CD40 ligand/trimer DNA enhances both humoral and cellular immune responses and induces protective immunity to infectious and tumor challenge (Q36454460)

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English	CD40 ligand/trimer DNA enhances both humoral and cellular immune responses and induces protective immunity to infectious and tumor challenge	scientific article

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scholarly article

1 reference

Europe PubMed Central

PMC publication ID

14 August 2017

CD40 ligand/trimer DNA enhances both humoral and cellular immune responses and induces protective immunity to infectious and tumor challenge (English)

1 reference

Europe PubMed Central

PMC publication ID

14 August 2017

author name string

S Gurunathan

1

1 reference

Europe PubMed Central

PMC publication ID

14 August 2017

K R Irvine

2

1 reference

Europe PubMed Central

PMC publication ID

14 August 2017

C Y Wu

3

1 reference

Europe PubMed Central

PMC publication ID

14 August 2017

J I Cohen

4

1 reference

Europe PubMed Central

PMC publication ID

14 August 2017

E Thomas

5

1 reference

Europe PubMed Central

PMC publication ID

14 August 2017

C Prussin

6

1 reference

Europe PubMed Central

PMC publication ID

14 August 2017

N P Restifo

7

1 reference

Europe PubMed Central

PMC publication ID

14 August 2017

R A Seder

8

1 reference

Europe PubMed Central

PMC publication ID

14 August 2017

language of work or name

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publication date

1 November 1998

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Europe PubMed Central

PMC publication ID

14 August 2017

Journal of Immunology

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Europe PubMed Central

PMC publication ID

14 August 2017

161

1 reference

Europe PubMed Central

PMC publication ID

14 August 2017

9

1 reference

Europe PubMed Central

PMC publication ID

14 August 2017

4563-4571

1 reference

Europe PubMed Central

PMC publication ID

14 August 2017

Immunostimulatory oligodeoxynucleotides containing the CpG motif are effective as immune adjuvants in tumor antigen immunization

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2239005

30 September 2017

Vaccination with DNA encoding the immunodominant LACK parasite antigen confers protective immunity to mice infected with Leishmania major

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2239005

30 September 2017

Enhanced CTL responses mediated by plasmid DNA immunogens encoding costimulatory molecules and cytokines.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2239005

30 September 2017

Identification of a costimulatory molecule rapidly induced by CD40L as CD44H.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2239005

30 September 2017

Interleukin (IL)-4-independent immunoglobulin class switch to immunoglobulin (Ig)E in the mouse

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2239005

30 September 2017

Gene vaccination with naked plasmid DNA: mechanism of CTL priming

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2239005

30 September 2017

CD40L is important for induction of, but not response to, costimulatory activity. ICAM-1 as the second costimulatory molecule rapidly up-regulated by CD40L.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2239005

30 September 2017

Ligation of CD40 on dendritic cells triggers production of high levels of interleukin-12 and enhances T cell stimulatory capacity: T-T help via APC activation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2239005

30 September 2017

High level IL-12 production by murine dendritic cells: upregulation via MHC class II and CD40 molecules and downregulation by IL-4 and IL-10.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2239005

30 September 2017

Induction of cytotoxic T lymphocytes by intramuscular immunization with plasmid DNA is facilitated by bone marrow-derived cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2239005

30 September 2017

Immunostimulatory DNA sequences necessary for effective intradermal gene immunization

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2239005

30 September 2017

Preferential induction of a Th1 immune response and inhibition of specific IgE antibody formation by plasmid DNA immunization

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2239005

30 September 2017

CD40 and its ligand in host defense

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2239005

30 September 2017

CD40/CD40 ligand interactions are required for T cell-dependent production of interleukin-12 by mouse macrophages

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2239005

30 September 2017

CpG motifs present in bacteria DNA rapidly induce lymphocytes to secrete interleukin 6, interleukin 12, and interferon gamma

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2239005

30 September 2017

Immunological memory and protective immunity: understanding their relation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2239005

30 September 2017

Cytokine enhancement of DNA immunization leads to effective treatment of established pulmonary metastases.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2239005

30 September 2017

Impairment of antigen-specific T-cell priming in mice lacking CD40 ligand

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2239005

30 September 2017

Resolution of cutaneous leishmaniasis: interleukin 12 initiates a protective T helper type 1 immune response

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2239005

30 September 2017

Expression cloning of a protective Leishmania antigen

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2239005

30 September 2017

Activated T cells induce expression of B7/BB1 on normal or leukemic B cells through a CD40-dependent signal

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2239005

30 September 2017

The regulation of immunity to Leishmania major

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2239005

30 September 2017

Structural characteristics of CD40 ligand that determine biological function

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2239005

30 September 2017

CD40L: a multi-functional ligand

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2239005

30 September 2017

The role of CD40 ligand in costimulation and T-cell activation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2239005

