Keeping p53 in check: essential and synergistic functions of Mdm2 and Mdm4. (Q36423924)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16543935%20AND%20SRC:MED&resulttype=core&format=json

18 January 2020

review article

1 reference

title

Keeping p53 in check: essential and synergistic functions of Mdm2 and Mdm4 (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16543935%20AND%20SRC:MED&resulttype=core&format=json

18 January 2020

author

Jean-Christophe Marine

1

1 reference

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18 January 2020

Sarah Francoz

2

1 reference

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18 January 2020

author name string

M Maetens

3

1 reference

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18 January 2020

G Wahl

4

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18 January 2020

F Toledo

5

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18 January 2020

G Lozano

6

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18 January 2020

publication date

1 June 2006

1 reference

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Cell Death & Differentiation

18 January 2020

published in

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18 January 2020

volume

13

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18 January 2020

issue

6

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18 January 2020

page(s)

927-934

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https://scigraph.springernature.com/pub.10.1038/sj.cdd.4401912

18 January 2020

exact match

0 references

cites work

WAF1, a potential mediator of p53 tumor suppression

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Rescue of early embryonic lethality in mdm2-deficient mice by deletion of p53

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Rescue of embryonic lethality in Mdm2-deficient mice by absence of p53

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Mdm2 promotes the rapid degradation of p53

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Oncoprotein MDM2 is a ubiquitin ligase E3 for tumor suppressor p53

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7 January 2021

Regulation of p53 stability by Mdm2

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7 January 2021

Activity of MDM2, a ubiquitin ligase, toward p53 or itself is dependent on the RING finger domain of the ligase

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7 January 2021

Polyubiquitination of p53 by a ubiquitin ligase activity of p300.

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7 January 2021

Mono- versus polyubiquitination: differential control of p53 fate by Mdm2.

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Pirh2, a p53-induced ubiquitin-protein ligase, promotes p53 degradation

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7 January 2021

The ubiquitin ligase COP1 is a critical negative regulator of p53

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Yin Yang 1 is a negative regulator of p53.

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ARF-BP1/Mule is a critical mediator of the ARF tumor suppressor

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Mdm2-mediated NEDD8 conjugation of p53 inhibits its transcriptional activity

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7 January 2021

Conditional allele of mdm2 which encodes a p53 inhibitor

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7 January 2021

A single nucleotide polymorphism in the MDM2 promoter attenuates the p53 tumor suppressor pathway and accelerates tumor formation in humans

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7 January 2021

Rescue of Mdm4-deficient mice by Mdm2 reveals functional overlap of Mdm2 and Mdm4 in development.

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7 January 2021

HdmX stimulates Hdm2-mediated ubiquitination and degradation of p53.

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7 January 2021

The tumorigenic potential and cell growth characteristics of p53-deficient cells are equivalent in the presence or absence of Mdm2.

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7 January 2021

The MDM2 gene amplification database

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7 January 2021

In vivo activation of the p53 pathway by small-molecule antagonists of MDM2

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7 January 2021

Small molecule inhibitors of HDM2 ubiquitin ligase activity stabilize and activate p53 in cells

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7 January 2021

Flexible lid to the p53-binding domain of human Mdm2: implications for p53 regulation

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7 January 2021