Role of gp130-mediated signalling pathways in the heart and its impact on potential therapeutic aspects (Q36497007)

14 August 2017

1 reference

title

Role of gp130-mediated signalling pathways in the heart and its impact on potential therapeutic aspects (English)

1 reference

14 August 2017

P Fischer

1

1 reference

PMCID

2268054

14 August 2017

D Hilfiker-Kleiner

series ordinal

2

1 reference

PMCID

2268054

14 August 2017

language of work or name

English

0 references

publication date

4 February 2008

1 reference

British Journal of Pharmacology

14 August 2017

1 reference

14 August 2017

153 Suppl 1

1 reference

14 August 2017

S414-27

1 reference

Classic interleukin-6 receptor signaling and interleukin-6 trans-signaling differentially control angiotensin II-dependent hypertension, cardiac signal transducer and activator of transcription-3 activation, and vascular hypertrophy in vivo

14 August 2017

1 reference

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Stat3 is tyrosine-phosphorylated through the interleukin-6/glycoprotein 130/Janus kinase pathway in breast cancer.

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1 reference

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Survival pathways in hypertrophy and heart failure: the gp130-STAT3 axis

30 September 2017

1 reference

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SOCS1 silencing enhances antitumor activity of type I IFNs by regulating apoptosis in neuroendocrine tumor cells

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1 reference

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Unphosphorylated STAT3 accumulates in response to IL-6 and activates transcription by binding to NFkappaB

30 September 2017

1 reference

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IFN-alpha-induced signal transduction, gene expression, and antitumor activity of immune effector cells are negatively regulated by suppressor of cytokine signaling proteins

30 September 2017

1 reference

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Evidence that IL-6-type cytokine signaling in cardiomyocytes is inhibited by oxidative stress: parthenolide targets JAK1 activation by generating ROS

30 September 2017

1 reference

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Opposing roles of gp130-mediated STAT-3 and ERK-1/ 2 signaling in liver progenitor cell migration and proliferation

30 September 2017

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Forced dimerization of gp130 leads to constitutive STAT3 activation, cytokine-independent growth, and blockade of differentiation of embryonic stem cells

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IFN-beta-induced SOCS-1 negatively regulates CD40 gene expression in macrophages and microglia

30 September 2017

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30 September 2017

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Transcriptome analysis of the ischemia-reperfused remodeling myocardium: temporal changes in inflammation and extracellular matrix.

30 September 2017

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Emerging evidence for the role of cardiotrophin-1 in cardiac repair in the infarcted heart.

30 September 2017

1 reference

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Hypertrophic responses to cardiotrophin-1 are not mediated by STAT3, but via a MEK5-ERK5 pathway in cultured cardiomyocytes

30 September 2017

1 reference

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STAT proteins as novel targets for cancer drug discovery

30 September 2017

1 reference

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Inhibition of gp130 signaling in breast cancer blocks constitutive activation of Stat3 and inhibits in vivo malignancy

30 September 2017

1 reference

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STAT3 is dispensable for maintenance of self-renewal in nonhuman primate embryonic stem cells

30 September 2017

1 reference

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LIF/STAT3 signaling fails to maintain self-renewal of human embryonic stem cells

30 September 2017

1 reference

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Maintenance of pluripotency in human embryonic stem cells is STAT3 independent

30 September 2017

1 reference

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Comparative study of the roles of cytokines and apoptosis in dilated and hypertrophic cardiomyopathies.

30 September 2017

1 reference

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Inflammation and ischemia: macrophages activated by fibronectin fragments enhance the survival of injured cardiac myocytes

30 September 2017

1 reference

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A decade of discoveries in cardiac biology

30 September 2017

1 reference

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Leukaemia inhibitory factor alters expression of genes involved in rat cardiomyocyte energy metabolism

30 September 2017

1 reference

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Acquiring signalling specificity from the cytokine receptor gp130.

30 September 2017

1 reference

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Are SOCS suppressors, regulators, and degraders?

30 September 2017

1 reference

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Cardiomyocyte-restricted knockout of STAT3 results in higher sensitivity to inflammation, cardiac fibrosis, and heart failure with advanced age

30 September 2017

1 reference

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C-reactive protein and interleukin-6 in vascular disease: culprits or passive bystanders?

