Use of in vitro transporter assays to understand hepatic and renal disposition of new drug candidates (Q36544962)

14 August 2017

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title

Use of in vitro transporter assays to understand hepatic and renal disposition of new drug candidates (English)

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14 August 2017

Jasminder Sahi

1

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14 August 2017

language of work or name

English

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publication date

1 October 2005

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Expert Opinion on Drug Metabolism & Toxicology

14 August 2017

published in

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14 August 2017

volume

1

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14 August 2017

issue

3

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14 August 2017

page(s)

409-427

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Role of transport proteins in drug absorption, distribution and excretion

14 August 2017

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Interactions between cyclosporin and lipid-lowering drugs: implications for organ transplant recipients

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Role of organic cation transporters in drug absorption and elimination

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Evaluation of drug-drug interaction in the hepatobiliary and renal transport of drugs

21 January 2018

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ADMET in silico modelling: towards prediction paradise?

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Factors associated with the initiation of alpha-interferon treatment in Medicaid patients diagnosed with hepatitis C.

21 January 2018

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Synthesis and evaluation of S-acyl-2-thioethyl esters of modified nucleoside 5'-monophosphates as inhibitors of hepatitis C virus RNA replication.

21 January 2018

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Effects of statin therapy on the progression of carotid atherosclerosis: a systematic review and meta-analysis

21 January 2018

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High plasma pravastatin concentrations are associated with single nucleotide polymorphisms and haplotypes of organic anion transporting polypeptide-C (OATP-C, SLCO1B1)

21 January 2018

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The effect of gemfibrozil on the pharmacokinetics of rosuvastatin

21 January 2018

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Role of kidney-specific organic anion transporters in the urinary excretion of methotrexate

21 January 2018

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A novel human hepatic organic anion transporting polypeptide (OATP2). Identification of a liver-specific human organic anion transporting polypeptide and identification of rat and human hydroxymethylglutaryl-CoA reductase inhibitor transporters

21 January 2018

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Quantitative evaluation of the drug-drug interactions between methotrexate and nonsteroidal anti-inflammatory drugs in the renal uptake process based on the contribution of organic anion transporters and reduced folate carrier

21 January 2018

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The effects of fruit juices on drug disposition: a new model for drug interactions

21 January 2018

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Gemfibrozil increases plasma pravastatin concentrations and reduces pravastatin renal clearance

21 January 2018

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Plasma concentrations of active lovastatin acid are markedly increased by gemfibrozil but not by bezafibrate

21 January 2018

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Gemfibrozil greatly increases plasma concentrations of cerivastatin

21 January 2018

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https://api.crossref.org/works/10.1517%2F17425255.1.3.409

Renal handling of captopril: effect of probenecid

21 January 2018

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https://api.crossref.org/works/10.1517%2F17425255.1.3.409

Cellular and molecular aspects of drug transport in the kidney

21 January 2018

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https://api.crossref.org/works/10.1517%2F17425255.1.3.409

Interaction between methotrexate and ciprofloxacin

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.3.409

Multiple interactions of cimetidine and probenecid with valaciclovir and its metabolite acyclovir

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.3.409

Mechanisms and clinical implications of renal drug excretion

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.3.409

Characterization of methotrexate transport and its drug interactions with human organic anion transporters

21 January 2018

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https://api.crossref.org/works/10.1517%2F17425255.1.3.409

Evaluation of hepatotoxic potential of drugs by inhibition of bile-acid transport in cultured primary human hepatocytes and intact rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.3.409

Inhibition of transporter-mediated hepatic uptake as a mechanism for drug-drug interaction between cerivastatin and cyclosporin A.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.3.409

Mechanism of the pharmacokinetic interaction between methotrexate and benzimidazoles: potential role for breast cancer resistance protein in clinical drug-drug interactions

21 January 2018

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Drug- and estrogen-induced cholestasis through inhibition of the hepatocellular bile salt export pump (Bsep) of rat liver

