Signal transduction underlying the vascular effects of sphingosine 1-phosphate and sphingosylphosphorylcholine (Q36434460)

14 August 2017

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title

Signal transduction underlying the vascular effects of sphingosine 1-phosphate and sphingosylphosphorylcholine (English)

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14 August 2017

1

Denise G Hemmings

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PubMed ID

16570136

14 August 2017

language of work or name

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1 April 2006

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Naunyn-Schmiedeberg's Archives of Pharmacology

14 August 2017

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14 August 2017

373

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14 August 2017

18-29

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14 August 2017

1

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https://scigraph.springernature.com/pub.10.1007/s00210-006-0046-5

14 August 2017

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Sphingosine 1-phosphate and control of vascular tone

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Signaling of sphingosine-1-phosphate via the S1P/EDG-family of G-protein-coupled receptors

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Sphingosylphosphorylcholine-biological functions and mechanisms of action

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Plasma lipoproteins behave as carriers of extracellular sphingosine 1-phosphate: is this an atherogenic mediator or an anti-atherogenic mediator?

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Ca2+ sensitivity of smooth muscle and nonmuscle myosin II: modulated by G proteins, kinases, and myosin phosphatase

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Predicting obstructive coronary artery disease with serum sphingosine-1-phosphate

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12 December 2020

Nitric oxide-induced decrease in calcium sensitivity of resistance arteries is attributable to activation of the myosin light chain phosphatase and antagonized by the RhoA/Rho kinase pathway

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12 December 2020

Sphingosylphosphocholine is a naturally occurring lipid mediator in blood plasma: a possible role in regulating cardiac function via sphingolipid receptors

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12 December 2020

Transactivation of vascular endothelial growth factor (VEGF) receptor Flk-1/KDR is involved in sphingosine 1-phosphate-stimulated phosphorylation of Akt and endothelial nitric-oxide synthase (eNOS).

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12 December 2020

Sphingosylphosphorylcholine induces Ca(2+)-sensitization of vascular smooth muscle contraction: possible involvement of rho-kinase.

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12 December 2020

Ca2+ signaling induced by sphingosylphosphorylcholine and sphingosine 1-phosphate via distinct mechanisms in rat glomerular mesangial cells

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12 December 2020

Inhibition of autotaxin by lysophosphatidic acid and sphingosine 1-phosphate

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12 December 2020

Immunomodulator FTY720 Induces eNOS-dependent arterial vasodilatation via the lysophospholipid receptor S1P3.

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12 December 2020

Photolysis of intracellular caged sphingosine-1-phosphate causes Ca2+ mobilization independently of G-protein-coupled receptors.

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12 December 2020

Sphingosylphosphorylcholine-induced vasoconstriction of pulmonary artery: activation of non-store-operated Ca2+ entry

1 reference

12 December 2020

Agonist-modulated targeting of the EDG-1 receptor to plasmalemmal caveolae. eNOS activation by sphingosine 1-phosphate and the role of caveolin-1 in sphingolipid signal transduction.

1 reference

12 December 2020

Sphingosine 1-phosphate induces sinus tachycardia and coronary vasoconstriction in the canine heart

1 reference

12 December 2020

Upregulation of endothelin-1 production by lysophosphatidic acid in rat aortic endothelial cells

1 reference

12 December 2020

Sphingosine-1-phosphate receptor expression and signaling correlate with uterine prostaglandin-endoperoxide synthase 2 expression and angiogenesis during early pregnancy

1 reference

12 December 2020

Sphingosylphosphorylcholine is a novel messenger for Rho-kinase-mediated Ca2+ sensitization in the bovine cerebral artery: unimportant role for protein kinase C

1 reference

12 December 2020

Marked perinatal lethality and cellular signaling deficits in mice null for the two sphingosine 1-phosphate (S1P) receptors, S1P(2)/LP(B2)/EDG-5 and S1P(3)/LP(B3)/EDG-3.

