Astrocytes generated from patient induced pluripotent stem cells recapitulate features of Huntington's disease patient cells (Q36423519)

14 August 2017

Astrocytes generated from patient induced pluripotent stem cells recapitulate features of Huntington's disease patient cells (English)

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14 August 2017

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Guo-li Ming

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Hongjun Song

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object named as

Hongjun Song

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Cheng-Hsuan Chiang

object named as

Cheng-Hsuan Chiang

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Christopher A Ross

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object named as

Christopher A Ross

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14 August 2017

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Tarja A Juopperi

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14 August 2017

2

Woon Ryoung Kim

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14 August 2017

5

Russell L Margolis

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14 August 2017

Huimei Yu

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14 August 2017

21 May 2012

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https://scigraph.springernature.com/pub.10.1186/1756-6606-5-17

14 August 2017

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CAG repeat expansion in Huntington disease determines age at onset in a fully dominant fashion.

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Convergent pathogenic pathways in Alzheimer's and Huntington's diseases: shared targets for drug development.

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Modeling neurological diseases using patient-derived induced pluripotent stem cells

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Induced pluripotent stem cells: a new revolution for clinical neurology?

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Integration-free induced pluripotent stem cells derived from schizophrenia patients with a DISC1 mutation

30 September 2017

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Glia: initiators and progressors of pathology in Parkinson's disease

30 September 2017

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Huntington's disease: from molecular pathogenesis to clinical treatment

30 September 2017

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A model for neural development and treatment of Rett syndrome using human induced pluripotent stem cells

30 September 2017

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Characterization of Human Huntington's Disease Cell Model from Induced Pluripotent Stem Cells

30 September 2017

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30 September 2017

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Cholesterol defect is marked across multiple rodent models of Huntington's disease and is manifest in astrocytes

30 September 2017

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Derivation of Huntington's disease-affected human embryonic stem cell lines

30 September 2017

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Reprogramming of human peripheral blood cells to induced pluripotent stem cells

30 September 2017

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In vivo expression of polyglutamine-expanded huntingtin by mouse striatal astrocytes impairs glutamate transport: a correlation with Huntington's disease subjects

30 September 2017

1 reference

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Cargo recognition failure is responsible for inefficient autophagy in Huntington's disease

30 September 2017

1 reference

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Do astrocytes really exocytose neurotransmitters?

30 September 2017

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Mutant huntingtin in glial cells exacerbates neurological symptoms of Huntington disease mice

30 September 2017

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Expression of mutant huntingtin in mouse brain astrocytes causes age-dependent neurological symptoms

30 September 2017

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Modelling pathogenesis and treatment of familial dysautonomia using patient-specific iPSCs.

30 September 2017

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Human embryonic stem cell models of Huntington disease.

30 September 2017

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Parkinson's disease patient-derived induced pluripotent stem cells free of viral reprogramming factors

30 September 2017

1 reference

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Induced pluripotent stem cells from a spinal muscular atrophy patient

30 September 2017

1 reference

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Human embryonic stem cell-derived motor neurons are sensitive to the toxic effect of glial cells carrying an ALS-causing mutation

30 September 2017

1 reference

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Guidelines and techniques for the generation of induced pluripotent stem cells

30 September 2017

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Induced pluripotent stem cells generated from patients with ALS can be differentiated into motor neurons

30 September 2017

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Rodent genetic models of Huntington disease

30 September 2017

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G9a and Jhdm2a regulate embryonic stem cell fusion-induced reprogramming of adult neural stem cells

30 September 2017

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Huntington's disease: from pathology and genetics to potential therapies

30 September 2017

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Assessment of stromal-derived inducing activity in the generation of dopaminergic neurons from human embryonic stem cells

30 September 2017

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Induction of pluripotent stem cells from adult human fibroblasts by defined factors

30 September 2017

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Huntington disease models and human neuropathology: similarities and differences

30 September 2017

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Disrupted-In-Schizophrenia 1 regulates integration of newly generated neurons in the adult brain

30 September 2017

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Integrative genomic and functional analyses reveal neuronal subtype differentiation bias in human embryonic stem cell lines

30 September 2017

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Non-cell autonomous effect of glia on motor neurons in an embryonic stem cell-based ALS model

30 September 2017

1 reference

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Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3506453

Derivation and characterization of neuronal precursors and dopaminergic neurons from human embryonic stem cells in vitro

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3506453

Huntington's disease: seeing the pathogenic process through a genetic lens

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3506453

Expression of mutant huntingtin in glial cells contributes to neuronal excitotoxicity

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3506453

GABA regulates synaptic integration of newly generated neurons in the adult brain

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3506453

LC3, GABARAP and GATE16 localize to autophagosomal membrane depending on form-II formation

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3506453

Diagnosis of Huntington Disease

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3506453

Amino-terminal fragments of mutant huntingtin show selective accumulation in striatal neurons and synaptic toxicity

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3506453

Embryonic stem cell lines derived from human blastocysts

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3506453

Aggregation of huntingtin in neuronal intranuclear inclusions and dystrophic neurites in brain

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3506453

Formation of neuronal intranuclear inclusions underlies the neurological dysfunction in mice transgenic for the HD mutation

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3506453

Neuronal loss in the hippocampus in Huntington's disease: a comparison with HIV infection

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3506453

A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes.

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3506453

The relationship between trinucleotide (CAG) repeat length and clinical features of Huntington's disease

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3506453

Anticipation and instability of IT-15 (CAG)n repeats in parent-offspring pairs with Huntington disease

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3506453

Evidence for degenerative and regenerative changes in neostriatal spiny neurons in Huntington's disease

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3506453

Modeling familial Alzheimer's disease with induced pluripotent stem cells

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3506453

Teratoma formation by human embryonic stem cells is site dependent and enhanced by the presence of Matrigel.

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3506453

Autophagosome-like vacuole formation in Huntington's disease lymphoblasts

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3506453

Widespread expression of Huntington's disease gene (IT15) protein product

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3506453

Induced pluripotent stem cells from patients with Huntington's disease show CAG-repeat-expansion-associated phenotypes

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3506453

Expression of mutant N-terminal huntingtin fragment (htt552-100Q) in astrocytes suppresses the secretion of BDNF.

21 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3506453

Generation of induced pluripotent stem cells from human terminally differentiated circulating T cells.

21 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3506453

Generation and characterization of human induced pluripotent stem cells.

21 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3506453

Astroglia induce neurogenesis from adult neural stem cells

21 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3506453

Neural stem cells from adult hippocampus develop essential properties of functional CNS neurons

21 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3506453

Huntingtin protein colocalizes with lesions of neurodegenerative diseases: An investigation in Huntington's, Alzheimer's, and Pick's diseases

21 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3506453

21 September 2018

Identifiers

DOI

10.1186/1756-6606-5-17

1 reference

PMCID

3506453

Dimensions Publication ID

14 August 2017

1023717039

0 references

Fatcat ID

release_vtha76wqmjd4xfqgpafun7et4u

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/vtha76wqmjd4xfqgpafun7et4u

mapped directly with Wikidata item

24 November 2022

based on heuristic

PMCID

3506453

1 reference

14 August 2017

1 reference

PMCID

3506453