The nuclear pore complex: the gateway to successful nonviral gene delivery (Q36416930)

14 August 2017

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title

The nuclear pore complex: the gateway to successful nonviral gene delivery (English)

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14 August 2017

4

Wim E Hennink

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14 August 2017

author name string

Marieke A E M van der Aa

1

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14 August 2017

Enrico Mastrobattista

2

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14 August 2017

Ronald S Oosting

3

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14 August 2017

Gerben A Koning

5

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14 August 2017

Daan J A Crommelin

6

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14 August 2017

publication date

15 March 2006

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14 August 2017

published in

Pharmaceutical Research

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14 August 2017

volume

23

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14 August 2017

issue

3

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14 August 2017

page(s)

447-459

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Nuclear pore complex number and distribution throughout the Saccharomyces cerevisiae cell cycle by three-dimensional reconstruction from electron micrographs of nuclear envelopes

14 August 2017

cites work

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https://api.crossref.org/works/10.1007%2FS11095-005-9445-4

Ufd2, a novel autoantigen in scleroderma, regulates sister chromatid separation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11095-005-9445-4

Fluorescence microphotolysis to measure nucleocytoplasmic transport and intracellular mobility

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11095-005-9445-4

The nuclear pore complex: nucleocytoplasmic transport and beyond

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11095-005-9445-4

Evidence for distinct substrate specificities of importin alpha family members in nuclear protein import

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11095-005-9445-4

The actions of melittin on membranes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11095-005-9445-4

Peptide nucleic acids: versatile tools for gene therapy strategies

21 January 2018

1 reference

12 December 2020

Nuclear import of DNA in digitonin-permeabilized cells

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12 December 2020

Two-way trafficking with Ran.

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12 December 2020

Efficient transfection of non-proliferating human airway epithelial cells with a synthetic vector system.

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12 December 2020

The cytoplasmic filaments of the nuclear pore complex are dispensable for selective nuclear protein import

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12 December 2020

Gene delivery by a steroid-peptide nucleic acid conjugate

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12 December 2020

A nuclear localization domain in the hnRNP A1 protein

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12 December 2020

Virtual gating and nuclear transport: the hole picture

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12 December 2020

Induction of nuclear transport with a synthetic peptide homologous to the SV40 T antigen transport signal

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12 December 2020

Coupling of nuclear localization signals to plasmid DNA and specific interaction of the conjugates with importin alpha.

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12 December 2020

Proteomic analysis of the mammalian nuclear pore complex

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12 December 2020

Can nuclear localization signals enhance nuclear localization of plasmid DNA?

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12 December 2020

Snurportin1, an m3G-cap-specific nuclear import receptor with a novel domain structure

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12 December 2020

Liposomes enhance delivery and expression of an RGD-oligolysine gene transfer vector in human tracheal cells.

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12 December 2020

Kinetic analysis of translocation through nuclear pore complexes

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12 December 2020

Branched cationic peptides for gene delivery: role of type and number of cationic residues in formation and in vitro activity of DNA polyplexes

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12 December 2020

Distinct nuclear import and export pathways mediated by members of the karyopherin beta family

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12 December 2020

Efficient DNA transfection mediated by the C-terminal domain of human immunodeficiency virus type 1 viral protein R

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12 December 2020

Nuclear envelope permeability

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12 December 2020

Nuclear transport and transcription

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12 December 2020

Nuclear import and export pathways

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12 December 2020

Transport between the cell nucleus and the cytoplasm

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12 December 2020

Enhancement of polylysine-mediated transferrinfection by nuclear localization sequences: polylysine does not function as a nuclear localization sequence

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12 December 2020

Direct translocation of histone molecules across cell membranes

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12 December 2020

Karyopherins: from nuclear-transport mediators to nuclear-function regulators

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12 December 2020

Nuclear transport of single molecules: dwell times at the nuclear pore complex.

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12 December 2020

Structural basis for the interaction between NTF2 and nucleoporin FxFG repeats

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12 December 2020

The nuclear pore complex: three-dimensional surface structure revealed by field emission, in-lens scanning electron microscopy, with underlying structure uncovered by proteolysis.

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12 December 2020

Interactions and three-dimensional localization of a group of nuclear pore complex proteins

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12 December 2020

Importin 7 and importin alpha/importin beta are nuclear import receptors for the glucocorticoid receptor

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12 December 2020

Gene delivery: a single nuclear localization signal peptide is sufficient to carry DNA to the cell nucleus

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12 December 2020

Coupling of a targeting peptide to plasmid DNA by covalent triple helix formation

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12 December 2020

The permeability barrier of nuclear pore complexes appears to operate via hydrophobic exclusion

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12 December 2020

Nuclear import of Ran is mediated by the transport factor NTF2.

