Function and pathophysiological importance of ABCB4 (MDR3 P-glycoprotein). (Q36452680)

14 August 2017

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title

Function and pathophysiological importance of ABCB4 (MDR3 P-glycoprotein). (English)

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14 August 2017

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2

Coen C Paulusma

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14 August 2017

Ronald P J Oude Elferink

series ordinal

1

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14 August 2017

19 April 2006

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14 August 2017

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14 August 2017

453

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14 August 2017

601-610

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14 August 2017

5

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https://scigraph.springernature.com/pub.10.1007/s00424-006-0062-9

14 August 2017

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Prevalence of Intrahepatic Cholestasis of Pregnancy in Chile

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MDR1 P-glycoprotein is a lipid translocase of broad specificity, while MDR3 P-glycoprotein specifically translocates phosphatidylcholine

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12 December 2020

Hepatic secretion of phospholipid vesicles in the mouse critically depends on mdr2 or MDR3 P-glycoprotein expression. Visualization by electron microscopy

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The human MDR3 P-glycoprotein promotes translocation of phosphatidylcholine through the plasma membrane of fibroblasts from transgenic mice

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Class III P-glycoproteins mediate the formation of lipoprotein X in the mouse

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A mouse model of sitosterolemia: absence of Abcg8/sterolin-2 results in failure to secrete biliary cholesterol

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Heterozygous MDR3 missense mutation associated with intrahepatic cholestasis of pregnancy: evidence for a defect in protein trafficking

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Imaging biliary lipid secretion in the rat: ultrastructural evidence for vesiculation of the hepatocyte canalicular membrane

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Developmental expression of canalicular transporter genes in human liver

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The wide spectrum of multidrug resistance 3 deficiency: from neonatal cholestasis to cirrhosis of adulthood

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Spontaneous cholecysto- and hepatolithiasis in Mdr2-/- mice: a model for low phospholipid-associated cholelithiasis.

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Hepatocyte-specific expression of the human MDR3 P-glycoprotein gene restores the biliary phosphatidylcholine excretion absent in Mdr2 (-/-) mice.

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12 December 2020

Serum conjugated bile acid profile during intrahepatic cholestasis of pregnancy

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12 December 2020

Regulation of biliary lipid secretion by mdr2 P-glycoprotein in the mouse

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12 December 2020

Bezafibrate in the treatment of primary biliary cirrhosis: comparison with ursodeoxycholic acid

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12 December 2020

Bezafibrate stimulates canalicular localization of NBD-labeled PC in HepG2 cells by PPARalpha-mediated redistribution of ABCB4.

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Sequence variation in the ATP8B1 gene and intrahepatic cholestasis of pregnancy

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Evaluation of risk for atherosclerosis in Alagille syndrome and progressive familial intrahepatic cholestasis: two congenital cholestatic diseases with different lipoprotein metabolisms

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ABCB4 gene sequence variation in women with intrahepatic cholestasis of pregnancy.

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Cholestatic properties and hepatic transport of steroid glucuronides

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Genetic evidence of heterogeneity in intrahepatic cholestasis of pregnancy

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Hepatic canalicular membrane 1: The role of mdr2 P-glycoprotein in hepatobiliary lipid transport

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Lack of biliary lipid excretion in the little skate, Raja erinacea, indicates the absence of functional Mdr2, Abcg5, and Abcg8 transporters

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Xenobiotic and endobiotic transporter mRNA expression in the blood-testis barrier

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Sphingomyelins of rat liver: biliary enrichment with molecular species containing 16:0 fatty acids as compared to canalicular-enriched plasma membranes

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Progressive familial intrahepatic cholestasis with high gamma-glutamyltranspeptidase levels in Taiwanese infants: role of MDR3 gene defect?

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Hepatic P-glycoprotein changes with total parenteral nutrition administration

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Obstetric cholestasis with elevated gamma glutamyl transpeptidase: incidence, presentation and treatment

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Benign recurrent intrahepatic cholestasis type 2 is caused by mutations in ABCB11

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Influence of total lipid concentration, bile salt:lecithin ratio, and cholesterol content on inter-mixed micellar/vesicular (non-lecithin-associated) bile salt concentrations in model bile

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ATP8B1 mutations in British cases with intrahepatic cholestasis of pregnancy.

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Correction of liver disease by hepatocyte transplantation in a mouse model of progressive familial intrahepatic cholestasis.

