Pharmacodynamic markers and clinical results from the phase 2 study of the SMAC mimetic birinapant in women with relapsed platinum-resistant or -refractory epithelial ovarian cancer (Q36547383)

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scientific article published on 13 November 2015

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English	Pharmacodynamic markers and clinical results from the phase 2 study of the SMAC mimetic birinapant in women with relapsed platinum-resistant or -refractory epithelial ovarian cancer	scientific article published on 13 November 2015

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scholarly article

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Europe PubMed Central

14 August 2017

Pharmacodynamic markers and clinical results from the phase 2 study of the SMAC mimetic birinapant in women with relapsed platinum-resistant or -refractory epithelial ovarian cancer (English)

1 reference

Europe PubMed Central

14 August 2017

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based on heuristic

inferred from title

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based on heuristic

inferred from title

pharmacodynamics

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based on heuristic

inferred from title

1

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7 June 2020

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Kristen P Bunch

2

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7 June 2020

Jin-Qiu Chen

3

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7 June 2020

Michelle A Herrmann

4

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7 June 2020

Jung-Min Lee

5

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7 June 2020

Elise C Kohn

6

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7 June 2020

Ciara C O'Sullivan

7

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7 June 2020

Elizabeth Jordan

8

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7 June 2020

Nicole Houston

9

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7 June 2020

Naoko Takebe

10

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7 June 2020

Robert J Kinders

11

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7 June 2020

Liang Cao

12

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7 June 2020

Cody J Peer

13

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7 June 2020

W Douglas Figg

14

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7 June 2020

Christina M Annunziata

15

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7 June 2020

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publication date

13 November 2015

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14 August 2017

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7 June 2020

122

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7 June 2020

4

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7 June 2020

588-597

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7 June 2020

Safety, pharmacokinetics, and pharmacodynamic properties of oral DEBIO1143 (AT-406) in patients with advanced cancer: results of a first-in-man study.

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Smac mimetics as IAP antagonists

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30 September 2017

Combination effects of SMAC mimetic birinapant with TNFα, TRAIL, and docetaxel in preclinical models of HNSCC.

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Synergistic effects of IAP inhibitor LCL161 and paclitaxel on hepatocellular carcinoma cells

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30 September 2017

Birinapant (TL32711), a bivalent SMAC mimetic, targets TRAF2-associated cIAPs, abrogates TNF-induced NF-κB activation, and is active in patient-derived xenograft models

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30 September 2017

Distinct expression and localization of TNF system in ovarian carcinoma tissues: possible involvement of TNF-α in morphological changes of ovarian cancerous cells

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Single-agent Smac-mimetic compounds induce apoptosis in B chronic lymphocytic leukaemia (B-CLL)

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The novel SMAC mimetic birinapant exhibits potent activity against human melanoma cells

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Activation of NF-kappaB signaling by inhibitor of NF-kappaB kinase beta increases aggressiveness of ovarian cancer

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30 September 2017

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30 September 2017

Design of small-molecule peptidic and nonpeptidic Smac mimetics

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30 September 2017

c-IAP1 and c-IAP2 are critical mediators of tumor necrosis factor alpha (TNFalpha)-induced NF-kappaB activation

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cIAP1 and cIAP2 facilitate cancer cell survival by functioning as E3 ligases that promote RIP1 ubiquitination

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30 September 2017

Design, synthesis, and characterization of a potent, nonpeptide, cell-permeable, bivalent Smac mimetic that concurrently targets both the BIR2 and BIR3 domains in XIAP

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30 September 2017

Dysfunctional apoptosome activation in ovarian cancer: implications for chemoresistance

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30 September 2017

Structural basis of IAP recognition by Smac/DIABLO

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30 September 2017

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IAP family proteins--suppressors of apoptosis

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Antitumor activity of a novel homodimeric SMAC mimetic in ovarian carcinoma.

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10.1002/CNCR.29783

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7 June 2020

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7 June 2020

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