Ad5:Ad48 hexon hypervariable region substitutions lead to toxicity and increased inflammatory responses following intravenous delivery (Q36445557)

14 August 2017

Ad5:Ad48 hexon hypervariable region substitutions lead to toxicity and increased inflammatory responses following intravenous delivery (English)

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14 August 2017

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Lynda Coughlan

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Alan L Parker

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Alan L Parker

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Stuart A Nicklin

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Stuart A Nicklin

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Jaap Goudsmit

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Jaap Goudsmit

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Dan H Barouch

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14 August 2017

Angela C Bradshaw

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Hollie Robinson

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Katie White

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Jerome Custers

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Nico Van Roijen

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Andrew H Baker

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28 August 2012

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2268-2281

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14 August 2017

ImageJ

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11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC3514487/fullTextXML

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cites work

Combined fiber modifications both to target α(v)β(6) and detarget the coxsackievirus-adenovirus receptor improve virus toxicity profiles in vivo but fail to improve antitumoral efficacy relative to adenovirus serotype 5.

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Biodistribution and inflammatory profiles of novel penton and hexon double-mutant serotype 5 adenoviruses

30 September 2017

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Identification of adenovirus serotype 5 hexon regions that interact with scavenger receptors

30 September 2017

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Adenovirus serotype 5 neutralizing antibodies target both hexon and fiber following vaccination and natural infection

30 September 2017

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Adenovirus serotype 5-specific neutralizing antibodies target multiple hexon hypervariable regions

30 September 2017

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Tropism-modification strategies for targeted gene delivery using adenoviral vectors

30 September 2017

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Rapid and efficient clearance of blood-borne virus by liver sinusoidal endothelium

30 September 2017

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Coagulation factor X mediates adenovirus type 5 liver gene transfer in non-human primates (Microcebus murinus)

30 September 2017

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30 September 2017

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Generation of a Kupffer cell-evading adenovirus for systemic and liver-directed gene transfer

30 September 2017

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Systemic delivery of a novel liver-detargeted oncolytic adenovirus causes reduced liver toxicity but maintains the antitumor response in a breast cancer bone metastasis model

30 September 2017

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Requirements for receptor engagement during infection by adenovirus complexed with blood coagulation factor X

30 September 2017

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Biodistribution and retargeting of FX-binding ablated adenovirus serotype 5 vectors

30 September 2017

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Insight into the mechanisms of adenovirus capsid disassembly from studies of defensin neutralization

30 September 2017

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Differential specificity and immunogenicity of adenovirus type 5 neutralizing antibodies elicited by natural infection or immunization

30 September 2017

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Identification of coagulation factor (F)X binding sites on the adenovirus serotype 5 hexon: effect of mutagenesis on FX interactions and gene transfer

30 September 2017

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In vivo retargeting of adenovirus type 5 to alphavbeta6 integrin results in reduced hepatotoxicity and improved tumor uptake following systemic delivery.

30 September 2017

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Redundant and synergistic mechanisms control the sequestration of blood-born adenovirus in the liver

30 September 2017

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Human erythrocytes bind and inactivate type 5 adenovirus by presenting Coxsackie virus-adenovirus receptor and complement receptor 1.

30 September 2017

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The Cell Adhesion Molecule “CAR” and Sialic Acid on Human Erythrocytes Influence Adenovirus In Vivo Biodistribution

30 September 2017

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Effect of neutralizing sera on factor x-mediated adenovirus serotype 5 gene transfer

30 September 2017

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Clearance of adenovirus by Kupffer cells is mediated by scavenger receptors, natural antibodies, and complement

30 September 2017

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Substitution of hexon hypervariable region 5 of adenovirus serotype 5 abrogates blood factor binding and limits gene transfer to liver

30 September 2017

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Adenovirus serotype 5 hexon is critical for virus infection of hepatocytes in vivo

30 September 2017

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Comparative seroprevalence and immunogenicity of six rare serotype recombinant adenovirus vaccine vectors from subgroups B and D

30 September 2017

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Innate immune response to adenoviral vectors is mediated by both Toll-like receptor-dependent and -independent pathways

30 September 2017

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Adenovirus type 5 interactions with human blood cells may compromise systemic delivery.

30 September 2017

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Biological activities of a recombinant adenovirus p53 (SCH 58500) administered by hepatic arterial infusion in a Phase 1 colorectal cancer trial

30 September 2017

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Adenovirus Binding to Blood Factors Results in Liver Cell Infection and Hepatotoxicity

30 September 2017

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Effect of adenovirus serotype 5 fiber and penton modifications on in vivo tropism in rats

30 September 2017

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Analysis of adenovirus sequestration in the liver, transduction of hepatic cells, and innate toxicity after injection of fiber-modified vectors

30 September 2017

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Quantifying Adenovirus-Neutralizing Antibodies by Luciferase Transgene Detection: Addressing Preexisting Immunity to Vaccine and Gene Therapy Vectors

30 September 2017

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30 September 2017

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The interaction between the fiber knob domain and the cellular attachment receptor determines the intracellular trafficking route of adenoviruses

30 September 2017

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Adenovirus fiber disrupts CAR-mediated intercellular adhesion allowing virus escape

30 September 2017

1 reference

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Activation of p38 and ERK signaling during adenovirus vector cell entry lead to expression of the C-X-C chemokine IP-10.

30 September 2017

1 reference

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A pilot study of in vivo liver-directed gene transfer with an adenoviral vector in partial ornithine transcarbamylase deficiency

30 September 2017

1 reference

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Adenovirus vector-induced expression of the C-X-C chemokine IP-10 is mediated through capsid-dependent activation of NF-kappaB.

30 September 2017

1 reference

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Adenoviral gene therapy leads to rapid induction of multiple chemokines and acute neutrophil-dependent hepatic injury in vivo

30 September 2017

1 reference

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The role of Kupffer cell activation and viral gene expression in early liver toxicity after infusion of recombinant adenovirus vectors.

30 September 2017

1 reference

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The role of capsid-endothelial interactions in the innate immune response to adenovirus vectors

30 September 2017

1 reference

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Virus binding to a plasma membrane receptor triggers interleukin-1 alpha-mediated proinflammatory macrophage response in vivo

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3514487

Scavenger receptor A: a new route for adenovirus 5.

21 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3514487

Adenovirus serotype 5 hexon mediates liver gene transfer

21 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3514487

Fiber-modified adenovirus vectors decrease liver toxicity through reduced IL-6 production

21 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3514487

Hexon-chimaeric adenovirus serotype 5 vectors circumvent pre-existing anti-vector immunity

21 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3514487

Neutralizing antibodies to adenovirus serotype 5 vaccine vectors are directed primarily against the adenovirus hexon protein

21 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3514487

A hemodynamic response to intravenous adenovirus vector particles is caused by systemic Kupffer cell-mediated activation of endothelial cells

21 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3514487

Blood clearance rates of adenovirus type 5 in mice

21 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3514487

International epidemiology of human pre-existing adenovirus (Ad) type-5, type-6, type-26 and type-36 neutralizing antibodies: Correlates of high Ad5 titers and implications for potential HIV vaccine trials

21 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3514487

21 October 2018

Identifiers

DOI

10.1038/MT.2012.162

1 reference

14 August 2017

1 reference

14 August 2017

PubMed publication ID

22929662

1 reference