The antinociceptive triterpene β-amyrin inhibits 2-arachidonoylglycerol (2-AG) hydrolysis without directly targeting cannabinoid receptors (Q36476729)

14 August 2017

The antinociceptive triterpene β-amyrin inhibits 2-arachidonoylglycerol (2-AG) hydrolysis without directly targeting cannabinoid receptors (English)

1 reference

14 August 2017

glyceryl 2-arachidonate

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A Chicca

1

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author name string

J Marazzi

series ordinal

2

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14 August 2017

J Gertsch

series ordinal

3

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14 August 2017

language of work or name

English

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publication date

1 December 2012

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British Journal of Pharmacology

14 August 2017

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14 August 2017

167

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14 August 2017

8

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14 August 2017

1596-1608

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Guide to Receptors and Channels (GRAC), 5th edition

14 August 2017

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Modulation of L-α-lysophosphatidylinositol/GPR55 mitogen-activated protein kinase (MAPK) signaling by cannabinoids

30 September 2017

1 reference

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Commentary: Functional Neuronal CB2 Cannabinoid Receptors in the CNS

30 September 2017

1 reference

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Activation of cannabinoid receptors by the pentacyclic triterpene α,β-amyrin inhibits inflammatory and neuropathic persistent pain in mice.

30 September 2017

1 reference

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The cannabinoid CB1 receptor antagonists rimonabant (SR141716) and AM251 directly potentiate GABA(A) receptors

30 September 2017

1 reference

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Botanical drugs, synergy, and network pharmacology: forth and back to intelligent mixtures

30 September 2017

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International Union of Basic and Clinical Pharmacology. LXXIX. Cannabinoid receptors and their ligands: beyond CB₁ and CB₂

30 September 2017

1 reference

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Endocannabinoid Overload: Fig. 1

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1 reference

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α,β-amyrin, a natural triterpenoid ameliorates L-arginine-induced acute pancreatitis in rats

30 September 2017

1 reference

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Inhibition of monoacylglycerol lipase by troglitazone, N‐arachidonoyl dopamine and the irreversible inhibitor JZL184: comparison of two different assays

30 September 2017

1 reference

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Quantitative in vitro and in vivo pharmacological profile of CE-178253, a potent and selective cannabinoid type 1 (CB1) receptor antagonist.

30 September 2017

1 reference

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The serine hydrolase ABHD6 controls the accumulation and efficacy of 2-AG at cannabinoid receptors

30 September 2017

1 reference

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Cannabinoid receptors and endocannabinoids: role in neuroinflammatory and neurodegenerative disorders

30 September 2017

1 reference

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Phytocannabinoids beyond the Cannabis plant - do they exist?

30 September 2017

1 reference

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Falcarinol is a covalent cannabinoid CB1 receptor antagonist and induces pro-allergic effects in skin

30 September 2017

1 reference

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Effects of triterpenes on the immune system

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3525863

Crystal structure of the human monoacylglycerol lipase, a key actor in endocannabinoid signaling

30 September 2017

1 reference

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Discovery of potent and reversible monoacylglycerol lipase inhibitors.

30 September 2017

1 reference

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A critical cysteine residue in monoacylglycerol lipase is targeted by a new class of isothiazolinone-based enzyme inhibitors

30 September 2017

1 reference

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Emerging strategies for exploiting cannabinoid receptor agonists as medicines

30 September 2017

1 reference

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Selective blockade of 2-arachidonoylglycerol hydrolysis produces cannabinoid behavioral effects

30 September 2017

1 reference

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Does the hydrolysis of 2-arachidonoylglycerol regulate its cellular uptake?

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3525863

Selectivity of inhibitors of endocannabinoid biosynthesis evaluated by activity-based protein profiling

30 September 2017

1 reference

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Beta-caryophyllene is a dietary cannabinoid

30 September 2017

1 reference

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Enzymatic pathways that regulate endocannabinoid signaling in the nervous system

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3525863

URB602 inhibits monoacylglycerol lipase and selectively blocks 2-arachidonoylglycerol degradation in intact brain slices.

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3525863

A comprehensive profile of brain enzymes that hydrolyze the endocannabinoid 2-arachidonoylglycerol

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3525863

Cannabinoid CB2 receptors: a therapeutic target for the treatment of inflammatory and neuropathic pain

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3525863

Meta-analysis of cannabinoid ligand binding affinity and receptor distribution: interspecies differences.

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3525863

New natural noncannabinoid ligands for cannabinoid type-2 (CB2) receptors

30 September 2017

1 reference

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The endocannabinoid system as an emerging target of pharmacotherapy

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3525863

Alkylamides from Echinacea are a new class of cannabinomimetics. Cannabinoid type 2 receptor-dependent and -independent immunomodulatory effects

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3525863

Structure-activity relationships for 1-alkyl-3-(1-naphthoyl)indoles at the cannabinoid CB(1) and CB(2) receptors: steric and electronic effects of naphthoyl substituents. New highly selective CB(2) receptor agonists

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3525863

A simple method for the isolation and purification of total lipides from animal tissues

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3525863

Enantiomeric resolution of a novel chiral cannabinoid receptor ligand.

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3525863

Pharmacophoric requirements for cannabinoid side chains: multiple bond and C1'-substituted delta 8-tetrahydrocannabinols

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3525863

Discovery of 1-[9-(4-chlorophenyl)-8-(2-chlorophenyl)-9H-purin-6-yl]-4-ethylaminopiperidine-4-carboxylic acid amide hydrochloride (CP-945,598), a novel, potent, and selective cannabinoid type 1 receptor antagonist

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3525863

Synergistic immunomopharmacological effects of N-alkylamides in Echinacea purpurea herbal extracts.

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3525863

Antinoceptive effect of triterpenoid alpha,beta-amyrin in rats on orofacial pain induced by formalin and capsaicin

21 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3525863

Behavioral methods in cannabinoid research.

21 September 2018

1 reference

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Cannabinoid receptor binding to membrane homogenates and cannabinoid-stimulated [35S]GTPgammaS binding to membrane homogenates or intact cultured cells

21 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3525863

Simultaneous determination of endocannabinoids (arachidonylethanolamide and 2-arachidonylglycerol) and isoprostane (8-epiprostaglandin F2alpha) by gas chromatography-mass spectrometry-selected ion monitoring for medical samples

21 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3525863

Modulation of CB1 mRNA upon activation of murine splenocytes

21 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3525863

Rapid generation of 2-arachidonoylglycerol, an endogenous cannabinoid receptor ligand, in rat brain after decapitation

21 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3525863

The biosynthesis of beta-amyrin. Mechanism of squalene cyclization

21 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3525863

Desulfohaplosamate, a new phosphate-containing steroid from Dasychalina sp., is a selective cannabinoid CB2 receptor ligand

21 September 2018

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12 December 2020

Quantification of α- and β-amyrin in rat plasma by gas chromatography-mass spectrometry: application to preclinical pharmacokinetic study

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12 December 2020

Endocannabinoid content in fetal bovine sera - unexpected effects on mononuclear cells and osteoclastogenesis

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12 December 2020

Anti-inflammatory effect of α,β-amyrin, a triterpene from Protium heptaphyllum, on cerulein-induced acute pancreatitis in mice

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12 December 2020

Triterpene alcohols from the flowers of compositae and their anti-inflammatory effects

1 reference

12 December 2020

10.1111/J.1476-5381.2012.02059.X

Identifiers

DOI

1 reference

14 August 2017

1 reference

14 August 2017

PubMed publication ID

22646533

1 reference