21 January 2018

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https://api.crossref.org/works/10.1517%2F17425255.1.3.409

Potential cholestatic activity of various therapeutic agents assessed by bile canalicular membrane vesicles isolated from rats and humans

21 January 2018

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https://api.crossref.org/works/10.1517%2F17425255.1.3.409

Inhibition of human organic anion transporting polypeptide OATP 1B1 as a mechanism of drug-induced hyperbilirubinemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.3.409

Involvement of rat organic anion transporter 3 (rOAT3) in cephaloridine-induced nephrotoxicity: in comparison with rOAT1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.3.409

Interaction of human and rat organic anion transporter 2 with various cephalosporin antibiotics.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.3.409

Nephrotoxicity of platinum complexes is related to basolateral organic cation transport

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.3.409

The complexities of hepatic drug transport: current knowledge and emerging concepts.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.3.409

The molecular pharmacology of organic anion transporters: from DNA to FDA?

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.3.409

Organic anion and cation transporters occur in pairs of similar and similarly expressed genes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.3.409

Identification and functional assessment of the novel murine organic anion transporter Oat5 (Slc22a19) expressed in kidney

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.3.409

Organic anion-transporting polypeptide B (OATP-B) and its functional comparison with three other OATPs of human liver

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.3.409

Fruit juices inhibit organic anion transporting polypeptide-mediated drug uptake to decrease the oral availability of fexofenadine

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.3.409

Involvement of organic anion transporting polypeptides in the transport of troglitazone sulfate: implications for understanding troglitazone hepatotoxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.3.409

Molecular cloning, chromosomal localization, and functional characterization of a human liver Na+/bile acid cotransporter

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.3.409

Identification of thyroid hormone transporters.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.3.409

Substrate specificity of sinusoidal bile acid and organic anion uptake systems in rat and human liver

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.3.409

Expression and regulation of hepatic drug and bile acid transporters

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.3.409

Structure-activity relationship studies of propafenone analogs based on P-glycoprotein ATPase activity measurements.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.3.409

Multidrug resistance3 is in situ detected in the liver of patients with primary biliary cirrhosis, and induced in human hepatoma cells by bezafibrate.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.3.409

Unexpected mexiletine responses of a mutant cardiac Na+ channel implicate the selectivity filter as a structural determinant of antiarrhythmic drug access

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.3.409

Excretion of GSSG and glutathione conjugates mediated by MRP1 and cMOAT/MRP2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.3.409

Mutational analysis of ABCG2: role of the GXXXG motif

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.3.409

ABCG2 transports sulfated conjugates of steroids and xenobiotics

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.3.409

Multidrug transporter ABCG2 prevents tumor cell death induced by the epidermal growth factor receptor inhibitor Iressa (ZD1839, Gefitinib).

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.3.409

Enterohepatic circulation: physiological, pharmacokinetic and clinical implications

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.3.409

The bile salt export pump: molecular properties, function and regulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.3.409

Glutathione stimulates sulfated estrogen transport by multidrug resistance protein 1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.3.409

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.3.409

Disrupted bile acid homeostasis reveals an unexpected interaction among nuclear hormone receptors, transporters, and cytochrome P450.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.3.409

Characterization of the transport properties of human multidrug resistance protein 7 (MRP7, ABCC10)

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.3.409

Transport of bile acids, sulfated steroids, estradiol 17-beta-D-glucuronide, and leukotriene C4 by human multidrug resistance protein 8 (ABCC11)

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.3.409

MRP8, ATP-binding cassette C11 (ABCC11), is a cyclic nucleotide efflux pump and a resistance factor for fluoropyrimidines 2',3'-dideoxycytidine and 9'-(2'-phosphonylmethoxyethyl)adenine

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.3.409

Renal interaction between itraconazole and cimetidine

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.3.409

Impaired tubular excretory function as a late renal side effect of chemotherapy in children

