Therapeutic implications of the gender-specific aspects of cardiovascular disease (Q36467824)

14 August 2017

1 reference

title

Therapeutic implications of the gender-specific aspects of cardiovascular disease (English)

1 reference

14 August 2017

cardiovascular disease

1 reference

1

Vera Regitz-Zagrosek

1 reference

14 August 2017

1 May 2006

1 reference

Nature Reviews Drug Discovery

14 August 2017

1 reference

14 August 2017

5

1 reference

14 August 2017

5

1 reference

14 August 2017

425-438

1 reference

https://scigraph.springernature.com/pub.10.1038/nrd2032

14 August 2017

0 references

cites work

Sex differences in coronary heart disease. Why are women so superior? The 1995 Ancel Keys Lecture

1 reference

The protective effects of estrogen on the cardiovascular system

21 January 2018

1 reference

Gender differences in the regulation of blood pressure

21 January 2018

1 reference

Sex hormones and hypertension

21 January 2018

1 reference

Gender differences in the metabolic syndrome and their role for cardiovascular disease.

21 January 2018

1 reference

Geschlechtsspezifische Trends von plötzlichem Herztod und akutem Herzinfarkt

21 January 2018

1 reference

Why is diabetes mellitus a stronger risk factor for fatal ischemic heart disease in women than in men? The Rancho Bernardo Study.

21 January 2018

1 reference

Isolated postchallenge hyperglycemia and the risk of fatal cardiovascular disease in older women and men. The Rancho Bernardo Study

21 January 2018

1 reference

Effect of potentially modifiable risk factors associated with myocardial infarction in 52 countries (the INTERHEART study): case-control study

21 January 2018

1 reference

The Seventh Report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure<SUBTITLE>The JNC 7 Report</SUBTITLE>

21 January 2018

1 reference

The progression from hypertension to congestive heart failure

21 January 2018

1 reference

Long-Term Trends in the Incidence of and Survival with Heart Failure

21 January 2018

1 reference

Sex differences in cardiac arrest survivors.

21 January 2018

1 reference

Role of noninvasive testing in the clinical evaluation of women with suspected coronary artery disease: Consensus statement from the Cardiac Imaging Committee, Council on Clinical Cardiology, and the Cardiovascular Imaging and Intervention Committee

21 January 2018

1 reference

Sex-based differences in early mortality after myocardial infarction. National Registry of Myocardial Infarction 2 Participants

21 January 2018

1 reference

Sex-based differences in clinical and angiographic outcomes after primary angioplasty or stenting for acute myocardial infarction

21 January 2018

1 reference

Gender-specific implications for cardiovascular medication use in the elderly optimizing therapy for older women

21 January 2018

1 reference

Prevalence of hypertrophic cardiomyopathy in a general population of young adults. Echocardiographic analysis of 4111 subjects in the CARDIA Study. Coronary Artery Risk Development in (Young) Adults

21 January 2018

1 reference

Neurohumoral features of myocardial stunning due to sudden emotional stress

21 January 2018

1 reference

Emotional stress-induced Tako-tsubo cardiomyopathy: animal model and molecular mechanism

21 January 2018

1 reference

Sex-associated differences in left ventricular function in aortic stenosis of the elderly

21 January 2018

1 reference

The EuroHeart Failure survey programme-- a survey on the quality of care among patients with heart failure in Europe. Part 1: patient characteristics and diagnosis

21 January 2018

1 reference

Sex differences in ventricular repolarization: from cardiac electrophysiology to Torsades de Pointes

21 January 2018

1 reference

Gender and the relationship between ventricular repolarization and cardiac cycle length during 24-h Holter recordings.

21 January 2018

1 reference

Female gender as a risk factor for torsades de pointes associated with cardiovascular drugs

21 January 2018

1 reference

21 January 2018

1 reference

Modulating effects of age and gender on the clinical course of long QT syndrome by genotype

21 January 2018

1 reference

Abnormal myocardial phosphorus-31 nuclear magnetic resonance spectroscopy in women with chest pain but normal coronary angiograms

21 January 2018

1 reference

Gender differences in the management and clinical outcome of stable angina.