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12 December 2020

Movement of a karyophilic protein through the nuclear pores of oocytes

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12 December 2020

An NLS peptide covalently linked to linear DNA does not enhance transfection efficiency of cationic polymer based gene delivery systems

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12 December 2020

Artificial viruses: a nanotechnological approach to gene delivery

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12 December 2020

Enhanced intracellular mobility and nuclear accumulation of DNA plasmids associated with a karyophilic protein

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12 December 2020

Finding nuclear localization signals

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12 December 2020

A distinct nuclear import pathway used by ribosomal proteins

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12 December 2020

Actin cytoskeleton as the principal determinant of size-dependent DNA mobility in cytoplasm: a new barrier for non-viral gene delivery

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12 December 2020

Nuclear localization signal peptides enhance cationic liposome-mediated gene therapy

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12 December 2020

Nuclear targeting sequences--a consensus?

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12 December 2020

In Vivo-Targeted Gene Delivery Using Antibody-Based Nonviral Vector

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12 December 2020

Nuclear import of RPA in Xenopus egg extracts requires a novel protein XRIPalpha but not importin alpha

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12 December 2020

Helper activity for gene expression, a novel function of the SV40 enhancer.

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12 December 2020

Coupling of a targeting peptide to plasmid DNA using a new type of padlock oligonucleotide

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12 December 2020

Histone H2A significantly enhances in vitro DNA transfection.

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12 December 2020

Histone-mediated transfer and expression of the HIV-1 tat gene in Jurkat cells

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12 December 2020

Gene transfer into mammalian cells using histone-condensed plasmid DNA.

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12 December 2020

Adenovirus hexon protein enhances nuclear delivery and increases transgene expression of polyethylenimine/plasmid DNA vectors

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12 December 2020

Effect of a DNA nuclear targeting sequence on gene transfer and expression of plasmids in the intact vasculature

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12 December 2020

RanGTP mediates nuclear pore complex assembly

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12 December 2020

A short amino acid sequence able to specify nuclear location

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12 December 2020

The nuclear pore complex: a jack of all trades?

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12 December 2020

Signals mediating nuclear targeting and their regulation: application in drug delivery

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12 December 2020

The HIV-1 Rev activation domain is a nuclear export signal that accesses an export pathway used by specific cellular RNAs

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12 December 2020

Glimpsing over the event horizon: evolution of nuclear pores and envelope

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12 December 2020

The yeast nuclear pore complex: composition, architecture, and transport mechanism

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12 December 2020

Nuclear entry of nonviral vectors

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12 December 2020

Metabolic instability of plasmid DNA in the cytosol: a potential barrier to gene transfer

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12 December 2020

Nuclear targeting peptide scaffolds for lipofection of nondividing mammalian cells

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12 December 2020

Coupling of importin beta binding peptide on plasmid DNA: transfection efficiency is increased by modification of lipoplex's physico-chemical properties

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12 December 2020

Crystallographic analysis of the recognition of a nuclear localization signal by the nuclear import factor karyopherin alpha

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12 December 2020

Two interdependent basic domains in nucleoplasmin nuclear targeting sequence: identification of a class of bipartite nuclear targeting sequence

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12 December 2020

Mechanisms of Receptor-Mediated Nuclear Import and Nuclear Export

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12 December 2020

Efficient in vitro and in vivo expression of covalently modified plasmid DNA.

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12 December 2020

Protein migration into nuclei. II. Frog oocyte nuclei accumulate a class of microinjected oocyte nuclear proteins and exclude a class of microinjected oocyte cytoplasmic proteins

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12 December 2020

Comparative genomics, evolution and origins of the nuclear envelope and nuclear pore complex

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12 December 2020

Importin α: a multipurpose nuclear-transport receptor

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12 December 2020

Enhanced nuclear import and transfection efficiency of plasmid DNA using streptavidin-fused importin-beta

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12 December 2020

Molecular basis for the recognition of a nonclassical nuclear localization signal by importin beta

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12 December 2020

Regulation of nuclear transport in proliferating and quiescent cells

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12 December 2020

A novel transfecting peptide comprising a tetrameric nuclear localization sequence

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12 December 2020

Translocation through the nuclear pore complex

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12 December 2020

The nuclear pore complex is involved in nuclear transfer of plasmid DNA condensed with an oligolysine-RGD peptide containing nuclear localisation properties

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12 December 2020

The cationic amphipathic alpha-helix of HIV-1 viral protein R (Vpr) binds to nucleic acids, permeabilizes membranes, and efficiently transfects cells.

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12 December 2020

The molecular mechanism of translocation through the nuclear pore complex is highly conserved.

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12 December 2020

Improved packing of poly(ethylenimine)/DNA complexes increases transfection efficiency

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12 December 2020

Mechanisms of nuclear transport and interventions

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12 December 2020

Nucleo-cytoplasmic distribution of human hnRNP proteins: a search for the targeting domains in hnRNP A1

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12 December 2020

Nuclear import of plasmid DNA in digitonin-permeabilized cells requires both cytoplasmic factors and specific DNA sequences

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12 December 2020

The permeability of the nuclear envelope in dividing and nondividing cell cultures

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12 December 2020

Importin beta: conducting a much larger cellular symphony

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12 December 2020

The vertebrate nuclear pore complex: from structure to function.

