PKCα activation of p120-catenin serine 879 phospho-switch disassembles VE-cadherin junctions and disrupts vascular integrity. (Q36456320)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22798526%20AND%20SRC:MED&resulttype=core&format=json

8 February 2020

title

PKCα activation of p120-catenin serine 879 phospho-switch disassembles VE-cadherin junctions and disrupts vascular integrity (English)

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8 February 2020

2

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8 February 2020

author name string

Emily Vandenbroucke St Amant

1

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8 February 2020

Stephen M Vogel

3

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8 February 2020

Xiao-Pei Gao

4

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8 February 2020

Dolly Mehta

5

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8 February 2020

Yulia A Komarova

6

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8 February 2020

Asrar B Malik

7

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8 February 2020

publication date

12 July 2012

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8 February 2020

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8 February 2020

volume

111

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8 February 2020

page(s)

739-749

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8 February 2020

issue

6

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Caveolin-1-eNOS signaling promotes p190RhoGAP-A nitration and endothelial permeability

8 February 2020

cites work

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Deletion of p120-catenin results in a tumor microenvironment with inflammation and cancer that establishes it as a tumor suppressor gene

30 September 2017

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p120 regulates endothelial permeability independently of its NH2 terminus and Rho binding

30 September 2017

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p120-catenin is essential for maintenance of barrier function and intestinal homeostasis in mice

30 September 2017

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Dynamic and static interactions between p120 catenin and E-cadherin regulate the stability of cell-cell adhesion

30 September 2017

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p120-Catenin is required for mouse vascular development

30 September 2017

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Src-induced tyrosine phosphorylation of VE-cadherin is not sufficient to decrease barrier function of endothelial monolayers.

30 September 2017

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p120-catenin inhibits VE-cadherin internalization through a Rho-independent mechanism

30 September 2017

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PDGF receptor activation induces p120-catenin phosphorylation at serine 879 via a PKCalpha-dependent pathway

30 September 2017

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Activation of sphingosine kinase-1 reverses the increase in lung vascular permeability through sphingosine-1-phosphate receptor signaling in endothelial cells

30 September 2017

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VE-cadherin: the major endothelial adhesion molecule controlling cellular junctions and blood vessel formation

30 September 2017

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Generation and characterization of a novel phospho-specific monoclonal antibody to p120-catenin serine 879.

30 September 2017

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Evolving functions of endothelial cells in inflammation

30 September 2017

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p120 serine and threonine phosphorylation is controlled by multiple ligand-receptor pathways but not cadherin ligation

30 September 2017

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Signaling mechanisms regulating endothelial permeability

30 September 2017

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Thermodynamics of beta-catenin-ligand interactions: the roles of the N- and C-terminal tails in modulating binding affinity

30 September 2017

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p120-Catenin regulates clathrin-dependent endocytosis of VE-cadherin

30 September 2017

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Cellular levels of p120 catenin function as a set point for cadherin expression levels in microvascular endothelial cells

30 September 2017

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A novel role for p120 catenin in E-cadherin function

30 September 2017

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Protein kinase C alpha (PKC alpha): regulation and biological function

30 September 2017

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Pores in the sieve and channels in the wall: control of paracellular permeability by junctional proteins in endothelial cells

30 September 2017

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Ca(2+) signalling and PKCalpha activate increased endothelial permeability by disassembly of VE-cadherin junctions

30 September 2017

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Identification of Src phosphorylation sites in the catenin p120ctn

30 September 2017

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Cardiovascular responses mediated by protease-activated receptor-2 (PAR-2) and thrombin receptor (PAR-1) are distinguished in mice deficient in PAR-2 or PAR-1

30 September 2017

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Plakophilins 1a and 1b: widespread nuclear proteins recruited in specific epithelial cells as desmosomal plaque components

30 September 2017

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Identification of a new human catenin gene family member (ARVCF) from the region deleted in velo-cardio-facial syndrome

30 September 2017

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Cloning and characterization of a new armadillo family member, p0071, associated with the junctional plaque: evidence for a subfamily of closely related proteins

30 September 2017

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The molecular organization of endothelial cell to cell junctions: differential association of plakoglobin, beta-catenin, and alpha-catenin with vascular endothelial cadherin (VE-cadherin)

30 September 2017

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Functional properties of human vascular endothelial cadherin (7B4/cadherin-5), an endothelium-specific cadherin

30 September 2017

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Transformation-specific tyrosine phosphorylation of a novel cellular protein in chicken cells expressing oncogenic variants of the avian cellular src gene

30 September 2017

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Identification and cloning of two species of cadherins in bovine endothelial cells

30 September 2017

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Increased endothelial albumin permeability mediated by protein kinase C activation

30 September 2017

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p120, a novel substrate of protein tyrosine kinase receptors and of p60v-src, is related to cadherin-binding factors beta-catenin, plakoglobin and armadillo

30 September 2017

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Adhesion-associated and PKC-modulated changes in serine/threonine phosphorylation of p120-catenin

30 September 2017

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N-cadherin mediates pericytic-endothelial interaction during brain angiogenesis in the chicken

28 June 2018

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delta-catenin is a nervous system-specific adherens junction protein which undergoes dynamic relocalization during development.

28 June 2018

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Specific phosphorylation of p120-catenin regulatory domain differently modulates its binding to RhoA.

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3518422

Tyrosine phosphorylation of VE-cadherin prevents binding of p120- and beta-catenin and maintains the cellular mesenchymal state

21 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3518422

VE-cadherin-p120 interaction is required for maintenance of endothelial barrier function.

21 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3518422

Protein kinase C modifications of VE-cadherin, p120, and β-catenin contribute to endothelial barrier dysregulation induced by thrombin

21 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3518422

TLR4-mediated inflammatory activation of human coronary artery endothelial cells by LPS.

21 September 2018

1 reference

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Unraveling the distinct distributions of VE- and N-cadherins in endothelial cells: A key role for p120-catenin

21 September 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22798526

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Abrogation of thrombin-induced increase in pulmonary microvascular permeability in PAR-1 knockout mice

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22798526

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1161/CIRCRESAHA.112.269654

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22798526%20AND%20SRC:MED&resulttype=core&format=json

8 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22798526%20AND%20SRC:MED&resulttype=core&format=json

8 February 2020

1 reference