21 January 2018

1 reference

Relationships between preclinical cardiac electrophysiology, clinical QT interval prolongation and torsade de pointes for a broad range of drugs: evidence for a provisional safety margin in drug development

21 January 2018

1 reference

Drug-induced QT prolongation in women during the menstrual cycle

21 January 2018

1 reference

The cardiovascular risk of young women with polycystic ovary syndrome: an observational, analytical, prospective case-control study

21 January 2018

1 reference

Hypertensive diseases of pregnancy and risk of hypertension and stroke in later life: results from cohort study

21 January 2018

1 reference

Lipid metabolism in women

21 January 2018

1 reference

Subcutaneous and visceral adipose tissue: their relation to the metabolic syndrome

21 January 2018

1 reference

Molecular and cellular basis of cardiovascular gender differences

21 January 2018

1 reference

Upregulation of myocardial estrogen receptors in human aortic stenosis.

21 January 2018

1 reference

Characterization of the ERbeta-/-mouse heart

21 January 2018

1 reference

Regulation of signal transduction pathways by estrogen and progesterone

21 January 2018

1 reference

Activation of estrogen receptor beta is a prerequisite for estrogen-dependent upregulation of nitric oxide synthases in neonatal rat cardiac myocytes

21 January 2018

1 reference

Genomic and nongenomic effects of estrogen in the vasculature

21 January 2018

1 reference

Estrogen receptor-alpha directs ordered, cyclical, and combinatorial recruitment of cofactors on a natural target promoter

21 January 2018

1 reference

The G protein-coupled receptor GPR30 mediates the proliferative effects induced by 17beta-estradiol and hydroxytamoxifen in endometrial cancer cells

21 January 2018

1 reference

Cardiovascular pharmacology of estradiol metabolites

21 January 2018

1 reference

Modulation of the ligand-independent activation of the human estrogen receptor by hormone and antihormone

21 January 2018

1 reference

In vivo imaging of transcriptionally active estrogen receptors.

21 January 2018

1 reference

Myocardial ischemia-reperfusion injury in estrogen receptor-alpha knockout and wild-type mice.

21 January 2018

1 reference

Increased mortality and aggravation of heart failure in estrogen receptor-beta knockout mice after myocardial infarction

21 January 2018

1 reference

17beta-estradiol attenuates the development of pressure-overload hypertrophy

21 January 2018

1 reference

Estrogen receptor-beta mediates male-female differences in the development of pressure overload hypertrophy.

21 January 2018

1 reference

Association between estrogen receptor alpha gene variation and cardiovascular disease

21 January 2018

1 reference

ER-α variants and the cardiovascular effects of hormone replacement therapy

21 January 2018

1 reference

Clinical review 110: Cardiovascular actions of estrogens in men.

21 January 2018

1 reference

Role of estrogen receptors in the vascular system

21 January 2018

1 reference

Src kinase mediates phosphatidylinositol 3-kinase/Akt-dependent rapid endothelial nitric-oxide synthase activation by estrogen

21 January 2018

1 reference

Interaction of oestrogen receptor with the regulatory subunit of phosphatidylinositol-3-OH kinase

21 January 2018

1 reference

Plasma membrane estrogen receptors are coupled to endothelial nitric-oxide synthase through Galpha(i).

21 January 2018

1 reference

RETRACTED: Estrogen receptor-interacting protein that modulates its nongenomic activity-crosstalk with Src/Erk phosphorylation cascade

21 January 2018

1 reference

Plasma membrane localization and function of the estrogen receptor alpha variant (ER46) in human endothelial cells

21 January 2018

1 reference

Sex dependence and temporal dependence of the left ventricular genomic response to pressure overload

21 January 2018

1 reference

Expression of oestrogen receptor alpha and beta in rat heart: role of local oestrogen synthesis.

21 January 2018

1 reference

Myocardial Akt activation and gender: increased nuclear activity in females versus males

21 January 2018

1 reference

Mechanisms of estrogen receptor action in the myocardium. Rapid gene activation via the ERK1/2 pathway and serum response elements

21 January 2018

1 reference

Phenotypical evidence for a gender difference in cardiac norepinephrine transporter function

21 January 2018

1 reference

Sex hormones as potential modulators of vascular function in hypertension

21 January 2018

1 reference

Androgens and coronary artery disease

21 January 2018

1 reference

Androgen receptors mediate hypertrophy in cardiac myocytes.

21 January 2018

1 reference

Risks and benefits of estrogen plus progestin in healthy postmenopausal women: principal results From the Women's Health Initiative randomized controlled trial

21 January 2018

1 reference

Effects of conjugated equine estrogen in postmenopausal women with hysterectomy: the Women's Health Initiative randomized controlled trial

21 January 2018

1 reference

Female-specific aspects in the pharmacotherapy of chronic cardiovascular diseases

21 January 2018

1 reference

Sex and racial differences in pharmacological response: where is the evidence? Pharmacogenetics, pharmacokinetics, and pharmacodynamics

21 January 2018

1 reference

The effect of carvedilol on morbidity and mortality in patients with chronic heart failure. U.S. Carvedilol Heart Failure Study Group

21 January 2018

1 reference

Sex differences in the prognosis of congestive heart failure: results from the Cardiac Insufficiency Bisoprolol Study (CIBIS II).

