Pharmacokinetic and pharmacodynamic properties of histamine H2-receptor antagonists. Relationship between intrinsic potency and effective plasma concentrations (Q36494169)

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English	Pharmacokinetic and pharmacodynamic properties of histamine H2-receptor antagonists. Relationship between intrinsic potency and effective plasma concentrations	scientific article

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scholarly article

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Europe PubMed Central

14 August 2017

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Europe PubMed Central

Pharmacokinetic and pharmacodynamic properties of histamine H2-receptor antagonists. Relationship between intrinsic potency and effective plasma concentrations (English)

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Europe PubMed Central

14 August 2017

pharmacokinetics

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based on heuristic

inferred from title

pharmacodynamics

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based on heuristic

inferred from title

author name string

Lin JH

1

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Europe PubMed Central

14 August 2017

language of work or name

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based on heuristic

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publication date

1 March 1991

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Europe PubMed Central

14 August 2017

Clinical Pharmacokinetics

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Europe PubMed Central

14 August 2017

20

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Europe PubMed Central

14 August 2017

218-236

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Europe PubMed Central

14 August 2017

3

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Europe PubMed Central

14 August 2017

https://scigraph.springernature.com/pub.10.2165/00003088-199120030-00004

0 references

Ranitidine (AH 19065): a new potent, selective histamine H2-receptor antagonist [proceedings]

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https://pubmed.ncbi.nlm.nih.gov/1673880

12 December 2020

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Prostaglandins, H2-receptor antagonists and peptic ulcer disease

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https://pubmed.ncbi.nlm.nih.gov/1673880

12 December 2020

based on heuristic

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Classification and biological distribution of histamine receptor sub-types

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https://pubmed.ncbi.nlm.nih.gov/1673880

12 December 2020

based on heuristic

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Comparison of bioavailability and pharmacokinetics of cimetidine in subjects with normal and impaired renal function

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https://pubmed.ncbi.nlm.nih.gov/1673880

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pharmacokinetics of roxatidine in healthy volunteers

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https://pubmed.ncbi.nlm.nih.gov/1673880

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pharmacokinetics and pharmacodynamics of oral nizatidine

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https://pubmed.ncbi.nlm.nih.gov/1673880

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cimetidine clearance and bioavailability in hepatic cirrhosis

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https://pubmed.ncbi.nlm.nih.gov/1673880

12 December 2020

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Renal excretion of cimetidine.

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https://pubmed.ncbi.nlm.nih.gov/1673880

12 December 2020

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Effect of mifentidine on histamine-stimulated human atrium "in vitro": comparison with ranitidine and cimetidine

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https://pubmed.ncbi.nlm.nih.gov/1673880

12 December 2020

based on heuristic

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Nomogram for drug dosage adjustment in patients with renal failure

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https://pubmed.ncbi.nlm.nih.gov/1673880

12 December 2020

based on heuristic

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Nizatidine, an H2-blocker. Its metabolism and disposition in man.

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https://pubmed.ncbi.nlm.nih.gov/1673880

12 December 2020

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Cimetidine, but not oxmetidine, penetrates into the cerebrospinal fluid after a single intravenous dose

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https://pubmed.ncbi.nlm.nih.gov/1673880

12 December 2020

based on heuristic

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Effects of H2-receptor antagonists cimetidine, ranitidine, and ICI 125,211 on histamine-stimulated adenylate cyclase activity in guinea pig gastric mucosa

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https://pubmed.ncbi.nlm.nih.gov/1673880

12 December 2020

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Adenyl and guanyl cyclase in rabbit gastric mucosa.

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https://pubmed.ncbi.nlm.nih.gov/1673880

12 December 2020

based on heuristic

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Investigations on the penetration of ranitidine into the cerebrospinal fluid and a comparison of the effects of ranitidine and cimetidine on male sex hormones

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https://pubmed.ncbi.nlm.nih.gov/1673880

12 December 2020

based on heuristic

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Effects of ranitidine and of cimetidine on pentagastrin-stimulated gastric acid secretion

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https://pubmed.ncbi.nlm.nih.gov/1673880

12 December 2020

based on heuristic

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Pharmacological evaluation of cimetidine, a new histamine H2-receptor antagonist, in healthy man

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https://pubmed.ncbi.nlm.nih.gov/1673880

12 December 2020

based on heuristic

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Definition and antagonism of histamine H 2 -receptors

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https://pubmed.ncbi.nlm.nih.gov/1673880

12 December 2020

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Dose and serum concentration relationships in cimetidine-associated mental confusion

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https://pubmed.ncbi.nlm.nih.gov/1673880

12 December 2020

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A comparison of some of the pharmacological properties of etintidine, a new histamine H2-receptor antagonist, with those of cimetidine, ranitidine and tiotidine

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https://pubmed.ncbi.nlm.nih.gov/1673880

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cimetidine plasma concentration-response relationships

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https://pubmed.ncbi.nlm.nih.gov/1673880

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Kinetics of the elimination and neuromuscular blocking effect of d-tubocurarine in man.