30 September 2017

Polyclonal activation of the murine immune system by a goat antibody to mouse IgD. IX. Induction of a polyclonal IgE response

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2239005

30 September 2017

Costimulation provided by DNA immunization enhances antitumor immunity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2239005

28 June 2018

Comparison of numerous delivery systems for the induction of cytotoxic T lymphocytes by immunization

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2239005

28 June 2018

CD40L-deficient mice show deficits in antiviral immunity and have an impaired memory CD8+ CTL response.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2239005

28 June 2018

The adjuvant effect of interleukin-12 in a vaccine against Leishmania major.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2239005

28 June 2018

Two types of mouse helper T cell clone. III. Further differences in lymphokine synthesis between Th1 and Th2 clones revealed by RNA hybridization, functionally monospecific bioassays, and monoclonal antibodies

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2239005

28 June 2018

Immunostimulatory effects of a plasmid expressing CD40 ligand (CD154) on gene immunization

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2239005

21 September 2018

Immunostimulatory DNA sequences function as T helper-1-promoting adjuvants.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2239005

21 September 2018

Immunomodulatory effects of a plasmid expressing B7-2 on human immunodeficiency virus-1-specific cell-mediated immunity induced by a plasmid encoding the viral antigen

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2239005

21 September 2018

Requirement for CD40 ligand in costimulation induction, T cell activation, and experimental allergic encephalomyelitis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2239005

21 September 2018

CD40 ligand-dependent T cell activation: requirement of B7-CD28 signaling through CD40.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2239005

21 September 2018

Studies on the interdependence of gp39 and B7 expression and function during antigen-specific immune responses

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2239005

21 October 2018

IL-12 enhances vaccine-induced immunity to schistosomes by augmenting both humoral and cell-mediated immune responses against the parasite

1 reference

https://pubmed.ncbi.nlm.nih.gov/9794383

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Antigen-driven but not lipopolysaccharide-driven IL-12 production in macrophages requires triggering of CD40

1 reference

https://pubmed.ncbi.nlm.nih.gov/9794383

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

In vivo engineering of a cellular immune response by coadministration of IL-12 expression vector with a DNA immunogen

1 reference

https://pubmed.ncbi.nlm.nih.gov/9794383

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Interleukin 12 alters the isotype-restricted antibody response of mice to hen eggwhite lysozyme

1 reference

https://pubmed.ncbi.nlm.nih.gov/9794383

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Prospects for new vaccines against tuberculosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/9794383

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Interleukin-12 induces interferon-gamma-dependent switching of IgG alloantibody subclass

1 reference

https://pubmed.ncbi.nlm.nih.gov/9794383

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

1 reference

https://pubmed.ncbi.nlm.nih.gov/9794383

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Microbial products induce autoimmune disease by an IL-12-dependent pathway

1 reference

https://pubmed.ncbi.nlm.nih.gov/9794383

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Adsorption to aluminum hydroxide promotes the activity of IL-12 as an adjuvant for antibody as well as type 1 cytokine responses to HIV-1 gp120

1 reference

https://pubmed.ncbi.nlm.nih.gov/9794383

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Intranasal immunization of a DNA vaccine with IL-12- and granulocyte-macrophage colony-stimulating factor (GM-CSF)-expressing plasmids in liposomes induces strong mucosal and cell-mediated immune responses against HIV-1 antigens

1 reference

https://pubmed.ncbi.nlm.nih.gov/9794383

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

CD40 ligand/CD40 stimulation regulates the production of IFN-gamma from human peripheral blood mononuclear cells in an IL-12- and/or CD28-dependent manner

1 reference

https://pubmed.ncbi.nlm.nih.gov/9794383

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Interleukin-12 profoundly up-regulates the synthesis of antigen-specific complement-fixing IgG2a, IgG2b and IgG3 antibody subclasses in vivo

1 reference

https://pubmed.ncbi.nlm.nih.gov/9794383

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effects of IL-12 on helper T cell-dependent immune responses in vivo

1 reference

https://pubmed.ncbi.nlm.nih.gov/9794383

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Interferon-gamma and B cell stimulatory factor-1 reciprocally regulate Ig isotype production

1 reference

https://pubmed.ncbi.nlm.nih.gov/9794383

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Membranes from both Th1 and Th2 T cell clones stimulate B cell proliferation and prepare B cells for lymphokine-induced differentiation to secrete Ig

1 reference

https://pubmed.ncbi.nlm.nih.gov/9794383

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Unique palindromic sequences in synthetic oligonucleotides are required to induce IFN [correction of INF] and augment IFN-mediated [correction of INF] natural killer activity

1 reference

https://pubmed.ncbi.nlm.nih.gov/9794383

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effects of IL-12 on in vivo cytokine gene expression and Ig isotype selection

1 reference

https://pubmed.ncbi.nlm.nih.gov/9794383

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

14 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

14 August 2017

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