30 September 2017

1 reference

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Activation of gp130 transduces hypertrophic signal through interaction of scaffolding/docking protein Gab1 with tyrosine phosphatase SHP2 in cardiomyocytes

30 September 2017

1 reference

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Principles of interleukin (IL)-6-type cytokine signalling and its regulation

30 September 2017

1 reference

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Targeted inhibition of Stat3 with a decoy oligonucleotide abrogates head and neck cancer cell growth

30 September 2017

1 reference

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Gp130-mediated pathway and left ventricular remodeling

30 September 2017

1 reference

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Signalling, cell cycle and pluripotency in embryonic stem cells

30 September 2017

1 reference

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Cardiotrophin-1 stimulation of cardiac fibroblast growth: roles for glycoprotein 130/leukemia inhibitory factor receptor and the endothelin type A receptor

30 September 2017

1 reference

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Suppressor of cytokine signaling-3 is a biomechanical stress-inducible gene that suppresses gp130-mediated cardiac myocyte hypertrophy and survival pathways

30 September 2017

1 reference

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A novel role for STAT3 in cardiac remodeling

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2268054

Functional significance of hemodynamic overload-induced expression of leukemia-inhibitory factor in the adult mammalian heart

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2268054

gp130-Dependent signalling pathway is not enhanced in gp130 transgenic heart after LIF stimulation

30 September 2017

1 reference

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The development of fatal myocarditis and polymyositis in mice heterozygous for IFN-gamma and lacking the SOCS-1 gene

30 September 2017

1 reference

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Interleukin 6 and liver regeneration

30 September 2017

1 reference

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Signal transducer and activator of transcription 3 is required for glycoprotein 130-mediated induction of vascular endothelial growth factor in cardiac myocytes

30 September 2017

1 reference

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Signal transducer and activator of transcription 3 in the heart transduces not only a hypertrophic signal but a protective signal against doxorubicin-induced cardiomyopathy

30 September 2017

1 reference

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STAT3 activation is sufficient to maintain an undifferentiated state of mouse embryonic stem cells

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2268054

Loss of a gp130 cardiac muscle cell survival pathway is a critical event in the onset of heart failure during biomechanical stress

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2268054

The presence in human serum of a circulating soluble leukemia inhibitory factor receptor (sgp190) and its evolution during pregnancy

30 September 2017

1 reference

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Paracrine induction of stem cell renewal by LIF-deficient cells: a new ES cell regulatory pathway

30 September 2017

1 reference

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Interleukin-6-type cytokine signalling through the gp130/Jak/STAT pathway

30 September 2017

1 reference

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Interleukin-6 spillover in the peripheral circulation increases with the severity of heart failure, and the high plasma level of interleukin-6 is an important prognostic predictor in patients with congestive heart failure

30 September 2017

1 reference

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Cardiotrophin-1 and the role of gp130-dependent signaling pathways in cardiac growth and development

30 September 2017

1 reference

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Cardiotrophin-1 activates a distinct form of cardiac muscle cell hypertrophy. Assembly of sarcomeric units in series VIA gp130/leukemia inhibitory factor receptor-dependent pathways

30 September 2017

1 reference

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Targeted disruption of gp130, a common signal transducer for the interleukin 6 family of cytokines, leads to myocardial and hematological disorders

30 September 2017

1 reference

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Cardiotrophin-1. Biological activities and binding to the leukemia inhibitory factor receptor/gp130 signaling complex

30 September 2017

1 reference

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Continuous activation of gp130, a signal-transducing receptor component for interleukin 6-related cytokines, causes myocardial hypertrophy in mice

30 September 2017

1 reference

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Hypoxic stress induces cardiac myocyte-derived interleukin-6.

30 September 2017

1 reference

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Oncostatin M-induced effects on EMT in human proximal tubular cells: differential role of ERK signaling.

30 September 2017

1 reference

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Overexpression of suppressor of cytokine signaling-3 in T cells exacerbates acetaminophen-induced hepatotoxicity.

28 June 2018

1 reference

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IFNgamma-dependent, spontaneous development of colorectal carcinomas in SOCS1-deficient mice

28 June 2018

1 reference

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Cross-talk among gp130 cytokines in adipocytes

28 June 2018

1 reference

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Loss of active MEK1-ERK1/2 restores epithelial phenotype and morphogenesis in transdifferentiated MDCK cells

28 June 2018

1 reference

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Glycoprotein 130 regulates cardiac myocyte survival in doxorubicin-induced apoptosis through phosphatidylinositol 3-kinase/Akt phosphorylation and Bcl-xL/caspase-3 interaction

28 June 2018

1 reference

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Signaling mechanisms through gp130: a model of the cytokine system.

