Role of AMP-activated protein kinase in healthy and diseased hearts (Q36537821)

14 August 2017

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title

Role of AMP-activated protein kinase in healthy and diseased hearts (English)

1 reference

14 August 2017

Vernon W Dolinsky

1

1 reference

PubMed ID

16844922

14 August 2017

Jason R B Dyck

series ordinal

2

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14 August 2017

14 July 2006

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American Journal of Physiology Heart and Circulatory Physiology

14 August 2017

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14 August 2017

291

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14 August 2017

6

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14 August 2017

H2557-69

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Intrasteric control of AMPK via the gamma1 subunit AMP allosteric regulatory site

14 August 2017

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.00329.2006

beta-Agonist stimulation produces changes in cardiac AMPK and coronary lumen LPL only during increased workload

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.00329.2006

Transgenic mice overexpressing mutant PRKAG2 define the cause of Wolff-Parkinson-White syndrome in glycogen storage cardiomyopathy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.00329.2006

Malonyl-CoA metabolism in cardiac myocytes and its relevance to the control of fatty acid oxidation

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.00329.2006

Activation of the tumour suppressor kinase LKB1 by the STE20-like pseudokinase STRAD

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.00329.2006

Dual mechanisms regulating AMPK kinase action in the ischemic heart.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.00329.2006

The stimulation of heart glycolysis by increased workload does not require AMP-activated protein kinase but a wortmannin-sensitive mechanism.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.00329.2006

AMPK activation restores the stimulation of glucose uptake in an in vitro model of insulin-resistant cardiomyocytes via the activation of protein kinase B.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.00329.2006

Mutations in the gamma(2) subunit of AMP-activated protein kinase cause familial hypertrophic cardiomyopathy: evidence for the central role of energy compromise in disease pathogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.00329.2006

AMP-activated protein kinase suppresses protein synthesis in rat skeletal muscle through down-regulated mammalian target of rapamycin (mTOR) signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.00329.2006

MO25alpha/beta interact with STRADalpha/beta enhancing their ability to bind, activate and localize LKB1 in the cytoplasm

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.00329.2006

Stimulation of the AMP-activated protein kinase leads to activation of eukaryotic elongation factor 2 kinase and to its phosphorylation at a novel site, serine 398

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.00329.2006

Purification and characterization of the AMP-activated protein kinase. Copurification of acetyl-CoA carboxylase kinase and 3-hydroxy-3-methylglutaryl-CoA reductase kinase activities

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.00329.2006

Activation of AMP-activated protein kinase inhibits protein synthesis associated with hypertrophy in the cardiac myocyte

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.00329.2006

Expression of the AMP-activated protein kinase beta1 and beta2 subunits in skeletal muscle

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.00329.2006

Characterization of AMP-activated protein kinase gamma-subunit isoforms and their role in AMP binding

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.00329.2006

Covalent activation of heart AMP-activated protein kinase in response to physiological concentrations of long-chain fatty acids

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.00329.2006

Metformin counters the insulin-induced suppression of fatty acid oxidation and stimulation of triacylglycerol storage in rodent skeletal muscle

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.00329.2006

Identification and characterization of a small molecule AMPK activator that treats key components of type 2 diabetes and the metabolic syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.00329.2006

Physiological role of AMP-activated protein kinase in the heart: graded activation during exercise

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.00329.2006

Functional domains of the alpha1 catalytic subunit of the AMP-activated protein kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.00329.2006

Functional analysis of mutations in the gamma 2 subunit of AMP-activated protein kinase associated with cardiac hypertrophy and Wolff-Parkinson-White syndrome.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.00329.2006

Characterization of the role of gamma2 R531G mutation in AMP-activated protein kinase in cardiac hypertrophy and Wolff-Parkinson-White syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.00329.2006

Purification of the AMP-activated protein kinase on ATP-gamma-sepharose and analysis of its subunit structure.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.00329.2006

5'-AMP inhibits dephosphorylation, as well as promoting phosphorylation, of the AMP-activated protein kinase. Studies using bacterially expressed human protein phosphatase-2C alpha and native bovine protein phosphatase-2AC.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.00329.2006

Regulation of 5'-AMP-activated protein kinase activity by the noncatalytic beta and gamma subunits

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.00329.2006

AMPK alterations in cardiac physiology and pathology: enemy or ally?

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.00329.2006

Activation of rat liver cytosolic 3-hydroxy-3-methylglutaryl coenzyme A reductase kinase by adenosine 5'-monophosphate.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.00329.2006

The Anti-diabetic drugs rosiglitazone and metformin stimulate AMP-activated protein kinase through distinct signaling pathways.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.00329.2006

Non-catalytic beta- and gamma-subunit isoforms of the 5'-AMP-activated protein kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.00329.2006

Glycogen storage disease as a unifying mechanism of disease in the PRKAG2 cardiac syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.00329.2006

Identification of a gene responsible for familial Wolff-Parkinson-White syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.00329.2006

Emerging role of AMP-activated protein kinase in coupling membrane transport to cellular metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.00329.2006

Regulation of glycogen synthase by glucose and glycogen: a possible role for AMP-activated protein kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.00329.2006

