Uncovering the uncharacterized and unexpected: unbiased phenotype-driven screens in the mouse (Q36488817)

14 August 2017

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title

Uncovering the uncharacterized and unexpected: unbiased phenotype-driven screens in the mouse (English)

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14 August 2017

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Tamara Caspary

1

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Kathryn V. Anderson

object named as

Kathryn V Anderson

series ordinal

2

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publication date

1 September 2006

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14 August 2017

Developmental Dynamics

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14 August 2017

235

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14 August 2017

9

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14 August 2017

2412-2423

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Mouse models of autism spectrum disorders: the challenge for behavioral genetics

14 August 2017

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.20853

Fog2 is required for normal diaphragm and lung development in mice and humans

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.20853

7 January 2021

Identification of Cd36 (Fat) as an insulin-resistance gene causing defective fatty acid and glucose metabolism in hypertensive rats.

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.20853

7 January 2021

The Drosophila smoothened gene encodes a seven-pass membrane protein, a putative receptor for the hedgehog signal

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.20853

7 January 2021

Functional identification of the mouse circadian Clock gene by transgenic BAC rescue

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.20853

7 January 2021

The knockout mouse project

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.20853

7 January 2021

Positional cloning and characterization of mouse mei8, a disrupted allelle of the meiotic cohesin Rec8.

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.20853

7 January 2021

Sequence-based analysis of mutagenized mice

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.20853

7 January 2021

Genetic dissection of innate immunity to infection: the mouse cytomegalovirus model

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.20853

7 January 2021

An N-ethyl-N-nitrosourea screen for genes involved in variegation in the mouse

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.20853

7 January 2021

Dispatched, a novel sterol-sensing domain protein dedicated to the release of cholesterol-modified hedgehog from signaling cells

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.20853

7 January 2021

Suppressor screen in Mpl-/- mice: c-Myb mutation causes supraphysiological production of platelets in the absence of thrombopoietin signaling

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.20853

7 January 2021

Mouse Dispatched homolog1 is required for long-range, but not juxtacrine, Hh signaling.

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.20853

7 January 2021

Dual roles for patched in sequestering and transducing Hedgehog

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.20853

7 January 2021

Genotype-based screen for ENU-induced mutations in mouse embryonic stem cells

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.20853

7 January 2021

Implementing large-scale ENU mutagenesis screens in North America

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.20853

7 January 2021

Mutation rate and predicted phenotypic target sizes in ethylnitrosourea-treated mice

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.20853

7 January 2021

Targeted mutation of the Hprt gene in mouse embryonic stem cells

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.20853

7 January 2021

Differential effects of the KitW mutation with other Kit allelic combinations on male sterility among inter- or intrasubspecific hybrids in mice

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.20853

7 January 2021

Essential role of glycosaminoglycans in Fgf signaling during mouse gastrulation.

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.20853

7 January 2021

Analysis of mouse embryonic patterning and morphogenesis by forward genetics

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.20853

7 January 2021

The dominant-white spotting (W) locus of the mouse encodes the c-kit proto-oncogene

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.20853

7 January 2021

The Ikaros gene is required for the development of all lymphoid lineages

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.20853

7 January 2021

Molecular basis of the Cd36 chromosomal deletion underlying SHR defects in insulin action and fatty acid metabolism.

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.20853

7 January 2021

Large-scale mutagenesis of the mouse to understand the genetic bases of nervous system structure and function

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.20853

7 January 2021

Efficient generation and mapping of recessive developmental mutations using ENU mutagenesis

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.20853

7 January 2021

Dose-repetition increases the mutagenic effectiveness of N-ethyl-N-nitrosourea in mouse spermatogonia

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.20853

7 January 2021

Unraveling innate immunity using large scale N-ethyl-N-nitrosourea mutagenesis

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.20853

7 January 2021

Identification of Lps2 as a key transducer of MyD88-independent TIR signalling

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.20853

7 January 2021

CD36 is a sensor of diacylglycerides

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.20853

7 January 2021

Genome-wide, large-scale production of mutant mice by ENU mutagenesis.

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.20853

7 January 2021

Cilia and Hedgehog responsiveness in the mouse

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.20853

7 January 2021

Hedgehog signalling in the mouse requires intraflagellar transport proteins

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.20853

7 January 2021

Identifying the MAGUK protein Carma-1 as a central regulator of humoral immune responses and atopy by genome-wide mouse mutagenesis.

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.20853

7 January 2021

Using targeted large deletions and high-efficiency N-ethyl-N-nitrosourea mutagenesis for functional analyses of the mammalian genome

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.20853

7 January 2021

The Polycomb group protein Eed protects the inactive X-chromosome from differentiation-induced reactivation

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.20853

7 January 2021

A phenotype-based screen for embryonic lethal mutations in the mouse

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.20853

7 January 2021

Unresponsiveness of MyD88-deficient mice to endotoxin

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.20853

7 January 2021

Mouse dispatched mutants fail to distribute hedgehog proteins and are defective in hedgehog signaling

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.20853

7 January 2021

A repository of ENU mutant mouse lines and their potential for male fertility research

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.20853

7 January 2021

The art and design of genetic screens: mouse

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.20853

7 January 2021

Functional genetic analysis of mouse chromosome 11

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.20853

7 January 2021

Positional cloning of the mouse circadian clock gene

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.20853

7 January 2021

Ikaros is critical for B cell differentiation and function.

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.20853

7 January 2021

The mouse meiotic mutation mei1 disrupts chromosome synapsis with sexually dimorphic consequences for meiotic progression.