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https://pubmed.ncbi.nlm.nih.gov/1673880

12 December 2020

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CSF concentrations of famotidine

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https://pubmed.ncbi.nlm.nih.gov/1673880

12 December 2020

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Omeprazole, cimetidine, and ranitidine: inhibition of acid production in isolated human parietal cells.

1 reference

https://pubmed.ncbi.nlm.nih.gov/1673880

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effects of hormones (calcitonin, GIP) and pharmacological antagonists (ranitidine and famotidine) on isolated rat parietal cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/1673880

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pharmacokinetics and bioavailability of cimetidine in gastric and duodenal ulcer patients.

1 reference

https://pubmed.ncbi.nlm.nih.gov/1673880

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Ranitidine bioavailability and kinetics in normal male subjects

1 reference

https://pubmed.ncbi.nlm.nih.gov/1673880

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Diminished absorption of cimetidine caused by antacids

1 reference

https://pubmed.ncbi.nlm.nih.gov/1673880

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Tiotidine and cimetidine—kinetics and dynamics

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https://pubmed.ncbi.nlm.nih.gov/1673880

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Ranitidine kinetics in normal subjects

1 reference

https://pubmed.ncbi.nlm.nih.gov/1673880

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibitory effect of etintidine (BL-5641), a new type of H2 receptor antagonist, on binding of [3H]-cimetidine to plasma membrane and histamine-stimulated cellular cAMP production in isolated guinea pig gastric glands

1 reference

https://pubmed.ncbi.nlm.nih.gov/1673880

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Metiamide--an orally active histamine H2-receptor antagonist

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https://pubmed.ncbi.nlm.nih.gov/1673880

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Bioavailability and pharmacokinetics of cimetidine

1 reference

https://pubmed.ncbi.nlm.nih.gov/1673880

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The pharmacodynamics and pharmacokinetics of multiple doses of the new H2-receptor antagonist, roxatidine acetate, in healthy men.

1 reference

https://pubmed.ncbi.nlm.nih.gov/1673880

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Impaired cimetidine absorption due to antacids and metoclopramide

1 reference

https://pubmed.ncbi.nlm.nih.gov/1673880

12 December 2020

based on heuristic

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Increased production of cyclic AMP in gastric tissue by stimulation of histamine2 (H2)-receptors.

1 reference

https://pubmed.ncbi.nlm.nih.gov/1673880

12 December 2020

based on heuristic

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Peptic ulceration in chronic renal failure

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https://pubmed.ncbi.nlm.nih.gov/1673880

12 December 2020

based on heuristic

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Interaction of roxatidine acetate with antacids, food and other drugs

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https://pubmed.ncbi.nlm.nih.gov/1673880

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Bioavailability of cimetidine in man

1 reference

https://pubmed.ncbi.nlm.nih.gov/1673880

12 December 2020

based on heuristic

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Correlation between in vitro and in vivo drug metabolism rate: oxidation of ethoxybenzamide in rat

1 reference

https://pubmed.ncbi.nlm.nih.gov/1673880

12 December 2020

based on heuristic

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Ranitidine: single dose pharmacokinetics and absolute bioavailability in man

1 reference

https://pubmed.ncbi.nlm.nih.gov/1673880

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Treatment of duodenal ulcer with enprostil, a prostaglandin E2 analogue

1 reference

https://pubmed.ncbi.nlm.nih.gov/1673880

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effects of antacids and food on absorption of famotidine

1 reference

https://pubmed.ncbi.nlm.nih.gov/1673880

12 December 2020

based on heuristic

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Receptors mediating some actions of histamine

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https://pubmed.ncbi.nlm.nih.gov/1673880

12 December 2020

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Inhibition of gastric secretion by a new H2-antagonist, YM-11170 in healthy subjects

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https://pubmed.ncbi.nlm.nih.gov/1673880

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Famotidine. Pharmacodynamic and pharmacokinetic properties and a preliminary review of its therapeutic use in peptic ulcer disease and Zollinger-Ellison syndrome

