Ewing's sarcoma oncoprotein EWS-FLI1: the perfect target without a therapeutic agent (Q36429538)

14 August 2017

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title

Ewing's sarcoma oncoprotein EWS-FLI1: the perfect target without a therapeutic agent (English)

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14 August 2017

Aykut Uren

1

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14 August 2017

Jeffrey A Toretsky

series ordinal

2

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14 August 2017

language of work or name

English

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publication date

1 August 2005

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14 August 2017

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14 August 2017

volume

1

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14 August 2017

issue

4

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14 August 2017

page(s)

521-528

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Common musculoskeletal tumors of childhood and adolescence

14 August 2017

cites work

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https://api.crossref.org/works/10.2217%2F14796694.1.4.521

Addition of ifosfamide and etoposide to standard chemotherapy for Ewing's sarcoma and primitive neuroectodermal tumor of bone

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.1.4.521

Does expression of different EWS chimeric transcripts define clinically distinct risk groups of Ewing tumor patients?

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.1.4.521

EWS-FLI1 fusion transcript structure is an independent determinant of prognosis in Ewing's sarcoma

21 January 2018

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https://api.crossref.org/works/10.2217%2F14796694.1.4.521

Inhibition of EWS-FLI-1 fusion protein with antisense oligodeoxynucleotides

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.1.4.521

EWS-Fli1 antisense oligodeoxynucleotide inhibits proliferation of human Ewing's sarcoma and primitive neuroectodermal tumor cells

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.1.4.521

Oligonucleotides targeted against a junction oncogene are made efficient by nanotechnologies

21 January 2018

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https://api.crossref.org/works/10.2217%2F14796694.1.4.521

Potentials for RNAi in sarcoma research and therapy: Ewing's sarcoma as a model.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.1.4.521

Small interfering RNAs expressed from a Pol III promoter suppress the EWS/Fli-1 transcript in an Ewing sarcoma cell line

21 January 2018

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https://api.crossref.org/works/10.2217%2F14796694.1.4.521

EWS fli-1 antisense nanocapsules inhibits ewing sarcoma-related tumor in mice

21 January 2018

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https://api.crossref.org/works/10.2217%2F14796694.1.4.521

Transformation induced by Ewing's sarcoma associated EWS/FLI-1 is suppressed by KRAB/FLI-1

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.1.4.521

Ewing sarcoma 11;22 translocation produces a chimeric transcription factor that requires the DNA-binding domain encoded by FLI1 for transformation.

21 January 2018

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https://api.crossref.org/works/10.2217%2F14796694.1.4.521

Oncogenic EWS-Fli1 interacts with hsRPB7, a subunit of human RNA polymerase II.

21 January 2018

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https://api.crossref.org/works/10.2217%2F14796694.1.4.521

COL11A2 collagen gene transcription is differentially regulated by EWS/ERG sarcoma fusion protein and wild-type ERG

21 January 2018

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https://api.crossref.org/works/10.2217%2F14796694.1.4.521

Identification of target genes for the Ewing's sarcoma EWS/FLI fusion protein by representational difference analysis

21 January 2018

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https://api.crossref.org/works/10.2217%2F14796694.1.4.521

Classification and diagnostic prediction of cancers using gene expression profiling and artificial neural networks

21 January 2018

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https://api.crossref.org/works/10.2217%2F14796694.1.4.521

Profiling and functional annotation of mRNA gene expression in pediatric rhabdomyosarcoma and Ewing's sarcoma

21 January 2018

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https://api.crossref.org/works/10.2217%2F14796694.1.4.521

The Id2 gene is a novel target of transcriptional activation by EWS-ETS fusion proteins in Ewing family tumors.

21 January 2018

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https://api.crossref.org/works/10.2217%2F14796694.1.4.521

Upregulation of Id2, an oncogenic helix-loop-helix protein, is mediated by the chimeric EWS/ets protein in Ewing sarcoma

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.1.4.521

Identification of p21WAF1/CIP1 as a direct target of EWS-Fli1 oncogenic fusion protein

21 January 2018

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https://api.crossref.org/works/10.2217%2F14796694.1.4.521

EWS-FLI1 target genes recovered from Ewing's sarcoma chromatin

21 January 2018

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https://api.crossref.org/works/10.2217%2F14796694.1.4.521

EWS/FLI-1 silencing and gene profiling of Ewing cells reveal downstream oncogenic pathways and a crucial role for repression of insulin-like growth factor binding protein 3.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.1.4.521

Repression of the gene encoding the TGF-beta type II receptor is a major target of the EWS-FLI1 oncoprotein

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.1.4.521

DNA binding domain-independent pathways are involved in EWS/FLI1-mediated oncogenesis.

21 January 2018

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https://api.crossref.org/works/10.2217%2F14796694.1.4.521

The splicing factor U1C represses EWS/FLI-mediated transactivation

21 January 2018

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https://api.crossref.org/works/10.2217%2F14796694.1.4.521

Mechanisms of sarcoma development

21 January 2018

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https://api.crossref.org/works/10.2217%2F14796694.1.4.521

Low molecular weight inhibitors of Myc-Max interaction and function

21 January 2018

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https://api.crossref.org/works/10.2217%2F14796694.1.4.521

EWS/FLI function varies in different cellular backgrounds.

21 January 2018

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https://api.crossref.org/works/10.2217%2F14796694.1.4.521

The Ews/Fli-1 fusion gene switches the differentiation program of neuroblastomas to Ewing sarcoma/peripheral primitive neuroectodermal tumors

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.1.4.521

Alteration of mesodermal cell differentiation by EWS/FLI-1, the oncogene implicated in Ewing's sarcoma

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.1.4.521

Structural basis for the interaction of the free SH2 domain EAT-2 with SLAM receptors in hematopoietic cells

21 January 2018

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https://api.crossref.org/works/10.2217%2F14796694.1.4.521

The dual-function CD150 receptor subfamily: the viral attraction

21 January 2018

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https://api.crossref.org/works/10.2217%2F14796694.1.4.521

EWS/FLI1 up regulates mE2-C, a cyclin-selective ubiquitin conjugating enzyme involved in cyclin B destruction

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.1.4.521

EWS/FLI1-induced manic fringe renders NIH 3T3 cells tumorigenic

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.1.4.521

DNA-binding and transcriptional activation properties of the EWS-FLI-1 fusion protein resulting from the t(11;22) translocation in Ewing sarcoma

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.1.4.521

PDGF-C is an EWS/FLI induced transforming growth factor in Ewing family tumors

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.1.4.521

Analysis of the expression of cell cycle regulators in Ewing cell lines: EWS-FLI-1 modulates p57KIP2and c-Myc expression

21 January 2018

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https://api.crossref.org/works/10.2217%2F14796694.1.4.521

PIM3 proto-oncogene kinase is a common transcriptional target of divergent EWS/ETS oncoproteins

21 January 2018

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https://api.crossref.org/works/10.2217%2F14796694.1.4.521

Induction of tenascin-C by tumor-specific EWS-ETS fusion genes

21 January 2018

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https://api.crossref.org/works/10.2217%2F14796694.1.4.521

Recombinant EWS-FLI1 oncoprotein activates transcription

21 January 2018

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https://api.crossref.org/works/10.2217%2F14796694.1.4.521

The invertor knock-in conditional chromosomal translocation mimic

21 January 2018

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https://api.crossref.org/works/10.2217%2F14796694.1.4.521

21 January 2018

Identifiers

DOI

10.2217/14796694.1.4.521

1 reference

14 August 2017

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