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The human multidrug resistance protein MRP1 translocates sphingolipid analogs across the plasma membrane

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12 December 2020

Lack of enteral nutrition during critical illness is associated with profound decrements in biliary lipid concentrations

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Genetic defects in hepatobiliary transport.

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12 December 2020

Coordinate transcriptional regulation of bile acid homeostasis and drug metabolism

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12 December 2020

BSEP and MDR3 haplotype structure in healthy Caucasians, primary biliary cirrhosis and primary sclerosing cholangitis.

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12 December 2020

Regulation of multidrug resistance 2 P-glycoprotein expression by bile salts in rats and in primary cultures of rat hepatocytes

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12 December 2020

Peroxisome proliferator-activated receptor alpha (PPARalpha)-mediated regulation of multidrug resistance 2 (Mdr2) expression and function in mice

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12 December 2020

Homozygous disruption of the murine mdr2 P-glycoprotein gene leads to a complete absence of phospholipid from bile and to liver disease

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12 December 2020

Fibrates induce mdr2 gene expression and biliary phospholipid secretion in the mouse

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12 December 2020

Farnesoid X Receptor Activates Transcription of the Phospholipid Pump MDR3

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12 December 2020

Uncoupling of biliary phospholipid and cholesterol secretion in mice with reduced expression of mdr2 P-glycoprotein.

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12 December 2020

Mutations identified in the human multidrug resistance P-glycoprotein 3 (ABCB4) gene in patients with primary hepatolithiasis.

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12 December 2020

Liver stem cells and model systems for liver repopulation

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12 December 2020

Disruption of Abcg5 and Abcg8 in mice reveals their crucial role in biliary cholesterol secretion

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12 December 2020

Bezafibrate treatment: a new medical approach for PBC patients?

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12 December 2020

Defect of multidrug-resistance 3 gene expression in a subtype of progressive familial intrahepatic cholestasis.

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12 December 2020

Evidence for a role of the multidrug resistance protein (MRP) in the outward translocation of NBD-phospholipids in the erythrocyte membrane.

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12 December 2020

ABCB4 gene mutation-associated cholelithiasis in adults

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12 December 2020

A phylogenetic survey of biliary lipids in vertebrates

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12 December 2020

Semi quantitative expression analysis of MDR3, FIC1, BSEP, OATP-A, OATP-C,OATP-D, OATP-E and NTCP gene transcripts in 1st and 3rd trimester human placenta

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12 December 2020

Mammalian ABC transporters in health and disease

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12 December 2020

Complementary stimulation of hepatobiliary transport and detoxification systems by rifampicin and ursodeoxycholic acid in humans

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12 December 2020

Mdr2 (Abcb4)-/- mice spontaneously develop severe biliary fibrosis via massive dysregulation of pro- and antifibrogenic genes

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12 December 2020

Peripheral neuropathy in mice transgenic for a human MDR3 P-glycoprotein mini-gene

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12 December 2020

Enrichment of canalicular membrane with cholesterol and sphingomyelin prevents bile salt-induced hepatic damage

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12 December 2020

Regulation of transbilayer plasma membrane phospholipid asymmetry

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12 December 2020

Multidrug resistance protein 1 regulates lipid asymmetry in erythrocyte membranes

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12 December 2020

A multidrug resistance 3 gene mutation causing cholelithiasis, cholestasis of pregnancy, and adulthood biliary cirrhosis

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12 December 2020

Regurgitation of bile acids from leaky bile ducts causes sclerosing cholangitis in Mdr2 (Abcb4) knockout mice

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12 December 2020

Cholesterol and sphingolipid enhance the Triton X-100 insolubility of glycosylphosphatidylinositol-anchored proteins by promoting the formation of detergent-insoluble ordered membrane domains

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12 December 2020

Tissue distribution of the human MDR3 P-glycoprotein

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12 December 2020

Regulation of drug and bile salt transporters in liver and intestine

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12 December 2020

Probing red cell membrane cholesterol movement with cyclodextrin

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12 December 2020

Heterozygous non-sense mutation of the MDR3 gene in familial intrahepatic cholestasis of pregnancy

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12 December 2020

Role of ABC transporters in secretion of cholesterol from liver into bile

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12 December 2020

Sequence analysis of bile salt export pump (ABCB11) and multidrug resistance p-glycoprotein 3 (ABCB4, MDR3) in patients with intrahepatic cholestasis of pregnancy

1 reference

12 December 2020

10.1007/S00424-006-0062-9

Identifiers

DOI

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14 August 2017

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PubMed ID

16622704