1 reference

https://pubmed.ncbi.nlm.nih.gov/1673880

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Kinetic studies on the competition between famotidine and cimetidine in rats. Evidence of multiple renal secretory systems for organic cations

1 reference

https://pubmed.ncbi.nlm.nih.gov/1673880

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Single-dose and multiple-dose pharmacokinetics of etintidine in healthy volunteers

1 reference

https://pubmed.ncbi.nlm.nih.gov/1673880

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Clinical pharmacology of etintidine in patients with duodenal ulcer

1 reference

https://pubmed.ncbi.nlm.nih.gov/1673880

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cimetidine Suppression of Nocturnal Gastric Secretion in Active Duodenal Ulcer

1 reference

https://pubmed.ncbi.nlm.nih.gov/1673880

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Duration of action of beta-blocking drugs

1 reference

https://pubmed.ncbi.nlm.nih.gov/1673880

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pharmacokinetics of famotidine in man

1 reference

https://pubmed.ncbi.nlm.nih.gov/1673880

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Potentiation by Carbachol and Aminophylline of Histamine- and db-cAMP-Induced Parietal Cell Activity in Isolated Gastric Glands

1 reference

https://pubmed.ncbi.nlm.nih.gov/1673880

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Studies on the H2-receptor antagonism of MK-208 in isolated rabbit gastric glands

1 reference

https://pubmed.ncbi.nlm.nih.gov/1673880

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Actions of nizatidine, a selective histamine H2-receptor antagonist, on gastric acid secretion in dogs, rats and frogs

1 reference

https://pubmed.ncbi.nlm.nih.gov/1673880

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Ranitidine upon meal-induced gastric secretion: oral pharmacokinetics and plasma concentration effect relationships

1 reference

https://pubmed.ncbi.nlm.nih.gov/1673880

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Plasma concentrations and the time-course of beta blockade due to propranolol

1 reference

https://pubmed.ncbi.nlm.nih.gov/1673880

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Intravenous nizatidine kinetics and acid suppression

1 reference

https://pubmed.ncbi.nlm.nih.gov/1673880

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A pharmacokinetic profile of nizatidine in man.

1 reference

https://pubmed.ncbi.nlm.nih.gov/1673880

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Single-dose pharmacokinetics and bioavailability of famotidine in man. Results of multicenter collaborative studies

1 reference

https://pubmed.ncbi.nlm.nih.gov/1673880

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The absorption of cimetidine before and during maintenance treatment with cimetidine and the influence of a meal on the absorption of cimetidine--studies in patients with peptic ulcer disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/1673880

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

High dose of antacid (Mylanta II) reduces bioavailability of ranitidine

1 reference

https://pubmed.ncbi.nlm.nih.gov/1673880

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A pharmacokinetic study of roxatidine acetate in chronic renal failure.

1 reference

https://pubmed.ncbi.nlm.nih.gov/1673880

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pharmacologically effective plasma concentrations of ranitidine

1 reference

https://pubmed.ncbi.nlm.nih.gov/1673880

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A review of the animal pharmacology of roxatidine acetate

1 reference

https://pubmed.ncbi.nlm.nih.gov/1673880

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pharmacokinetics of the H2- receptor antagonist ranitidine in man

1 reference

https://pubmed.ncbi.nlm.nih.gov/1673880

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Altered disposition and availability of cimetidine in liver cirrhotic patients

1 reference

https://pubmed.ncbi.nlm.nih.gov/1673880

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The effect of various dose regimens of famotidine on basal nocturnal and meal-stimulated gastric secretion.

1 reference

https://pubmed.ncbi.nlm.nih.gov/1673880

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Nocturnal doses of H2 receptor antagonists for duodenal ulcer

1 reference

https://pubmed.ncbi.nlm.nih.gov/1673880

12 December 2020

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inferred from PubMed ID database lookup

The pathologic physiology of chronic Bright's disease. An exposition of the "intact nephron hypothesis"

1 reference

https://pubmed.ncbi.nlm.nih.gov/1673880

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pharmacokinetics of cimetidine after single doses and during continuous treatment

1 reference

https://pubmed.ncbi.nlm.nih.gov/1673880

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The pharmacokinetics of cimetidine and its sulphoxide metabolite in patients with normal and impaired renal function

1 reference

https://pubmed.ncbi.nlm.nih.gov/1673880

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pharmacokinetics and pharmacodynamics in young normal and elderly hypertensive subjects: a study using sotalol as a model drug

1 reference

https://pubmed.ncbi.nlm.nih.gov/1673880

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effects of age and chronic renal failure on the urinary excretion kinetics of famotidine in man.

