerosis

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7 January 2021

Comparative effect of ace inhibition and angiotensin II type 1 receptor antagonism on bioavailability of nitric oxide in patients with coronary artery disease: role of superoxide dismutase

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7 January 2021

Beneficial effect of cholesterol-lowering therapy on coronary endothelium-dependent relaxation in hypercholesterolaemic patients

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7 January 2021

Beneficial effects of cholesterol-lowering therapy on the coronary endothelium in patients with coronary artery disease

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7 January 2021

Insulin therapy improves insulin-stimulated endothelial function in patients with type 2 diabetes and ischemic heart disease

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7 January 2021

Improved endothelial function with metformin in type 2 diabetes mellitus

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7 January 2021

Nuclear factor-kappaB: a pivotal transcription factor in chronic inflammatory diseases

1 reference

7 January 2021

Effect of exercise on coronary endothelial function in patients with coronary artery disease.

1 reference

7 January 2021

Exercise training enhances endothelial function in young men

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7 January 2021

Cigarette smoking is associated with dose-related and potentially reversible impairment of endothelium-dependent dilation in healthy young adults

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7 January 2021

Restoration of endothelium-dependent relaxation by dietary treatment of atherosclerosis

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7 January 2021

The effect of cholesterol-lowering and antioxidant therapy on endothelium-dependent coronary vasomotion

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7 January 2021

Does a glass of red wine improve endothelial function?

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7 January 2021

Cloning of adiponectin receptors that mediate antidiabetic metabolic effects

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7 January 2021

Atherosclerosis — An Inflammatory Disease

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7 January 2021

Systemic endothelial dysfunction is related to the extent and severity of coronary artery disease.

1 reference

7 January 2021

Identifiers

DOI

10.1002/DMRR.634

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14 August 2017

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PubMed ID

16506274