21 January 2018

1 reference

Metoprolol CR/XL in female patients with heart failure: analysis of the experience in Metoprolol Extended-Release Randomized Intervention Trial in Heart Failure (MERIT-HF).

21 January 2018

1 reference

Overview of randomized trials of angiotensin-converting enzyme inhibitors on mortality and morbidity in patients with heart failure. Collaborative Group on ACE Inhibitor Trials.

21 January 2018

1 reference

A comparison of outcomes with angiotensin-converting--enzyme inhibitors and diuretics for hypertension in the elderly.

21 January 2018

1 reference

Cough and angiotensin II receptor antagonists: cause or confounding?

21 January 2018

1 reference

Cardiac actions of erythromycin: influence of female sex.

21 January 2018

1 reference

Sex difference in risk of torsade de pointes with d,l-sotalol

21 January 2018

1 reference

Is gender a risk factor for adverse drug reactions? The example of drug-induced long QT syndrome

21 January 2018

1 reference

Male/female differences in pharmacology: safety issues with QT-prolonging drugs

21 January 2018

1 reference

Effect of d-sotalol on mortality in patients with left ventricular dysfunction after recent and remote myocardial infarction. The SWORD Investigators. Survival With Oral d-Sotalol.

21 January 2018

1 reference

A randomized trial of low-dose aspirin in the primary prevention of cardiovascular disease in women

21 January 2018

1 reference

Age and sex distribution of suspected adverse drug reactions to newly marketed drugs in general practice in England: analysis of 48 cohort studies

21 January 2018

1 reference

Sex differences in pharmacokinetics and pharmacodynamics

21 January 2018

1 reference

How important are gender differences in pharmacokinetics?

21 January 2018

1 reference

The influence of sex on pharmacokinetics

21 January 2018

1 reference

Peroxisome proliferator--activated receptor alpha gene regulates left ventricular growth in response to exercise and hypertension

21 January 2018

1 reference

The Gly482Ser polymorphism in the peroxisome proliferator-activated receptor-gamma coactivator-1 gene is associated with hypertension in type 2 diabetic men.

21 January 2018

1 reference

21 January 2018

1 reference

Nuclear receptor signaling and cardiac energetics

21 January 2018

1 reference

Direct thiazolidinedione action in the human ovary: insulin-independent and insulin-sensitizing effects on steroidogenesis and insulin-like growth factor binding protein-1 production

21 January 2018

1 reference

Sex differences in the pharmacokinetics of pioglitazone in rats

21 January 2018

1 reference

Troglitazone treatment increases plasma vascular endothelial growth factor in diabetic patients and its mRNA in 3T3-L1 adipocytes

21 January 2018

1 reference

Secondary prevention of macrovascular events in patients with type 2 diabetes in the PROactive Study (PROspective pioglitAzone Clinical Trial In macroVascular Events): a randomised controlled trial

21 January 2018

1 reference

A common substitution (Asn291Ser) in lipoprotein lipase is associated with increased risk of ischemic heart disease

21 January 2018

1 reference

Common promoter polymorphisms of inflammation and thrombosis genes and longevity in older adults: The cardiovascular health study

21 January 2018

1 reference

Association analysis between hypertension and CYBA, CLCNKB, and KCNMB1 functional polymorphisms in the Japanese population--the Suita Study

21 January 2018

1 reference

X-inactivation profile reveals extensive variability in X-linked gene expression in females

21 January 2018

1 reference

Sex difference in vascular injury and the vasoprotective effect of valsartan are related to differential AT2 receptor expression

21 January 2018

1 reference

Sex is a potent modifier of the cardiovascular system

21 January 2018

1 reference

Gender modulates cardiac phenotype development in genetically modified mice

21 January 2018

1 reference

Oestrogen protects FKBP12.6 null mice from cardiac hypertrophy

21 January 2018

1 reference

Soy diet worsens heart disease in mice.