Complexes between the LKB1 tumor suppressor, STRAD alpha/beta and MO25 alpha/beta are upstream kinases in the AMP-activated protein kinase cascade

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.00329.2006

Characterization of the AMP-activated protein kinase kinase from rat liver and identification of threonine 172 as the major site at which it phosphorylates AMP-activated protein kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.00329.2006

Calmodulin-dependent protein kinase kinase-beta is an alternative upstream kinase for AMP-activated protein kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.00329.2006

A serine/threonine kinase gene defective in Peutz-Jeghers syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.00329.2006

Free fatty acid metabolism during myocardial ischemia and reperfusion

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.00329.2006

21 January 2018

Protons and anaerobiosis

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.00329.2006

Activation of yeast Snf1 and mammalian AMP-activated protein kinase by upstream kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.00329.2006

Myocardial ischemia and increased heart work modulate the phosphorylation state of eukaryotic elongation factor-2

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.00329.2006

Insulin antagonizes ischemia-induced Thr172 phosphorylation of AMP-activated protein kinase alpha-subunits in heart via hierarchical phosphorylation of Ser485/491.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.00329.2006

A novel domain in AMP-activated protein kinase causes glycogen storage bodies similar to those seen in hereditary cardiac arrhythmias.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.00329.2006

The Ca2+/calmodulin-dependent protein kinase kinases are AMP-activated protein kinase kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.00329.2006

TSC2 mediates cellular energy response to control cell growth and survival

21 January 2018

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https://api.crossref.org/works/10.1152%2FAJPHEART.00329.2006

AMP-activated protein kinase beta subunit tethers alpha and gamma subunits via its C-terminal sequence (186-270)

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.00329.2006

Knockout of the alpha2 but not alpha1 5'-AMP-activated protein kinase isoform abolishes 5-aminoimidazole-4-carboxamide-1-beta-4-ribofuranosidebut not contraction-induced glucose uptake in skeletal muscle.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.00329.2006

AMP-activated protein kinase: ancient energy gauge provides clues to modern understanding of metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.00329.2006

Regulation of pyruvate dehydrogenase in rat heart. Mechanism of regulation of proportions of dephosphorylated and phosphorylated enzyme by oxidation of fatty acids and ketone bodies and of effects of diabetes: role of coenzyme A, acetyl-coenzyme A a

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.00329.2006

Glucagon represses signaling through the mammalian target of rapamycin in rat liver by activating AMP-activated protein kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.00329.2006

Akt activity negatively regulates phosphorylation of AMP-activated protein kinase in the heart

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.00329.2006

Control of p70 ribosomal protein S6 kinase and acetyl-CoA carboxylase by AMP-activated protein kinase and protein phosphatases in isolated hepatocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.00329.2006

Fatty acid translocase/CD36 deficiency does not energetically or functionally compromise hearts before or after ischemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.00329.2006

Characterization of 5'AMP-activated protein kinase activity in the heart and its role in inhibiting acetyl-CoA carboxylase during reperfusion following ischemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.00329.2006

Free fatty acids during acute myocardial infarction

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.00329.2006

Molecular cloning, genomic organization, and mapping of PRKAG2, a heart abundant gamma2 subunit of 5'-AMP-activated protein kinase, to human chromosome 7q36

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.00329.2006

Gene regulatory mechanisms governing energy metabolism during cardiac hypertrophic growth

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.00329.2006

Exogenous nitric oxide reduces glucose transporters translocation and lactate production in ischemic myocardium in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.00329.2006

The molecular basis of skeletal muscle atrophy

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.00329.2006

AMP-activated protein kinase activates p38 mitogen-activated protein kinase by increasing recruitment of p38 MAPK to TAB1 in the ischemic heart

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.00329.2006

Constitutively active adenosine monophosphate-activated protein kinase regulates voltage-gated sodium channels in ventricular myocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.00329.2006

Regulation of myocardial fatty acid oxidation by substrate supply

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.00329.2006

5-Aminoimidazole-4-carboxamide 1-beta -D-ribofuranoside (AICAR) stimulates myocardial glycogenolysis by allosteric mechanisms

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.00329.2006

Regulation of fatty acid oxidation in the mammalian heart in health and disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.00329.2006

Plasma fatty acid levels in infants and adults after myocardial ischemia.

21 January 2018

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https://api.crossref.org/works/10.1152%2FAJPHEART.00329.2006

Energy substrate utilization by isolated working hearts from newborn rabbits

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.00329.2006

Contraction-Induced Fatty Acid Translocase/CD36 Translocation in Rat Cardiac Myocytes Is Mediated Through AMP-Activated Protein Kinase Signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.00329.2006

Familial Hypertrophic cardiomyopathy with Wolff-Parkinson-White syndrome maps to a locus on chromosome 7q3

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.00329.2006

Phosphorylation and activation of heart PFK-2 by AMPK has a role in the stimulation of glycolysis during ischaemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.00329.2006

Leptin stimulates fatty-acid oxidation by activating AMP-activated protein kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.00329.2006

