Inorganic pyrophosphate generation by transforming growth factor-beta-1 is mainly dependent on ANK induction by Ras/Raf-1/extracellular signal-regulated kinase pathways in chondrocytes. (Q36465483)

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English	Inorganic pyrophosphate generation by transforming growth factor-beta-1 is mainly dependent on ANK induction by Ras/Raf-1/extracellular signal-regulated kinase pathways in chondrocytes.	scientific article

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27 December 2019

Inorganic pyrophosphate generation by transforming growth factor-beta-1 is mainly dependent on ANK induction by Ras/Raf-1/extracellular signal-regulated kinase pathways in chondrocytes (English)

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27 December 2019

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27 December 2019

author name string

Frederic Cailotto

1

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27 December 2019

Arnaud Bianchi

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27 December 2019

Sylvie Sebillaud

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27 December 2019

Narayanan Venkatesan

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27 December 2019

Jean-Yves Jouzeau

6

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27 December 2019

Patrick Netter

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27 December 2019

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1 January 2007

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27 December 2019

Arthritis Research and Therapy

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27 December 2019

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27 December 2019

6

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27 December 2019

R122

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27 December 2019

https://scigraph.springernature.com/pub.10.1186/ar2330

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Antitumor activity of enzastaurin (LY317615.HCl) against human cancer cell lines and freshly explanted tumors investigated in in-vitro [corrected] soft-agar cloning experiments

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30 September 2017

Agonists of peroxisome proliferators-activated receptors (PPAR) alpha, beta/delta or gamma reduce transforming growth factor (TGF)-beta-induced proteoglycans' production in chondrocytes

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30 September 2017

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30 September 2017

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30 September 2017

Association of sporadic chondrocalcinosis with a -4-basepair G-to-A transition in the 5'-untranslated region of ANKH that promotes enhanced expression of ANKH protein and excess generation of extracellular inorganic pyrophosphate.

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30 September 2017

TGF-beta signaling in chondrocytes

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30 September 2017

TGF-beta-induced expression of tissue inhibitor of metalloproteinases-3 gene in chondrocytes is mediated by extracellular signal-regulated kinase pathway and Sp1 transcription factor

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30 September 2017

Adenoviral overexpression of Smad-7 and Smad-6 differentially regulates TGF-β-mediated chondrocyte proliferation and proteoglycan synthesis

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30 September 2017

Up-regulated expression of cartilage intermediate-layer protein and ANK in articular hyaline cartilage from patients with calcium pyrophosphate dihydrate crystal deposition disease

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30 September 2017

Mutations in ANKH cause chondrocalcinosis

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30 September 2017

Tissue-nonspecific alkaline phosphatase and plasma cell membrane glycoprotein-1 are central antagonistic regulators of bone mineralization

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30 September 2017

Smad regulation in TGF-beta signal transduction

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30 September 2017

Autosomal dominant craniometaphyseal dysplasia is caused by mutations in the transmembrane protein ANK

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30 September 2017

Transcriptional cross-talk between Smad, ERK1/2, and p38 mitogen-activated protein kinase pathways regulates transforming growth factor-beta-induced aggrecan gene expression in chondrogenic ATDC5 cells

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30 September 2017

Role of the mouse ank gene in control of tissue calcification and arthritis

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30 September 2017

Protein kinase C in the treatment of disease: signal transduction pathways, inhibitors, and agents in development.

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30 September 2017

The MAD-related protein Smad7 associates with the TGFbeta receptor and functions as an antagonist of TGFbeta signaling

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30 September 2017

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30 September 2017

Interleukin 1 beta suppresses transforming growth factor-induced inorganic pyrophosphate (PPi) production and expression of the PPi-generating enzyme PC-1 in human chondrocytes

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30 September 2017

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30 September 2017

Synthesis of cartilage matrix by mammalian chondrocytes in vitro. I. Isolation, culture characteristics, and morphology

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Measurement of protein using bicinchoninic acid

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30 September 2017

Pyrophosphohydrolase activity and inorganic pyrophosphate content of cultured human skin fibroblasts. Elevated levels in some patients with calcium pyrophosphate dihydrate deposition disease

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30 September 2017

Inorganic pyrophosphate metabolism in arthritis

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30 September 2017

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30 September 2017

Differential effects of aging on human chondrocyte responses to transforming growth factor beta: increased pyrophosphate production and decreased cell proliferation

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28 June 2018

Activation of p21ras by transforming growth factor beta in epithelial cells

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28 June 2018

Upregulated ank expression in osteoarthritis can promote both chondrocyte MMP-13 expression and calcification via chondrocyte extracellular PPi excess.

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21 September 2018

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21 September 2018

Developmental and TGF-beta-mediated regulation of Ank mRNA expression in cartilage and bone

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21 September 2018

Investigation of the role ofANKHin ankylosing spondylitis

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4 December 2018

Transforming growth factor-beta levels in synovial fluid of osteoarthritis with or without calcium pyrophosphate dihydrate crystals

1 reference

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12 December 2020

based on heuristic

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NTP pyrophosphohydrolase in human chondrocalcinotic and osteoarthritic cartilage. II. Further studies on histologic and subcellular distribution

1 reference

https://pubmed.ncbi.nlm.nih.gov/18034874

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A comparison of the effect of transforming growth factor beta 1 on pyrophosphate elaboration from various articular tissues

1 reference

https://pubmed.ncbi.nlm.nih.gov/18034874

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Causal link between nucleotide pyrophosphohydrolase overactivity and increased intracellular inorganic pyrophosphate generation demonstrated by transfection of cultured fibroblasts and osteoblasts with plasma cell membrane glycoprotein-1. Relevance

1 reference

https://pubmed.ncbi.nlm.nih.gov/18034874

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Probenecid inhibits transforming growth factor-beta 1 induced pyrophosphate elaboration by chondrocytes

1 reference

https://pubmed.ncbi.nlm.nih.gov/18034874

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Characterization of chondrocyte alkaline phosphatase as a potential mediator in the dissolution of calcium pyrophosphate dihydrate crystals

1 reference

https://pubmed.ncbi.nlm.nih.gov/18034874

12 December 2020

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inferred from PubMed ID database lookup

Growth factor responsiveness of human articular chondrocytes in aging and development

1 reference

https://pubmed.ncbi.nlm.nih.gov/18034874

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Transforming growth factor-beta1 induces activation of Ras, Raf-1, MEK and MAPK in rat hepatic stellate cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/18034874

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Up-regulation of tissue inhibitor of metalloproteinases-3 gene expression by TGF-beta in articular chondrocytes is mediated by serine/threonine and tyrosine kinases

1 reference

https://pubmed.ncbi.nlm.nih.gov/18034874

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Transduction mechanisms of porcine chondrocyte inorganic pyrophosphate elaboration

1 reference

https://pubmed.ncbi.nlm.nih.gov/18034874

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Differential effects of SB 242235, a selective p38 mitogen-activated protein kinase inhibitor, on IL-1 treated bovine and human cartilage/chondrocyte cultures

1 reference

https://pubmed.ncbi.nlm.nih.gov/18034874

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27 December 2019

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27 December 2019

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27 December 2019

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