T-bet and GATA3 orchestrate Th1 and Th2 differentiation through lineage-specific targeting of distal regulatory elements. (Q36503230)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23232398%20AND%20SRC:MED&resulttype=core&format=json

20 February 2020

title

T-bet and GATA3 orchestrate Th1 and Th2 differentiation through lineage-specific targeting of distal regulatory elements (English)

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20 February 2020

4

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20 February 2020

Esperanza Perucha

5

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20 February 2020

Graham M Lord

7

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20 February 2020

Richard G. Jenner

8

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20 February 2020

author name string

Aditi Kanhere

1

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20 February 2020

Arnulf Hertweck

2

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20 February 2020

Urvashi Bhatia

3

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20 February 2020

Ian Jackson

6

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20 February 2020

language of work or name

English

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publication date

1 January 2012

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20 February 2020

published in

Nature Communications

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20 February 2020

volume

3

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20 February 2020

page(s)

1268

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Creative Commons Attribution-NonCommercial-ShareAlike 3.0 Unported

20 February 2020

copyright license

start time

1 January 2012

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

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exact match

https://scigraph.springernature.com/pub.10.1038/ncomms2260

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cites work

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TGF-beta-induced Foxp3 inhibits T(H)17 cell differentiation by antagonizing RORgammat function

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Comprehensive epigenetic profiling identifies multiple distal regulatory elements directing transcription of the gene encoding interferon-gamma

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GATA3 up-regulation associated with surface expression of CD294/CRTH2: a unique feature of human Th cells

30 September 2017

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A critical control element for interleukin-4 memory expression in T helper lymphocytes

30 September 2017

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Conditional deletion of Gata3 shows its essential function in T(H)1-T(H)2 responses.

30 September 2017

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Evolutionarily conserved sequence elements that positively regulate IFN-gamma expression in T cells

30 September 2017

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Loss of T-bet, but not STAT1, prevents the development of experimental autoimmune encephalomyelitis

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30 September 2017

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30 September 2017

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30 September 2017

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30 September 2017

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28 June 2018

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28 June 2018

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21 September 2018

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The transcription factor T-bet controls regulatory T cell homeostasis and function during type 1 inflammation

21 September 2018

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Dynamic changes in histone-methylation 'marks' across the locus encoding interferon-gamma during the differentiation of T helper type 2 cells.

21 September 2018

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A distal conserved sequence element controls Ifng gene expression by T cells and NK cells.

21 September 2018

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SATB1 packages densely looped, transcriptionally active chromatin for coordinated expression of cytokine genes.

21 September 2018

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T-bet is required for protection against vaccinia virus infection

21 September 2018

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Induction of T helper type 1-like regulatory cells that express Foxp3 and protect against airway hyper-reactivity

21 September 2018

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Genetic Reprogramming of Primary Human T Cells Reveals Functional Plasticity in Th Cell Differentiation

21 September 2018

1 reference

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Stat6-independent GATA-3 autoactivation directs IL-4-independent Th2 development and commitment.

21 September 2018

1 reference

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Transcription factors T-bet and Runx3 cooperate to activate Ifng and silence Il4 in T helper type 1 cells

21 September 2018

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12 December 2020

Regulation of IL-4 gene expression by distal regulatory elements and GATA-3 at the chromatin level

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12 December 2020

The cell type-specific expression of the murine IL-13 gene is regulated by GATA-3

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12 December 2020

Development of spontaneous airway changes consistent with human asthma in mice lacking T-bet

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12 December 2020

Identification of a conserved GATA3 response element upstream proximal from the interleukin-13 gene locus

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12 December 2020

A Distal Enhancer in the Interferon-γ (IFN-γ) Locus Revealed by Genome Sequence Comparison

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12 December 2020

Long-range intrachromosomal interactions in the T helper type 2 cytokine locus

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12 December 2020

Deletion of a conserved Il4 silencer impairs T helper type 1–mediated immunity

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12 December 2020

Identifiers

DOI

10.1038/NCOMMS2260

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23232398%20AND%20SRC:MED&resulttype=core&format=json

20 February 2020

0 references

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23232398%20AND%20SRC:MED&resulttype=core&format=json

20 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23232398%20AND%20SRC:MED&resulttype=core&format=json