Preclinical studies of Apogossypolone: a new nonpeptidic pan small-molecule inhibitor of Bcl-2, Bcl-XL and Mcl-1 proteins in Follicular Small Cleaved Cell Lymphoma model (Q36491547)

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English	Preclinical studies of Apogossypolone: a new nonpeptidic pan small-molecule inhibitor of Bcl-2, Bcl-XL and Mcl-1 proteins in Follicular Small Cleaved Cell Lymphoma model	scientific article

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scholarly article

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Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18275607%20AND%20SRC:MED&resulttype=core&format=json

2 January 2020

Preclinical studies of Apogossypolone: a new nonpeptidic pan small-molecule inhibitor of Bcl-2, Bcl-XL and Mcl-1 proteins in Follicular Small Cleaved Cell Lymphoma model (English)

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18275607%20AND%20SRC:MED&resulttype=core&format=json

2 January 2020

5

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18275607%20AND%20SRC:MED&resulttype=core&format=json

2 January 2020

author name string

Alan A Arnold

1

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18275607%20AND%20SRC:MED&resulttype=core&format=json

2 January 2020

Amro Aboukameel

2

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18275607%20AND%20SRC:MED&resulttype=core&format=json

2 January 2020

Jianyong Chen

3

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18275607%20AND%20SRC:MED&resulttype=core&format=json

2 January 2020

Dajun Yang

4

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2 January 2020

Ayad Al-Katib

6

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18275607%20AND%20SRC:MED&resulttype=core&format=json

2 January 2020

Ramzi M Mohammad

7

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2 January 2020

publication date

14 February 2008

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2 January 2020

Molecular Cancer

1 reference

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18275607%20AND%20SRC:MED&resulttype=core&format=json

2 January 2020

7

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Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18275607%20AND%20SRC:MED&resulttype=core&format=json

2 January 2020

20

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Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18275607%20AND%20SRC:MED&resulttype=core&format=json

2 January 2020

Preclinical studies of TW-37, a new nonpeptidic small-molecule inhibitor of Bcl-2, in diffuse large cell lymphoma xenograft model reveal drug action on both Bcl-2 and Mcl-1.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2265299

30 September 2017

Studies leading to potent, dual inhibitors of Bcl-2 and Bcl-xL

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2265299

30 September 2017

The Bcl-2 family protein inhibitor, ABT-737, has substantial antimyeloma activity and shows synergistic effect with dexamethasone and melphalan.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2265299

30 September 2017

HA14-1, a small molecule inhibitor of Bcl-2, bypasses chemoresistance in leukaemia cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2265299

30 September 2017

Chronic lymphocytic leukemia requires BCL2 to sequester prodeath BIM, explaining sensitivity to BCL2 antagonist ABT-737.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2265299

30 September 2017

Novel Bcl-2 inhibitors: Discovery and mechanism study of small organic apoptosis-inducing agents

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2265299

30 September 2017

Structure-based design of potent small-molecule inhibitors of anti-apoptotic Bcl-2 proteins

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2265299

30 September 2017

One single dose of rituximab added to a standard regimen of CHOP in primary treatment of follicular lymphoma appears to result in a high clearance rate from circulating bcl-2/IgH positive cells: Is the end of molecular monitoring near?

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2265299

30 September 2017

New treatment options have changed the survival of patients with follicular lymphoma

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2265299

30 September 2017

HA14-1, a small molecule Bcl-2 antagonist, induces apoptosis and modulates action of selected anticancer drugs in follicular lymphoma B cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2265299

30 September 2017

Looking at lymphoma and leukemia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2265299

30 September 2017

An inhibitor of Bcl-2 family proteins induces regression of solid tumours

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2265299

30 September 2017

Follicular lymphoma: expanding therapeutic options.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2265299

30 September 2017

Targeting the proapoptotic factor Bcl-2 in non-Hodgkin's lymphoma.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2265299

30 September 2017

Pro-apoptotic therapy with the oligonucleotide Genasense (oblimersen sodium) targeting Bcl-2 protein expression enhances the biological anti-tumour activity of rituximab

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2265299

30 September 2017

Proteasome inhibitor PS-341 causes cell growth arrest and apoptosis in human glioblastoma multiforme (GBM).

