Recombinant Toxins for Cancer Treatment (Q36533609)

14 August 2017

1 reference

title

Recombinant toxins for cancer treatment (English)

1 reference

14 August 2017

Recombinant Toxins for Cancer Treatment (English)

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.1683495

28 October 2022

main subject

ADP ribose transferases

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A1683495

28 October 2022

virulence factor

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A1683495

28 October 2022

author name string

FitzGerald D

2

1 reference

14 August 2017

I. Pastan

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A1683495

28 October 2022

D. FitzGerald

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A1683495

28 October 2022

language of work or name

English

0 references

publication date

1 November 1991

1 reference

14 August 2017

22 November 1991

1 reference

National Center for Biotechnology Information

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=1683495

full work available at URL

28 October 2022

https://syndication.highwire.org/content/doi/10.1126/science.1683495

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.1683495

28 October 2022

1 reference

14 August 2017

254

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14 August 2017

1173-1177

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14 August 2017

5035

1 reference

Structure of exotoxin A of Pseudomonas aeruginosa at 3.0-Angstrom resolution

14 August 2017

1

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.1683495

Molecular and Cellular Biology

28 October 2022

2

11

2200

1991

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.1683495

Antitumor activity in mice of an immunotoxin made with anti-transferrin receptor and a recombinant form of Pseudomonas exotoxin

28 October 2022

3

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.1683495

Single-chain antigen-binding proteins

28 October 2022

4

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.1683495

Immunotoxins: hybrid molecules of monoclonal antibodies and a toxin subunit specifically kill tumour cells

28 October 2022

5

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.1683495

B3(Fv)-PE38KDEL, a single-chain immunotoxin that causes complete regression of a human carcinoma in mice

28 October 2022

6

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.1683495

A recombinant immunotoxin consisting of two antibody variable domains fused to Pseudomonas exotoxin

28 October 2022

8

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.1683495

A rapid method of cloning functional variable-region antibody genes in Escherichia coli as single-chain immunotoxins

28 October 2022

9

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.1683495

A recombinant single-chain immunotoxin composed of anti-Tac variable regions and a truncated diphtheria toxin

28 October 2022

10

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.1683495

Receptor-mediated endocytosis of epidermal growth factor by rat hepatocytes: receptor pathway

28 October 2022

12

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.1683495

Clinical and Experimental Immunology

28 October 2022

13

75

258

1989

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.1683495

Receptor-mediated internalization of Pseudomonas toxin by mouse fibroblasts

28 October 2022

14

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.1683495

Targeted toxin therapy for the treatment of cancer

28 October 2022

15

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.1683495

Pseudomonas exotoxin-anti-TAC. Cell-specific immunotoxin active against cells expressing the human T cell growth factor receptor

28 October 2022

17

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.1683495

Pseudomonas exotoxin--immunotoxins.

28 October 2022

18

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.1683495

Journal of biological response modifiers

28 October 2022

19

4

273

1985

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.1683495

Phase I Study of an Anti-Breast Cancer Immunotoxin by Continuous Infusion: Report of a Targeted Toxic Effect Not Predicted by Animal Studies

28 October 2022

21

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.1683495

Mutations in diphtheria toxin separate binding from entry and amplify immunotoxin selectivity

28 October 2022

22

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.1683495

Transforming growth factor alpha-Pseudomonas exotoxin fusion protein prolongs survival of nude mice bearing tumor xenografts

28 October 2022

25

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.1683495

Oncogene-associated tumor antigens as targets for immunotherapy

28 October 2022

26

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.1683495

Human squamous cell lung cancers express increased epidermal growth factor receptors

28 October 2022

27

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.1683495

Journal of biological response modifiers

28 October 2022

28

7

97

1988

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.1683495

Protein engineering of antibody binding sites: recovery of specific activity in an anti-digoxin single-chain Fv analogue produced in Escherichia coli

28 October 2022

29

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.1683495

Functional domains of Pseudomonas exotoxin identified by deletion analysis of the gene expressed in E. coli.

