Cannabinoids mediate analgesia largely via peripheral type 1 cannabinoid receptors in nociceptors (Q36447081)

14 August 2017

Cannabinoids mediate analgesia largely via peripheral type 1 cannabinoid receptors in nociceptors (English)

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14 August 2017

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14 August 2017

3

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14 August 2017

Ken Mackie

11

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Peter W. Reeh

Peter Reeh

16

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Fumimasa Amaya

Fumimasa Amaya

4

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Giovanni Marsicano

Giovanni Marsicano

9

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Tiziana Rubino

Tiziana Rubino

7

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Michaela Kress

Michaela Kress

18

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Daniela Parolaro

14

Daniela Parolaro

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14 August 2017

Nitin Agarwal

1

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14 August 2017

Cristina E Constantin

5

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14 August 2017

Gary J Brenner

6

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14 August 2017

Christoph W Michalski

8

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14 August 2017

Krisztina Monory

10

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14 August 2017

Claudiu Marian

12

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14 August 2017

Sandor Batkai

13

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14 August 2017

Michael J Fischer

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14 August 2017

George Kunos

17

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14 August 2017

Beat Lutz

19

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14 August 2017

Clifford J Woolf

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14 August 2017

Rohini Kuner

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14 August 2017

language of work or name

English

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publication date

10 June 2007

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14 August 2017

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14 August 2017

10

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14 August 2017

870-879

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14 August 2017

7

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https://scigraph.springernature.com/pub.10.1038/nn1916

14 August 2017

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cites work

The endocannabinoid system as an emerging target of pharmacotherapy

1 reference

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Co-expression of the voltage-gated potassium channel Kv1.4 with transient receptor potential channels (TRPV1 and TRPV2) and the cannabinoid receptor CB1 in rat dorsal root ganglion neurons

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2234438

The cannabinoid WIN 55,212-2 inhibits transient receptor potential vanilloid 1 (TRPV1) and evokes peripheral antihyperalgesia via calcineurin

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2234438

Site-specific increases in peripheral cannabinoid receptors and their endogenous ligands in a model of neuropathic pain.

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2234438

Cannabinoid receptors and endocannabinoids: evidence for new players.

30 September 2017

1 reference

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Cannabinoid mechanisms of pain suppression.

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2234438

The endocannabinoid system: a drug discovery perspective.

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2234438

CB1 cannabinoid receptors and on-demand defense against excitotoxicity

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2234438

Inhibition of Inflammatory Hyperalgesia by Activation of Peripheral CB2Cannabinoid Receptors

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2234438

Role of endogenous cannabinoids in synaptic signaling

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2234438

Endocannabinoid signaling via cannabinoid receptor 1 is involved in ethanol preference and its age-dependent decline in mice

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2234438

The synthetic cannabinoid WIN55,212-2 attenuates hyperalgesia and allodynia in a rat model of neuropathic pain

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2234438

The role of central and peripheral Cannabinoid1 receptors in the antihyperalgesic activity of cannabinoids in a model of neuropathic pain

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2234438

Spared nerve injury: an animal model of persistent peripheral neuropathic pain

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2234438

Increased mortality, hypoactivity, and hypoalgesia in cannabinoid CB1 receptor knockout mice

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2234438

An analgesia circuit activated by cannabinoids

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2234438

Control of pain initiation by endogenous cannabinoids.

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2234438

An amino-terminal variant of the central cannabinoid receptor resulting from alternative splicing

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2234438

Inducible gene targeting in mice

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2234438

The ring test: a quantitative method for assessing the ‘cataleptic’ effect of cannabis in mice

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2234438

Experimental acute pancreatitis. In vitro magnetic resonance characteristics

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2234438

The AMPA receptor subunits GluR-A and GluR-B reciprocally modulate spinal synaptic plasticity and inflammatory pain

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2234438

Spinal cannabinoids are anti-allodynic in rats with persistent inflammation.

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2234438

Localization of central cannabinoid CB1 receptor messenger RNA in neuronal subpopulations of rat dorsal root ganglia: a double-label in situ hybridization study.

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2234438

Unresponsiveness to cannabinoids and reduced addictive effects of opiates in CB1 receptor knockout mice.

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2234438

CB2 cannabinoid receptor mediation of antinociception.

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2234438

A cannabinoid agonist, WIN 55,212-2, reduces neuropathic nociception induced by paclitaxel in rats

21 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2234438

Circuitry for associative plasticity in the amygdala involves endocannabinoid signaling.

21 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2234438

The effect of WIN 55,212-2, a cannabinoid agonist, on tactile allodynia in diabetic rats.

21 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2234438

Transdermal delivery of the synthetic cannabinoid WIN 55,212-2: in vitro/in vivo correlation.

21 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2234438

Conditional gene deletion in primary nociceptive neurons of trigeminal ganglia and dorsal root ganglia.

21 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2234438

Functional conversion between A-type and delayed rectifier K+ channels by membrane lipids

21 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2234438

Effects of direct periaqueductal grey administration of a cannabinoid receptor agonist on nociceptive and aversive responses in rats

21 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2234438

Intraplantar injection of anandamide inhibits mechanically-evoked responses of spinal neurones via activation of CB2 receptors in anaesthetised rats

21 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2234438

The endogenous cannabinoid system controls extinction of aversive memories

21 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2234438

Localisation of cannabinoid CB(1) receptor immunoreactivity in the guinea pig and rat myenteric plexus

21 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2234438

Cannabinoids attenuate capsaicin-evoked hyperalgesia through spinal and peripheral mechanisms

21 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2234438

Nociceptive-specific activation of ERK in spinal neurons contributes to pain hypersensitivity.

21 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2234438

Cannabinoids reduce hyperalgesia and inflammation via interaction with peripheral CB1 receptors.

21 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2234438

Changes in the cannabinoid receptor binding, G protein coupling, and cyclic AMP cascade in the CNS of rats tolerant to and dependent on the synthetic cannabinoid compound CP55,940

21 September 2018

1 reference

12 December 2020

Localisation of cannabinoid receptor 1 in rat dorsal root ganglion using in situ hybridisation and immunohistochemistry

1 reference

12 December 2020

Topical cannabinoid antinociception: synergy with spinal sites

1 reference

12 December 2020

Peripheral Opioid Analgesia

1 reference

12 December 2020

Antinociceptive actions of cannabinoids following intraventricular administration in rats

1 reference

12 December 2020

Peripheral morphine analgesia: synergy with central sites and a target of morphine tolerance

1 reference

12 December 2020

Role of [Ca2+]i in the ATP-induced heat sensitization process of rat nociceptive neurons

1 reference

12 December 2020

Identifiers

DOI

10.1038/NN1916

1 reference

14 August 2017

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14 August 2017

1 reference