Proinsulin intermolecular interactions during secretory trafficking in pancreatic β cells (Q36543789)

14 August 2017

Proinsulin intermolecular interactions during secretory trafficking in pancreatic β cells (English)

1 reference

14 August 2017

2

Erik Snapp

1 reference

14 August 2017

Jordan Wright

3

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Michael B. Wheeler

object named as

Michael B Wheeler

6

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author name string

Leena Haataja

1

1 reference

14 August 2017

Ming Liu

4

1 reference

14 August 2017

Alexandre B Hardy

5

1 reference

14 August 2017

Michele L Markwardt

7

1 reference

14 August 2017

Mark Rizzo

8

1 reference

14 August 2017

Peter Arvan

9

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14 August 2017

language of work or name

English

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publication date

6 December 2012

1 reference

Journal of Biological Chemistry

14 August 2017

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14 August 2017

288

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14 August 2017

1896-1906

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14 August 2017

3

1 reference

describes a project that uses

14 August 2017

ImageJ

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC3548498/fullTextXML

inferred from PubMed Central ID database lookup

cites work

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Action of protein disulfide isomerase on proinsulin exit from endoplasmic reticulum of pancreatic β-cells

30 September 2017

1 reference

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In vivo misfolding of proinsulin below the threshold of frank diabetes.

30 September 2017

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Endoplasmic reticulum oxidoreductin-1-like β (ERO1lβ) regulates susceptibility to endoplasmic reticulum stress and is induced by insulin flux in β-cells

30 September 2017

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Superfolder GFP is fluorescent in oxidizing environments when targeted via the Sec translocon

30 September 2017

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Mutant INS-gene induced diabetes of youth: proinsulin cysteine residues impose dominant-negative inhibition on wild-type proinsulin transport

30 September 2017

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Proinsulin misfolding and diabetes: mutant INS gene-induced diabetes of youth

30 September 2017

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PERK (EIF2AK3) regulates proinsulin trafficking and quality control in the secretory pathway

30 September 2017

1 reference

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ERO1-beta, a pancreas-specific disulfide oxidase, promotes insulin biogenesis and glucose homeostasis

30 September 2017

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Insulin gene mutations resulting in early-onset diabetes: marked differences in clinical presentation, metabolic status, and pathogenic effect through endoplasmic reticulum retention

30 September 2017

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In vitro processing and secretion of mutant insulin proteins that cause permanent neonatal diabetes

30 September 2017

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Misfolded proinsulin affects bystander proinsulin in neonatal diabetes

30 September 2017

1 reference

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Insulin storage and glucose homeostasis in mice null for the granule zinc transporter ZnT8 and studies of the type 2 diabetes-associated variants

30 September 2017

1 reference

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FRET by fluorescence polarization microscopy

30 September 2017

1 reference

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Proinsulin maturation, misfolding, and proteotoxicity

30 September 2017

1 reference

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In vivo expression and functional characterization of the zinc transporter ZnT8 in glucose-induced insulin secretion

30 September 2017

1 reference

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Monitoring chaperone engagement of substrates in the endoplasmic reticulum of live cells

30 September 2017

1 reference

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Lumenal protein sorting to the constitutive secretory pathway of a regulated secretory cell

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3548498

Engineering and characterization of a superfolder green fluorescent protein

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3548498

Control of mRNA translation preserves endoplasmic reticulum function in beta cells and maintains glucose homeostasis

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3548498

High-contrast imaging of fluorescent protein FRET by fluorescence polarization microscopy

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3548498

Identification and cloning of a beta-cell-specific zinc transporter, ZnT-8, localized into insulin secretory granules

30 September 2017

1 reference

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Aggregation and lack of secretion of most newly synthesized proinsulin in non-beta-cell lines

30 September 2017

1 reference

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An improved cyan fluorescent protein variant useful for FRET

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3548498

Imaging molecular interactions in cells by dynamic and static fluorescence anisotropy (rFLIM and emFRET).

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3548498

Severe block in processing of proinsulin to insulin accompanied by elevation of des-64,65 proinsulin intermediates in islets of mice lacking prohormone convertase 1/3.

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3548498

A variant of yellow fluorescent protein with fast and efficient maturation for cell-biological applications

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3548498

Oligomerization of green fluorescent protein in the secretory pathway of endocrine cells

30 September 2017

1 reference

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Isolation of INS-1-derived cell lines with robust ATP-sensitive K+ channel-dependent and -independent glucose-stimulated insulin secretion

30 September 2017

1 reference

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The role of assembly in insulin's biosynthesis

30 September 2017

1 reference

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Differential sorting of lysosomal enzymes out of the regulated secretory pathway in pancreatic beta-cells

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3548498

The vesicle docking protein p115 binds GM130, a cis-Golgi matrix protein, in a mitotically regulated manner

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3548498

Distinct molecular mechanisms for protein sorting within immature secretory granules of pancreatic beta-cells

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3548498

Electron microscopic immunocytochemical evidence for the involvement of the convertases PC1 and PC2 in the processing of proinsulin in pancreatic beta-cells

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3548498

(Pro)insulin associates with Golgi membranes of pancreatic B cells

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3548498

The Effects of Fasting and Feeding on Preproinsulin Messenger RNA in Rats

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3548498

Direct identification of prohormone conversion site in insulin-secreting cells

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3548498

Conversion of proinsulin to insulin occurs coordinately with acidification of maturing secretory vesicles

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3548498

Transport of secretory and membrane glycoproteins from the rough endoplasmic reticulum to the Golgi. A rate-limiting step in protein maturation and secretion.

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3548498

Regulation of protein export from the endoplasmic reticulum

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3548498

Protein oligomerization in the endoplasmic reticulum

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3548498

Control of protein exit from the endoplasmic reticulum

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3548498

Transport and assembly processes in the endoplasmic reticulum

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3548498

Protein targeting via the "constitutive-like" secretory pathway in isolated pancreatic islets: passive sorting in the immature granule compartment

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3548498

A 13-amino acid n-terminal domain of a basic proline-rich protein is necessary for storage in secretory granules and facilitates exit from the endoplasmic reticulum

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3548498

Establishment of 2-mercaptoethanol-dependent differentiated insulin-secreting cell lines

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3548498

Intracellular transport of proinsulin in pancreatic beta-cells. Structural maturation probed by disulfide accessibility

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3548498

Beta cell-specific Znt8 deletion in mice causes marked defects in insulin processing, crystallisation and secretion.

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3548498

Optimization of pairings and detection conditions for measurement of FRET between cyan and yellow fluorescent proteins.

21 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3548498

Imaging secretory vesicles by fluorescent protein insertion in propeptide rather than mature secreted peptide

21 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3548498

Human type 2 diabetes: morphological evidence for abnormal beta-cell function

21 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3548498

Studies on the molecular organization of rat insulin secretory granules.

21 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3548498

Physical studies on proinsulin — Association behavior and conformation in solution

21 September 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/23223446

12 December 2020

inferred from PubMed ID database lookup

Interaction of zing with proinsulin

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/23223446

12 December 2020

inferred from PubMed ID database lookup

Localization of proinsulin and insulin in human insulinoma: preliminary immunohistochemical results

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/23223446

12 December 2020

inferred from PubMed ID database lookup

Identifiers

DOI

10.1074/JBC.M112.420018

1 reference

14 August 2017

1 reference

14 August 2017

1 reference