28 October 2022

30

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.1683495

Epidermal growth factor receptor expression in 72 meningiomas

28 October 2022

32

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.1683495

Autocrine generation and requirement of BSF-2/IL-6 for human multiple myelomas

28 October 2022

33

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.1683495

28 October 2022

36

145

2766

1990

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.1683495

The recombinant immunotoxin anti-Tac(Fv)-Pseudomonas exotoxin 40 is cytotoxic toward peripheral blood malignant cells from patients with adult T-cell leukemia

28 October 2022

37

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.1683495

In vivo therapy of a murine B cell tumor (BCL1) using antibody-ricin A chain immunotoxins

28 October 2022

38

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.1683495

The galactose-binding sites of the cytotoxic lectin ricin can be chemically blocked in high yield with reactive ligands prepared by chemical modification of glycopeptides containing triantennary N-linked oligosaccharides

28 October 2022

39

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.1683495

Epidermal growth factor in the normal and neoplastic kidney and bladder

28 October 2022

40

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.1683495

Treatment of leukemia patients with T101 ricin A chain immunotoxins

28 October 2022

41

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.1683495

Cytotoxic activity of an interleukin 2-Pseudomonas exotoxin chimeric protein produced in Escherichia coli

28 October 2022

42

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.1683495

Intracellular routing rather than cross-linking or rate of internalization determines the potency of immunotoxins directed against different epitopes of sIgD on murine B cells

28 October 2022

44

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.1683495

Survey and synthesis of pathology research

28 October 2022

45

4

34

1985

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.1683495

28 October 2022

47

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.1683495

28 October 2022

48

131

244

1983

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.1683495

Transmembrane transport of diphtheria toxin, related toxins, and colicins

28 October 2022

49

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.1683495

28 October 2022

52

141

4224

1988

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.1683495

Cytotoxic activity of a recombinant fusion protein between interleukin 4 and Pseudomonas exotoxin

28 October 2022

53

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.1683495

Cytotoxicity of a recombinant ricin-A-chain fusion protein containing a proteolytically-cleavable spacer sequence

28 October 2022

54

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.1683495

Clinical evaluation of intraperitoneal Pseudomonas exotoxin immunoconjugate OVB3-PE in patients with ovarian cancer

28 October 2022

57

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.1683495

Anti-tumor activities of immunotoxins made of monoclonal antibody B3 and various forms of Pseudomonas exotoxin

28 October 2022

58

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.1683495

28 October 2022

Diphtheria Toxin

59

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.1683495

28 October 2022

Immunotoxins

61

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.1683495

28 October 2022

65

141

4410

1988

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.1683495

Cytotoxic activity of an interleukin 6-Pseudomonas exotoxin fusion protein on human myeloma cells

28 October 2022

72

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.1683495

Assembly of a functional immunoglobulin Fv fragment in Escherichia coli

28 October 2022

73

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.1683495

Use of bacteriophage T7 RNA polymerase to direct selective high-level expression of cloned genes

28 October 2022

75

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.1683495

Blockade of the galactose-binding sites of ricin by its linkage to antibody. Specific cytotoxic effects of the conjugates

28 October 2022

77

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.1683495

Epidermal-growth-factor-dependent transformation by a human EGF receptor proto-oncogene

28 October 2022

80

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.1683495

Redesigning nature's poisons to create anti-tumor reagents

28 October 2022

82

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.1683495

The interleukin-2 receptor on malignant cells: a target for diagnosis and therapy.

28 October 2022

83

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.1683495

Sequential effects of interleukin 2-diphtheria toxin fusion protein on T-cell activation

28 October 2022

84

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.1683495

Diphtheria toxin receptor binding domain substitution with interleukin-2: genetic construction and properties of a diphtheria toxin-related interleukin-2 fusion protein

28 October 2022

88

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.1683495

Pseudomonas exotoxin coupled to a monoclonal antibody against ovarian cancer inhibits the growth of human ovarian cancer cells in a mouse model

28 October 2022

89

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.1683495

One molecule of diphtheria toxin fragment A introduced into a cell can kill the cell

28 October 2022

90

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.1683495

28 October 2022

Identifiers

1 reference

14 August 2017

1 reference