Unique gene-silencing and structural properties of 2'-fluoro-modified siRNAs (Q36452421)

14 August 2017

Unique gene-silencing and structural properties of 2'-fluoro-modified siRNAs (English)

1 reference

14 August 2017

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15

Martin Egli

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author name string

Muthiah Manoharan

1

1 reference

14 August 2017

Akin Akinc

2

1 reference

14 August 2017

Rajendra K Pandey

3

1 reference

14 August 2017

June Qin

4

1 reference

14 August 2017

Philipp Hadwiger

5

1 reference

14 August 2017

Matthias John

6

1 reference

14 August 2017

Kathy Mills

7

1 reference

14 August 2017

Klaus Charisse

8

1 reference

14 August 2017

Martin A Maier

9

1 reference

14 August 2017

Lubomir Nechev

10

1 reference

14 August 2017

Emily M Greene

11

1 reference

14 August 2017

Pradeep S Pallan

12

1 reference

14 August 2017

Eriks Rozners

13

1 reference

14 August 2017

Kallanthottathil G Rajeev

14

1 reference

14 August 2017

language of work or name

English

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publication date

31 January 2011

1 reference

Angewandte Chemie International Edition

14 August 2017

0 references

volume

50

1 reference

14 August 2017

10

1 reference

14 August 2017

2284-2288

1 reference

Recent advances in small interfering RNA sensing by the immune system

14 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3516925

The RNA-induced silencing complex: a versatile gene-silencing machine

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3516925

Development of lipidoid-siRNA formulations for systemic delivery to the liver

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3516925

Molecular imaging study on in vivo distribution and pharmacokinetics of modified small interfering RNAs (siRNAs).

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3516925

The many roles for fluorine in medicinal chemistry

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3516925

A combinatorial library of lipid-like materials for delivery of RNAi therapeutics

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3516925

Effective RNAi-mediated gene silencing without interruption of the endogenous microRNA pathway

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3516925

RNAi therapeutics: a potential new class of pharmaceutical drugs

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3516925

Competition for RISC binding predicts in vitro potency of siRNA.

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3516925

Potent and persistent in vivo anti-HBV activity of chemically modified siRNAs

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3516925

Positional effect of chemical modifications on short interference RNA activity in mammalian cells

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3516925

Activity of stabilized short interfering RNA in a mouse model of hepatitis B virus replication

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3516925

Sequence-specific potent induction of IFN-alpha by short interfering RNA in plasmacytoid dendritic cells through TLR7

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3516925

RNA interference and chemically modified small interfering RNAs

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3516925

Organic fluorine: odd man out.

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3516925

In vivo activity of nuclease-resistant siRNAs

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3516925

Hydration of short DNA, RNA and 2'-OMe oligonucleotides determined by osmotic stressing

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3516925

Sequence, chemical, and structural variation of small interfering RNAs and short hairpin RNAs and the effect on mammalian gene silencing

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3516925

Crystal structure and improved antisense properties of 2'-O-(2-methoxyethyl)-RNA

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3516925

RNA hydration: a detailed look

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3516925

Uniformly modified 2'-deoxy-2'-fluoro phosphorothioate oligonucleotides as nuclease-resistant antisense compounds with high affinity and specificity for RNA targets

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3516925

siRNA function in RNAi: a chemical modification analysis

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3516925

RNA interference tolerates 2'-fluoro modifications at the Argonaute2 cleavage site.

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3516925

Improving RNA interference in mammalian cells by 4'-thio-modified small interfering RNA (siRNA): effect on siRNA activity and nuclease stability when used in combination with 2'-O-alkyl modifications.

21 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3516925

Structural insights into mRNA recognition from a PIWI domain-siRNA guide complex

21 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3516925

Fully 2'-modified oligonucleotide duplexes with improved in vitro potency and stability compared to unmodified small interfering RNA.

21 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3516925

RNA interference in mammalian cells by chemically-modified RNA.

21 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3516925

X-ray crystal structure of a locked nucleic acid (LNA) duplex composed of a palindromic 10-mer DNA strand containing one LNA thymine monomer

21 September 2018

1 reference

Crossref

https://api.crossref.org/works/10.1002%2FANIE.201006519

Gene Expression Analysis in Blood Cells in Response to Unmodified and 2′-Modified siRNAs Reveals TLR-dependent and Independent Effects

21 January 2018

1 reference

Crossref

https://api.crossref.org/works/10.1002%2FANIE.201006519

Single-stranded small interfering RNA are more immunostimulatory than their double-stranded counterparts: a central role for 2'-hydroxyl uridines in immune responses

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21351337

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Kinetic Characterization of Ribonuclease-Resistant 2′-Modified Hammerhead Ribozymes

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21351337

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Hydrophobic Groups Stabilize the Hydration Shell of 2'-O-Methylated RNA Duplexes

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21351337

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1002/ANIE.201006519

1 reference

14 August 2017

1 reference

14 August 2017

1 reference