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2265299

30 September 2017

Bcl-2 antisense oligonucleotides are effective against systemic but not central nervous system disease in severe combined immunodeficient mice bearing human t(14;18) follicular lymphoma.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2265299

30 September 2017

Cancer surveillance series: non-Hodgkin's lymphoma incidence by histologic subtype in the United States from 1978 through 1995.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2265299

30 September 2017

Caspase-8 activation and bid cleavage contribute to MCF7 cellular execution in a caspase-3-dependent manner during staurosporine-mediated apoptosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2265299

30 September 2017

Molecular characterization of mitochondrial apoptosis-inducing factor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2265299

30 September 2017

Ordering the cytochrome c-initiated caspase cascade: hierarchical activation of caspases-2, -3, -6, -7, -8, and -10 in a caspase-9-dependent manner

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2265299

30 September 2017

Crystal structure of rat Bcl-xL. Implications for the function of the Bcl-2 protein family

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2265299

30 September 2017

X-ray and NMR structure of human Bcl-xL, an inhibitor of programmed cell death

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2265299

30 September 2017

Oral gossypol in the treatment of metastatic adrenal cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2265299

30 September 2017

Antisense oligodeoxyribonucleotide down-regulation of bcl-2 gene expression inhibits growth of the low-grade non-Hodgkin's lymphoma cell line WSU-FSCCL.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2265299

30 September 2017

A unique EBV-negative low-grade lymphoma line (WSU-FSCCL) exhibiting both t(14;18) and t(8;11).

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2265299

28 June 2018

Phase II trial of CHOP chemotherapy followed by tositumomab/iodine I-131 tositumomab for previously untreated follicular non-Hodgkin's lymphoma: five-year follow-up of Southwest Oncology Group Protocol S9911.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2265299

21 September 2018

The relationship between BcI2, Bax and p53: consequences for cell cycle progression and cell death.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2265299

21 September 2018

Gateways to clinical trials

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2265299

21 October 2018

Differential cytotoxic effect of gossypol on human melanoma, colon carcinoma, and other tissue culture cell lines

1 reference

https://pubmed.ncbi.nlm.nih.gov/18275607

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Histological conversion of follicular lymphoma with structural alterations of t(14;18) and immunoglobin genes

1 reference

https://pubmed.ncbi.nlm.nih.gov/18275607

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Preclinical studies of a nonpeptidic small-molecule inhibitor of Bcl-2 and Bcl-X(L) [(-)-gossypol] against diffuse large cell lymphoma

1 reference

https://pubmed.ncbi.nlm.nih.gov/18275607

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Comparison of chemical inhibitors of antiapoptotic Bcl-2-family proteins

1 reference

https://pubmed.ncbi.nlm.nih.gov/18275607

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Rituximab maintenance improves clinical outcome of relapsed/resistant follicular non-Hodgkin lymphoma in patients both with and without rituximab during induction: results of a prospective randomized phase 3 intergroup trial

1 reference

https://pubmed.ncbi.nlm.nih.gov/18275607

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A closer look at follicular lymphoma

1 reference

https://pubmed.ncbi.nlm.nih.gov/18275607

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Introduction of rituximab in front-line and salvage therapies has improved outcome of advanced-stage follicular lymphoma patients

1 reference

https://pubmed.ncbi.nlm.nih.gov/18275607

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A preliminary clinical study of gossypol in advanced human cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/18275607

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1186/1476-4598-7-20

1 reference

Europe PubMed Central

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2 January 2020

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2 January 2020

PubMed publication ID

1 reference

Europe PubMed Central

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2 January 2020

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