A new site and mechanism of action for the widely used adenylate cyclase inhibitor SQ22,536 (Q36497784)

14 August 2017

A new site and mechanism of action for the widely used adenylate cyclase inhibitor SQ22,536 (English)

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14 August 2017

Andrew C Emery

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Lee E. Eiden

object named as

Lee E Eiden

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3

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author name string

Maribeth V Eiden

series ordinal

2

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14 August 2017

10 October 2012

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14 August 2017

Molecular Pharmacology

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14 August 2017

83

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14 August 2017

1

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14 August 2017

95-105

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PMC publication ID

3533470

describes a project that uses

14 August 2017

ImageJ

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC3533470/fullTextXML

inferred from PubMed Central ID database lookup

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STC1 induction by PACAP is mediated through cAMP and ERK1/2 but not PKA in cultured cortical neurons

30 September 2017

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PAC1hop, null and hip receptors mediate differential signaling through cyclic AMP and calcium leading to splice variant-specific gene induction in neural cells

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Cyclic AMP is both a pro-apoptotic and anti-apoptotic second messenger

30 September 2017

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Capturing adenylyl cyclases as potential drug targets

30 September 2017

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A cAMP-dependent, protein kinase A-independent signaling pathway mediating neuritogenesis through Egr1 in PC12 cells

30 September 2017

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30 September 2017

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30 September 2017

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30 September 2017

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30 September 2017

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cAMP effector mechanisms. Novel twists for an 'old' signaling system

30 September 2017

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Signaling pathways for PC12 cell differentiation: making the right connections

30 September 2017

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Fusion-defective gibbon ape leukemia virus vectors can be rescued by homologous but not heterologous soluble envelope proteins

30 September 2017

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The molecular biology of memory storage: a dialogue between genes and synapses

30 September 2017

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The neurobiology of slow synaptic transmission

30 September 2017

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The interactions of adenylate cyclases with P-site inhibitors

30 September 2017

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A family of cAMP-binding proteins that directly activate Rap1

30 September 2017

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Epac is a Rap1 guanine-nucleotide-exchange factor directly activated by cyclic AMP

30 September 2017

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A surface on the G protein beta-subunit involved in interactions with adenylyl cyclases

30 September 2017

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Complexity and diversity of mammalian adenylyl cyclases

30 September 2017

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Cloning and characterization of the signal transduction of four splice variants of the human pituitary adenylate cyclase activating polypeptide receptor. Evidence for dual coupling to adenylate cyclase and phospholipase C.

30 September 2017

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Identification and characterization of a widely expressed form of adenylyl cyclase

30 September 2017

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Inhibition of adenylyl cyclase by Gi alpha

30 September 2017

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Type VIII adenylyl cyclase. A Ca2+/calmodulin-stimulated enzyme expressed in discrete regions of rat brain

30 September 2017

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Nobel Lecture. G proteins and regulation of adenylyl cyclase

30 September 2017

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Cyclic nucleotide-dependent protein kinases. IV. Widespread occurrence of adenosine 3',5'-monophosphate-dependent protein kinase in various tissues and phyla of the animal kingdom

30 September 2017

1 reference

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Studies on the mechanism of hormone action

30 September 2017

1 reference

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A cyclic nucleotide-gated conductance in olfactory receptor cilia

30 September 2017

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Type-specific regulation of adenylyl cyclase by G protein beta gamma subunits

30 September 2017

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Inhibition of adenylate cyclase by adenosine analogues in preparations of broken and intact human platelets. Evidence for the unidirectional control of platelet function by cyclic AMP

30 September 2017

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A protein kinase A-dependent molecular switch in synapsins regulates neurite outgrowth

30 September 2017

1 reference

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The adenylate cyclase inhibitor MDL-12330A has a non-specific effect on glycine transport in Müller cells from the retina

28 June 2018

1 reference

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The role of cAMP in regulating tumour cell growth.

28 June 2018

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The role of cAMP in nerve growth factor-promoted neurite outgrowth in PC12 cells

28 June 2018

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Nerve growth factor and fibroblast growth factor regulate neurite outgrowth and gene expression in PC12 cells via both protein kinase C- and cAMP-independent mechanisms

28 June 2018

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Nerve growth factor-induced neuronal differentiation after dominant repression of both type I and type II cAMP-dependent protein kinase activities.

28 June 2018

1 reference

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Coincident elevation of cAMP and calcium influx by PACAP-27 synergistically regulates vasoactive intestinal polypeptide gene transcription through a novel PKA-independent signaling pathway.

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3533470

Type-specific regulation of adenylyl cyclase. Selective pharmacological stimulation and inhibition of adenylyl cyclase isoforms

21 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3533470

Isozyme-dependent sensitivity of adenylyl cyclases to P-site-mediated inhibition by adenine nucleosides and nucleoside 3'-polyphosphates

21 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3533470

Capacitative Ca2+ entry exclusively inhibits cAMP synthesis in C6-2B glioma cells. Evidence that physiologically evoked Ca2+ entry regulates Ca(2+)-inhibitable adenylyl cyclase in non-excitable cells.

21 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3533470

The Action of Adenosine Analogs on PC12 Cells

21 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3533470

Ca2+ entry mediated by store depletion, S-nitrosylation, and TRP3 channels. Comparison of coupling and function

21 September 2018

1 reference

12 December 2020

RMI 12330A, an inhibitor of cyclic nucleotide phosphodiesterases and adenylate cyclase in kidney preparations

1 reference

12 December 2020

Stimulation of the type III olfactory adenylyl cyclase by calcium and calmodulin

1 reference

12 December 2020

MDL 12330A inhibits the non-neuronal adenylyl cyclase from the freshwater snail Planorbarius corneus, but the neuronal enzyme is activated by this compound

1 reference

12 December 2020

Identifiers

DOI

10.1124/MOL.112.081760

1 reference

14 August 2017

1 reference

PMC publication ID

3533470

14 August 2017

PubMed publication ID

23053667

1 reference

PMC publication ID

3533470