1 reference

12 December 2020

Targeting Rho and Rho-kinase in the treatment of cardiovascular disease

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12 December 2020

The regulation and pharmacology of endothelial nitric oxide synthase

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12 December 2020

Lysosphingolipid receptor-mediated diuresis and natriuresis in anaesthetized rats

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12 December 2020

The coordination of prostaglandin E2 production by sphingosine-1-phosphate and ceramide-1-phosphate

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12 December 2020

Sphingosine-1-phosphate activates BKCa channels independently of G protein-coupled receptor in human endothelial cells

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12 December 2020

Does the coronary risk factor low density lipoprotein alter growth and signaling in vascular smooth muscle cells?

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12 December 2020

Essential role for sphingosine kinases in neural and vascular development

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12 December 2020

Sphingosine-1-phosphate-induced intracellular Ca2+ mobilization in human endothelial cells

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12 December 2020

Augmented sphingosylphosphorylcholine-induced Ca2+-sensitization of mesenteric artery contraction in spontaneously hypertensive rat.

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12 December 2020

Dihydrosphingosine 1-phosphate stimulates MMP1 gene expression via activation of ERK1/2-Ets1 pathway in human fibroblasts.

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12 December 2020

Involvement of endothelial nitric oxide in sphingosine-1-phosphate-induced angiogenesis

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12 December 2020

Estrogen modulation of endothelial nitric oxide synthase

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12 December 2020

Rho-Rho-kinase pathway in smooth muscle contraction and cytoskeletal reorganization of non-muscle cells

1 reference

12 December 2020

The role of sphingosine-1-phosphate in smooth muscle contraction

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12 December 2020

Essential requirement for sphingosine kinase activity in eNOS-dependent NO release and vasorelaxation.

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12 December 2020

Sphingosylphosphorylcholine-induced contraction of feline ileal smooth muscle cells is mediated by Galphai3 protein and MAPK.

1 reference

12 December 2020

Endothelial nitric oxide synthase activation by tumor necrosis factor alpha through neutral sphingomyelinase 2, sphingosine kinase 1, and sphingosine 1 phosphate receptors: a novel pathway relevant to the pathophysiology of endothelium

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12 December 2020

Lipids: potential regulators of nitric oxide generation

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12 December 2020

Sphingosine-1-phosphate and sphingosylphosphorylcholine constrict renal and mesenteric microvessels in vitro.

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12 December 2020

Sphingosine-1-phosphate: a platelet-activating sphingolipid released from agonist-stimulated human platelets

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12 December 2020

Enhancement of intracellular sphingosine-1-phosphate production by inositol 1,4,5-trisphosphate-evoked calcium mobilisation in HEK-293 cells: endogenous sphingosine-1-phosphate as a modulator of the calcium response.

1 reference

12 December 2020

Autotaxin hydrolyzes sphingosylphosphorylcholine to produce the regulator of migration, sphingosine-1-phosphate

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12 December 2020

C2-ceramide induces vasodilation in phenylephrine-induced pre-contracted rat thoracic aorta: role of RhoA/Rho-kinase and intracellular Ca2+ concentration.

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12 December 2020

GPR4 plays a critical role in endothelial cell function and mediates the effects of sphingosylphosphorylcholine

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12 December 2020

High-density lipoprotein stimulates myocardial perfusion in vivo.

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12 December 2020

Stimulation of intracellular sphingosine-1-phosphate production by G-protein-coupled sphingosine-1-phosphate receptors

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12 December 2020

Comparison of noradrenaline and lysosphingolipid-induced vasoconstriction in mouse and rat small mesenteric arteries

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12 December 2020

Interaction of sphingosine 1-phosphate with plasma components, including lipoproteins, regulates the lipid receptor-mediated actions

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12 December 2020

Distinct Ca(2+) signalling mechanisms induced by ATP and sphingosylphosphorylcholine in porcine aortic smooth muscle cells

1 reference

12 December 2020

Antiproliferative properties of sphingosine 1-phosphate in human hepatic myofibroblasts. A cyclooxygenase-2 mediated pathway

1 reference

12 December 2020

Regulation of vascular reactivity by established and emerging GPCRs

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12 December 2020

Emerging medicinal roles for lysophospholipid signaling

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12 December 2020

HDL action on the vascular wall: is the answer NO?

