Current views on the fundamental mechanisms of cytochrome P450 allosterism (Q36543108)

14 August 2017

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title

Current views on the fundamental mechanisms of cytochrome P450 allosterism (English)

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14 August 2017

William M Atkins

1

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PubMed ID

16859405

14 August 2017

language of work or name

English

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publication date

1 August 2006

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Expert Opinion on Drug Metabolism & Toxicology

14 August 2017

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14 August 2017

2

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14 August 2017

4

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14 August 2017

573-579

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Polymorphic variants (CYP2C9*3 and CYP2C9*5) and the F114L active site mutation of CYP2C9: effect on atypical kinetic metabolism profiles

14 August 2017

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.4.573

Atypical Enzyme Kinetics: Their Effect on In Vitro-In Vivo Pharmacokinetic Predictions and Drug Interactions

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.4.573

Non-Michaelis-Menten kinetics in cytochrome P450-catalyzed reactions

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.4.573

Modelling atypical CYP3A4 kinetics: principles and pragmatism

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.4.573

Modeling kinetic data from in vitro drug metabolism enzyme experiments

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.4.573

Allosteric phenomena in cytochrome P450-catalyzed monooxygenations

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.4.573

Heterotropic cooperativity of cytochrome P450 3A4 and potential drug-drug interactions

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.4.573

Predictive models of CYP3A4 Heteroactivation: in vitro-in vivo scaling and pharmacophore modeling

21 January 2018

1 reference

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In vivo CYP3A4 heteroactivation is a possible mechanism for the drug interaction between felbamate and carbamazepine

21 January 2018

1 reference

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Minimal in vivo activation of CYP2C9-mediated flurbiprofen metabolism by dapsone

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.4.573

Multisite kinetic analysis of interactions between prototypical CYP3A4 subgroup substrates: midazolam, testosterone, and nifedipine

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.4.573

Kinetic analysis for multiple substrate interaction at the active site of cytochrome P450.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.4.573

Catalytic turnover of pyrene by CYP3A4: evidence that cytochrome b5 directly induces positive cooperativity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.4.573

Role of cytochrome B5 in modulating peroxide-supported cyp3a4 activity: evidence for a conformational transition and cytochrome P450 heterogeneity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.4.573

Resolution of multiple substrate binding sites in cytochrome P450 3A4: the stoichiometry of the enzyme-substrate complexes probed by FRET and Job's titration

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.4.573

Resolution of two substrate-binding sites in an engineered cytochrome P450eryF bearing a fluorescent probe

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.4.573

Kinetics and thermodynamics of ligand binding by cytochrome P450 3A4.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.4.573

Crystal structures of human cytochrome P450 3A4 bound to metyrapone and progesterone

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.4.573

The structure of human microsomal cytochrome P450 3A4 determined by X-ray crystallography to 2.05-A resolution

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.4.573

Crystal structure of human cytochrome P450 2C9 with bound warfarin

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.4.573

Cooperative binding of midazolam with testosterone and alpha-naphthoflavone within the CYP3A4 active site: a NMR T1 paramagnetic relaxation study

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.4.573

Effector-mediated alteration of substrate orientation in cytochrome P450 2C9.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.4.573

NMR studies of ligand binding to P450(eryF) provides insight into the mechanism of cooperativity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.4.573

Surface plasmon resonance analysis of antifungal azoles binding to CYP3A4 with kinetic resolution of multiple binding orientations

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.4.573

Structure of microsomal cytochrome P450 2B4 complexed with the antifungal drug bifonazole: insight into P450 conformational plasticity and membrane interaction.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.4.573

The thermodynamic landscape of testosterone binding to cytochrome P450 3A4: ligand binding and spin state equilibria

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.4.573

"Allosterism" in the elementary steps of the cytochrome P450 reaction cycle

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.4.573

Allosteric mechanisms in P450eryF probed with 1-pyrenebutanol, a novel fluorescent substrate

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.4.573

Conformational heterogeneity of cytochrome P450 3A4 revealed by high pressure spectroscopy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.4.573

CO binding kinetics of human cytochrome P450 3A4. Specific interaction of substrates with kinetically distinguishable conformers.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.4.573

Structure of mammalian cytochrome P450 2B4 complexed with 4-(4-chlorophenyl)imidazole at 1.9-A resolution: insight into the range of P450 conformations and the coordination of redox partner binding

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.4.573

Observation of ligand binding to cytochrome P450 BM-3 by means of solid-state NMR spectroscopy

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.4.573

Homotropic cooperativity of monomeric cytochrome P450 3A4 in a nanoscale native bilayer environment

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.4.573

Kinetics of dithionite-dependent reduction of cytochrome P450 3A4: heterogeneity of the enzyme caused by its oligomerization.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.4.573

Directed self-assembly of monodisperse phospholipid bilayer Nanodiscs with controlled size

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.4.573

Single-molecule height measurements on microsomal cytochrome P450 in nanometer-scale phospholipid bilayer disks

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.4.573

Activation of cytochrome P450 2C9-mediated metabolism: mechanistic evidence in support of kinetic observations

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.4.573

21 January 2018

Identifiers

DOI

10.1517/17425255.2.4.573

1 reference

14 August 2017

1 reference

PubMed ID

16859405