Overexpression of isocitrate dehydrogenase mutant proteins renders glioma cells more sensitive to radiation. (Q36500377)

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16 February 2020

title

Overexpression of isocitrate dehydrogenase mutant proteins renders glioma cells more sensitive to radiation (English)

1 reference

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16 February 2020

1 reference

10

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16 February 2020

Linda Liau

14

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16 February 2020

13

Timothy Cloughesy

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16 February 2020

15

Albert Lai

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16 February 2020

7

Julia Selfridge

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16 February 2020

8

Mira Zurayk

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16 February 2020

6

Heidi S Phillips

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16 February 2020

author name string

Sichen Li

1

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16 February 2020

Arthur P Chou

2

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16 February 2020

Weidong Chen

3

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16 February 2020

Ruihuan Chen

4

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16 February 2020

Yuzhong Deng

5

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16 February 2020

Jerry J Lou

9

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16 February 2020

Kuan-Chung Wu

11

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16 February 2020

Kym F Faull

12

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16 February 2020

publication date

31 October 2012

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16 February 2020

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16 February 2020

volume

15

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16 February 2020

issue

1

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16 February 2020

page(s)

57-68

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Transformation by the (R)-enantiomer of 2-hydroxyglutarate linked to EGLN activation.

16 February 2020

cites work

1 reference

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Hypoxia promotes isocitrate dehydrogenase-dependent carboxylation of α-ketoglutarate to citrate to support cell growth and viability

30 September 2017

1 reference

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Evidence for sequenced molecular evolution of IDH1 mutant glioblastoma from a distinct cell of origin.

30 September 2017

1 reference

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IDH1 R132H decreases proliferation of glioma cell lines in vitro and in vivo

30 September 2017

1 reference

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Establishment of a novel monoclonal antibody SMab-1 specific for IDH1-R132S mutation

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3534418

Proliferative neural stem cells have high endogenous ROS levels that regulate self-renewal and neurogenesis in a PI3K/Akt-dependant manner

30 September 2017

1 reference

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Inhibition of glutaminase preferentially slows growth of glioma cells with mutant IDH1.

30 September 2017

1 reference

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IDH1 mutations are detected in 6.6% of 1414 AML patients and are associated with intermediate risk karyotype and unfavorable prognosis in adults younger than 60 years and unmutated NPM1 status

30 September 2017

1 reference

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Isocitrate dehydrogenase 1 and 2 mutations in cancer: alterations at a crossroads of cellular metabolism

30 September 2017

1 reference

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Oligodendroglioma cell lines containing t(1;19)(q10;p10).

30 September 2017

1 reference

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The common feature of leukemia-associated IDH1 and IDH2 mutations is a neomorphic enzyme activity converting alpha-ketoglutarate to 2-hydroxyglutarate

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3534418

IDH1 and IDH2 mutations are prognostic but not predictive for outcome in anaplastic oligodendroglial tumors: a report of the European Organization for Research and Treatment of Cancer Brain Tumor Group

30 September 2017

1 reference

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The prognostic IDH1( R132 ) mutation is associated with reduced NADP+-dependent IDH activity in glioblastoma

30 September 2017

1 reference

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IDH1 mutations in low-grade astrocytomas predict survival but not response to temozolomide

30 September 2017

1 reference

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A monoclonal antibody IMab-1 specifically recognizes IDH1R132H, the most common glioma-derived mutation

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3534418

Recurring mutations found by sequencing an acute myeloid leukemia genome

30 September 2017

1 reference

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The AMPK agonist AICAR inhibits the growth of EGFRvIII-expressing glioblastomas by inhibiting lipogenesis

30 September 2017

1 reference

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Glioma-derived mutations in IDH1 dominantly inhibit IDH1 catalytic activity and induce HIF-1alpha

30 September 2017

1 reference

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IDH1 and IDH2 mutations in gliomas

30 September 2017

1 reference

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Analysis of the IDH1 codon 132 mutation in brain tumors

30 September 2017

1 reference

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An integrated genomic analysis of human glioblastoma multiforme

30 September 2017

1 reference

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The 2007 WHO classification of tumours of the central nervous system

30 September 2017

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In vitro scratch assay: a convenient and inexpensive method for analysis of cell migration in vitro

30 September 2017

1 reference

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Adaptation of the dichlorofluorescein assay for detection of radiation-induced oxidative stress in cultured cells

30 September 2017

1 reference

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IDH1 gene transcription is sterol regulated and activated by SREBP-1a and SREBP-2 in human hepatoma HepG2 cells: evidence that IDH1 may regulate lipogenesis in hepatic cells

30 September 2017

1 reference

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Cell proliferation induced by reactive oxygen species is mediated via mitogen-activated protein kinase in Chinese hamster lung fibroblast (V79) cells.

30 September 2017

1 reference

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Glioma classification: a molecular reappraisal

30 September 2017

1 reference

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The tumor-suppressor activity of PTEN is regulated by its carboxyl-terminal region

30 September 2017

1 reference

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PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer

30 September 2017

1 reference

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Design of a novel bicistronic expression vector with demonstration of a p16INK4-induced G(1)-S block(1).

30 September 2017

1 reference

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IDH1 or IDH2 mutations predict longer survival and response to temozolomide in low-grade gliomas.

30 September 2017

1 reference

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Cancer-associated IDH1 mutations produce 2-hydroxyglutarate

28 June 2018

1 reference

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IDH1 mutations are present in the majority of common adult gliomas but rare in primary glioblastomas

28 June 2018

1 reference

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The L84F polymorphic variant of human O6-methylguanine-DNA methyltransferase alters stability in U87MG glioma cells but not temozolomide sensitivity

28 June 2018

1 reference

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Role of reactive oxygen species in bradykinin-induced proliferation of vascular smooth muscle cells.

28 June 2018

1 reference

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Deletion and tandem duplication of exons 2 - 7 in the epidermal growth factor receptor gene of a human malignant glioma

28 June 2018

1 reference

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Analysis of the p53 gene and its expression in human glioblastoma cells

28 June 2018

1 reference

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IDH1 and IDH2 mutations are frequent genetic alterations in acute myeloid leukemia and confer adverse prognosis in cytogenetically normal acute myeloid leukemia with NPM1 mutation without FLT3 internal tandem duplication

28 June 2018

1 reference

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Dummy run and conformity indices in the ongoing EORTC low-grade glioma trial 22033-26033: First evaluation of quality of radiotherapy planning.

21 September 2018

1 reference

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Cancer-associated metabolite 2-hydroxyglutarate accumulates in acute myelogenous leukemia with isocitrate dehydrogenase 1 and 2 mutations

21 September 2018

1 reference

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Characterization of R132H mutation-specific IDH1 antibody binding in brain tumors

21 September 2018

1 reference

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Regulation of ionizing radiation-induced apoptosis by mitochondrial NADP+-dependent isocitrate dehydrogenase.

21 September 2018

1 reference

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Reactive oxygen species as double-edged swords in cellular processes: low-dose cell signaling versus high-dose toxicity.

21 September 2018

1 reference

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Osteopontin-induced, integrin-dependent migration of human mammary epithelial cells involves activation of the hepatocyte growth factor receptor (Met)

21 September 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/23115158

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Oxalomalate regulates ionizing radiation-induced apoptosis in mice

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/23115158

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1093/NEUONC/NOS261

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23115158%20AND%20SRC:MED&resulttype=core&format=json

16 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23115158%20AND%20SRC:MED&resulttype=core&format=json

16 February 2020

PubMed publication ID

23115158

1 reference