Vascular endothelial growth factor (VEGF)-Receptor2: its biological functions, major signaling pathway, and specific ligand VEGF-E. (Q36489757)

14 August 2017

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title

Vascular endothelial growth factor (VEGF)-Receptor2: its biological functions, major signaling pathway, and specific ligand VEGF-E. (English)

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14 August 2017

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Masabumi Shibuya

1

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14 August 2017

1 March 2006

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Endothelium: Journal of Endothelial Cell Research

14 August 2017

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14 August 2017

13

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14 August 2017

2

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14 August 2017

63-69

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Molecular mechanisms of lymphangiogenesis in health and disease

14 August 2017

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Bone marrow origin of endothelial progenitor cells responsible for postnatal vasculogenesis in physiological and pathological neovascularization

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Abnormal blood vessel development and lethality in embryos lacking a single VEGF allele

21 January 2018

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Synergism between vascular endothelial growth factor and placental growth factor contributes to angiogenesis and plasma extravasation in pathological conditions.

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Developmental control of blood cell migration by the Drosophila VEGF pathway

21 January 2018

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The fms-like tyrosine kinase, a receptor for vascular endothelial growth factor

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Guidance of cell migration by the Drosophila PDGF/VEGF receptor

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Vascular permeability factor/vascular endothelial growth factor: a critical cytokine in tumor angiogenesis and a potential target for diagnosis and therapy

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Ligand-dependent development of the endothelial and hemopoietic lineages from embryonic mesodermal cells expressing vascular endothelial growth factor receptor 2.

21 January 2018

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Heterozygous embryonic lethality induced by targeted inactivation of the VEGF gene

21 January 2018

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The biology of vascular endothelial growth factor

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Role of the Flt-1 receptor tyrosine kinase in regulating the assembly of vascular endothelium

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Requirements for binding and signaling of the kinase domain receptor for vascular endothelial growth factor

21 January 2018

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Complete structure of an increasing capillary permeability protein (ICPP) purified from Vipera lebetina venom. ICPP is angiogenic via vascular endothelial growth factor receptor signalling

21 January 2018

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Vascular endothelial growth factor regulates endothelial cell survival through the phosphatidylinositol 3'-kinase/Akt signal transduction pathway. Requirement for Flk-1/KDR activation

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Patterns and emerging mechanisms of the angiogenic switch during tumorigenesis

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VEGF-A induces tumor and sentinel lymph node lymphangiogenesis and promotes lymphatic metastasis

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Vascular endothelial growth factor A (VEGF-A) is involved in guidance of VEGF receptor-positive cells to the anterior portion of early embryos

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Bevacizumab plus irinotecan, fluorouracil, and leucovorin for metastatic colorectal cancer

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PVR plays a critical role via JNK activation in thorax closure during Drosophila metamorphosis

21 January 2018

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21 January 2018

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Identification of vascular endothelial growth factor determinants for binding KDR and FLT-1 receptors. Generation of receptor-selective VEGF variants by site-directed mutagenesis

21 January 2018

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A set of loop-1 and -3 structures in the novel vascular endothelial growth factor (VEGF) family member, VEGF-ENZ-7, is essential for the activation of VEGFR-2 signaling

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VEGF/VPF overexpression in skin of transgenic mice induces angiogenesis, vascular hyperpermeability and accelerated tumor development.

21 January 2018

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Impaired recruitment of bone-marrow-derived endothelial and hematopoietic precursor cells blocks tumor angiogenesis and growth

21 January 2018

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Impaired angiogenesis and endochondral bone formation in mice lacking the vascular endothelial growth factor isoforms VEGF164 and VEGF188.

21 January 2018

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VEGF receptor-2 Y951 signaling and a role for the adapter molecule TSAd in tumor angiogenesis

21 January 2018

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A receptor tyrosine kinase cDNA isolated from a population of enriched primitive hematopoietic cells and exhibiting close genetic linkage to c-kit

21 January 2018

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A novel vascular endothelial growth factor encoded by Orf virus, VEGF-E, mediates angiogenesis via signalling through VEGFR-2 (KDR) but not VEGFR-1 (Flt-1) receptor tyrosine kinases

21 January 2018

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High affinity VEGF binding and developmental expression suggest Flk-1 as a major regulator of vasculogenesis and angiogenesis

21 January 2018

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Expression of functional tyrosine kinases on immortalized Kaposi's sarcoma cells

21 January 2018

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A novel type of vascular endothelial growth factor, VEGF-E (NZ-7 VEGF), preferentially utilizes KDR/Flk-1 receptor and carries a potent mitotic activity without heparin-binding domain

21 January 2018

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Mechanisms of angiogenesis

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Essential role of Flk-1 (VEGF receptor 2) tyrosine residue 1173 in vasculogenesis in mice

21 January 2018

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Failure of blood-island formation and vasculogenesis in Flk-1-deficient mice

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VEGF receptor 2 and the adherens junction as a mechanical transducer in vascular endothelial cells

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Vascular endothelial growth factor receptor family genes: when did the three genes phylogenetically segregate?

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Integrins and angiogenesis

21 January 2018

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VEGF activates protein kinase C-dependent, but Ras-independent Raf-MEK-MAP kinase pathway for DNA synthesis in primary endothelial cells

21 January 2018

1 reference

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A single autophosphorylation site on KDR/Flk-1 is essential for VEGF-A-dependent activation of PLC-gamma and DNA synthesis in vascular endothelial cells

21 January 2018

1 reference

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Signalling via vascular endothelial growth factor receptor-3 is sufficient for lymphangiogenesis in transgenic mice

21 January 2018

1 reference

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Vascular endothelial growth factor (VEGF)-like protein from orf virus NZ2 binds to VEGFR2 and neuropilin-1

21 January 2018

1 reference

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Characterization of vascular endothelial growth factor's effect on the activation of protein kinase C, its isoforms, and endothelial cell growth

21 January 2018

1 reference

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Tyrosine residues 951 and 1059 of vascular endothelial growth factor receptor-2 (KDR) are essential for vascular permeability factor/vascular endothelial growth factor-induced endothelium migration and proliferation, respectively

21 January 2018

1 reference

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Mapping of the Sites Involved in Ligand Association and Dissociation at the Extracellular Domain of the Kinase Insert Domain-containing Receptor for Vascular Endothelial Growth Factor

21 January 2018

1 reference

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Flk1-positive cells derived from embryonic stem cells serve as vascular progenitors

21 January 2018

1 reference

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10.1080/10623320600697955

21 January 2018

Identifiers

DOI

1 reference

14 August 2017

1 reference

PubMed ID

16728325