A role for AMP-activated protein kinase in contraction- and hypoxia-regulated glucose transport in skeletal muscle

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.00329.2006

PI3K rescues the detrimental effects of chronic Akt activation in the heart during ischemia/reperfusion injury

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.00329.2006

Mechanisms for increased glycolysis in the hypertrophied rat heart

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.00329.2006

Effects of glucose and fatty acids on myocardial ischaemia and arrhythmias

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.00329.2006

Adenosine 5'-monophosphate-activated protein kinase and p38 mitogen-activated protein kinase participate in the stimulation of glucose uptake by dinitrophenol in adult cardiomyocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.00329.2006

Dual regulation of the AMP-activated protein kinase provides a novel mechanism for the control of creatine kinase in skeletal muscle.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.00329.2006

AMP-activated protein kinase mediates ischemic glucose uptake and prevents postischemic cardiac dysfunction, apoptosis, and injury

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.00329.2006

Deficiency of LKB1 in heart prevents ischemia-mediated activation of AMPKalpha2 but not AMPKalpha1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.00329.2006

Glycogen debranching enzyme association with beta-subunit regulates AMP-activated protein kinase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.00329.2006

Estradiol-mediated endothelial nitric oxide synthase association with heat shock protein 90 requires adenosine monophosphate-dependent protein kinase.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.00329.2006

CBS domains form energy-sensing modules whose binding of adenosine ligands is disrupted by disease mutations

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.00329.2006

Adiponectin-mediated modulation of hypertrophic signals in the heart

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.00329.2006

Adiponectin protects against myocardial ischemia-reperfusion injury through AMPK- and COX-2-dependent mechanisms

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.00329.2006

Disruption of coordinated cardiac hypertrophy and angiogenesis contributes to the transition to heart failure

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.00329.2006

Transgenic mouse model of ventricular preexcitation and atrioventricular reentrant tachycardia induced by an AMP-activated protein kinase loss-of-function mutation responsible for Wolff-Parkinson-White syndrome.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.00329.2006

Mammalian AMP-activated protein kinase subfamily

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.00329.2006

Elm1p is one of three upstream kinases for the Saccharomyces cerevisiae SNF1 complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.00329.2006

Linking gene expression to function: metabolic flexibility in the normal and diseased heart

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.00329.2006

Utilization of energy-providing substrates in the isolated working rat heart

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.00329.2006

Effects of low-intensity prolonged exercise on PGC-1 mRNA expression in rat epitrochlearis muscle

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.00329.2006

Identification of a novel AMP-activated protein kinase beta subunit isoform that is highly expressed in skeletal muscle

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.00329.2006

Increased adenosine monophosphate-activated protein kinase activity in rat hearts with pressure-overload hypertrophy

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.00329.2006

Contraction-induced changes in acetyl-CoA carboxylase and 5'-AMP-activated kinase in skeletal muscle

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.00329.2006

Induced adiposity and adipocyte hypertrophy in mice lacking the AMP-activated protein kinase-alpha2 subunit

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.00329.2006

The AMP-activated protein kinase alpha2 catalytic subunit controls whole-body insulin sensitivity

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.00329.2006

Fatty acids stimulate AMP-activated protein kinase and enhance fatty acid oxidation in L6 myotubes

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.00329.2006

Inactivation of acetyl-CoA carboxylase and activation of AMP-activated protein kinase in muscle during exercise

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.00329.2006

Glycogen-dependent effects of 5-aminoimidazole-4-carboxamide (AICA)-riboside on AMP-activated protein kinase and glycogen synthase activities in rat skeletal muscle

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.00329.2006

Ca2+/calmodulin-dependent protein kinase kinase-beta acts upstream of AMP-activated protein kinase in mammalian cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.00329.2006

Identification of phosphorylation sites in AMP-activated protein kinase (AMPK) for upstream AMPK kinases and study of their roles by site-directed mutagenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.00329.2006

Glucose metabolism and energy homeostasis in mouse hearts overexpressing dominant negative alpha2 subunit of AMP-activated protein kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.00329.2006

Adiponectin stimulates glucose utilization and fatty-acid oxidation by activating AMP-activated protein kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.00329.2006

Insulin and contraction stimulate exocytosis, but increased AMP-activated protein kinase activity resulting from oxidative metabolism stress slows endocytosis of GLUT4 in cardiomyocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.00329.2006

Long-term metformin treatment stimulates cardiomyocyte glucose transport through an AMP-activated protein kinase-dependent reduction in GLUT4 endocytosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.00329.2006

Cloning and characterization of mouse 5′-AMP-activated protein kinase γ3 subunit

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.00329.2006

AMP kinase is required for mitochondrial biogenesis in skeletal muscle in response to chronic energy deprivation

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.00329.2006

N488I mutation of the gamma2-subunit results in bidirectional changes in AMP-activated protein kinase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.00329.2006

Translocation of myocardial GLUT-4 and increased glucose uptake through activation of AMPK by AICAR.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.00329.2006

10.1152/AJPHEART.00329.2006

21 January 2018

Identifiers

DOI

1 reference

14 August 2017

1 reference

PubMed ID

16844922