Metabolism and neurotoxicity of homocysteine thiolactone in mice: evidence for a protective role of paraoxonase 1. (Q36530843)

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25 January 2020

title

Metabolism and neurotoxicity of homocysteine thiolactone in mice: evidence for a protective role of paraoxonase 1 (English)

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25 January 2020

1 reference

1 reference

1

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25 January 2020

Hieronim Jakubowski

series ordinal

3

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25 January 2020

author name string

Diana M Shih

series ordinal

2

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25 January 2020

publication date

1 January 2012

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Journal of Alzheimer's Disease

25 January 2020

published in

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25 January 2020

volume

30

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25 January 2020

issue

2

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25 January 2020

page(s)

225-231

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Serum paraoxonase activity is associated with variants in the PON gene cluster and risk of Alzheimer disease

25 January 2020

cites work

1 reference

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Homocysteine-lowering by B vitamins slows the rate of accelerated brain atrophy in mild cognitive impairment: a randomized controlled trial

30 September 2017

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The role of paraoxonase 1 in the detoxification of homocysteine thiolactone

30 September 2017

1 reference

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Homocystamides promote free-radical and oxidative damage to proteins

30 September 2017

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Genetic or nutritional disorders in homocysteine or folate metabolism increase protein N-homocysteinylation in mice

30 September 2017

1 reference

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Immunohistochemical detection of N-homocysteinylated proteins in humans and mice.

30 September 2017

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Relationship of paraoxonase 1 (PON1) gene polymorphisms and functional activity with systemic oxidative stress and cardiovascular risk

30 September 2017

1 reference

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Dietary methionine effects on plasma homocysteine and HDL metabolism in mice

30 September 2017

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Protein homocysteinylation: possible mechanism underlying pathological consequences of elevated homocysteine levels

30 September 2017

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Mice lacking serum paraoxonase are susceptible to organophosphate toxicity and atherosclerosis

30 September 2017

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Anticonvulsant action of both NMDA and non-NMDA receptor antagonists against seizures induced by homocysteine in immature rats.

30 September 2017

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Synthesis of homocysteine thiolactone by methionyl-tRNA synthetase in cultured mammalian cells

28 June 2018

1 reference

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Identification of N-homocysteinylated apolipoprotein AI in normal human serum

28 June 2018

1 reference

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Protein N-homocysteinylation induces the formation of toxic amyloid-like protofibrils.

21 September 2018

1 reference

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Reduced homocysteine-thiolactonase activity in Alzheimer's disease

21 September 2018

1 reference

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Paraoxonase activity and dementia

21 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3544478

The activity of erythrocyte and brain Na+/K+ and Mg2+-ATPases in rats subjected to acute homocysteine and homocysteine thiolactone administration.

21 September 2018

1 reference

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Mutations in cystathionine beta-synthase or methylenetetrahydrofolate reductase gene increase N-homocysteinylated protein levels in humans

21 September 2018

1 reference

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Immunohistochemical analysis of paraoxonases-1, 2, and 3 expression in normal mouse tissues

21 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3544478

Determinants of homocysteine-thiolactonase activity of the paraoxonase-1 (PON1) protein in humans.

21 September 2018

1 reference

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The determination of homocysteine-thiolactone in human plasma.

21 September 2018

1 reference

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Urinary excretion of homocysteine-thiolactone in humans

21 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3544478

Cross-talk between Cys34 and lysine residues in human serum albumin revealed by N-homocysteinylation

21 September 2018

1 reference

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Effect of homocysteinylation on human high-density lipoproteins: a correlation with paraoxonase activity

21 September 2018

1 reference

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Paraoxonase 1 activity: a new vascular marker of dementia?

21 September 2018

1 reference

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Serum paraoxonase activity changes in patients with Alzheimer's disease and vascular dementia

21 September 2018

1 reference

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Homocysteine is a protein amino acid in humans. Implications for homocysteine-linked disease

21 September 2018

1 reference

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Toxicity, biodistribution and radioprotective capacity of L-homocysteine thiolactone in CNS tissues and tumors in rodents: comparison with prior results with phosphorothioates.

21 September 2018

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Convulsant activity of homocysteine and other short-chain mercaptoacids: protection therefrom

21 September 2018

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12 December 2020

Metabolism of homocysteine thiolactone in human cell cultures. Possible mechanism for pathological consequences of elevated homocysteine levels

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12 December 2020

Mechanism of the condensation of homocysteine thiolactone with aldehydes

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12 December 2020

Mutations in methylenetetrahydrofolate reductase or cystathionine beta-synthase gene, or a high-methionine diet, increase homocysteine thiolactone levels in humans and mice

1 reference

12 December 2020

Homocysteine thiolactone and protein homocysteinylation in human endothelial cells: implications for atherosclerosis

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12 December 2020

Identifiers

DOI

10.3233/JAD-2012-111940

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25 January 2020

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25 January 2020

1 reference

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