The CDKN2A (p16) gene and human cancer. (Q36437816)

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2 November 2019

review article

1 reference

title

The CDKN2A (p16) gene and human cancer (English)

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2 November 2019

author

William David Foulkes

1

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2 November 2019

author name string

T Y Flanders

2

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2 November 2019

P M Pollock

3

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2 November 2019

N K Hayward

4

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2 November 2019

language of work or name

English

0 references

publication date

1 January 1997

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2 November 2019

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2 November 2019

volume

3

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2 November 2019

issue

1

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2 November 2019

page(s)

5-20

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Compilation of somatic mutations of the CDKN2 gene in human cancers: non-random distribution of base substitutions

2 November 2019

cites work

1 reference

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Involvement of the pRb/p16/cdk4/cyclin D1 pathway in the tumorigenesis of sporadic malignant melanomas

30 September 2017

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Frequent mutations of CDKN2 in primary pancreatic adenocarcinomas

30 September 2017

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Mutational analysis of the p16 family cyclin-dependent kinase inhibitors p15INK4b and p18INK4c in tumor-derived cell lines and primary tumors.

30 September 2017

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Mutational analysis of the CDKN2 gene in metastases from patients with cutaneous malignant melanoma

30 September 2017

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30 September 2017

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30 September 2017

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30 September 2017

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30 September 2017

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Deletion of p16 and p15 genes in brain tumors

30 September 2017

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Germline p16 mutations in familial melanoma

30 September 2017

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Mutations and altered expression of p16INK4 in human cancer.

30 September 2017

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Database of p53 gene somatic mutations in human tumors and cell lines

30 September 2017

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Identification of the von Hippel-Lindau (VHL) gene. Its role in renal cancer

30 September 2017

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Frequent somatic mutations and homozygous deletions of the p16 (MTS1) gene in pancreatic adenocarcinoma

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2230107

High Frequency of Chromosome 9p Allelic Loss and CDKN2 Tumor Suppressor Gene Alterations in Squamous Cell Carcinoma of the Bladder

30 September 2017

1 reference

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Germline p16INK4A mutation and protein dysfunction in a family with inherited melanoma

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2230107

Infrequent CDKN2 (MTS1/p16) gene alterations in human primary breast cancer

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2230107

Tumour spectrum in the FAMMM syndrome

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2230107

A cancer family syndrome in twenty-four kindreds

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2230107

Systemic cancer and the FAMMM syndrome

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2230107

Identification of a chromosome 18q gene that is altered in colorectal cancers

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2230107

Homozygous deletions within human chromosome band 9p21 in melanoma

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2230107

Rarity of somatic and germline mutations of the cyclin-dependent kinase 4 inhibitor gene, CDK4I, in melanoma

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2230107

Chromosome 9p allelic loss and p16/CDKN2 in breast cancer and evidence of p16 inactivation in immortal breast epithelial cells

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2230107

Mutations of p16Ink4/CDKN2 and p15Ink4B/MTS2 genes in biliary tract cancers.

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2230107

Mutation frequency of the p16/CDKN2 gene in primary cancers in the upper digestive tract

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2230107

Alterations of the p16 (MTS1) gene in testicular, ovarian, and endometrial malignancies

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2230107

Mechanism of inactivation of CDKN2 and MTS2 in non-small cell lung cancer and association with advanced stage

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2230107

Abnormalities in the CDKN2 (p16INK4/MTS-1) gene in human melanoma cells: relevance to tumor growth and metastasis

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2230107

Deletion mapping of chromosome region 9p21-p22 surrounding the CDKN2 locus in melanoma.

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2230107

Multiple tumor-suppressor gene 1 inactivation is the most frequent genetic alteration in T-cell acute lymphoblastic leukemia.

28 June 2018

1 reference

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Low frequency of p16/CDKN2 gene mutations in esophageal carcinomas

28 June 2018

1 reference

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Are malignant melanoma patients at higher risk for a second cancer?

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2230107

Assignment of a locus for familial melanoma, MLM, to chromosome 9p13-p22

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2230107

5′ CpG island methylation is associated with transcriptional silencing of the tumour suppressor p16/CDKN2/MTS1 in human cancers

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2230107

Frequent codeletion of p16/MTS1 and p15/MTS2 and genetic alterations in p16/MTS1 in pancreatic tumors.

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2230107

Mutations of the p16 gene in gliomas.

21 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2230107

CDKN2/p16 or RB alterations occur in the majority of glioblastomas and are inversely correlated.

21 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2230107

A Familial Syndrome of Pancreatic Cancer and Melanoma with a Mutation in theCDKN2Tumor-Suppressor Gene

21 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2230107

Mutations associated with familial melanoma impair p16INK4 function.

21 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2230107

Homozygous deletions of p16INK4A/MTS1 and p15INK4B/MTS2 genes in glioma cells and primary glioma tissues.

21 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2230107

Homozygous deletion of the MTS1/p16 and MTS2/p15 genes and amplification of the CDK4 gene in glioma.