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12 December 2020

PCR-generated linear DNA fragments utilized as a hantavirus DNA vaccine

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12 December 2020

Emerging significance of plasmid DNA nuclear import in gene therapy

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12 December 2020

A peptide nucleic acid-nuclear localization signal fusion that mediates nuclear transport of DNA.

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12 December 2020

Dominant-negative mutants of importin-beta block multiple pathways of import and export through the nuclear pore complex

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12 December 2020

Export of importin alpha from the nucleus is mediated by a specific nuclear transport factor

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12 December 2020

Analysis and prediction of leucine-rich nuclear export signals

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12 December 2020

Nuclear localization signal of SV40 T antigen directs import of plasmid DNA into sea urchin male pronuclei in vitro

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12 December 2020

Polyethylenimine but not cationic lipids promotes transgene delivery to the nucleus in mammalian cells

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12 December 2020

NTF2 mediates nuclear import of Ran.

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12 December 2020

Towards synthetic viruses

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12 December 2020

Nuclear localisation sequence templated nonviral gene delivery vectors: investigation of intracellular trafficking events of LMD and LD vector systems

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12 December 2020

Karyopherins and nuclear import

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12 December 2020

The nuclear localization sequence of the SV40 T antigen promotes transgene uptake and expression in zebrafish embryo nuclei.

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12 December 2020

Nuclear protein migration involves two steps: rapid binding at the nuclear envelope followed by slower translocation through nuclear pores

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12 December 2020

Sequence requirements for plasmid nuclear import

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12 December 2020

The nuclear annuli as pathways for nucleocytoplasmic exchanges

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12 December 2020

The nuclear pore complex as a transport machine.

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12 December 2020

Cell-specific nuclear import of plasmid DNA.

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12 December 2020

A nuclear localization signal can enhance both the nuclear transport and expression of 1 kb DNA

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12 December 2020

Cryo-electron tomography provides novel insights into nuclear pore architecture: implications for nucleocytoplasmic transport

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12 December 2020

Autoinhibition by an internal nuclear localization signal revealed by the crystal structure of mammalian importin alpha

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12 December 2020

Remodelling the walls of the nucleus

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12 December 2020

Rapid translocation of NTF2 through the nuclear pore of isolated nuclei and nuclear envelopes

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12 December 2020

Nuclear localization signals: a driving force for nuclear transport of plasmid DNA in zebrafish

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12 December 2020

Domain-specific antibodies reveal multiple-site topology of Nup153 within the nuclear pore complex

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12 December 2020

The importin beta/importin 7 heterodimer is a functional nuclear import receptor for histone H1.

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12 December 2020

Towards safe, non-viral therapeutic gene expression in humans.

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12 December 2020

A novel receptor-mediated nuclear protein import pathway

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12 December 2020

Plasmid DNA entry into postmitotic nuclei of primary rat myotubes

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12 December 2020

A 41 amino acid motif in importin-alpha confers binding to importin-beta and hence transit into the nucleus

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12 December 2020

Import of plasmid DNA into the nucleus is sequence specific

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12 December 2020

Protein migration into nuclei. I. Frog oocyte nuclei in vivo accumulate microinjected histones, allow entry to small proteins, and exclude large proteins

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12 December 2020

Dissection of a nuclear localization signal

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12 December 2020

Toward a more complete 3-D structure of the nuclear pore complex

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12 December 2020

Putative nuclear localization signals (NLS) in protein transcription factors

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12 December 2020

Structure of importin-beta bound to the IBB domain of importin-alpha

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12 December 2020

CRM1 is an export receptor for leucine-rich nuclear export signals

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12 December 2020

Gradient of increasing affinity of importin beta for nucleoporins along the pathway of nuclear import

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12 December 2020

An integrin-targeted non-viral vector for pulmonary gene therapy

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12 December 2020

Critical assessment of the nuclear import of plasmid during cationic lipid-mediated gene transfer.

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12 December 2020

Isolation of a protein that is essential for the first step of nuclear protein import

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12 December 2020

The nuclear pore complex: from molecular architecture to functional dynamics

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12 December 2020

No Enhancement of Nuclear Entry by Direct Conjugation of a Nuclear Localization Signal Peptide to Linearized DNA

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12 December 2020

Architecture and design of the nuclear pore complex

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12 December 2020

Breaking and making of the nuclear envelope

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12 December 2020

The nuclear pore complex: a protein machine bridging the nucleus and cytoplasm

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12 December 2020

DNA vector chemistry: the covalent attachment of signal peptides to plasmid DNA

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12 December 2020

A regulated, NFkappaB-assisted import of plasmid DNA into mammalian cell nuclei

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12 December 2020

Selective enhancement of gene transfer by steroid-mediated gene delivery

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12 December 2020

10.1007/S11095-005-9445-4

Identifiers

DOI

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14 August 2017

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