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2268054

Cardiotrophin-1 displays early expression in the murine heart tube and promotes cardiac myocyte survival

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2268054

Loss of myocardial LIF receptor in experimental heart failure reduces cardiotrophin-1 cytoprotection. A role for neurohumoral agonists?

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2268054

Generation of functional cardiomyocytes from adult mouse spermatogonial stem cells.

21 September 2018

1 reference

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A cathepsin D-cleaved 16 kDa form of prolactin mediates postpartum cardiomyopathy.

21 September 2018

1 reference

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Innate defense mechanism against virus infection within the cardiac myocyte requiring gp130-STAT3 signaling

21 September 2018

1 reference

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Leukemia inhibitory factor enhances formation of germ cell colonies in neonatal mouse testis culture.

21 September 2018

1 reference

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Differential hypertrophic effects of cardiotrophin-1 on adult cardiomyocytes from normotensive and spontaneously hypertensive rats.

21 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2268054

Beta 4 integrin amplifies ErbB2 signaling to promote mammary tumorigenesis.

21 September 2018

1 reference

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Interleukin-6/soluble interleukin-6 receptor complex reduces infarct size via inhibiting myocardial apoptosis

21 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2268054

Molecular and functional signature of heart hypertrophy during pregnancy

21 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2268054

Novel roles of unphosphorylated STAT3 in oncogenesis and transcriptional regulation

21 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2268054

In vivo antitumor efficacy of STAT3 blockade using a transcription factor decoy approach: implications for cancer therapy.

21 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2268054

Leukemia inhibitory factor reduces contractile function and induces alterations in energy metabolism in isolated cardiomyocytes

21 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2268054

Different contributions of STAT3, ERK1/2, and PI3-K signaling to cardiomyocyte hypertrophy by cardiotrophin-1.

21 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2268054

CNTO 328, a monoclonal antibody to IL-6, inhibits human tumor-induced cachexia in nude mice

21 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2268054

Signal transducer and activator of transcription 3 is required for myocardial capillary growth, control of interstitial matrix deposition, and heart protection from ischemic injury

21 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2268054

Role of interleukin-6 for LV remodeling and survival after experimental myocardial infarction

21 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2268054

Leukemia inhibitory factor enhances survival of cardiomyocytes and induces regeneration of myocardium after myocardial infarction

21 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2268054

IL-6 induces an anti-inflammatory response in the absence of SOCS3 in macrophages

21 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2268054

Requirement of gp130 signaling for the AGM hematopoiesis

21 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2268054

The functional role of the JAK-STAT pathway in post-infarction remodeling

21 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2268054

Overexpression of thioredoxin-1 in transgenic mice attenuates adriamycin-induced cardiotoxicity

21 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2268054

Cardiac-specific activation of signal transducer and activator of transcription 3 promotes vascular formation in the heart.

21 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2268054

Activation of signal transducer and activator of transcription 3 protects cardiomyocytes from hypoxia/reoxygenation-induced oxidative stress through the upregulation of manganese superoxide dismutase

21 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2268054

gp130 plays a critical role in pressure overload-induced cardiac hypertrophy.

21 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2268054

Vascular Endothelial Growth Factor Is Induced by the Inflammatory Cytokines Interleukin-6 and Oncostatin M in Human Adipose Tissue In Vitro and in Murine Adipose Tissue In Vivo

21 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2268054

Activation of JAK-STAT and MAP kinases by leukemia inhibitory factor through gp130 in cardiac myocytes

4 December 2018

1 reference

12 December 2020

Leukemia inhibitory factor, a potent cardiac hypertrophic cytokine, activates the JAK/STAT pathway in rat cardiomyocytes

1 reference

12 December 2020

Activation of phosphatidylinositol 3-kinase through glycoprotein 130 induces protein kinase B and p70 S6 kinase phosphorylation in cardiac myocytes

1 reference

12 December 2020

Activation of gp130 transduces hypertrophic signals via STAT3 in cardiac myocytes

1 reference

12 December 2020

Serum interleukin-6 in congestive heart failure secondary to idiopathic dilated cardiomyopathy