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.20853

7 January 2021

Positional cloning and characterization of Mei1, a vertebrate-specific gene required for normal meiotic chromosome synapsis in mice

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.20853

7 January 2021

Towards construction of a high resolution map of the mouse genome using PCR-analysed microsatellites

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.20853

7 January 2021

Hedgehog-mediated patterning of the mammalian embryo requires transporter-like function of dispatched

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.20853

7 January 2021

Genome imprinting regulated by the mouse Polycomb group protein Eed

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.20853

7 January 2021

A genetic screen for mutations that affect cranial nerve development in the mouse.

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.20853

7 January 2021

Genome sequencing in microfabricated high-density picolitre reactors

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.20853

7 January 2021

Embryonic expression of a haematopoietic growth factor encoded by the SI locus and the ligand for c-kit

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.20853

7 January 2021

Loss of the retrograde motor for IFT disrupts localization of Smo to cilia and prevents the expression of both activator and repressor functions of Gli

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.20853

7 January 2021

Analysis of an ethylnitrosourea-generated mouse mutation defines a cell intrinsic role of nuclear factor kappaB2 in regulating circulating B cell numbers

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.20853

7 January 2021

Utilization of a whole genome SNP panel for efficient genetic mapping in the mouse

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.20853

7 January 2021

Mouse mutants from chemically mutagenized embryonic stem cells

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.20853

7 January 2021

Zic2 regulates the kinetics of neurulation

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.20853

7 January 2021

Inactivation of dispatched 1 by the chameleon mutation disrupts Hedgehog signalling in the zebrafish embryo

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.20853

7 January 2021

Genome-wide ENU mutagenesis to reveal immune regulators

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.20853

7 January 2021

A systematic, genome-wide, phenotype-driven mutagenesis programme for gene function studies in the mouse

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.20853

7 January 2021

Connecting mammalian genome with phenome by ENU mouse mutagenesis: gene combinations specifying the immune system.

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.20853

7 January 2021

Widespread failure of hematolymphoid differentiation caused by a recessive niche-filling allele of the Ikaros transcription factor

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.20853

7 January 2021

A novel mouse model of hypogonadotrophic hypogonadism: N-ethyl-N-nitrosourea-induced gonadotropin-releasing hormone receptor gene mutation

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.20853

7 January 2021

Autosomal dominant mutations affecting X inactivation choice in the mouse.

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.20853

7 January 2021

Development of a SNP genotyping panel for genetic monitoring of the laboratory mouse

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.20853

7 January 2021

An efficient SNP system for mouse genome scanning and elucidating strain relationships.

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.20853

7 January 2021

Defective LPS Signaling in C3H/HeJ and C57BL/10ScCr Mice: Mutations in Tlr4 Gene

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.20853

7 January 2021

A strategy for fine-structure functional analysis of a 6- to 11-centimorgan region of mouse chromosome 7 by high-efficiency mutagenesis

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.20853

7 January 2021

Germ-line transmission of genes introduced into cultured pluripotential cells by retroviral vector

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.20853

7 January 2021

Molecular characterization of ENU mouse mutagenesis and archives

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.20853

7 January 2021

Functional genomics in the mouse: phenotype-based mutagenesis screens

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.20853

7 January 2021

Erratum: Positional cloning of a global regulator of anterior–posterior patterning in mice

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.20853

7 January 2021

Advanced sequencing technologies: methods and goals

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.20853

7 January 2021

Accurate multiplex polony sequencing of an evolved bacterial genome

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.20853

7 January 2021

Forward genetic screens to identify circadian rhythm mutants in mice

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.20853

7 January 2021

A genetic screen for behavioral mutations that perturb dopaminergic homeostasis in mice

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.20853

7 January 2021

Site-directed mutagenesis by gene targeting in mouse embryo-derived stem cells

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.20853

7 January 2021

Tissue morphogenesis and vascular stability require the Frem2 protein, product of the mouse myelencephalic blebs gene

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.20853

7 January 2021

Evidence for translational regulation of the imprinted Snurf-Snrpn locus in mice

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.20853

7 January 2021

smoothened encodes a receptor-like serpentine protein required for hedgehog signalling

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.20853

7 January 2021

A RING-type ubiquitin ligase family member required to repress follicular helper T cells and autoimmunity

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.20853

7 January 2021

An allelic series of mutations in Smad2 and Smad4 identified in a genotype-based screen of N-ethyl-N- nitrosourea-mutagenized mouse embryonic stem cells

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.20853

7 January 2021

Imprinted X inactivation maintained by a mouse Polycomb group gene

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.20853

7 January 2021

Selective defects in the development of the fetal and adult lymphoid system in mice with an Ikaros null mutation

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.20853

7 January 2021

Toward the genetics of mammalian reproduction: induction and mapping of gametogenesis mutants in mice

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.20853

7 January 2021

A genetic screen for mouse mutations with defects in serotonin responsiveness

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.20853

7 January 2021

Random mutagenesis of proximal mouse chromosome 5 uncovers predominantly embryonic lethal mutations

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.20853

7 January 2021

A focused and efficient genetic screening strategy in the mouse: identification of mutations that disrupt cortical development

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.20853

7 January 2021

Smoothened mutants reveal redundant roles for Shh and Ihh signaling including regulation of L/R symmetry by the mouse node

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.20853

7 January 2021

Using genomewide mutagenesis screens to identify the genes required for neural tube closure in the mouse

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.20853

7 January 2021

A genome sequencing center in every lab

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.20853

7 January 2021

Identifiers

DOI

10.1002/DVDY.20853

1 reference

14 August 2017

1 reference

PubMed ID

16724327