21 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2230107

Analysis of the p16 gene, CDKN2, in 17 Australian melanoma kindreds

21 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2230107

Linkage analysis in Dutch familial atypical multiple mole-melanoma (FAMMM) syndrome families. Effect of naevus count

21 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2230107

Analysis of the p16 gene (CDKN2) as a candidate for the chromosome 9p melanoma susceptibility locus

21 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2230107

Homozygotes for CDKN2 (p16) germline mutation in Dutch familial melanoma kindreds

4 December 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2230107

Increased Risk of Pancreatic Cancer in Melanoma-Prone Kindreds withp16INK4Mutations

4 December 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2230107

Germline mutations of the BRCA1 gene in breast and ovarian cancer families provide evidence for a genotype–phenotype correlation

4 December 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2230107

Novel germline p16 mutation in familial malignant melanoma in southern Sweden

4 December 2018

1 reference

12 December 2020

Deletion and mutation analyses of the P16/MTS-1 tumor suppressor gene in human ductal pancreatic cancer reveals a higher frequency of abnormalities in tumor-derived cell lines than in primary ductal adenocarcinomas

1 reference

12 December 2020

Evaluation of candidate tumour suppressor genes on chromosome 18 in colorectal cancers

1 reference

12 December 2020

Status and expression of thep16INK4 gene in human thyroid tumors and thyroid-tumor cell lines

1 reference

12 December 2020

High frequency of p16 (CDKN2/MTS-1/INK4A) inactivation in head and neck squamous cell carcinoma

1 reference

12 December 2020

Familial tumor syndrome associated with a germline nonfunctional p16INK4a allele

1 reference

12 December 2020

Hereditary melanoma and the dysplastic nevus syndrome: the risk of cancers other than melanoma

1 reference

12 December 2020

Rates of p16 (MTS1) mutations in primary tumors with 9p loss

1 reference

12 December 2020

Mutational analysis of the CDKN2 (MTS1/p16ink4A) gene in primary B-cell lymphomas

1 reference

12 December 2020

Inactivation of the CDKN2/p16/MTS1 gene is frequently associated with aberrant DNA methylation in all common human cancers

1 reference

12 December 2020

P16 gene in uncultured tumours

1 reference

12 December 2020

Mutational analysis of CDKN2 (MTS1/p16ink4) in human breast carcinomas

1 reference

12 December 2020

Homozygous deletions of p16/MTS1 gene are frequent but mutations are infrequent in childhood T-cell acute lymphoblastic leukemia

1 reference

12 December 2020

Methylation of the 5' CpG island of the p16/CDKN2 tumor suppressor gene in normal and transformed human tissues correlates with gene silencing

1 reference

12 December 2020

Frequency of homozygous deletion at p16/CDKN2 in primary human tumours

1 reference

12 December 2020

Loh and mutation analysis ofCDKN2 in primary human ovarian cancers

1 reference

12 December 2020

Structural integrity of the cyclin‐dependent kinase inhibitor genes, p15, p16 and p18 in myeloid leukaemias

1 reference

12 December 2020

MTS1/CDKN2 gene mutations are rare in primary human astrocytomas with allelic loss of chromosome 9p

1 reference

12 December 2020

p15ink4B and p16ink4 gene inactivation in acute lymphocytic leukemia

1 reference

12 December 2020

Loss of expression of the p16/cyclin-dependent kinase inhibitor 2 tumor suppressor gene in melanocytic lesions correlates with invasive stage of tumor progression

1 reference

12 December 2020

Expression of the cyclin‐dependent kinase inhibitors p16INK4, p15INK4B and p21Waf1/cip1 in human breast cancer

1 reference

12 December 2020

Loss of heterozygosity at 9p21 loci and mutations of the MTS1 and MTS2 genes in human lung cancers

1 reference

12 December 2020

Mutations of the CDKN2/p16INK4 gene in Australian melanoma kindreds

1 reference

12 December 2020

Loss of heterozygosity on chromosome 9 in human breast cancer: Association with clinical variables and genetic changes at other chromosome regions

1 reference

12 December 2020

Familial melanoma and pancreatic cancer. Ligurian Skin Tumor Study Group

1 reference

12 December 2020

Alterations of CDKN2 (p16) in non-small cell lung cancer

1 reference

12 December 2020

Infrequent CDKN2 mutation in human differentiated thyroid cancers

1 reference

12 December 2020

Alterations of the p15, p16,and p18 genes in osteosarcoma

1 reference

12 December 2020

Alterations of CDKN2 gene structure in childhood acute lymphoblastic leukemia: mutations of CDKN2 are observed preferentially in T lineage

1 reference

12 December 2020

Intragenic mutations of the p16(INK4), p15(INK4B) and p18 genes in primary non-small-cell lung cancers

1 reference

12 December 2020

Reduced survival in patients with ductal pancreatic adenocarcinoma associated with CDKN2 mutation

1 reference

12 December 2020

Infrequent somatic alteration of p16/MTS1 in human primary superficial bladder cancers

1 reference

12 December 2020

Identifiers

DOI

10.1007/BF03401664

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9132280%20AND%20SRC:MED&resulttype=core&format=json

2 November 2019

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9132280%20AND%20SRC:MED&resulttype=core&format=json

2 November 2019

PubMed publication ID

9132280

1 reference