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.3.409

Isolation and characterization of a digoxin transporter and its rat homologue expressed in the kidney

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.3.409

Mucosal uptake of gabapentin (neurontin) vs. pregabalin in the small intestine

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.3.409

Transport of amino acid-related compounds mediated by L-type amino acid transporter 1 (LAT1): insights into the mechanisms of substrate recognition

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.3.409

A high-throughput assay for measurement of multidrug resistance protein-mediated transport of leukotriene C4 into membrane vesicles

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.3.409

Single amino acid (482) variants of the ABCG2 multidrug transporter: major differences in transport capacity and substrate recognition

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.3.409

Transport of ethinylestradiol glucuronide and ethinylestradiol sulfate by the multidrug resistance proteins MRP1, MRP2, and MRP3.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.3.409

Vectorial transport of the peptide CCK-8 by double-transfected MDCKII cells stably expressing the organic anion transporter OATP1B3 (OATP8) and the export pump ABCC2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.3.409

High-efficiency expression and characterization of the synaptic-vesicle monoamine transporter from baculovirus-infected insect cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.3.409

Contribution of multidrug resistance protein 2 (MRP2/ABCC2) to the renal excretion of p-aminohippurate (PAH) and identification of MRP4 (ABCC4) as a novel PAH transporter.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.3.409

Arsenic transport by the human multidrug resistance protein 1 (MRP1/ABCC1). Evidence that a tri-glutathione conjugate is required

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.3.409

Mechanisms of impaired biliary excretion of acetaminophen glucuronide after acute phenobarbital treatment or phenobarbital pretreatment

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.3.409

The human multidrug-resistance-associated protein MRP1 mediates ATP-dependent transport of unconjugated bilirubin

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.3.409

Mrp2 is involved in benzylpenicillin-induced choleresis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.3.409

Genipin enhances Mrp2 (Abcc2)-mediated bile formation and organic anion transport in rat liver

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.3.409

Glucuronidation as a mechanism of intrinsic drug resistance in colon cancer cells: contribution of drug transport proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.3.409

Interplay between MRP inhibition and metabolism of MRP inhibitors: the case of curcumin.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.3.409

Predicting P-glycoprotein effects on oral absorption: correlation of transport in Caco-2 with drug pharmacokinetics in wild-type and mdr1a(-/-) mice in vivo.

21 January 2018

1 reference

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Functional induction and de-induction of P-glycoprotein by St. John's wort and its ingredients in a human colon adenocarcinoma cell line.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.3.409

Alteration in copy numbers of genes as a mechanism for acquired drug resistance

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.3.409

Modulation of P-glycoprotein function and reversal of multidrug resistance by (-)-epigallocatechin gallate in human cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.3.409

Mediation of highly concentrative uptake of pregabalin by L-type amino acid transport in Chinese hamster ovary and Caco-2 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.3.409

Functional characterization of coding polymorphisms in the human MDR1 gene using a vaccinia virus expression system.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.3.409

A natural vaccinia virus promoter with exceptional capacity to direct protein synthesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.3.409

Microarray transfection analysis of transcriptional regulation by cAMP-dependent protein kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.3.409

Recombinant vaccinia viruses. Design, generation, and isolation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.3.409

Genetically engineered poxviruses for recombinant gene expression, vaccination, and safety

21 January 2018

1 reference

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A tribute to the Xenopus laevis oocyte and egg.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.3.409

Poliovirus escape from RNA interference: short interfering RNA-target recognition and implications for therapeutic approaches

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.3.409

Membrane transporters and channels: role of the transportome in cancer chemosensitivity and chemoresistance

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.3.409

The dopamine precursor L-dihydroxyphenylalanine is transported by the amino acid transporters rBAT and LAT2 in renal cortex

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.3.409

Identification of HAX-1 as a protein that binds bile salt export protein and regulates its abundance in the apical membrane of Madin-Darby canine kidney cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.3.409

Induction of the cholesterol transporter ABCA1 in central nervous system cells by liver X receptor agonists increases secreted Abeta levels

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.3.409

Transport of anthelmintic benzimidazole drugs by breast cancer resistance protein (BCRP/ABCG2).

