Triptolide directly inhibits dCTP pyrophosphatase. (Q36415832)

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4 February 2020

title

Triptolide directly inhibits dCTP pyrophosphatase (English)

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4 February 2020

1

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author name string

Hüseyin Cavga

series ordinal

2

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4 February 2020

Nicholas Aberle

series ordinal

3

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4 February 2020

Craig M Crews

series ordinal

4

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publication date

10 June 2011

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4 February 2020

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4 February 2020

volume

12

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issue

11

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4 February 2020

page(s)

1767-1773

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XPB, a subunit of TFIIH, is a target of the natural product triptolide.

4 February 2020

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3503517

Total Synthesis and Biological Evaluation of Tyroscherin

30 September 2017

1 reference

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Triptolide reduces cyst formation in a neonatal to adult transition Pkd1 model of ADPKD

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3503517

Identification and characterization of a peptidic ligand for Ras.

30 September 2017

1 reference

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RNA polymerase - an important molecular target of triptolide in cancer cells

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3503517

Triptolide is an inhibitor of RNA polymerase I and II-dependent transcription leading predominantly to down-regulation of short-lived mRNA.

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3503517

Triptolide: An inhibitor of a disintegrin and metalloproteinase 10 (ADAM10) in cancer cells

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3503517

Mouse RS21-C6 is a mammalian 2'-deoxycytidine 5'-triphosphate pyrophosphohydrolase that prefers 5-iodocytosine

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3503517

Triptolide reduces cystogenesis in a model of ADPKD.

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3503517

Triptolide-induced transcriptional arrest is associated with changes in nuclear substructure

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3503517

Synthesis of gemcitabine triphosphate (dFdCTP) as a tris(triethylammonium) salt

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3503517

Molecular understanding and modern application of traditional medicines: triumphs and trials.

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3503517

Triptolide binds covalently to a 90 kDa nuclear protein. Role of epoxides in binding and activity

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3503517

Triptolide is a traditional Chinese medicine-derived inhibitor of polycystic kidney disease

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3503517

Crystal structure of RS21-C6, involved in nucleoside triphosphate pyrophosphohydrolysis

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3503517

Studies on calcium dependence reveal multiple modes of action for triptolide

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3503517

Dimeric dUTPases, HisE, and MazG belong to a new superfamily of all-alpha NTP pyrophosphohydrolases with potential "house-cleaning" functions

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3503517

Immunosuppressive and anti-inflammatory mechanisms of triptolide, the principal active diterpenoid from the Chinese medicinal herb Tripterygium wilfordii Hook. f.

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3503517

Triptolide, a novel immunosuppressive and anti-inflammatory agent purified from a Chinese herb Tripterygium wilfordii Hook F.

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3503517

The Chinese anti-inflammatory and immunosuppressive herbal remedy Tripterygium wilfordii Hook F.

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3503517

5-Bromo-2'-deoxycytidine (BCDR). II. Studies with murine neoplastic cells in culture and in vitro

30 September 2017

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21671327

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1002/CBIC.201100007

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21671327%20AND%20SRC:MED&resulttype=core&format=json

4 February 2020

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4 February 2020

PubMed publication ID

21671327

1 reference