1 reference

12 December 2020

Involvement of gp130-mediated signaling in pressure overload-induced activation of the JAK/STAT pathway in rodent heart

1 reference

12 December 2020

Prognostic value of interleukin-6, plasma viscosity, fibrinogen, von Willebrand factor, tissue factor and vascular endothelial growth factor levels in congestive heart failure

1 reference

12 December 2020

Oncostatin M, a cytokine released by activated mononuclear cells, induces epithelial cell-myofibroblast transdifferentiation via Jak/Stat pathway activation

1 reference

12 December 2020

Activation of distinct signal transduction pathways in hypertrophied hearts by pressure and volume overload

1 reference

12 December 2020

Circulating interleukin-6 family cytokines and their receptors in patients with congestive heart failure

1 reference

12 December 2020

Targeted overexpression of leukemia inhibitory factor to preserve myocardium in a rat model of postinfarction heart failure

1 reference

12 December 2020

The threshold of gp130-dependent STAT3 signaling is critical for normal regulation of hematopoiesis

1 reference

12 December 2020

SOCS1/JAB likely mediates the protective effect of cardiotrophin-1 against lipopolysaccharide-induced left ventricular dysfunction in vivo

1 reference

12 December 2020

Mechanism of IL-6-mediated cardiac dysfunction following trauma-hemorrhage

1 reference

12 December 2020

Anti-rat soluble IL-6 receptor antibody down-regulates cardiac IL-6 and improves cardiac function following trauma-hemorrhage

1 reference

12 December 2020

Deficiency of TNFR1 protects myocardium through SOCS3 and IL-6 but not p38 MAPK or IL-1beta

1 reference

12 December 2020

Identification of cardiac myocytes as the target of interleukin 11, a cardioprotective cytokine

1 reference

12 December 2020

Overexpression of interleukin-6 aggravates viral myocarditis: impaired increase in tumor necrosis factor-alpha

1 reference

12 December 2020

Quantitative myocardial cytokine expression and activation of the apoptotic pathway in patients who require left ventricular assist devices

1 reference

12 December 2020

Regulation of cardiac fibroblast cellular function by leukemia inhibitory factor

1 reference

12 December 2020

Alterations in Janus kinase (JAK)-signal transducers and activators of transcription (STAT) signaling in patients with end-stage dilated cardiomyopathy

1 reference

12 December 2020

Human cardiomyocyte hypertrophy induced in vitro by gp130 stimulation

1 reference

12 December 2020

Glycoprotein 130 ligand oncostatin-M induces expression of vascular endothelial growth factor in human adult cardiac myocytes

1 reference

12 December 2020

Signal transducer and activator of transcription STAT3 plays a major role in gp130-mediated acute phase protein gene activation

1 reference

12 December 2020

STAT3-dependent mouse embryonic stem cell differentiation into cardiomyocytes: analysis of molecular signaling and therapeutic efficacy of cardiomyocyte precommitted mES transplantation in a mouse model of myocardial infarction

1 reference

12 December 2020

Prognostic value of serum cytokines in patients with congestive heart failure

1 reference

12 December 2020

Oncostatin M is produced during pregnancy by decidual cells and stimulates the release of HCG

1 reference

12 December 2020

Activation of JAK/STAT pathway transduces cytoprotective signal in rat acute myocardial infarction

1 reference

12 December 2020

Significance of ERK cascade compared with JAK/STAT and PI3-K pathway in gp130-mediated cardiac hypertrophy

1 reference

12 December 2020

High levels of plasma brain natriuretic peptide and interleukin-6 after optimized treatment for heart failure are independent risk factors for morbidity and mortality in patients with congestive heart failure

1 reference

12 December 2020

Normal pharmacologically-induced, but decreased regenerative liver growth in interleukin-6-deficient (IL-6(-/-)) mice

1 reference

12 December 2020

Myocardial gene expression of leukaemia inhibitory factor, interleukin-6 and glycoprotein 130 in end-stage human heart failure

1 reference

12 December 2020

Soluble interleukin-6 (IL-6) receptor in the sera of pregnant women forms a complex with IL-6 and augments human chorionic gonadotropin production by normal human trophoblasts through binding to the IL-6 signal transducer

1 reference

12 December 2020

Identifiers

DOI

10.1038/BJP.2008.1

1 reference

14 August 2017

1 reference

14 August 2017

1 reference

PMCID

2268054