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.3.409

Function of uptake transporters for taurocholate and estradiol 17beta-D-glucuronide in cryopreserved human hepatocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.3.409

Vectorial transport of bile salts across MDCK cells expressing both rat Na+-taurocholate cotransporting polypeptide and rat bile salt export pump

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.3.409

Characterization of multidrug resistance-associated protein 2 in the hepatocellular disposition of 4-hydroxynonenal

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.3.409

Inhibitors of mdr1-dependent transport activity delay accumulation of the mdr1 substrate rhodamine 123 in primary rat hepatocyte cultures.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.3.409

P-glycoprotein expression, localization, and function in sandwich-cultured primary rat and human hepatocytes: relevance to the hepatobiliary disposition of a model opioid peptide.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.3.409

Coordinate regulation of UDP-glucuronosyltransferase UGT1A6 induction by 3-methylcholanthrene and multidrug resistance protein MRP2 expression by dexamethasone in primary rat hepatocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.3.409

Hepatobiliary function and toxicity in vitro using isolated hepatocyte couplets

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.3.409

Impaired localisation and transport function of canalicular Bsep in taurolithocholate induced cholestasis in the rat.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.3.409

Hepatic sequestration and modulation of the canalicular transport of the organic cation, daunorubicin, in the Rat.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.3.409

Depolarization of the liver cell membrane by metformin

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.3.409

The applicability of rat and human liver slices to the study of mechanisms of hepatic drug uptake.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.3.409

Ex vivo stimulation of renal tubular p-aminohippurate transport by dexamethasone and triiodothyronine in human renal cell carcinoma.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.3.409

Ex vivo stimulation of renal transport of the cytostatic drugs methotrexate, cisplatin, topotecan (Hycamtin) and raltitrexed (Tomudex) by dexamethasone, T3 and EGF in intact human and rat kidney tissue and in human renal cell carcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.3.409

The nephrotoxicity, cytotoxicity and renal handling of a cisplatin-methionine complex in male Wistar rats.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.3.409

Characterization of drug transport, ATP hydrolysis, and nucleotide trapping by the human ABCG2 multidrug transporter. Modulation of substrate specificity by a point mutation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.3.409

Functional detection of MDR1/P170 and MRP/P190-mediated multidrug resistance in tumour cells by flow cytometry

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.3.409

Drug efflux transport properties of 2',7'-bis(2-carboxyethyl)-5(6)-carboxyfluorescein acetoxymethyl ester (BCECF-AM) and its fluorescent free acid, BCECF.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.3.409

Fluorescence-based assay for the interaction of small molecules with the human renal organic anion transporter 1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.3.409

A fluorescent hPept1 transporter substrate for uptake screening

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.3.409

Online fluorescent method to assess BCRP/ABCG2 activity in suspension cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.3.409

A continuous fluorescence assay for the study of P-glycoprotein-mediated drug efflux using inside-out membrane vesicles.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.3.409

Functional multidrug resistance protein (MRP1) lacking the N-terminal transmembrane domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.3.409

Purification of the human apical conjugate export pump MRP2 reconstitution and functional characterization as substrate-stimulated ATPase

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.3.409

Interaction of the P-glycoprotein multidrug transporter (MDR1) with high affinity peptide chemosensitizers in isolated membranes, reconstituted systems, and intact cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.3.409

A high-throughput screening microplate test for the interaction of drugs with P-glycoprotein

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.3.409

Structure-pharmacokinetics relationship of quaternary ammonium compounds. Correlation of physicochemical and pharmacokinetic parameters.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.3.409