1 reference

https://pubmed.ncbi.nlm.nih.gov/1673880

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pharmacokinetics of ranitidine in patients with chronic renal failure

1 reference

https://pubmed.ncbi.nlm.nih.gov/1673880

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effect of antacids on absorption of cimetidine

1 reference

https://pubmed.ncbi.nlm.nih.gov/1673880

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Single bedtime dose of famotidine: assessment of its antisecretory action by 24-hour intragastric pH monitoring

1 reference

https://pubmed.ncbi.nlm.nih.gov/1673880

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effects of cirrhosis and ageing on the elimination and bioavailability of ranitidine

1 reference

https://pubmed.ncbi.nlm.nih.gov/1673880

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Urinary excretion kinetics of famotidine in rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/1673880

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Physiological pharmacokinetics of ethoxybenzamide based on biochemical data obtained in vitro as well as on physiological data

1 reference

https://pubmed.ncbi.nlm.nih.gov/1673880

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Age and renal clearance of cimetidine

1 reference

https://pubmed.ncbi.nlm.nih.gov/1673880

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cimetidine: Does Neurotoxicity Occur? Report of Three Cases

1 reference

https://pubmed.ncbi.nlm.nih.gov/1673880

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Relationship between ranitidine plasma levels and reduction of postprandial intragastric acidity in healthy man

1 reference

https://pubmed.ncbi.nlm.nih.gov/1673880

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pharmacokinetic-pharmacodynamic relationships of alpha-adrenoceptor antagonists

1 reference

https://pubmed.ncbi.nlm.nih.gov/1673880

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibition of food-stimulated gastric acid secretion by cimetidine

1 reference

https://pubmed.ncbi.nlm.nih.gov/1673880

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Age, disease, and cimetidine disposition in healthy subjects and chronically ill patients

1 reference

https://pubmed.ncbi.nlm.nih.gov/1673880

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Further analysis of anomalous pKB values for histamine H2-receptor antagonists on the mouse isolated stomach assay

1 reference

https://pubmed.ncbi.nlm.nih.gov/1673880

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Clinical and pharmacological effectiveness of cimetidine in duodenal ulcer patients

1 reference

https://pubmed.ncbi.nlm.nih.gov/1673880

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

In vivo evaluation of Michaelis-Menten constants of hepatic drug-eliminating systems

1 reference

https://pubmed.ncbi.nlm.nih.gov/1673880

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Oral and intravenous pharmacokinetics of cimetidine in liver cirrhosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/1673880

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effect of a new potent H2-receptor antagonist 3[[[2-[(diaminomethylene)amino]-4-thiazolyl]methyl]thio]-N2-sulfamoylpropionamidine (YM-11170) on gastric mucosal histamine-sensitive adenylate cyclase from guinea pig

1 reference

https://pubmed.ncbi.nlm.nih.gov/1673880

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

24 hour intragastric acidity and single night-time dose of three H-2-blockers

1 reference

https://pubmed.ncbi.nlm.nih.gov/1673880

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The metabolism and elimination of cimetidine, a histamine H2-receptor antagonist, in the rat, dog, and man

1 reference

https://pubmed.ncbi.nlm.nih.gov/1673880

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

High dose of antacid reduces bioavailability of ranitidine

1 reference

https://pubmed.ncbi.nlm.nih.gov/1673880

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Comparative pharmacology of histamine H2-receptor antagonists

1 reference

https://pubmed.ncbi.nlm.nih.gov/1673880

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effects of H2-receptor antagonists on 3H-cimetidine binding and histamine-stimulation of cellular cAMP in isolated guinea pig gastric glands

1 reference

https://pubmed.ncbi.nlm.nih.gov/1673880

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibition of gastric acid secretion by cimetidine in patients with duodenal ulcer

1 reference

https://pubmed.ncbi.nlm.nih.gov/1673880

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pharmacokinetics of CM 57755, a new histamine H2-receptor antagonist, after single oral doses in man

1 reference

https://pubmed.ncbi.nlm.nih.gov/1673880

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Ranitidine kinetics and dynamics: I. Oral dose studies

1 reference

https://pubmed.ncbi.nlm.nih.gov/1673880

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Influence of phenobarbital treatment on cimetidine kinetics

1 reference

https://pubmed.ncbi.nlm.nih.gov/1673880

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.2165/00003088-199120030-00004

1 reference

Europe PubMed Central

14 August 2017

Dimensions Publication ID

0 references

1 reference

Europe PubMed Central

14 August 2017

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