The role of Na,K-ATPase alpha subunit serine 775 and glutamate 779 in determining the extracellular K+ and membrane potential-dependent properties of the Na,K-pump (Q36436731)

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scientific article published in July 2000

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English	The role of Na,K-ATPase alpha subunit serine 775 and glutamate 779 in determining the extracellular K+ and membrane potential-dependent properties of the Na,K-pump	scientific article published in July 2000

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scholarly article

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7 November 2019

The role of Na,K-ATPase alpha subunit serine 775 and glutamate 779 in determining the extracellular K+ and membrane potential-dependent properties of the Na,K-pump (English)

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7 November 2019

2

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7 November 2019

author name string

R D Peluffo

1

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7 November 2019

J R Berlin

3

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7 November 2019

publication date

1 July 2000

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7 November 2019

The Journal of General Physiology

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7 November 2019

116

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7 November 2019

1

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7 November 2019

47-59

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7 November 2019

Electrogenic sodium-sodium exchange carried out by Na,K-ATPase containing the amino acid substitution Glu779Ala

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2229616

30 September 2017

Substitutions of glutamate 781 in the Na,K-ATPase alpha subunit demonstrate reduced cation selectivity and an increased affinity for ATP.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2229616

30 September 2017

Charge movement by the Na/K pump in Xenopus oocytes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2229616

30 September 2017

Pre-steady-state charge translocation in NaK-ATPase from eel electric organ

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2229616

30 September 2017

Na+,K(+)-ATPase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2229616

30 September 2017

Access channel model for the voltage dependence of the forward-running Na+/K+ pump

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2229616

30 September 2017

Structure-function relationships of cation translocation by Ca(2+)- and Na+, K(+)-ATPases studied by site-directed mutagenesis.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2229616

30 September 2017

Partial reactions of the Na,K-ATPase: determination of rate constants

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2229616

30 September 2017

Membrane disposition of the M5-M6 hairpin of Na+,K(+)-ATPase alpha subunit is ligand dependent.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2229616

30 September 2017

[Na] and [K] dependence of the Na/K pump current-voltage relationship in guinea pig ventricular myocytes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2229616

30 September 2017

Steady-state current-voltage relationship of the Na/K pump in guinea pig ventricular myocytes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2229616

30 September 2017

A 19-kDa C-terminal tryptic fragment of the alpha chain of Na/K-ATPase is essential for occlusion and transport of cations

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2229616

30 September 2017

Voltage dependence of the Na/K pump

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2229616

30 September 2017

Substitution of glutamic 779 with alanine in the Na,K-ATPase alpha subunit removes voltage dependence of ion transport.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2229616

28 June 2018

Substitutions of serine 775 in the alpha subunit of the Na,K-ATPase selectively disrupt K+ high affinity activation without affecting Na+ interaction.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2229616

28 June 2018

Structure-function relationships in the Na,K-ATPase alpha subunit: site-directed mutagenesis of glutamine-111 to arginine and asparagine-122 to aspartic acid generates a ouabain-resistant enzyme

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2229616

28 June 2018

Voltage dependence of Na translocation by the Na/K pump.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2229616

28 June 2018

A negative slope in the current-voltage relationship of the Na+/K+ pump in Xenopus oocytes produced by reduction of external [K+].

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2229616

28 June 2018

Comparison of the substrate dependence properties of the rat Na,K-ATPase alpha 1, alpha 2, and alpha 3 isoforms expressed in HeLa cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2229616

28 June 2018

Interactions between fragments of trypsinized Na,K-ATPase detected by thermal inactivation of Rb+ occlusion and dissociation of the M5/M6 fragment.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2229616

21 September 2018

Significance of the glutamic acid residues Glu334, Glu959, and Glu960 of the alpha subunits of Torpedo Na+, K+ pumps for transport activity and ouabain binding

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2229616

21 September 2018

Electrogenic K+ transport by the Na(+)-K+ pump in rat cardiac ventricular myocytes.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2229616

21 September 2018

Electrogenicity of the sodium transport pathway in the Na,K-ATPase probed by charge-pulse experiments

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2229616

21 September 2018

Glutamate 779, an intramembrane carboxyl, is essential for monovalent cation binding by the Na,K-ATPase.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2229616

21 September 2018

Mutant Glu781-->Ala of the rat kidney Na+,K(+)-ATPase displays low cation affinity and catalyzes ATP hydrolysis at a high rate in the absence of potassium ions.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2229616

21 September 2018

Interpretation of current-voltage relationships for "active" ion transport systems: I. Steady-state reaction-kinetic analysis of class-I mechanisms.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2229616

21 September 2018

Charge translocation by the Na,K-pump: I. Kinetics of local field changes studied by time-resolved fluorescence measurements.

1 reference

https://pubmed.ncbi.nlm.nih.gov/10871639

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Extracellular access to the Na,K pump: pathway similar to ion channel

1 reference

https://pubmed.ncbi.nlm.nih.gov/10871639

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effects of competitive sodium-like antagonists on Na,K-ATPase suggest that cation occlusion from the cytoplasmic surface occurs in two steps

1 reference

https://pubmed.ncbi.nlm.nih.gov/10871639

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Channel-like function of the Na,K pump probed at microsecond resolution in giant membrane patches

1 reference

https://pubmed.ncbi.nlm.nih.gov/10871639

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mechanism of electrogenic reaction steps during K+ transport by the NA,K-ATPase

1 reference

https://pubmed.ncbi.nlm.nih.gov/10871639

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Importance of intramembrane carboxylic acids for occlusion of K+ ions at equilibrium in renal Na,K-ATPase

1 reference

https://pubmed.ncbi.nlm.nih.gov/10871639

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Contribution to Tl+, K+, and Na+ binding of Asn776, Ser775, Thr774, Thr772, and Tyr771 in cytoplasmic part of fifth transmembrane segment in alpha-subunit of renal Na,K-ATPase

1 reference

https://pubmed.ncbi.nlm.nih.gov/10871639

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Evidence that the cation occlusion domain of Na/K-ATPase consists of a complex of membrane-spanning segments. Analysis of limit membrane-embedded tryptic fragments

1 reference

https://pubmed.ncbi.nlm.nih.gov/10871639

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Functional consequences of substitutions of the carboxyl residue glutamate 779 of the Na,K-ATPase

1 reference

https://pubmed.ncbi.nlm.nih.gov/10871639

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Evidence for the existence of two ATP-sensitive Rb+ occlusion pockets within the transmembrane domains of Na+/K+-ATPase

1 reference

https://pubmed.ncbi.nlm.nih.gov/10871639

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Evidence that Ser775 in the alpha subunit of the Na,K-ATPase is a residue in the cation binding pocket

1 reference

https://pubmed.ncbi.nlm.nih.gov/10871639

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Changes to Na,K-ATPase alpha-subunit E779 separate the structural basis for VM and ion dependence of Na,K-pump current

1 reference

https://pubmed.ncbi.nlm.nih.gov/10871639

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The interaction of amines with the occluded state of the Na,K-pump

1 reference

https://pubmed.ncbi.nlm.nih.gov/10871639

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1085/JGP.116.1.47

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10871639%20AND%20SRC:MED&resulttype=core&format=json

7 November 2019

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10871639%20AND%20SRC:MED&resulttype=core&format=json

7 November 2019

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10871639%20AND%20SRC:MED&resulttype=core&format=json

7 November 2019

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