1 reference

12 December 2020

Sphingosine 1-phosphate induces contraction of coronary artery smooth muscle cells via S1P2.

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12 December 2020

Involvement of Rho-kinase in hypertensive vascular disease: a novel therapeutic target in hypertension

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12 December 2020

Effects of exogenous sphinganine, sphingosine, and sphingosine-1-phosphate on relaxation and contraction of porcine thoracic aortic and pulmonary arterial rings

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12 December 2020

Cystic fibrosis transmembrane regulator regulates uptake of sphingoid base phosphates and lysophosphatidic acid: modulation of cellular activity of sphingosine 1-phosphate

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12 December 2020

Comparison of sphingosine 1-phosphate-induced intracellular signaling pathways in vascular smooth muscles: differential role in vasoconstriction.

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12 December 2020

Sphingosylphosphorylcholine induces cytosolic Ca(2+) elevation in endothelial cells in situ and causes endothelium-dependent relaxation through nitric oxide production in bovine coronary artery

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12 December 2020

Sphingosine 1-phosphate enhances portal pressure in isolated perfused liver via S1P2 with Rho activation

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12 December 2020

Comparison of signalling mechanisms involved in rat mesenteric microvessel contraction by noradrenaline and sphingosylphosphorylcholine

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12 December 2020

Sphingosine 1-phosphate in amniotic fluid modulates cyclooxygenase-2 expression in human amnion-derived WISH cells

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12 December 2020

Extracellular export of sphingosine kinase-1 enzyme. Sphingosine 1-phosphate generation and the induction of angiogenic vascular maturation

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12 December 2020

Sphingosine 1-phosphate activates Akt, nitric oxide production, and chemotaxis through a Gi protein/phosphoinositide 3-kinase pathway in endothelial cells

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12 December 2020

Sphingosine 1-phosphate receptors mediate the lipid-induced cAMP accumulation through cyclooxygenase-2/prostaglandin I2 pathway in human coronary artery smooth muscle cells

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12 December 2020

Immune cell regulation and cardiovascular effects of sphingosine 1-phosphate receptor agonists in rodents are mediated via distinct receptor subtypes.

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12 December 2020

Lysophospholipid receptor-dependent and -independent calcium signaling.

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12 December 2020

Sphingosylphosphorylcholine stimulates mitogen-activated protein kinase via a Ca2+-dependent pathway

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12 December 2020

Involvement of Src family protein tyrosine kinases in Ca(2+) sensitization of coronary artery contraction mediated by a sphingosylphosphorylcholine-Rho-kinase pathway

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12 December 2020

Sphingosine 1-phosphate contracts canine basilar arteries in vitro and in vivo: possible role in pathogenesis of cerebral vasospasm

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12 December 2020

Sphingosine-1-phosphate reduces rat renal and mesenteric blood flow in vivo in a pertussis toxin-sensitive manner

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12 December 2020

HDL induces NO-dependent vasorelaxation via the lysophospholipid receptor S1P3.