Factors influencing rates and clearance in P450-mediated reactions: QSARs for substrates of the xenobiotic-metabolizing hepatic microsomal P450s.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.3.409

Comparative effects of thiazolidinediones on in vitro P450 enzyme induction and inhibition

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.3.409

Effect of troglitazone on cytochrome P450 enzymes in primary cultures of human and rat hepatocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.3.409

Bosentan, a new endothelin receptor antagonist: prediction of the systemic plasma clearance in man from combined in vivo and in vitro data

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.3.409

Insight into hepatotoxicity: The troglitazone experience

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.3.409

The endothelin antagonist bosentan inhibits the canalicular bile salt export pump: a potential mechanism for hepatic adverse reactions

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.3.409

Glyburide-induced hepatitis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.3.409

Novel cyclopropyl beta-amino acid analogues of pregabalin and gabapentin that target the alpha2-delta protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.3.409

The conduct of in vitro and in vivo drug-drug interaction studies: a Pharmaceutical Research and Manufacturers of America (PhRMA) perspective

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.3.409

NMDA receptor antagonists to characterize rat renal organic cation transporter function

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.3.409

Transporter-Enzyme Interactions: Implications for Predicting Drug-Drug Interactions from In Vitro Data

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.3.409

Unmasking the dynamic interplay between efflux transporters and metabolic enzymes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.3.409

Impact of drug transporter studies on drug discovery and development

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.3.409

Drug-drug interactions for UDP-glucuronosyltransferase substrates: a pharmacokinetic explanation for typically observed low exposure (AUCi/AUC) ratios

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.3.409

Evaluation of pharmacokinetic interactions after oral administration of mycophenolate mofetil and valaciclovir or aciclovir to healthy subjects

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.3.409

Fexofenadine does not affect omeprazole pharmacokinetics: both are putative P-glycoprotein substrates

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.3.409

Different effects of three transporting inhibitors, verapamil, cimetidine, and probenecid, on fexofenadine pharmacokinetics

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.3.409

Neither cimetidine nor probenecid affect the pharmacokinetics of tenoxicam in normal volunteers

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.3.409

Effect of ketoprofen and its enantiomers on the renal disposition of methotrexate in the isolated perfused rat kidney.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.3.409

Characterization of pentamidine excretion in the isolated perfused rat kidney

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.3.409

Isolated rat kidney perfused with dextran and bovine serum albumin: a stable model for investigating renal drug handling

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.3.409

The impact of P-glycoprotein on the disposition of drugs targeted for indications of the central nervous system: evaluation using the MDR1A/1B knockout mouse model

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.3.409

Multidrug resistance protein 1 protects the choroid plexus epithelium and contributes to the blood-cerebrospinal fluid barrier

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.3.409

Involvement of multidrug resistance associated protein 1 (Mrp1) in the efflux transport of 17beta estradiol-D-17beta-glucuronide (E217betaG) across the blood-brain barrier

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.3.409

Role of breast cancer resistance protein (Bcrp1/Abcg2) in the extrusion of glucuronide and sulfate conjugates from enterocytes to intestinal lumen

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.3.409

Pharmacological and physiological functions of the polyspecific organic cation transporters: OCT1, 2, and 3 (SLC22A1-3).

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.3.409

Targeted disruption of the peptide transporter Pept2 gene in mice defines its physiological role in the kidney

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.3.409

Genomic interval engineering of mice identifies a novel modulator of triglyceride production

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.3.409

Regulation of renal amino acid (AA) transport by hormones, drugs and xenobiotics - a review

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.3.409

Organic cation transporters in intestine, kidney, liver, and brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.3.409

Reconstitution into liposomes and functional characterization of the carnitine transporter from renal cell plasma membrane

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.3.409

Drug interactions and hepatitis produced by some macrolide antibiotics

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.3.409

21 January 2018

Identifiers

DOI

10.1517/17425255.1.3.409

1 reference

14 August 2017

1 reference