p53 signaling in response to increased DNA damage sensitizes AML1-ETO cells to stress-induced death (Q36445874)

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9 January 2020

title

p53 signaling in response to increased DNA damage sensitizes AML1-ETO cells to stress-induced death (English)

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9 January 2020

0 references

4

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9 January 2020

author name string

Ondrej Krejci

1

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9 January 2020

Mark Wunderlich

2

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9 January 2020

Hartmut Geiger

3

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9 January 2020

David Schleimer

5

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9 January 2020

Michael Jansen

6

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9 January 2020

Paul R Andreassen

7

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9 January 2020

James C Mulloy

8

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9 January 2020

language of work or name

English

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publication date

1 November 2007

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9 January 2020

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9 January 2020

volume

111

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9 January 2020

issue

4

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9 January 2020

page(s)

2190-2199

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Gene-expression profiling identifies distinct subclasses of core binding factor acute myeloid leukemia

9 January 2020

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The p21Waf1 pathway is involved in blocking leukemogenesis by the t(8;21) fusion protein AML1-ETO.

30 September 2017

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A leukemia fusion protein attenuates the spindle checkpoint and promotes aneuploidy

30 September 2017

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Human CD34+ cells expressing the inv(16) fusion protein exhibit a myelomonocytic phenotype with greatly enhanced proliferative ability

30 September 2017

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30 September 2017

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Acute myeloid leukemia fusion proteins deregulate genes involved in stem cell maintenance and DNA repair

30 September 2017

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8-Oxoguanine DNA damage: at the crossroad of alternative repair pathways.

30 September 2017

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30 September 2017

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The t(8;21) fusion protein contacts co-repressors and histone deacetylases to repress the transcription of the p14ARF tumor suppressor

30 September 2017

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p53 activates ICAM-1 (CD54) expression in an NF-kappaB-independent manner

30 September 2017

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The mechanism of action of radiosensitization of conventional chemotherapeutic agents

30 September 2017

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Hematopoietic stem cell expansion and distinct myeloid developmental abnormalities in a murine model of the AML1-ETO translocation

30 September 2017

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Expression of a conditional AML1-ETO oncogene bypasses embryonic lethality and establishes a murine model of human t(8;21) acute myeloid leukemia

30 September 2017

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The AML1-ETO fusion protein promotes the expansion of human hematopoietic stem cells

30 September 2017

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AML1 and the AML1-ETO fusion protein in the pathogenesis of t(8;21) AML.

30 September 2017

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Establishment of a cell line with AML1-MTG8, TP53, and TP73 abnormalities from acute myelogenous leukemia

30 September 2017

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AML1-ETO expression is directly involved in the development of acute myeloid leukemia in the presence of additional mutations

30 September 2017

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Modeling pO(2) distributions in the bone marrow hematopoietic compartment. II. Modified Kroghian models

30 September 2017

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Modeling pO(2) distributions in the bone marrow hematopoietic compartment. I. Krogh's model

30 September 2017

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The t(8;21) translocation is not consistently associated with high Bcl-2 expression in de novo acute myeloid leukemias of adults

30 September 2017

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DNA double-stranded breaks induce histone H2AX phosphorylation on serine 139

30 September 2017

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Negative regulation of granulocytic differentiation in the myeloid precursor cell line 32Dcl3 by ear-2, a mammalian homolog of Drosophila seven-up, and a chimeric leukemogenic gene, AML1/ETO.

30 September 2017

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The AML1/ETO fusion protein activates transcription of BCL-2

30 September 2017

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The t(8;21) translocation in acute myeloid leukemia results in production of an AML1-MTG8 fusion transcript

30 September 2017

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30 September 2017

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The t(8;21) fusion protein interferes with AML-1B-dependent transcriptional activation

30 September 2017

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30 September 2017

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t(8;21) breakpoints on chromosome 21 in acute myeloid leukemia are clustered within a limited region of a single gene, AML1

30 September 2017

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Identification of breakpoints in t(8;21) acute myelogenous leukemia and isolation of a fusion transcript, AML1/ETO, with similarity to Drosophila segmentation gene, runt

30 September 2017

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The AML1/ETO fusion protein blocks transactivation of the GM-CSF promoter by AML1B.

30 September 2017

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Establishment of a myeloid leukaemic cell line (SKNO-1) from a patient with t(8;21) who acquired monosomy 17 during disease progression

30 September 2017

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Transgenic mouse models for studying mutations in vivo: applications in aging research

30 September 2017

1 reference

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Oncogenic transcription factors in the human acute leukemias

28 June 2018

1 reference

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Embryonic lethality and impairment of haematopoiesis in mice heterozygous for an AML1-ETO fusion gene.

28 June 2018

1 reference

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Establishment of a human acute myeloid leukemia cell line (Kasumi-1) with 8;21 chromosome translocation.

28 June 2018

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Stringent regulation of DNA repair during human hematopoietic differentiation: a gene expression and functional analysis.

28 June 2018

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AML1/ETO promotes the maintenance of early hematopoietic progenitors in NOD/SCID mice but does not abrogate their lineage specific differentiation

21 September 2018

1 reference

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Gene expression profiling of pediatric acute myelogenous leukemia

21 September 2018

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Analysis of the spindle-assembly checkpoint in HeLa cells

21 September 2018

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Maintaining the self-renewal and differentiation potential of human CD34+ hematopoietic cells using a single genetic element.

21 September 2018

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The AML1-ETO fusion gene promotes extensive self-renewal of human primary erythroid cells

21 September 2018

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The t(8;21) fusion protein, AML1 ETO, specifically represses the transcription of the p14(ARF) tumor suppressor in acute myeloid leukemia.

21 September 2018

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In utero origin of t(8;21) AML1-ETO translocations in childhood acute myeloid leukemia

21 September 2018

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Immunological adjuvants promote activated T cell survival via induction of Bcl-3.

21 September 2018

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Characterization of color mutants in lacZ plasmid-based transgenic mice, as detected by positive selection

21 September 2018

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Mammalian base excision repair by DNA polymerases delta and epsilon

21 September 2018

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Expression of a knocked-in AML1-ETO leukemia gene inhibits the establishment of normal definitive hematopoiesis and directly generates dysplastic hematopoietic progenitors.

21 September 2018

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Evaluation of a plasmid-based transgenic mouse model for detecting in vivo mutations.

21 September 2018

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Tumor-suppressor p53: implications for tumor development and prognosis

21 September 2018

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12 December 2020

Roles for p53 in growth arrest and apoptosis: putting on the brakes after genotoxic stress

1 reference

12 December 2020

Mutagenic potential of temozolomide in bone marrow cells in vivo

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12 December 2020

c-Myc can induce DNA damage, increase reactive oxygen species, and mitigate p53 function: a mechanism for oncogene-induced genetic instability

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12 December 2020

Background mutations and polymorphisms in lacZ-plasmid transgenic mice

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12 December 2020

Aberrant p15 promoter methylation in adult and childhood acute leukemias of nearly all morphologic subtypes: potential prognostic implications

1 reference

12 December 2020

Cellular drug resistance profiles in childhood acute myeloid leukemia: differences between FAB types and comparison with acute lymphoblastic leukemia

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The tumor-suppressive functions of the human INK4A locus

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12 December 2020

Kinetics of hemopoietic stem cells in a hypoxic culture

1 reference

12 December 2020

10.1182/BLOOD-2007-06-093682

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17975013%20AND%20SRC:MED&resulttype=core&format=json

9 January 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17975013%20AND%20SRC:MED&resulttype=core&format=json

9 January 2020

PubMed publication ID

17975013

1 reference