Activation of heat shock and antioxidant responses by the natural product celastrol: transcriptional signatures of a thiol-targeted molecule. (Q36489064)

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English	Activation of heat shock and antioxidant responses by the natural product celastrol: transcriptional signatures of a thiol-targeted molecule.	scientific article

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1 January 2020

Activation of heat shock and antioxidant responses by the natural product celastrol: transcriptional signatures of a thiol-targeted molecule (English)

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1 January 2020

natural product

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1 January 2020

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Amy Trott

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1 January 2020

Lada Klaić

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1 January 2020

Sandy D Westerheide

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Richard B Silverman

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Richard I Morimoto

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16 January 2008

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Molecular Biology of the Cell

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3

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1 January 2020

1104-1112

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1 January 2020

Molecular understanding and modern application of traditional medicines: triumphs and trials.

1 reference

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30 September 2017

Celastrol, a novel triterpene, potentiates TNF-induced apoptosis and suppresses invasion of tumor cells by inhibiting NF-kappaB-regulated gene products and TAK1-mediated NF-kappaB activation

1 reference

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Gene expression signature-based chemical genomic prediction identifies a novel class of HSP90 pathway modulators

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Celastrol, a triterpene extracted from the Chinese "Thunder of God Vine," is a potent proteasome inhibitor and suppresses human prostate cancer growth in nude mice

1 reference

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A stress regulatory network for co-ordinated activation of proteasome expression mediated by yeast heat shock transcription factor.

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The role of Keap1 in cellular protective responses

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Alterations in gene expression induced by the lipid peroxidation product, 4-hydroxy-2-nonenal

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Inhibition of Hsp72-mediated protein refolding by 4-hydroxy-2-nonenal

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30 September 2017

Celastrols as inducers of the heat shock response and cytoprotection.

1 reference

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30 September 2017

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30 September 2017

The redox domain of the Yap1p transcription factor contains two disulfide bonds

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A thiol peroxidase is an H2O2 receptor and redox-transducer in gene activation

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Regulatory mechanisms controlling gene expression mediated by the antioxidant response element

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Regulation of the yeast Yap1p nuclear export signal is mediated by redox signal-induced reversible disulfide bond formation

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30 September 2017

Genomic expression programs in the response of yeast cells to environmental changes

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30 September 2017

H2O2 sensing through oxidation of the Yap1 transcription factor

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30 September 2017

Formation of nuclear HSF1 granules varies depending on stress stimuli

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30 September 2017

Yap1p activates gene transcription in an oxidant-specific fashion

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30 September 2017

Heat shock factor function and regulation in response to cellular stress, growth, and differentiation signals

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30 September 2017

A trans-activation domain in yeast heat shock transcription factor is essential for cell cycle progression during stress

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30 September 2017

Crm1p mediates regulated nuclear export of a yeast AP-1-like transcription factor

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30 September 2017

Heat shock element architecture is an important determinant in the temperature and transactivation domain requirements for heat shock transcription factor

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30 September 2017

AP1-mediated multidrug resistance in Saccharomyces cerevisiae requires FLR1 encoding a transporter of the major facilitator superfamily

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30 September 2017

Regulation of yAP-1 nuclear localization in response to oxidative stress

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30 September 2017

Copper-dependent degradation of the Saccharomyces cerevisiae plasma membrane copper transporter Ctr1p in the apparent absence of endocytosis.

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30 September 2017

YAP1 dependent activation of TRX2 is essential for the response of Saccharomyces cerevisiae to oxidative stress by hydroperoxides

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28 June 2018

The yeast heat shock transcription factor contains a transcriptional activation domain whose activity is repressed under nonshock conditions

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Modification of heat shock protein 90 by 4-hydroxynonenal in a rat model of chronic alcoholic liver disease

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21 September 2018

Two redox centers within Yap1 for H2O2 and thiol-reactive chemicals signaling

1 reference

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1 reference

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1 reference

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21 September 2018

Structural basis for redox regulation of Yap1 transcription factor localization

1 reference

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1 reference

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Neurologists strike gold in drug screen effort

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https://pubmed.ncbi.nlm.nih.gov/18199679

12 December 2020

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Teaching old drugs new tricks. Meeting of the Neurodegeneration Drug Screening Consortium, 7-8 April 2002, Washington, DC, USA

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https://pubmed.ncbi.nlm.nih.gov/18199679

12 December 2020

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Saccharomyces cerevisiae basic region-leucine zipper protein regulatory networks converge at the ATR1 structural gene

1 reference

https://pubmed.ncbi.nlm.nih.gov/18199679

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Stress-inducible responses and heat shock proteins: new pharmacologic targets for cytoprotection

1 reference

https://pubmed.ncbi.nlm.nih.gov/18199679

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Crm1 (XpoI) dependent nuclear export of the budding yeast transcription factor yAP-1 is sensitive to oxidative stress

1 reference

https://pubmed.ncbi.nlm.nih.gov/18199679

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Novel cytokine release inhibitors. Part I: Triterpenes

1 reference

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based on heuristic

inferred from PubMed ID database lookup

Quercetin suppresses heat shock response by down regulation of HSF1

1 reference

https://pubmed.ncbi.nlm.nih.gov/18199679

12 December 2020

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inferred from PubMed ID database lookup

Oxidative stress induced heat shock factor phosphorylation and HSF-dependent activation of yeast metallothionein gene transcription

1 reference

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12 December 2020

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yAP-1- and yAP-2-mediated, heat shock-induced transcriptional activation of the multidrug resistance ABC transporter genes in Saccharomyces cerevisiae

1 reference

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inferred from PubMed ID database lookup

Novel cytokine release inhibitors. Part III: Truncated analogs of tripterine

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Inhibition of NF-κB activation through targeting IκB kinase by celastrol, a quinone methide triterpenoid

1 reference

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based on heuristic

inferred from PubMed ID database lookup

Multistep disulfide bond formation in Yap1 is required for sensing and transduction of H2O2 stress signal

1 reference

https://pubmed.ncbi.nlm.nih.gov/18199679

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Yeast heat shock factor contains separable transient and sustained response transcriptional activators

1 reference

https://pubmed.ncbi.nlm.nih.gov/18199679

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1091/MBC.E07-10-1004

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1 January 2020

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