1 reference

12 December 2020

Role of the sphingosine-1-phosphate receptor EDG-1 in PDGF-induced cell motility

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12 December 2020

HDL-associated estradiol stimulates endothelial NO synthase and vasodilation in an SR-BI–dependent manner

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12 December 2020

Platelet-activating factor increases endothelial [Ca2+]i and NO production in individually perfused intact microvessels

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12 December 2020

S1P3 receptors mediate the potent constriction of cerebral arteries by sphingosine-1-phosphate

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12 December 2020

Effects of neutral sphingomyelinase on phenylephrine-induced vasoconstriction and Ca(2+) mobilization in rat aortic smooth muscle

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12 December 2020

Sphingosine kinase 1 is up-regulated in colon carcinogenesis

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12 December 2020

Lysophospholipid G protein-coupled receptors

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12 December 2020

Sphingosine 1‐phosphate effect on endothelial cell PAF synthesis: Role in cellular migration

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12 December 2020

Sphingosine 1-phosphate induces CREB activation in rat cerebral artery via a protein kinase C-mediated inhibition of voltage-gated K+ channels.

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12 December 2020

Nifedipine inhibits sphinogosine-1-phosphate-induced renovascular contraction in vitro and in vivo

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12 December 2020

Sphingosine 1-phosphate and activation of endothelial nitric-oxide synthase. differential regulation of Akt and MAP kinase pathways by EDG and bradykinin receptors in vascular endothelial cells

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12 December 2020

LPC in oxidized LDL elicits vasocontraction and inhibits endothelium- dependent relaxation

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12 December 2020

Sphingosine 1-phosphate and ceramide 1-phosphate: expanding roles in cell signaling

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12 December 2020

Sphingolipids differentially regulate mitogen-activated protein kinases and intracellular Ca2+ in vascular smooth muscle: effects on CREB activation.

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12 December 2020

Indomethacin differentiates the renal effects of sphingosine-1-phosphate and sphingosylphosphorylcholine

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12 December 2020

The sphingosine kinase 1/sphingosine-1-phosphate pathway mediates COX-2 induction and PGE2 production in response to TNF-alpha

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12 December 2020

Lysophosphatidic acid-induced Ca2+ mobilization requires intracellular sphingosine 1-phosphate production. Potential involvement of endogenous EDG-4 receptors

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12 December 2020

Prostaglandin H synthase and vascular function

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12 December 2020

Cardiovascular effects of sphingosine-1-phosphate and other sphingomyelin metabolites

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12 December 2020

Sphingosine-1-phosphate acts via rho-associated kinase and nitric oxide to regulate human placental vascular tone.

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12 December 2020

Evidence that estrogen suppresses rho-kinase function in the cerebral circulation in vivo

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12 December 2020

Exogenous and intracellularly generated sphingosine 1-phosphate can regulate cellular processes by divergent pathways

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12 December 2020

Atheroprotective effects of high-density lipoprotein-associated lysosphingolipids

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12 December 2020

Lipid phosphate phosphatases and related proteins: signaling functions in development, cell division, and cancer

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12 December 2020

Blood lipid mediator sphingosine 1-phosphate potently stimulates platelet-derived growth factor-A and -B chain expression through S1P1-Gi-Ras-MAPK-dependent induction of Kruppel-like factor 5

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12 December 2020

Sphingosine 1-phosphate protects human umbilical vein endothelial cells from serum-deprived apoptosis by nitric oxide production

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12 December 2020

Effects of synthetic sphingosine-1-phosphate analogs on arachidonic acid metabolism and cell death.

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12 December 2020

Thrombogenic and atherogenic activities of lysophosphatidic acid

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12 December 2020

Sphingosine kinase: a mediator of vital cellular functions

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12 December 2020

Sphingosine-1-phosphate and sphingosylphosphorylcholine: two of a kind?

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12 December 2020

Lysophosphatidic acid alters cerebrovascular reactivity in piglets.

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12 December 2020

Sphingosine kinase modulates microvascular tone and myogenic responses through activation of RhoA/Rho kinase

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12 December 2020

Sphingosine 1-phosphate-induced vasoconstriction is elevated in mesenteric resistance arteries from aged female rats

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12 December 2020

Inhibition of Ca2+ signalling by the sphingosine 1-phosphate receptor S1P1

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12 December 2020

10.1007/S00210-006-0046-5

Identifiers

DOI

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14 August 2017

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PubMed ID

16570136