21 January 2018

1 reference

Human liver catechol-O-methyltransferase pharmacogenetics

21 January 2018

1 reference

Sex-specific changes in platelet aggregation and secretion with sexual maturity in pigs

21 January 2018

1 reference

Interaction of hemostatic genetics with hormone therapy: new insights to explain arterial thrombosis in postmenopausal women

21 January 2018

1 reference

Platelet-active drugs: the relationships among dose, effectiveness, and side effects: the Seventh ACCP Conference on Antithrombotic and Thrombolytic Therapy

21 January 2018

1 reference

Estrogen-receptor polymorphisms and effects of estrogen replacement on high-density lipoprotein cholesterol in women with coronary disease

21 January 2018

1 reference

Sexual dimorphism in angiotensin II-induced hypertension and vascular alterations

21 January 2018

1 reference

Role of oxidative stress in the sex differences in blood pressure in spontaneously hypertensive rats

21 January 2018

1 reference

Comparison of the effects of omapatrilat and irbesartan/hydrochlorothiazide on endothelial function and cardiac hypertrophy in the stroke-prone spontaneously hypertensive rat: sex differences

21 January 2018

1 reference

Synergistic effects of male sex and obesity on hepatic insulin dynamics in SHR/Mcc-cp rat.

21 January 2018

1 reference

Sex modifies exercise and cardiac adaptation in mice

21 January 2018

1 reference

Gender as a risk factor in young, not in old, women undergoing coronary artery bypass grafting

21 January 2018

1 reference

21 January 2018

1 reference

Diabetes as a risk factor for myocardial infarction: population and gender perspectives

21 January 2018

1 reference

Sex differences in hospital mortality after coronary artery bypass surgery: evidence for a higher mortality in younger women

31 March 2020

1 reference

Left ventricular hypertrophy has a greater impact on survival in women than in men

31 March 2020

1 reference

Women's Ischemic Syndrome Evaluation: current status and future research directions: report of the National Heart, Lung and Blood Institute workshop: October 2-4, 2002: Section 2: stable ischemia: pathophysiology and gender differences

31 March 2020

1 reference

Type II diabetes abrogates sex differences in endothelial function in premenopausal women

31 March 2020

1 reference

Polycystic ovary syndrome, insulin resistance, and molecular defects of insulin signaling

31 March 2020

1 reference

Gender differences in recovery after coronary artery bypass surgery

31 March 2020

1 reference

Patients with depressive symptoms have lower health status benefits after coronary artery bypass surgery

31 March 2020

1 reference

Female mice lacking estrogen receptor beta display prolonged ventricular repolarization and reduced ventricular automaticity after myocardial infarction

31 March 2020

1 reference

Differential effects of estrogen and progesterone on AT(1) receptor gene expression in vascular smooth muscle cells

31 March 2020

1 reference

Sex-based differences in the effect of digoxin for the treatment of heart failure

31 March 2020

1 reference

Association of serum digoxin concentration and outcomes in patients with heart failure

31 March 2020

1 reference

Effect of metoprolol CR/XL in chronic heart failure: Metoprolol CR/XL Randomised Intervention Trial in Congestive Heart Failure (MERIT-HF)

31 March 2020

1 reference

Myocardial dysfunction and male mortality in peroxisome proliferator-activated receptor alpha knockout mice overexpressing lipoprotein lipase in muscle.

31 March 2020

1 reference

The DD genotype of the angiotensin converting enzyme gene is negatively associated with right ventricular hypertrophy in male patients with chronic obstructive pulmonary disease

31 March 2020

1 reference

Depression in Alzheimer's disease might be associated with apolipoprotein E epsilon 4 allele frequency in women but not in men

31 March 2020

1 reference

Angiotensin II type 2 receptors and cardiac hypertrophy in women with hypertrophic cardiomyopathy

31 March 2020

1 reference

Effect of dietary fat on the development of non-insulin dependent diabetes mellitus in obese Zucker diabetic fatty male and female rats

31 March 2020

1 reference

Greater quinidine-induced QTc interval prolongation in women

31 March 2020

1 reference

Gender mediated cardiac protection from adverse ventricular remodeling is abolished by ovariectomy

31 March 2020

1 reference

Susceptibility of the heart to ischaemia-reperfusion injury and exercise-induced cardioprotection are sex-dependent in the rat

31 March 2020

1 reference

Gender Differences in Postinfarction Left Ventricular Remodeling

31 March 2020

1 reference

Gender differences in blood pressure and heart rate in spontaneously hypertensive and Wistar-Kyoto rats

31 March 2020

1 reference

Comparison of cardiac function in male and female diabetic rats

31 March 2020

1 reference

31 March 2020

Identifiers

DOI

10.1038/NRD2032

1 reference

PubMed ID

16672926

Dimensions Publication ID

14 August 2017

0 references

1 reference

PubMed ID

16672926