Selective killing of preneoplastic and neoplastic cells by methotrexate with leucovorin (Q36476217)

14 August 2017

Selective killing of preneoplastic and neoplastic cells by methotrexate with leucovorin (English)

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14 August 2017

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M Chow

1

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14 August 2017

H Rubin

series ordinal

2

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14 August 2017

language of work or name

English

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publication date

1 April 1998

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Proceedings of the National Academy of Sciences of the United States of America

14 August 2017

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14 August 2017

95

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14 August 2017

8

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14 August 2017

4550-4555

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Temporary remissions in acute leukemia in children produced by folic acid antagonist, 4-aminopteroyl-glutamic acid

14 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=22527

Cellular aging, destabilization, and cancer

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=22527

Experimental control of neoplastic progression in cell populations: Foulds' rules revisited

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=22527

Incipient and overt stages of neoplastic transformation

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=22527

Accumulation of DNA strand breaks and methotrexate cytotoxicity

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=22527

Genetic predisposition to breast cancer

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=22527

Murine sarcoma and leukemia viruses: assay using clonal lines of contact-inhibited mouse cells

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=22527

Evidence for the progressive and adaptive nature of spontaneous transformation in the NIH 3T3 cell line

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=22527

Skin fibroblasts from individuals hemizygous for the familial adenopolyposis susceptibility gene show delayed crisis in vitro

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=22527

Adaptive evolution of degrees and kinds of neoplastic transformation in cell culture

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=22527

Gene amplification; what are we learning?

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=22527

Cell aging in vivo and in vitro

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=22527

Heritable colonic cancer syndromes: induction of anchorage-independence in dermal cultures derived from patients with adenomatosis of the colon and rectum

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=22527

The inhibition of chick embryo cell growth by medium obtained from cultures of Rous sarcoma cells.

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=22527

The transformed (initiated) human cell phenotype: study of cultured skin fibroblasts from individuals predisposed to cancer

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=22527

Human fibroblasts from cancer patients: lifespan and transformed phenotype in vitro and role of mesenchyme in vivo.

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=22527

Further characterization of the defects of skin fibroblasts from cancer patients.

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=22527

The biology of human cells in tissue culture. I. Characterization of cells derived from osteogenic sarcomas

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=22527

Resistance of resting 3T6 mouse fibroblasts to methotrexate cytotoxicity

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=22527

Rescue of human lymphoid cells from the effects of methotrexate in vitro

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=22527

Genetic toxicology: can we design predictive in vivo assays?

28 June 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.95.8.4550

Role of the cellular oxidation-reduction state in methotrexate binding to dihydrofolate reductase and dissociation induced by reduced folates.

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=22527

Thymidine and hypoxanthine requirements of normal and malignant human cells for protection against methotrexate cytotoxicity

21 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=22527

The Pineal Gland and Mammalian Photoperiodism

21 September 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.95.8.4550

The reversal of methotrexate toxicity by thymidine with maintenance of antitumour effects

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.95.8.4550

New approaches to cancer chemotherapy with methotrexate

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.95.8.4550

Mammalian folylpoly-gamma-glutamate synthetase. 4. In vitro and in vivo metabolism of folates and analogues and regulation of folate homeostasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.95.8.4550

The reversal of methotrexate cytotoxicity to mouse bone marrow cells by leucovorin and nucleosides

21 January 2018

1 reference

12 December 2020

Further evidence for a basis of selective activity and relative responsiveness during antifolate therapy of murine tumors

1 reference

12 December 2020

Eradication Of Leukaemic Cells (L1210) by Methotrexate and Methotrexate Plus Citrovorum Factor

1 reference

12 December 2020

Antifolate polyglutamylation and competitive drug displacement at dihydrofolate reductase as important elements in leucovorin rescue in L1210 cells

1 reference

12 December 2020

Improved therapeutic index of methotrexate with "leucovorin rescue"

1 reference

12 December 2020

Purineless death as a link between growth rate and cytotoxicity by methotrexate

1 reference

12 December 2020

Chemotherapeutic effects on mammalian tumor cells. 3. Modification of leukemia L1210 growth kinetics with an antimetabolite

1 reference

12 December 2020

Differential synthesis of methotrexate polyglutamates in normal proliferative and neoplastic mouse tissues in vivo

1 reference

12 December 2020

Polyglutamylation, an important element in methotrexate cytotoxicity and selectivity in tumor versus murine granulocytic progenitor cells in vitro

1 reference

12 December 2020

Potentiation of the antitumor activity of methotrexate by concurrent infusion of thymidine

1 reference

12 December 2020

Random population-wide genetic damage induced in replicating cells treated with methotrexate

1 reference

12 December 2020

Identifiers

DOI

10.1073/PNAS.95.8.4550

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14 August 2017

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1 reference

14 August 2017

PubMed publication ID

9539775

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